Yang Li

ORCID: 0000-0001-8950-1212
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About
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Research Areas
  • Nanoplatforms for cancer theranostics
  • Nanoparticle-Based Drug Delivery
  • RNA Interference and Gene Delivery
  • Advanced Nanomaterials in Catalysis
  • Graphene and Nanomaterials Applications
  • Advanced biosensing and bioanalysis techniques
  • Extracellular vesicles in disease
  • Photodynamic Therapy Research Studies
  • Luminescence and Fluorescent Materials
  • Photoacoustic and Ultrasonic Imaging
  • Ultrasound and Hyperthermia Applications
  • Advanced Drug Delivery Systems
  • Lipid metabolism and biosynthesis
  • Radiomics and Machine Learning in Medical Imaging
  • Microbial Metabolic Engineering and Bioproduction
  • Perovskite Materials and Applications
  • Photosynthetic Processes and Mechanisms
  • Analytical Chemistry and Chromatography
  • Advanced Manufacturing and Logistics Optimization
  • Supramolecular Self-Assembly in Materials
  • Advanced Photocatalysis Techniques
  • Curcumin's Biomedical Applications
  • Microfluidic and Capillary Electrophoresis Applications
  • Power Systems and Technologies
  • Covalent Organic Framework Applications

Nanjing Medical University
2017-2025

Jiangsu Province Hospital
2025

Shanghai East Hospital
2025

University of Chinese Academy of Sciences
2011-2025

Fujian Medical University
2019-2025

Yanbian University Hospital
2025

Wuhan Institute of Technology
2025

First Affiliated Hospital of Fujian Medical University
2025

Chinese Academy of Sciences
2013-2024

Fujian Institute of Research on the Structure of Matter
2019-2024

The increasing occurrence of antibiotic-resistant pathogens, especially superbugs, is compromising the efficacy traditional antibiotics. Silver nanoparticles (AgNPs) loaded graphene oxide (GO) nanocomposite (GO-Ag) has drawn great interest as a promising alternative antibacterial material. However, GO-Ag often irreversibly aggregates in physiological solutions, severely influencing its capacity and practical application. Herein, PEGylated AgNPs GO (GO-PEG-Ag) synthesized through facile...

10.1021/acsami.7b03987 article EN ACS Applied Materials & Interfaces 2017-04-19

Abstract Despite the pivotal role of molecular oxygen (O 2 ) activation in artificial photosynthesis, efficiency is often restricted by sluggish exciton dissociation and charge transfer kinetics within polymer photocatalysts. Herein, we propose two tetrathiafulvalene (TTF)‐based imine‐linked covalent organic frameworks (COFs) with tailored donor‐acceptor (D–A) structures, TTF‐PDI‐COF TTF‐TFPP‐COF, to promote O activation. Because enhanced electron push‐pull interactions that facilitated...

10.1002/anie.202405476 article EN Angewandte Chemie International Edition 2024-05-06

10.1016/j.tre.2025.104022 article EN Transportation Research Part E Logistics and Transportation Review 2025-03-05

Aiming at development of a micellar nanoparticle system for intracellular drug release triggered by glutathione in tumor cells, disulfide-linked biodegradable diblock copolymer poly(ε-caprolactone) and poly(ethyl ethylene phosphate) was synthesized. It formed biocompatible micelles loaded with doxorubicin aqueous solution but detached the shell material under stimulus, resulting rapid destruction structure. These glutathione-sensitive also rapidly released molecules intracellularly led to...

10.1021/bc900144m article EN Bioconjugate Chemistry 2009-05-13

To precisely deliver drug molecules at a targeted site and in controllable manner, there has been great interest designing synergistical delivery system that can achieve both surface charge-conversion controlled release of response to different stimuli. Here we outline simple method construct an intelligent carrier, which respond two pH values, therefore achieving charge conversion chemical-bond-cleavage-induced stepwise fashion. This carrier comes from the self-assembly block copolymer-DOX...

10.1021/acsami.6b04247 article EN ACS Applied Materials & Interfaces 2016-06-09

Tumor microenvironment responsive multimodal synergistic theranostic strategies can significantly improve the therapeutic efficacy while avoiding severe side effects. Inspired by fact that special morphology could enhance photothermal conversion efficiency (PCE) and cellular delivery, we developed an acidic tumor shape-reversal metal–organic virus-inspired nanodrug for enhancing near-infrared (NIR)-II PCE, increasing cell adhesion, activating targeting. First, a NIR-I fluorescence probe...

10.1021/acsnano.9b05425 article EN ACS Nano 2019-10-25

Multifunctional nanocomposites hold great potential to integrate therapeutic and diagnostic functions into a single nanoscale structure. In this paper, we prepared the MTX-PEG-CS-IONPs-Cy5.5 by functionalizing surface of chitosan-decorated iron oxide nanoparticles (CS-IONPs) with polyethylene glycolated methotraxate (MTX-PEG) near-infrared fluorescent cyanin dye (Cy5.5). A clinically useful PEGylated anticancer prodrug, MTX-PEG, was also developed as tumor cell-specific targeting ligand for...

10.1021/acsami.5b01685 article EN ACS Applied Materials & Interfaces 2015-05-15

“All-in-one” carrier-free-based nano-multi-drug self-delivery system could combine triple advantages of small molecules, nanoscale characteristics, and synergistic combination therapy together. Researches have showed that dual-acting small-molecular methotrexate (MTX) target kill the folate-receptor-overexpressing cancer cells. Inspired by this mechanism, a novel collaborative early-phase tumor-selective targeting late-phase anticancer approach was developed for self-assembly...

10.1021/acsami.7b10027 article EN ACS Applied Materials & Interfaces 2017-09-18

Graphene oxide (GO) has attracted intensive interest in the biomedical field recent years. We investigate whether use of functional graphene as an efficient delivery system for delivering specific molecular antitumor therapeutics vivo could achieve a more excellent effect. Constitutive activation signal transducer and activator transcription 3 (Stat3) promotes survival wide spectrum human cancers. In this paper, we study behavior chemically functionalized with polyethylenimine polyethylene...

10.1088/0957-4484/24/10/105102 article EN Nanotechnology 2013-02-20

The therapeutic efficacy of fluorescence image-guided tumor surgery and photodynamic therapy (PDT) is impaired by the penetration depth limitation, low signal-to-noise ratio traditional first near-infrared window (NIR I) hypoxic microenvironment. Here, a "red blood cell-based multimodal probe" was proposed to achieve enhanced targeting retention fluorescent probes after an intravenous injection, so that second II) bioimaging-guided complete resection high-efficiency could then be realized....

10.7150/thno.29817 article EN cc-by Theranostics 2019-01-01

Nanoparticles camouflaged by red blood cell (RBC) membranes have attracted considerable attention owing to reservation of structure membrane and surface proteins, endowing prominent cell-specific function including biocompatibility, prolonged circulation lifetime, reduced reticular endothelial system (RES) uptake ability. Considering the drawbacks carrier-free nanomedicine serious drug burst release, poor stability, lack immune escape function, herein we developed fabricated a novel RBC...

10.1021/acsami.9b00897 article EN ACS Applied Materials & Interfaces 2019-04-09

Abstract Lipid droplets (LDs) are multi-functional organelles consisting of a neutral lipid core surrounded by phospholipid monolayer, and exist in organisms ranging from bacteria to humans. Here we study the functions LDs oleaginous bacterium Rhodococcus jostii . We show that these bind genomic DNA through major LD protein, MLDS, which increases survival rate bacterial cells under nutritional genotoxic stress. MLDS expression is regulated transcriptional regulator, MLDSR, binds operator...

10.1038/ncomms15979 article EN cc-by Nature Communications 2017-07-06

Ion-interference therapy, which utilizes ions to disturb intracellular biological processes, provides inspiration for tumor therapy. Artificially reversing osmotic pressure by transporting large amounts of physiological cells is a straightforward yet low-toxic strategy ion-interference However, it hard achieve due the serious limitations single-ion delivery. Herein, we skillfully deliver NaCl nanocrystals sites and sequentially realize explosive release Na+/Cl– inside utilizing...

10.1021/acsnano.1c09496 article EN ACS Nano 2022-04-18

Abstract The adhesion strategies of the gecko's toe through surface adaptation spatulas to increase contact area and snail's epiphragm via dehydration‐induced solidification lock interfaces are combined design a class adhesion‐switchable hydrogels. hydrogels made incorporating CH 3 COONa·3H 2 O salt (SA) into polyacrylamide (PAM) aqueous networks construct supersaturated stimuli‐responsive phase change materials (PAM‐SA). crystallization dramatically strengthens mechanical properties,...

10.1002/adfm.202301505 article EN Advanced Functional Materials 2023-03-23
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