A5102891932- Research in Cotton Cultivation
- Plant Molecular Biology Research
- Fibroblast Growth Factor Research
- Prenatal Screening and Diagnostics
- Plant and Fungal Interactions Research
- Plant Virus Research Studies
- Connexins and lens biology
- Neurological Disease Mechanisms and Treatments
- Wnt/β-catenin signaling in development and cancer
- Neuroinflammation and Neurodegeneration Mechanisms
- Plant Gene Expression Analysis
- Neuroscience and Neuropharmacology Research
- Nitrogen and Sulfur Effects on Brassica
- Connective tissue disorders research
- Genomic variations and chromosomal abnormalities
- Plant Stress Responses and Tolerance
- Hematopoietic Stem Cell Transplantation
- Photosynthetic Processes and Mechanisms
- Plant Reproductive Biology
- Cancer, Hypoxia, and Metabolism
- Mitochondrial Function and Pathology
- Congenital Anomalies and Fetal Surgery
- Chromosomal and Genetic Variations
- Fetal and Pediatric Neurological Disorders
- Effects of Radiation Exposure
Zhengzhou University
2006-2025
Chinese Academy of Agricultural Sciences
2017-2025
Cotton Research Institute
2020-2025
Columbia University
2018-2025
Sichuan University of Arts and Science
2024
Sanya University
2024
Affiliated Hospital of Youjiang Medical University for Nationalities
2022-2023
Nanjing Agricultural University
2022-2023
Indiana University – Purdue University Indianapolis
2013-2023
Indiana University School of Medicine
2013-2023
Plants experience diverse abiotic stresses, encompassing low or high temperature, drought, water logging and salinity. The challenge of maintaining worldwide crop cultivation food sustenance becomes particularly serious due to drought salinity stress. Sustainable agriculture has significant promise with the use nano-biotechnology. Nanoparticles (NPs) have evolved into remarkable assets improve agricultural productivity under robust climate alteration increasing stress severity. Drought...
Elevated salinity significantly threatens cotton growth, particularly during the germination and seedling stages. The utilization of primitive species Gossypium hirsutum, specifically purpurascens, has potential to facilitate restoration genetic diversity that been depleted due selective breeding in modern cultivars. This investigation evaluated 45 G. purpurascens varieties a salt-tolerant variety based on 34 morphological, physiological, biochemical indicators comprehensive salt tolerance...
Fibroblast growth factor (FGF) signaling elicits multiple downstream pathways, most notably the Ras/MAPK cascade facilitated by adaptor protein Grb2. However, mechanism which Grb2 is recruited to FGF complex remains unresolved. Here we showed that genetic ablation of prevented lens induction disrupting transcriptional regulation and actin cytoskeletal arrangements, could be reproduced deleting juxtamembrane region receptor rescued Kras activation. Conversely, mutations affecting Frs2-binding...
Specific cell shapes are fundamental to the organization and function of multicellular organisms. Fibroblast Growth Factor (FGF) signaling induces elongation lens fiber cells during vertebrate development. Nonetheless, exactly how this extracellular FGF signal is transmitted cytoskeletal network has previously not been determined. Here, we show that Crk family adaptor proteins, Crkl, required for mouse morphogenesis but differentiation. Genetic ablation epistasis experiments demonstrated...
As changes occur in climate, abiotic stress to agricultural production is an inevitable threat farmers' ability meet increasing demand feed people. Plants have developed a tolerance mechanism reduce the effects of such environmental conditions by engaging various stress-responsive genes. Accordingly, signal transduction networks are used fabricate tolerance. Engineering phytohormone abscisic acid (ABA) could be choice method for scientists mitigate because its widespread role response salt,...
Cotton production is adversely effected by drought stress. It exposed to stress at various critical growth stages grown under a water scarcity environment. Roots are the sensors of plants; they detect osmotic and play an important role in plant tolerance mechanisms. The seedling stage very sensitive stress, it needed explore methods characteristics that contribute cotton.Initially, seedlings 18 genotypes from three Gossypium species: G. hirsutum, barbadense, arboreum, were evaluated for...
FGF signaling plays a pivotal role in eye development. Previous studies using vitro chick models and systemic zebrafish mutants have suggested that is required for the patterning specification of optic vesicle, but due to lack genetic models, its mammalian retinal development remains elusive. In this study, we show specific deletion Fgfr1 Fgfr2 vesicle disrupts ERK signaling, which results disc nerve dysgenesis and, ultimately, ocular coloboma. Defective does not abrogate Shh or BMP nor it...
The apetalous genotype is a morphological ideotype for increasing seed yield and should be of considerable agricultural use; however, only few studies have focused on the genetic control this trait in Brassica napus. In present study, recombinant inbred line, AH population, containing 189 individuals was derived from cross between an line 'APL01' normally petalled variety 'Holly'. 60 K Infinium BeadChip Array harboring 52,157 single nucleotide polymorphism (SNP) markers used to individuals....
Plant architecture is vital not only for crop yield, but also field management, such as mechanical harvesting. The branch angle one of the key factors determining plant architecture. With aim revealing genetic control underlying in rapeseed (Brassica napus L.), positional variation angles on individual plants was evaluated, and increased with elevation position. Furthermore, three middle branches were selected to measure because they exhibited most representative phenotypic values. An...
SUMMARY During the domestication and improvement processes, interspecific introgression from Gossypium hirsutum has reorganized genomic architecture of barbadense ; however, details trait‐related genetic loci remain largely unknown. Here, we perform a genome‐wide population analysis genetically recategorize 365 G. accessions into four subgroups which is different previous categorizations. A total 315 events to , primarily contributed divergence agronomic trait variation in are identified. We...
Neuronal differentiation is tightly regulated by a variety of factors. In search for neuron-specific genes, we identified highly conserved novel zinc finger protein, ZNF536. We observed that ZNF536 most abundant in the brain and, particular, expressed developing central nervous system and dorsal root ganglia localized cerebral cortex, hippocampus, hypothalamic area. During neuronal P19 cells induced retinoic acid (RA), expression increased at an early stage, it maintained constant level...
How multiple receptor tyrosine kinases coordinate cell fate determination is yet to be elucidated. We show here that the for platelet-derived growth factor (PDGF) signaling recruits p85 subunit of Phosphoinositide 3-kinase (PI3K) regulate mammalian lens development. Activation PI3K not only prevents B-cell lymphoma 2 (BCL2)-Associated X (Bax)- and BCL2 Antagonist/Killer (Bak)-mediated apoptosis but also promotes Notch prevent premature differentiation. Reducing activity destabilizes...
Endothelial cells (ECs) are components of the hematopoietic microenvironment and regulate stem progenitor cell (HSPC) homeostasis. Cytokine treatments that cause HSPC trafficking to peripheral blood associated with an increase in dipeptidylpeptidase 4/CD26 (DPP4/CD26), enzyme truncates neurotransmitter neuropeptide Y (NPY). Here, we show enzymatically altered NPY signaling ECs caused reduced VE-cadherin CD31 expression along EC junctions, resulting increased vascular permeability egress....
Abstract Gossypium purpurascens is a member of the Malvaceae family, holds immense economic significance as fiber crop worldwide. Abiotic stresses harm cotton crops, reduce yields, and cause losses. Generating high-quality reference genomes large-scale transcriptomic datasets across diverse conditions can offer valuable insights into identifying preferred agronomic traits for breeding. The present research used leaf tissues to conduct PacBio Iso-seq RNA-seq analysis. We carried out an...
FGF signaling requires a plethora of adaptor proteins to elicit downstream responses, but the functional significances these docking remain controversial. In this study, we used lens development as model investigate Frs2α and its structurally related scaffolding protein Gab1 Gab2 in signaling. We show that genetic ablation alone has modest effect, additional deletion tyrosine phosphatase Shp2 causes complete arrest vesicle development. Biochemical evidence suggests Frs2α-Shp2 synergy...
Ionizing radiation exposure results in acute and delayed bone marrow suppression. Treatment of mice with 16,16-dimethyl prostaglandin E2 (dmPGE2) prior to lethal ionizing (IR) facilitates survival, but the cellular molecular mechanisms are unclear. In this study we show that dmPGE2 attenuates loss enhances recovery cellularity, corresponding a less severe hematopoietic stem cell nadir, significantly preserves long-term repopulation capacity progenitor function. Mechanistically, suppressed...
Metformin is a first-line anti-diabetic agent with powerful hypoglycemic effect. Several studies have reported that metformin can improve the prognosis of stroke patients and this effect independent its effect; however, specific mechanism remains unclear. In research, we explored in cerebral ischemia-reperfusion (I/R) injury by constructing transient middle artery occlusion model vivo glucose oxygen deprivation/reoxygenation (OGD/R) vitro. The results experiments showed acute treatment...
Brown cotton fiber (BCF) is a unique raw material of naturally colored (NCC). But characteristics the regulatory gene network and metabolic components related to proanthocyanidins biosynthesis pathway at various stages its development remain unclear. Here, dynamic changes in transcripts BCF variety "Zong 1-61" white near-isogenic lines (NILs) "RT" were characterized five developmental (0, 5, 10, 15, 20 days post-anthesis; DPA). Enrichment analysis differentially expressed genes (DEGs),...
Aflatoxin is the most common type of mycotoxins in contaminated corn, peanuts and rice, which affects livestock ultimately endangers human health. reported to have carcinogenicity, mutation, growth retardation, immunosuppression reproductive toxicity. In present study we causes for declined porcine oocyte quality under aflatoxin exposure. We set up an vitro exposure model showed that B1 disturbed cumulus cell expansion polar body extrusion. found disrupted ER distribution elevated expression...