A5100371277- Plant Molecular Biology Research
- Ubiquitin and proteasome pathways
- Plant Stress Responses and Tolerance
- Photosynthetic Processes and Mechanisms
- Plant tissue culture and regeneration
- Plant Reproductive Biology
- Cancer-related Molecular Pathways
- Plant nutrient uptake and metabolism
- Animal Disease Management and Epidemiology
- Microtubule and mitosis dynamics
- Aquaculture disease management and microbiota
- RNA modifications and cancer
- DNA Repair Mechanisms
- Cancer-related molecular mechanisms research
- Autophagy in Disease and Therapy
- Plant Genetic and Mutation Studies
- Insect-Plant Interactions and Control
- Algal biology and biofuel production
- Genomics and Chromatin Dynamics
- Insect and Pesticide Research
- Seed Germination and Physiology
- Chromosomal and Genetic Variations
- Vector-Borne Animal Diseases
- Aluminum toxicity and tolerance in plants and animals
- Invertebrate Immune Response Mechanisms
Beijing University of Technology
2025
University of Saskatchewan
2014-2025
Global Institute for Water Security
2025
Sun Yat-sen University
2005-2024
Northeast Agricultural University
2023-2024
Xinjiang University
2024
Huazhong Agricultural University
2019-2022
Chinese Academy of Medical Sciences & Peking Union Medical College
2018-2022
Southern Marine Science and Engineering Guangdong Laboratory (Guangzhou)
2022
Xinjiang Agricultural University
2022
The ICK/KRP cyclin-dependent kinase (CDK) inhibitors are important plant cell cycle factors sharing only limited similarity with the metazoan CIP/KIP family of CDK inhibitors. Little is known about specific functions different genes in planta. In this study, we created double and multiple mutants from five single Arabidopsis T-DNA mutants, used a set 20 lines for functional investigation gene family. There were gradual increases activity to indicating that ICK/KRPs act as under normal...
In most plants, the female germline starts with differentiation of one megaspore mother cell (MMC) in each ovule that produces four megaspores through meiosis, which survives to become functional (FM). The FM further develops into an embryo sac. Little is known regarding control MMC formation per and selective survival FM. ICK/KRPs (interactor/inhibitor cyclin-dependent kinase (CDK)/Kip-related proteins) are plant CDK inhibitors cycle regulators. Here we report ovules Arabidopsis mutant all...
Summary Unlike conventional lysine (K) 48–linked polyubiquitination, K63‐linked polyubiquitination plays signaling roles in yeast and animals. Thus far, UBC 13 is the only known ubiquitin‐conjugating enzyme (E2) specialized polyubiquitination. Previous identification of Arabidopsis genes encoding as well its interacting partner UEV 1 indicates that 13‐mediated ubiquitination pathway conserved plants; however, little about functions mediated through plants. To address plants, we created ubc13...
Calmodulin-binding transcription activators (CAMTAs) are well-characterized calmodulin-binding factors in the plant kingdom. Previous work shows that CAMTAs play important roles various biological processes including disease resistance, herbivore attack response and abiotic stress tolerance. However, studies address function of during establishment symbiosis between legumes rhizobia still lacking. This study undertook comprehensive identification analysis CAMTA genes using latest updated M....
Soil salinity is a growing concern for global crop production and the sustainable development of humanity. Therefore, it crucial to comprehend salt tolerance mechanisms identify salt-tolerance genes enhance stress. Suaeda glauca, halophyte species well adapted seawater environment, possesses unique ability absorb retain high concentrations within its cells, particularly in leaves, suggesting presence distinct mechanism tolerance. In this study, we performed de novo sequencing S. glauca...
Protein ubiquitination is critical for numerous processes in eukaryotes. The ubiquitin-conjugating enzyme (E2) required ubiquitination. Arabidopsis genome has approximately 37 E2 genes, but vivo functions most of them remain unknown. In this study we observed that knockout mutants UBC22 had much-reduced silique length and seed number, with nearly 90% ovules aborted. Analyses revealed the majority mutant embryo sacs displayed severe defects often contained no gamete nuclei. There was...
The actin cytoskeleton regulates an array of diverse cellular activities that support the establishment plant-microbe interactions and plays a critical role in execution plant immunity. However, molecular mechanisms regulating assembly rearrangement filaments (AFs) at plant-pathogen interaction sites remain largely elusive. Here, using live-cell imaging, we show one earliest responses Arabidopsis thaliana upon powdery mildew attack is formation patch-like AF structures beneath fungal...
Expression of key transcription factors can induce transdifferentiation in somatic cells; however, this conversion is usually incomplete due to undefined intrinsic barriers. Here, we employ MyoD-induced fibroblasts as a model illustrate the chromatin structures that impede cell-fate transition. Focusing on three-dimensional (3D) interactions, show MyoD directly establishes loops activate myogenic transcriptional program. Similarly, dynamic changes CTCF-mediated interactions are favorable for...
The incidence of pancreatic cancer is increasing annually in Asia as a whole. Pancreatic ranks sixth terms all malignant tumors. Circular RNA (circRNA) type non-coding which forms covalently closed continuous loop. CircRNA extensively expressed the cytoplasm, and markedly conservative stable. MicroRNA (miR)-378a-3p human (hsa)_circ_0006215 were detected using reverse transcription-quantitative polymerase chain reaction (RT-qPCR) tissue cells. Western blot analysis SERPINA4 hsa_circ_0006215...
The auxin response factor (ARF) transcription factors are a key component in signaling and play diverse functions plant growth, development, stress response. ARFs regulated at the transcript level posttranslationally by protein modifications. However, relatively little is known regarding control of ARF levels. We expressed five different with an HA (hemagglutinin) tag observed that their levels under same promoter varied considerably. Interestingly, were affected several hormonal...
Skeletal muscle myogenesis is a sophisticated process controlled by genetic and epigenetic regulators. In animals, one of the key enzymes for DNA demethylation 5-methylcytosine TET2. Although TET2 essential development, mechanisms which regulates myogenesis, particularly implication stem cells, remains unclear. present study, we employed knockout mouse model to investigate function in development regeneration. We observed that deficiency caused impaired cell proliferation differentiation,...
The ICK/KRP cyclin-dependent kinase (CDK) inhibitors are important plant cell cycle regulators sharing only limited similarity with the metazoan CIP/KIP family of CDK inhibitors. Information is still regarding specific functions different genes in planta. We have shown previously that down-regulation multiple inhibitor up-regulates E2F pathway and increases proliferation, organ seed sizes Arabidopsis. In this study, we observed quintuple ick1/2/5/6/7 mutant had more cells cortical layer root...
How plant seeds age remains poorly understood and effective tools for monitoring seed aging are lacking. Dry contain various stored mRNAs which believed to be required protein synthesis during early stages of germination. We reasoned that would undergo degradation aging, based on the propensity degrade. performed RT-PCR qPCR analyses study changes in mRNA levels Arabidopsis aging. All analyzed were gradually degraded both naturally artificially aged seeds. The difference Ct values between...
<title>Abstract</title> Combined methylmalonic acidemia and homocystinemia (cblC) is an autosomal recessive disorder characterized by aberrant organic acid metabolism. The c.80A > G mutation in the <italic>MMACHC</italic> gene has been documented numerous studies linked to cblC phenotypes. However, this mutation's pathogenic mechanisms remain elusive, as it not yet validated through functional studies. In a previous study, we developed murine model with Mmachc elucidate intricacies of...
Tertiary structure-based RNA design plays a crucial role in synthetic biology and therapeutics. While existing methods have explored structure-to-sequence mappings, they focus solely on structures overlook the of complex-level information, which is for effective design. To address this limitation, we propose Complex-Aware tertiary Design model, CARD, that integrates information to enhance sequence be specific, our method incorporates protein features extracted by language model (e.g.,...
<title>Abstract</title> Combined methylmalonic acidemia and homocystinemia (cblC) is an autosomal recessive disorder characterized by aberrant organic acid metabolism. The c.80A > G mutation in the <italic>MMACHC</italic> gene has been documented numerous studies linked to cblC phenotypes. However, this mutation's pathogenic mechanisms remain elusive, as it not yet validated through functional studies. In a previous study, we developed murine model with Mmachc elucidate intricacies of...
The HKT protein family plays a vital role in plant responses to salt stress by mediating sodium (Na + ) and potassium (K transport maintaining Na -K balance. Ipomoea pes-caprae ( IPC ), pantropical creeping distributed along coastal regions tropical subtropical zones, exhibits exceptional tolerance. Understanding its tolerance mechanisms provides valuable insights for developing salt-tolerant crops identifying candidate genes genetic engineering. In this study, we identified two genes,...
Water use efficiency is an important target for breeding of improved drought resistance. Minimizing leaf transpirational water loss plays a key role in But this reduces CO2 levels leaves, which often photosynthetic and yield. Signaling pathways play roles stress responses, identifying the molecular, biochemical, physiological determinants underlying signaling may offer new mitigating strategies. To explore these possibilities, because importance stomata response photosynthesis, we employed...
Forsythia suspensa is a traditional Chinese medicine and commonly used landscaping plant. Its dried fruit in for its functions of clearing heat, removing toxins, reducing swelling, dissipating masses, dispersing wind heat. It possesses extremely high medicinal economic value. However, the genetic differentiation diversity wild populations remain unclear. In this study, chloroplast genome sequences were obtained from 15 individuals F. using high-throughput sequencing technology. The sequence...