A5100638980- Polysaccharides and Plant Cell Walls
- Seaweed-derived Bioactive Compounds
- Animal Nutrition and Physiology
- Immune Response and Inflammation
- Herpesvirus Infections and Treatments
- Fungal Biology and Applications
- NF-κB Signaling Pathways
- Plant biochemistry and biosynthesis
- Photosynthetic Processes and Mechanisms
- Ginseng Biological Effects and Applications
- Essential Oils and Antimicrobial Activity
- Polysaccharides Composition and Applications
- interferon and immune responses
- Plant Gene Expression Analysis
- Minerals Flotation and Separation Techniques
- Natural product bioactivities and synthesis
- Virus-based gene therapy research
- Antibiotic Resistance in Bacteria
- Cancer-related molecular mechanisms research
- Antimicrobial Resistance in Staphylococcus
- Parkinson's Disease Mechanisms and Treatments
- Healthcare and Venom Research
- Acupuncture Treatment Research Studies
- Plant Molecular Biology Research
- Microbial Metabolites in Food Biotechnology
Sichuan Agricultural University
2016-2025
Yantai University
2005-2025
Shanghai Jiao Tong University
2021-2025
XinHua Hospital
2014-2025
Shanxi Agricultural University
2022-2025
Guangdong Medical College
2010-2025
Foshan University
2019-2025
University of South China
2025
Shanghai Hospital Development Center
2025
Mineral Resources
2025
Phosphorylation sites on proteins in the phosphatidylinositol 3-kinase pathway that are regulated by candidate drugs can serve as useful biomarkers to predict tumor sensitivity AKT inhibitors.
Sensory functions of primary cilia rely on ciliary-localized membrane proteins, but little is known about how these receptors are targeted to the cilium. To further our understanding this process, we dissected ciliary targeting sequence (CTS) fibrocystin, human autosomal recessive polycystic kidney disease gene product. We show that fibrocystin CTS an 18-residue motif localized in cytoplasmic tail. This sufficient target green fluorescent protein (GFP) ciliated cells and targets GFP lipid...
Changes in membrane lipid composition play important roles plant adaptation to and survival after freezing. Plant response cold freezing involves three distinct phases: acclimation, freezing, post-freezing recovery. Considerable progress has been made toward understanding changes during acclimation but little is known about alteration We previously showed that phospholipase D (PLD) involved hydrolysis Arabidopsis thaliana tolerance. This study was undertaken determine how species change...
Stem rot caused by Sclerotinia sclerotiorum in many important dicotyledonous crops, including oilseed rape (Brassica napus), is one of the most devastating fungal diseases and imposes huge yield loss each year worldwide. Currently, breeding for resistance B. napus, as other can only rely on germplasms with quantitative genes. Thus, identification trait locus (QTL) S. resistance/tolerance this crop holds immediate promise genetic improvement disease resistance. In study, ten QTLs stem (SR) at...
Endothelial basement membranes constitute barriers to extravasating leukocytes during inflammation, a process where laminin isoforms define sites of leukocyte exit; however, how this occurs is poorly understood. In addition direct effect on transmigration, we show that 511 affects endothelial barrier function by stabilizing VE-cadherin at junctions and downregulating expression CD99L2, correlating with reduced neutrophil extravasation. Binding cells 511, but not 411 or non-endothelial 111,...
The aim of the present study was to analyze expression matrix metalloproteinase 9 (MMP9) in nasopharyngeal carcinoma (NPC) and its correlation with clinicopathologic features, including survival patients NPC.Using real-time PCR, we detected mRNA MMP9 normal tissues tissues. Using immunohistochemistry analysis, analyzed protein clinicopathologically characterized 164 NPC cases (116 male 48 female) age ranging from 17 80 years (median = 48.4 years) 32 Cases greater than or equal 6 less score...
Constipation is one of the most frequent non-motor symptoms Parkinson disease (PD) and it may be ignored by PD patients, leading to this problem not reported in time. The relationships between constipation demographic variables, motor other are still unknown. patients were evaluated diagnostic criteria functional Rome III divided into with (PD-C) no (PD-NC) groups. assessed rating scales symptoms, activity daily living quality life. frequency was 61.4%, 24.5% had before onset symptoms. PD-C...
Resveratrol (RSV) is a natural compound exhibiting anti-inflammatory effect, but the mechanism has not been fully understood. This study aimed to evaluate activity and of RSV in lipopolysaccharides-induced rats' model. The visceral wet/dry weight ratios changes hematologic biochemical indices indicated that LPS- stimulation mainly caused damages liver lung, while pretreatment with could alleviate lesions. cytokine assays showed markedly decrease production proinflammatory mediators cytokines...
Based on previous studies about microflora regulation and immunity enhancement activities of polysaccharides from Codonopsis pilosula Nannf. var. modesta (Nannf.) L. T. Shen (CPP), there is little study intestinal mucosal immunity, which a possible medium for contacting immunity. In the present study, BALB/c mice were divided into five groups (eight in each group), including normal group (Con), model control (Model), that administered CPP (50, 100, 200 mg/kg/d) orally day seven days after...
Glycerolipids are the principal constituent of cellular membranes; remodelling glycerolipids plays important roles in temperature adaptation plants. Temperate plants can endure freezing stress, but even chilling at above-zero temperatures induce death tropical species. However, little is known about differences glycerolipid response to low between chilling-sensitive and freezing-tolerant Using ESI-MS/MS-based lipidomic analysis, we compared glycerolipidome (4 10 °C)-treated rice with that...
The ICK/KRP cyclin-dependent kinase (CDK) inhibitors are important plant cell cycle factors sharing only limited similarity with the metazoan CIP/KIP family of CDK inhibitors. Little is known about specific functions different genes in planta. In this study, we created double and multiple mutants from five single Arabidopsis T-DNA mutants, used a set 20 lines for functional investigation gene family. There were gradual increases activity to indicating that ICK/KRPs act as under normal...
Gambogic acid (GA), a natural product with xanthone structure, was previously demonstrated to exert anti-inflammatory effects. The aim of this study evaluate the activity GA on LPS-stimulated mouse macrophage RAW264.7 and its mechanism. Pretreatment inhibited LPS-induced production nitric oxide (NO) prostaglandin E2 (PGE2) through reducing expressions inducible synthase (iNOS) cyclooxygenase-2 (COX-2). also decreased pro-inflammatory cytokines, including TNF-α, IL-6 IL-1β. activation nuclear...