A5100430100- Mesenchymal stem cell research
- Periodontal Regeneration and Treatments
- Dermatologic Treatments and Research
- X-ray Diffraction in Crystallography
- Crystallization and Solubility Studies
- Wound Healing and Treatments
- Oral microbiology and periodontitis research
- Extracellular vesicles in disease
- Advanced Drug Delivery Systems
- MicroRNA in disease regulation
- Laser Applications in Dentistry and Medicine
- Tendon Structure and Treatment
- Tissue Engineering and Regenerative Medicine
- Advanced Cellulose Research Studies
- Immune cells in cancer
- Reconstructive Surgery and Microvascular Techniques
- Cleft Lip and Palate Research
- Polymer Nanocomposites and Properties
- Traditional Chinese Medicine Studies
- Nanocomposite Films for Food Packaging
- Bone and Dental Protein Studies
- Advanced Chemical Physics Studies
- Silk-based biomaterials and applications
- Nasal Surgery and Airway Studies
- Reconstructive Facial Surgery Techniques
Qingdao University
2015-2025
Affiliated Hospital of Qingdao University
2014-2025
Sichuan University
2022-2025
Nanjing Forestry University
2024
Second Military Medical University
2021
Shanghai Changzheng Hospital
2021
Jiangnan University
2021
Shandong Institute of Automation
2021
University of Liège
2019
Hubei University
2015-2018
Abstract The differentiation, migration, and proliferation of skin fibroblasts are identified as key factors in cutaneous wound healing. Adipose-derived mesenchymal stem cells (ADMSCs) their exosomes (ADMSC-Exos) have been considered potential therapeutic tools for tissue regeneration; however, the underlying mechanisms on healing still not well understood. In this study, we successfully obtained ADMSC-Exos found significantly promoted migration a dose-dependent manner vitro. expression...
To examine the immunomodulatory effect of exosomes originating from gingival mesenchymal stem cells (GMSC-Exo) on periodontal bone regeneration and its role in regulation nuclear-factor kappaB (NF-κB) Wnt/β-catenin pathways inflammatory microenvironment.First, ligament (PDLSCs) were treated with GMSC-Exo or Porphyromonas gingivalis-derived lipopolysaccharide (P.g-LPS) vitro. Quantitative real-time PCR (qRT-PCR) western blot carried out to detect expressions osteogenic differentiation-related...
Periodontitis is a chronic inflammatory disease induced by plaque biofilm, which can lead to the destruction of periodontal support tissue and even teeth loss. The common strategies periodontitis treatment are eliminate bacterial/biofilm-related inflammation subsequently inhibit alveolar bone resorption, for antibiotic therapy most traditional one. However, impenetrable polymeric substances on bacterial biofilms make it difficult antimicrobial agents take effect. In this study, novel...
The treatment of infected wounds faces substantial challenges due to the high incidence and serious infection-related complications. Natural-based hydrogel dressings with favorable antibacterial properties strong applicability are urgently needed. Herein, we developed a composite by constructing multiple networks loading ciprofloxacin for wound healing. was synthesized via Schiff base reaction between carboxymethyl chitosan oxidized sodium alginate, followed polymerization acrylamide...
This study aimed to explore the effects of exosomes derived from human gingival mesenchymal stem cells (GMSC-Exo) on inflammatory response periodontal ligament (PDLSCs) in an microenvironment order restore regenerative potential PDLSCs, which promotes tissue regeneration patients with periodontitis. Periodontitis is a chronic infectious disease characterized by inflammation and alveolar bone destruction. PDLSCs are regarded as promising seed for restoring defects because their ability...
Keloid is a kind of unique human fibroproliferative dermal disease, and there are still no optimal treatment methods for it. In the present study, thermosensitive hydroxybutyl chitosan (HBC) hydrogel as co-delivery matrix 5-fluorouracil (5-FU) dexamethasone sodium phosphate (DEXSP) in keloid was developed. The gelation temperature HBC observed to be 25.7 °C by rheology analysis. showed sustained drug release capacity (5-FU, 89.3 ± 3.4%; DEXSP, 95.6 3.9%) delivery. shown cytocompatible, while...
Pathological scars (PS), including hypertrophic (HTS) and keloids, are a common complication of poor wound healing that significantly affects patients’ quality life. Currently, there several treatment options for PS, surgery, drug therapy, radiation biological therapy. However, these treatments still face major challenges such as low efficacy, high side effects, risk recurrence. Therefore, the search safer more effective is particularly urgent. New materials often have less immune rejection,...
Electrospinning provides exceptional flexibility in fabricating wound dressings. However, constructing 3D fibrous dressings presents a challenge. Herein, multifunctional electrospinning fiber sponge (EFS) is developed by combining the humidity-controlled with freeze-drying solidification for chronic healing. The moisture-induced phase separation triggered spontaneous crimping and stacking of polylactic acid electrospun fibers into unique fluffy structure, endowing EFS excellent water...
ABSTRACT Aim To investigate the influence and mechanism of exosomes derived from human gingival mesenchymal stem cells (GMSC‐Exo) regulating macrophage polarisation through metabolic reprogramming. Materials Methods Human acute monocytic leukaemia (THP‐1)‐derived macrophages were treated with GMSC‐Exo or Porphyromonas gingivalis lipopolysaccharide ( P.g ‐LPS) in vitro. Metabolic inhibitors used to study role reprogramming GMSC‐Exo‐induced polarisation, while hypoxia‐inducible factor‐1 alpha...
Cell-based tissue engineering is a promising alternative for periodontal regeneration as current therapies fail to reconstitute damage caused by periodontitis. As newly identified postnatal stem cells, gingiva-derived mesenchymal cells (GMSCs) have been focused on isolation and expansion in vitro of with multi-differentiation potential immunomodulatory capacities. It has demonstrated that systemically delivered GMSCs can home the mandibular bone defect sites promote regeneration. However,...