A5054789980- Nanoplatforms for cancer theranostics
- Luminescence and Fluorescent Materials
- Nanoparticle-Based Drug Delivery
- Lipid metabolism and biosynthesis
- Advanced biosensing and bioanalysis techniques
- Molecular Sensors and Ion Detection
- Semiconductor Quantum Structures and Devices
- Crystallization and Solubility Studies
- X-ray Diffraction in Crystallography
- Cardiac Valve Diseases and Treatments
- Electrospun Nanofibers in Biomedical Applications
- Mass Spectrometry Techniques and Applications
- Advanced Nanomaterials in Catalysis
- Porphyrin and Phthalocyanine Chemistry
- Polymer Surface Interaction Studies
- Metabolomics and Mass Spectrometry Studies
- Photodynamic Therapy Research Studies
- Advanced Polymer Synthesis and Characterization
- Cardiac and Coronary Surgery Techniques
- RNA Interference and Gene Delivery
- Lipid Membrane Structure and Behavior
- Electrochemical sensors and biosensors
- Quantum and electron transport phenomena
- Infective Endocarditis Diagnosis and Management
- Analytical Chemistry and Sensors
West China Hospital of Sichuan University
2002-2025
Sichuan University
2016-2025
Jiangmen Central Hospital
2024
Chengdu University
2015-2021
Central South University of Forestry and Technology
2021
Central South University
2021
Xuzhou University of Technology
2017-2021
State Council of the People's Republic of China
2020
Shandong University
2006
Institute of Semiconductors
1988-1991
Inflammation is a protective response to stimuli trauma, which can also lead severe tissue injury. The existing anti-inflammatory drugs, such as corticosteroids and glucocorticoids, generally exhibit side effects poor accumulation in inflammatory tissue. Hence, theranostic nanoplatform with serial reactive oxygen species (ROS) responsiveness two-photon AIE bioimaging has been constructed for dimensional diagnosis accurate therapy of inflammation. Prednisolone (Pred) bridged fluorophore (TP)...
In recent years, photodynamic therapy (PDT) has drawn much attention as a noninvasive and safe cancer method due to its fine controllability, good selectivity, low systemic toxicity, minimal drug resistance in contrast the conventional methods (for example, chemotherapy, radiotherapy, surgery). However, some drawbacks still remain for current organic photosensitizers such singlet oxygen (1O2) quantum yield, poor photostability, inability of absorption near-infrared (NIR) region, short...
Intelligent polymeric micelles for antitumor drug delivery and tumor bioimaging have drawn a broad attention because of their reduced systemic toxicity, enhanced efficacy drugs, potential application diagnosis. Herein, we developed multifunctional micelle system based on pH redox dual-responsive mPEG-P(TPE-co-AEMA) copolymer stimuli-triggered release aggregation-induced emission (AIE) active imaging. These mPEG-P(TPE-co-AEMA)-based showed excellent biocompatibility property, exhibiting great...
Atherosclerosis, characterized by endothelial injury, progressive inflammation, and lipid deposition, can cause cardiovascular diseases. Although conventional anti-inflammatory drugs reveal a certain amount of therapeutic effect, more reasonable design on plaque targeting, local anti-inflammation, removal are still required for comprehensive atherosclerosis therapy. In this work, theranostic nanoplatform is developed recognition inhibition. A two-photon aggregation-induced emission (AIE)...
Atherosclerosis is one of the leading causes cardiovascular diseases and triggered by endothelial damage, local lipid cumulation, inflammation. Despite conventional medication treatment, nanosized drug carriers have become promising candidates for efficient delivery with lower side effects. However, development problems in nanocarriers such as leakage, accumulating efficiency, accurate release, well specific recognition atherosclerotic plaques, still needs to be checked. In this study, a...
Fluorescence imaging plays an important role in researching the biological function of lipid droplets (LDs). However, short-wave emission, tedious synthesis process and insufficient specificity have significantly limited applications commercially available probes. Herein, we prepared a novel one-step synthesized near-infrared (NIR) fluorescent probe, TNBD, with very low emission aqueous solution solid state, but enhanced fluorescence is exhibited oleic acid. Moreover, TNBD impressive droplet...
A lipid droplets (LDs) specific fluorescent probe TTIE is prepared for LDs image-guided photodynamic therapy (PDT), which can light up the in human clear cell renal carcinoma cells and tissues, kill tumor <italic>via</italic> PDT process.
Intelligent polymeric micelles have been developed as potential nanoplatforms for efficient drug delivery and diagnosis. Herein, we successfully prepared redox-sensitive combined aggregation-induced emission (AIE) imaging an outstanding anticancer carrier system simultaneous chemotherapy bioimaging. The amphiphilic copolymer TPE-SS-PLAsp-b-PMPC could self-assemble into spherical micelles, these biomimetic exhibited great biocompatibility remarkable ability in antiprotein adsorption, showing...
Tunable/sustained drug loading/releasing are of significance in addressing low cytotoxicity, long-term performance, and localized mild healing response biomedical applications. With an ingenious design, a self-healing sandwiched layer-by-layer (LBL) coating was constructed by using chitosan/heparin as adopted polyelectrolytes with embedding micelles, which the chitosan backbone grafted catechol micelle modified exposed phenylboronic acid, endowing enhanced stability abundant interactions...
Multifunctional coatings that mimic the endothelial function in terms of nitric oxide generation and membrane-bound active heparin species are prepared <italic>via</italic> immobilization cystamine-modified heparin/polyethyleneimine (Hep-Cys/PEI) nanoparticles.
The strategy of novel multi-stimuli response and synergistic chemo–photodynamic therapy nanoplatform will be helpful for exploiting intelligent cancer therapy.
A smart lipid droplet specific fluorescent probe (LDs-DM) with dual-emission in water (706 nm) and oil (535 under single-excitation was prepared for revealing the ultra-structure of aqueous lipidic microenvironment living cells, fatty liver tissues atherosclerotic plaques without fluorescence emission crosstalk. This work is expected to provide inspiration designing a novel color switching ability.
Nanozymes have demonstrated significant potential as promising alternatives to natural enzymes in biomedical applications. However, their lower catalytic activity compared that of has limited practical utility. Addressing this challenge necessitates the development innovative enzymatic systems capable achieving specific levels enzymes. In study, we focus on enhancing performance nanozymes by introducing Ru atoms into single-atom-thick A layer V2SnC MAX phase, resulting formation...
In recent years, intelligent polymeric micelles with multifunctions are in urgent demand for cancer diagnosis and therapy. Herein, pH redox dual-responsive prodrug aggregation-induced emission (AIE) active cellular imaging charge conversion have been prepared combined chemotherapy bioimaging based on a novel doxorubicin-conjugated amphiphilic PMPC-PAEMA-P (TPE-co-HD)-ss-P (TPE-co-HD)-PAEMA-PMPC copolymer. The doxorubicin is conjugated via cleavable imine linkage can be packed the hydrophobic...
As nano-scale drug delivery systems, smart micelles that are sensitive to specific biological environment and allowed for target site-triggered release by reversible stabilization of micelle structure attractive. In this work, a biocompatible pH-sensitive copolymer is synthesized through bridging poly (2-methacryloyloxyethyl phosphorylcholine) (PMPC) block (D, L-lactide) (PLA) benzoyl imine linkage (Blink). Biomimetic with excellent biocompatibility based on such PLA-Blink-PMPC prepared as...
Intelligent polymeric micelles with fluorescence imaging feature have been emerged as promising tools for theranostics.However, conventional fluorescent dyes are limited by short wavelength excitation, interference of tissue autofluorescence, depth and quenched emission in aggregation state.Methods: We synthesized a novel mPEG-SS-Poly (AEMA-co-TBIS) (mPEATss) copolymer to develop multifunctional great AIE cancer therapy active two-photon bioimaging.The stimuli-responsive behavior cell well...
Lipid deposition is closely related to the pathogenesis of valvular heart disease (VHD), which a potential target for early diagnosis VHD. However, VHD and valve-specific delivery imaging or therapeutic agents remain challenging. In this work, we hypothesized that lipid droplet-specific probe-loaded nanoparticles simultaneously responsive acidic pH lysosomes could be used as an effective nanosystem precise probes diseased aortic valves in endothelial layer was damaged. A probe, namely,...
To realize desirable functions in the rather complex biological systems, a suitable surface coating is for gold nanoparticles, which plays an important role their colloidal stability and biocompatibility.