A5100769864- Nanoplatforms for cancer theranostics
- Nanoparticle-Based Drug Delivery
- RNA Interference and Gene Delivery
- Advanced Nanomaterials in Catalysis
- Graphene and Nanomaterials Applications
- Advanced biosensing and bioanalysis techniques
- Extracellular vesicles in disease
- Photodynamic Therapy Research Studies
- Luminescence and Fluorescent Materials
- Photoacoustic and Ultrasonic Imaging
- Ultrasound and Hyperthermia Applications
- Advanced Drug Delivery Systems
- Lipid metabolism and biosynthesis
- Radiomics and Machine Learning in Medical Imaging
- Microbial Metabolic Engineering and Bioproduction
- Perovskite Materials and Applications
- Photosynthetic Processes and Mechanisms
- Analytical Chemistry and Chromatography
- Advanced Manufacturing and Logistics Optimization
- Supramolecular Self-Assembly in Materials
- Advanced Photocatalysis Techniques
- Curcumin's Biomedical Applications
- Microfluidic and Capillary Electrophoresis Applications
- Power Systems and Technologies
- Covalent Organic Framework Applications
Nanjing Medical University
2017-2025
Jiangsu Province Hospital
2025
Shanghai East Hospital
2025
University of Chinese Academy of Sciences
2011-2025
Fujian Medical University
2019-2025
Yanbian University Hospital
2025
Wuhan Institute of Technology
2025
First Affiliated Hospital of Fujian Medical University
2025
Chinese Academy of Sciences
2013-2024
Fujian Institute of Research on the Structure of Matter
2019-2024
The increasing occurrence of antibiotic-resistant pathogens, especially superbugs, is compromising the efficacy traditional antibiotics. Silver nanoparticles (AgNPs) loaded graphene oxide (GO) nanocomposite (GO-Ag) has drawn great interest as a promising alternative antibacterial material. However, GO-Ag often irreversibly aggregates in physiological solutions, severely influencing its capacity and practical application. Herein, PEGylated AgNPs GO (GO-PEG-Ag) synthesized through facile...
Abstract Despite the pivotal role of molecular oxygen (O 2 ) activation in artificial photosynthesis, efficiency is often restricted by sluggish exciton dissociation and charge transfer kinetics within polymer photocatalysts. Herein, we propose two tetrathiafulvalene (TTF)‐based imine‐linked covalent organic frameworks (COFs) with tailored donor‐acceptor (D–A) structures, TTF‐PDI‐COF TTF‐TFPP‐COF, to promote O activation. Because enhanced electron push‐pull interactions that facilitated...
Aiming at development of a micellar nanoparticle system for intracellular drug release triggered by glutathione in tumor cells, disulfide-linked biodegradable diblock copolymer poly(ε-caprolactone) and poly(ethyl ethylene phosphate) was synthesized. It formed biocompatible micelles loaded with doxorubicin aqueous solution but detached the shell material under stimulus, resulting rapid destruction structure. These glutathione-sensitive also rapidly released molecules intracellularly led to...
To precisely deliver drug molecules at a targeted site and in controllable manner, there has been great interest designing synergistical delivery system that can achieve both surface charge-conversion controlled release of response to different stimuli. Here we outline simple method construct an intelligent carrier, which respond two pH values, therefore achieving charge conversion chemical-bond-cleavage-induced stepwise fashion. This carrier comes from the self-assembly block copolymer-DOX...
Tumor microenvironment responsive multimodal synergistic theranostic strategies can significantly improve the therapeutic efficacy while avoiding severe side effects. Inspired by fact that special morphology could enhance photothermal conversion efficiency (PCE) and cellular delivery, we developed an acidic tumor shape-reversal metal–organic virus-inspired nanodrug for enhancing near-infrared (NIR)-II PCE, increasing cell adhesion, activating targeting. First, a NIR-I fluorescence probe...
Multifunctional nanocomposites hold great potential to integrate therapeutic and diagnostic functions into a single nanoscale structure. In this paper, we prepared the MTX-PEG-CS-IONPs-Cy5.5 by functionalizing surface of chitosan-decorated iron oxide nanoparticles (CS-IONPs) with polyethylene glycolated methotraxate (MTX-PEG) near-infrared fluorescent cyanin dye (Cy5.5). A clinically useful PEGylated anticancer prodrug, MTX-PEG, was also developed as tumor cell-specific targeting ligand for...
“All-in-one” carrier-free-based nano-multi-drug self-delivery system could combine triple advantages of small molecules, nanoscale characteristics, and synergistic combination therapy together. Researches have showed that dual-acting small-molecular methotrexate (MTX) target kill the folate-receptor-overexpressing cancer cells. Inspired by this mechanism, a novel collaborative early-phase tumor-selective targeting late-phase anticancer approach was developed for self-assembly...
Graphene oxide (GO) has attracted intensive interest in the biomedical field recent years. We investigate whether use of functional graphene as an efficient delivery system for delivering specific molecular antitumor therapeutics vivo could achieve a more excellent effect. Constitutive activation signal transducer and activator transcription 3 (Stat3) promotes survival wide spectrum human cancers. In this paper, we study behavior chemically functionalized with polyethylenimine polyethylene...
The therapeutic efficacy of fluorescence image-guided tumor surgery and photodynamic therapy (PDT) is impaired by the penetration depth limitation, low signal-to-noise ratio traditional first near-infrared window (NIR I) hypoxic microenvironment. Here, a "red blood cell-based multimodal probe" was proposed to achieve enhanced targeting retention fluorescent probes after an intravenous injection, so that second II) bioimaging-guided complete resection high-efficiency could then be realized....
Nanoparticles camouflaged by red blood cell (RBC) membranes have attracted considerable attention owing to reservation of structure membrane and surface proteins, endowing prominent cell-specific function including biocompatibility, prolonged circulation lifetime, reduced reticular endothelial system (RES) uptake ability. Considering the drawbacks carrier-free nanomedicine serious drug burst release, poor stability, lack immune escape function, herein we developed fabricated a novel RBC...
Abstract Lipid droplets (LDs) are multi-functional organelles consisting of a neutral lipid core surrounded by phospholipid monolayer, and exist in organisms ranging from bacteria to humans. Here we study the functions LDs oleaginous bacterium Rhodococcus jostii . We show that these bind genomic DNA through major LD protein, MLDS, which increases survival rate bacterial cells under nutritional genotoxic stress. MLDS expression is regulated transcriptional regulator, MLDSR, binds operator...
Ion-interference therapy, which utilizes ions to disturb intracellular biological processes, provides inspiration for tumor therapy. Artificially reversing osmotic pressure by transporting large amounts of physiological cells is a straightforward yet low-toxic strategy ion-interference However, it hard achieve due the serious limitations single-ion delivery. Herein, we skillfully deliver NaCl nanocrystals sites and sequentially realize explosive release Na+/Cl– inside utilizing...
Abstract The adhesion strategies of the gecko's toe through surface adaptation spatulas to increase contact area and snail's epiphragm via dehydration‐induced solidification lock interfaces are combined design a class adhesion‐switchable hydrogels. hydrogels made incorporating CH 3 COONa·3H 2 O salt (SA) into polyacrylamide (PAM) aqueous networks construct supersaturated stimuli‐responsive phase change materials (PAM‐SA). crystallization dramatically strengthens mechanical properties,...