A5100785355- Polymer Surface Interaction Studies
- Immunotherapy and Immune Responses
- Electrospun Nanofibers in Biomedical Applications
- RNA Interference and Gene Delivery
- Nanoplatforms for cancer theranostics
- Cardiac Valve Diseases and Treatments
- Immune Response and Inflammation
- Tissue Engineering and Regenerative Medicine
- Antimicrobial Peptides and Activities
- Nanoparticle-Based Drug Delivery
- vaccines and immunoinformatics approaches
- Bone Tissue Engineering Materials
- Cardiac and Coronary Surgery Techniques
- Magnesium Alloys: Properties and Applications
- Infective Endocarditis Diagnosis and Management
- Immune Cell Function and Interaction
- Corrosion Behavior and Inhibition
- Angiogenesis and VEGF in Cancer
- Monoclonal and Polyclonal Antibodies Research
- Cell Adhesion Molecules Research
- Glycosylation and Glycoproteins Research
- Advanced Sensor and Energy Harvesting Materials
- Antimicrobial agents and applications
- Lipid Membrane Structure and Behavior
- Extracellular vesicles in disease
Jilin University
2023-2025
Shanghai Institute of Materia Medica
2024-2025
Nanjing University of Chinese Medicine
2024-2025
Huashan Hospital
2024-2025
Fudan University
2024-2025
Sun Yat-sen University
2021-2025
Northwest University
2024-2025
Nanchang University
2025
Fifth Affiliated Hospital of Sun Yat-sen University
2025
Yibin University
2025
Three-dimensional (3D) printing technology has great potential in advancing clinical medicine. Currently, the vivo application strategies for 3D-printed macroscale products are limited to surgical implantation or situ 3D at exposed trauma, both requiring exposure of site. Here, we show a digital near-infrared (NIR) photopolymerization (DNP)-based that enables noninvasive bioprinting tissue constructs. In this technology, NIR is modulated into customized pattern by micromirror device, and...
Abstract The combination of chemotherapy and photodynamic therapy (PDT) has promising potential in the synergistic treatment cancer. However, are impeded by uncontrolled chemotherapeutics release behavior, targeting deficiencies, hypoxia‐associated poor PDT efficacy solid tumors. Here, a platinum nanozyme (PtNP) loaded reactive oxygen species (ROS)‐responsive prodrug nanoparticle (CPT‐TK‐HPPH/Pt NP) is created to overcome these limitations. ROS‐responsive consists thioketal bond linked with...
Recently, near-infrared (NIR) light-based photothermal therapy (PTT) has been widely applied in cancer treatment. However, most cases, the tissue penetration depth of NIR light is not sufficient and thus unable to completely eradicate deep, seated tumors inevitably leading recurrence tumor. Due this significant limitation NIR, improved therapeutic strategies are urgently needed. Methods: We developed an endogenous vaccine based on a novel nanoparticle platform for combinatorial ablation...
ABSTRACT To design and discover new antimicrobial peptides (AMPs) with high levels of activity, a number machine-learning methods prediction have been developed. Here, we present method that can identify novel AMPs are highly similar in sequence to known but offer improved activity along lower host cytotoxicity. Using previously generated AMP amino acid substitution data, developed an contribution matrix contained value for each position the model peptide. A series were designed this method....
Localized drug delivery from drug-eluting stents (DESs) to target sites provides therapeutic efficacy with minimal systemic toxicity. However, DESs failure may cause thrombosis, delay arterial healing, and impede re-endothelialization. Bivalirudin (BVLD) nitric oxide (NO) promote healing. Nevertheless, it is difficult combine hydrophilic signal molecules hydrophobic antiproliferative drugs while maintaining their bioactivity. Here, we fabricated a micro- nanoscale network assembly consisting...
Atherosclerosis, the principle cause of cardiovascular disease (CVD) worldwide, is mainly characterized by pathological accumulation diseased vascular cells and apoptotic cellular debris. Atherogenesis associated with upregulation CD47, a key antiphagocytic molecule that known to render malignant resistant programmed cell removal, or “efferocytosis.” Here, we have developed platelet membrane-coated mesoporous silicon nanoparticles (PMSN) as drug delivery system target atherosclerotic plaques...
Abstract Long‐term blood‐contacting devices (e.g., central venous catheters, CVCs) still face the highest incidence of blood stream infection and thrombosis in clinical application. To effectively address these complications, this work reports a dual‐functional surface engineering strategy for CVCs by organic integration endothelium‐mimicking fibrinolytic functions. In proposal, lysine (Lys)/Cu 2+ ‐incorporated zwitterionic polymer coating (defined as PDA/Lys/Cu‐SB) is designed robustly...
Graphene and its derivatives have been confirmed to be among the best fillers for rubber due their excellent properties, such as high mechanical strength, improved interface interaction, strain-induced crystallization capabilities. materials can widely used in tires, shoes, high-barrier conductive seals, electromagnetic shielding shock absorbers, etc. In order reduce graphene loading endow more desirable functions materials, graphene-based hybrid are extensively employed, which effectively...
Although minimally invasive interventional occluders can effectively seal heart defect tissue, they still have some limitations, including poor endothelial healing, intense inflammatory response, and thrombosis formation. Herein, a polyphenol-reinforced medicine/peptide glycocalyx-like coating was prepared on cardiac occluders. A consisting of carboxylated chitosan, epigallocatechin-3-gallate (EGCG), tanshinone IIA sulfonic sodium (TSS), hyaluronic acid grafted with 3-aminophenylboronic...
Photothermal therapy (PTT), which uses the high thermal conversion ability of photothermal agents to ablate tumor cells at temperatures, has gained significant attention because it advantages selectivity and specificity, precise targeting sites, low invasiveness trauma. However, PTT guided by NIR-I limitations in tissue penetration depth, resulting limited imaging monitoring therapeutic effects on deep-seated tissues. Moreover, nanoparticles are easily cleared immune system difficult...
The objective of this study was to identify existing clinical compounds that either possess a fungicidal activity alone or can act synergistically with fungistatic antifungals. We screened compound library for drugs exhibited anti-Aspergillus activity. Among selected compounds, the cationic peptide antibiotic polymyxin B chosen further characterization because it be used parenterally and topically. effect its synergistic interactions azole antifungals were tested against variety fungal...
Abstract Postoperative peritoneal adhesion is one of the serious issues because it induces severe clinical disorders. In this study, we prepared biodegradable and injectable hydrogel composed N,O-carboxymethyl chitosan (NOCC) aldehyde hyaluronic acid (AHA), assessed its anti-adhesion effect in a rigorous recurrent model which closer to conditions. The flexible hydrogel, gelated 66 seconds at 37 °C, was cross-linked by schiff base derived from amino groups NOCC AHA. vitro cytotoxicity test...
As a promising biodegradable metallic material, magnesium (Mg) and its alloys have attracted special attention in the recent decade. However, challenges still remain due to high corrosion rate insufficient biocompatibility after implantation. In this work, we prepare simple versatile green tea phenol–metal induced multilayer conversion coating (Mg2+ incorporated epigallocatechin gallate (EGCG) coating) on alloys' (AZ31) substrate by layer-by-layer (LBL) method. The surface morphology results...
Atherosclerosis is one of the leading causes cardiovascular diseases and triggered by endothelial damage, local lipid cumulation, inflammation. Despite conventional medication treatment, nanosized drug carriers have become promising candidates for efficient delivery with lower side effects. However, development problems in nanocarriers such as leakage, accumulating efficiency, accurate release, well specific recognition atherosclerotic plaques, still needs to be checked. In this study, a...
Although dressing blood-contacting devices with robust and synergistic antibacterial antithrombus properties has been explored for several decades, it still remains a great challenge. In order to endow materials remarkable abilities, stable antifouling hydrogel coating was developed via surface-initiated polymerization of sulfobetaine methacrylate acrylic acid on polymeric substrate followed by embedding antimicrobial peptides (AMPs), including WR (sequence: WRWRWR-NH2) or Bac2A...
A conformally adapted all-in-one hydrogel coatings that exhibit both hemocompatibility and bactericidal activity possess the potential for applications in blood-contacting devices.