A5100423970- Cancer Immunotherapy and Biomarkers
- Immunotherapy and Immune Responses
- Lung Cancer Treatments and Mutations
- Immune Cell Function and Interaction
- Inflammatory Bowel Disease
- Ferroptosis and cancer prognosis
- CAR-T cell therapy research
- Inflammasome and immune disorders
- Lung Cancer Research Studies
- Immune Response and Inflammation
- Immune cells in cancer
- Pharmacological Effects of Natural Compounds
- Cancer Cells and Metastasis
- Drug-Induced Hepatotoxicity and Protection
- IL-33, ST2, and ILC Pathways
- Cancer Genomics and Diagnostics
- Hepatocellular Carcinoma Treatment and Prognosis
- MicroRNA in disease regulation
- T-cell and B-cell Immunology
- Hip and Femur Fractures
- RNA modifications and cancer
- Pancreatic and Hepatic Oncology Research
- Polysaccharides and Plant Cell Walls
- Hemostasis and retained surgical items
- Curcumin's Biomedical Applications
Fujian Agriculture and Forestry University
2025
China Academy of Chinese Medical Sciences
2025
Jiangxi University of Traditional Chinese Medicine
2025
Chinese Academy of Medical Sciences & Peking Union Medical College
2012-2025
Peking University
2021-2024
BeiGene (China)
2024
Air Force Medical University
2022-2024
First Affiliated Hospital of Bengbu Medical College
2024
Harbin Medical University
2012-2023
Second Affiliated Hospital of Harbin Medical University
2012-2023
Inhibitors of programmed cell death 1 (PD-1) administered as single agents have resulted in durable tumor regression advanced cancer patients. However, only a minority patients respond to anti-PD-1 immunotherapy. Here, we show that PD-1 expression hepatocellular carcinoma promotes growth independently adaptive immunity. Knockdown suppresses growth, whereas overexpression enhances tumorigenesis immunodeficient xenografted mice. Mechanistically, binds the downstream mammalian target rapamycin...
Glucocorticoids (GCs) show powerful treatment effect on rheumatoid arthritis (RA). However, the clinical application is limited by their nonspecific distribution after systemic administration, serious adverse reactions during long-term administration. To achieve better treatment, reduce side effect, we here established a biomimetic exosome (Exo) encapsulating dexamethasone sodium phosphate (Dex) nanoparticle (Exo/Dex), whose surface was modified with folic acid (FA)-polyethylene glycol...
Melatonin is a hormone produced by the pineal gland, and it has extensive beneficial effects on various tissue organs; however, whether melatonin any effect cardiac fibrosis in pathogenesis of diabetic cardiomyopathy (DCM) still unknown. Herein, we found that administration significantly ameliorated dysfunction reduced collagen production inhibiting TGF-β1/Smads signaling NLRP3 inflammasome activation, as manifested downregulating expression TGF-β1, p-Smad2, p-Smad3, NLRP3, ASC, cleaved...
Tumor-associated tertiary lymphoid structures (TLS) play a critical role in the progression of various tumors. However, dynamics lymphocyte recruitment during hepatocellular carcinoma (HCC) clinical have not been fully elucidated. In present study, tissue microarrays and hematoxylin-eosin staining were used to evaluate existence degree TLS HCC patients. Nine immune biomarkers intratumoral tissues examined by immunohistochemical staining. A total 462 patients recruited for study. Kaplan-Meier...
Antibiotics-induceds changes in intestinal flora (dysbiosis) may have various effects on the host. Dysbiosis is associated with numerous metabolites including bile acids, which are produced liver from cholesterol and metabolized gut by microbiota. Total phenolic extracts of Citrus aurantium L. (TPE-CA) rich dietary flavanones their glycosyl derivatives, flavones, flavonols, polymethoxyflavones coumarins, exert positive health The aim this study to elucidate interplays between microbiota...
In this study, we investigated the physicochemical properties and composition of monosaccharidex from Polygonatum sibiricum. Simultaneously, explored in vivo vitro immunomodulatory activity mechanism sibiricum polysaccharide (PSP) by monitoring changes immune organs, cells, cytokines. The average molecular weight (Mw) PSP was 9.514 × 104 Da. monosaccharide components were galactose, rhamnose, arabinose, mannose, glucose at a molar ratio 11.72 : 1.78 4.15 1.00 2.48. increased thymus spleen...
Diabetes mellitus (DM) patients are at a higher risk of developing brain injury characterized by neuronal death. Melatonin, hormone produced the pineal gland, exerts neuroprotective effects against damage. However, effect melatonin on diabetes-induced has not been elucidated. This study was to evaluate role death in DM and elucidate underlying mechanisms. Herein, we found that administration significantly alleviated both streptozotocin (STZ)-induced diabetic mice high glucose (HG)-treated...
Diabetes mellitus (DM) is considered as a risk factor for cognitive dysfunction. Harmine not only effective in improving DM, but also provides neuroprotective effect central never system diseases. However, whether harmine has any on diabetes-induced dysfunction and the underlying mechanisms remain still unknown. In this study, learning memory ability rat were detected by Morris water maze. The changes of nucleotide-binding oligomerization domain-containing protein (NOD)-like receptor family,...
Antitumor T lymphocytes play an essential part in immune surveillance of cancer cells. Cytotoxic lymphocyte-associated Protein 4 (CTLA-4) is a negative regulator cell activation and proliferation therefore influences carcinogenesis pancreas. Thus, this study examined the association between functional CTLA-4 49G-to-A (49G>A) single-nucleotide polymorphism pancreatic risk.Genotypes were determined 368 patients with 926 controls, odds ratios (ORs) 95% confidence intervals (CIs) estimated by...
Jatrorrhizine hydrochloride (JH), an active component isolated from the traditional Chinese herb Coptis chinensis, has been reported to have antimicrobial, antitumor, antihypercholesterolemic, and neuroprotective activities. However, its antirheumatoid arthritis (RA) property remains unknown. In this study, a collagen-induced (CIA) rat model was used evaluate therapeutic effects of JH on RA by using score, radiological evaluation, histopathological assessment. The in vitro proliferation,...
Sepsis remains a significant health care issue in clinical practice due to its high mortality rate and healthcare cost, despite extensive efforts better understand the pathophysiology of sepsis. The systemic inflammatory response often leads severe liver injury, even acute dysfunction failure. Acetic acid, as type chemical compound, has been reported be an emerging drug for improving metabolic syndrome inhibiting inflammation rats human. To verify effects acetic acid protecting reducing...
Immune checkpoint inhibitors (ICIs) prolong overall survival (OS) in patients with advanced lung squamous cell carcinoma (LUSC). However, predictive and prognostic factors related to ICIs LUSC remain elusive. This study aimed identify predictors that are better clinical benefit outcomes treated immunotherapy.Capture-based targeted sequencing was performed 64 who underwent immunotherapy. Tumor mutational burden (TMB) defined as the sum of nonsynonymous single nucleotide indel variants....
The HKT protein family plays a vital role in plant responses to salt stress by mediating sodium (Na + ) and potassium (K transport maintaining Na -K balance. Ipomoea pes-caprae ( IPC ), pantropical creeping distributed along coastal regions tropical subtropical zones, exhibits exceptional tolerance. Understanding its tolerance mechanisms provides valuable insights for developing salt-tolerant crops identifying candidate genes genetic engineering. In this study, we identified two genes,...
Chemotherapy is a prevalent and extensively utilized cancer treatment modality. However, it can result in immunosuppression. Shengxian Decoction (SXD) Traditional Chinese Medicine formula that has been demonstrated to improve immunosuppression caused by chemotherapy clinical settings. Nevertheless, the therapeutic evaluation mechanism of SXD regulating remain unclear. The aim this study was ascertain efficacy immunocompromised mice elucidate underlying immunological mechanisms. mouse model...