A5100666865- Hereditary Neurological Disorders
- Amyotrophic Lateral Sclerosis Research
- Neurological diseases and metabolism
- Neurogenetic and Muscular Disorders Research
- Sports injuries and prevention
- Vagus Nerve Stimulation Research
- Genetic Neurodegenerative Diseases
- Inflammatory Bowel Disease
- EEG and Brain-Computer Interfaces
- Shoulder Injury and Treatment
- Microscopic Colitis
- Climate Change and Health Impacts
- Heart Rate Variability and Autonomic Control
- Remote Sensing in Agriculture
- Parkinson's Disease Mechanisms and Treatments
- Air Quality and Health Impacts
- Neuroscience and Neuropharmacology Research
- Intracerebral and Subarachnoid Hemorrhage Research
- Diet and metabolism studies
- RNA Research and Splicing
- RNA regulation and disease
- Mesenchymal stem cell research
- Acute Ischemic Stroke Management
- Stroke Rehabilitation and Recovery
- Gut microbiota and health
Peking University Third Hospital
2008-2025
Peking University
2008-2025
The University of Tokyo
2021-2025
Hebei Medical University
2022-2025
Second Hospital of Hebei Medical University
2022-2025
China Pharmaceutical University
2023-2025
Yunnan University
2023-2025
Hubei University of Medicine
2025
Tianjin Medical University General Hospital
2020-2024
Central South University
2022-2024
Abstract Dysregulated prefrontal control over amygdala is engaged in the pathogenesis of psychiatric diseases including depression and anxiety disorders. Here we show that, a rodent model induced by chronic restraint stress (CRS), dysregulation occurs basolateral projection neurons receiving mono-directional inputs from dorsomedial cortex (dmPFC→BLA PNs) rather than those reciprocally connected with dmPFC (dmPFC↔BLA PNs). Specifically, CRS shifts dmPFC-driven excitatory-inhibitory balance...
Abstract Ferroptosis is a regulatory cell death process pivotal in myocardial ischemia–reperfusion (I/R) injury. However, the precise mechanism underlying ferroptosis remains less known. In this study, we investigated pathophysiological mechanisms of methylmalonic acid (MMA) associated with activation cardiomyocytes after I/R. We found an increase level MMA patients acute injury reperfusion and AC16 cells under hypoxia/reoxygenation (H/R) condition. treatment was to be excessive oxidative...
Intracerebral hemorrhage (ICH) is the devastating subtype of stroke with cardiovascular complications, resulting in high rates mortality and morbidity release inflammatory factors. Previous studies have demonstrated that activation α7nAChR can reduce immune inflammation-related diseases by triggering cholinergic anti-inflammatory pathway (CAIP). mediates protection from nervous system inflammation through AMPK-mTOR-p70S6K-associated autophagy. Therefore, purpose this study to explore whether...
•Mean fasting plasma glucose (FPG) levels increased globally from 1990 to 2019.•High FPG-related disease burden 2050.•FPG and their showed age socioeconomic heterogeneities.•Aging, unhealthy lifestyles, elevated body mass index, low temperatures are risk factors. Hyperglycemia is a key factor for death disability worldwide. To better inform prevention strategies, we aimed delineate predict the temporal, spatial, demographic patterns in mean related globally. Based on Global Burden of Disease...
Background and purpose Distal hereditary motor neuropathies (dHMNs) are a clinically genetically heterogeneous group of disorders. The this study was to identify the genetic distribution dHMNs in large cohort Chinese patients provide insight into underlying common pathophysiology dHMNs. Methods Multi‐gene panel testing or whole‐exome sequencing performed 70 index with diagnosed dHMN between January 2007 December 2018. clinical features, Charcot–Marie–Tooth (CMT) neuropathy scores...
Although many studies have reported the negative effects of microplastics on aquatic organisms, most research is focused individual scales. Individual highlight harm mechanisms, but understanding broader ecological necessitates evidence from multiscale perspectives, particularly those based interspecific interactions. Therefore, in this study, we investigated impacts different microplastic concentrations (0, 0.4, 2, and 10 mg/L) characteristics (physiology, behavior, grazing rate) population...
Objective Charcot–Marie–Tooth (CMT) disease is the most common inherited neuromuscular disorder. Multi-echo Dixon MRI technique a highly sensitive method for quantifying muscle fatty infiltration, which may provide excellent value assessment of CMT. Due to rareness disease, its use in CMT has been rarely evaluated, especially subtypes. Methods Thirty-four CMT1 patients, 25 CMT2 and 10 healthy controls were recruited. All recruited patients are CMT1A with PMP22 duplication. Among 7 CMT2A MFN2...
Background and Objective Gut microbiota dysbiosis following stroke affects the recovery of neurological function. Administration prebiotics to counteract post-stroke may be a potential therapeutic strategy improve We aim observe effect lactulose on function outcomes, gut composition, plasma metabolites in mice after stroke. Methods Male C57BL/6 (20–25 g) were randomly divided into three groups: healthy control, photothrombotic + triple-distilled water, lactulose. After 14 consecutive days...
Ovarian cancer is the leading cause of death among all gynecological malignancies, and drug resistance renders current chemotherapy agents ineffective for patients with advanced metastatic tumors. We report an effective treatment strategy targeting ovarian involving a nanoformulation (Bola/IM)─bola-amphiphilic dendrimer (Bola)-encapsulated imatinib (IM)─to target critical mediator stem cells (CSCs) CD117 (c-Kit). Bola/IM offered significantly more CSCs compared to IM alone, through novel...
Purpose: To analyze the clinical distribution and antimicrobial resistance of Pseudomonas aeruginosa ( P. ) isolated from blood specimens in 75 hospitals Hebei Province 2016 to 2021 aid rational selection drugs. Patients Methods: WHONET 5.6 SPSS 24.0 were used retrospectively characteristics variations drug-resistance. Results: Between 2021, 2208 strains detected Province. The median age patients with was 63 years, a male-to-female ratio 2.1:1. Predominantly, hematology (20.7%) critical care...
Objective Hereditary transthyretin amyloidosis (ATTRv) is an autosomal dominant genetic disease characterized by the misfolding and deposition of (TTR) protein. This study aimed to describe clinical characteristics ATTRv in a large multicenter Chinese cohort. Methods Patients from 14 centers were included study. The all patients summarized. peripheral blood white cell mitochondrial DNA (mtDNA) was detected offspring different genders. Results A total 202 individuals with 148 families...
Antibiotic pollution in natural water bodies has reached alarming levels, posing a significant threat to the delicate balance of aquatic ecosystems. Bacteria and phytoplankton are foundational components these ecosystems, playing crucial roles as decomposers primary producers, respectively, their symbiotic relationships essential for maintaining ecological stability. Despite accumulating research focusing on direct toxic effects antibiotics, disruptions complex bacteria–phytoplankton...
Exercise duration and intensity are important parameters in exercise prescription play a major role improving insulin sensitivity (including transient persistent improvement effects following cessation of training) patients with type 2 diabetes mellitus (T2DM). However, whether or is the more factor has yet to be established. Therefore, we aimed determine prescriptions differing differ their ability aid T2DM retain conclusion period training. Sedentary (age 51.2 ± 1.3 years) were assigned...
Glioblastoma multiforme (GBM) is a refractory tumor with poor prognosis and requires more effective treatment regimens. It has been confirmed that long noncoding RNAs (lncRNAs) substantially regulate various human disease including GBM. However, the biological roles its underlying molecular mechanisms still need to be further investigated. In this study, function potential mechanism of lncHAS2-AS1 in GBM were explored. was discovered HAS2-AS1 elevated glioma tissues correlated patients...