A5080712506- Cytokine Signaling Pathways and Interactions
- Immune cells in cancer
- Lipoproteins and Cardiovascular Health
- Dermatological and Skeletal Disorders
- Essential Oils and Antimicrobial Activity
- Inflammatory Myopathies and Dermatomyositis
- Cellular transport and secretion
- Viral Infectious Diseases and Gene Expression in Insects
- Vitamin K Research Studies
- Genetic factors in colorectal cancer
- Phytochemistry and Biological Activities
- Congenital heart defects research
- Traditional Chinese Medicine Analysis
- Attention Deficit Hyperactivity Disorder
- Amyloidosis: Diagnosis, Treatment, Outcomes
- Cholesterol and Lipid Metabolism
- Myasthenia Gravis and Thymoma
- Vitamin C and Antioxidants Research
- Thyroid and Parathyroid Surgery
- Autoimmune Bullous Skin Diseases
- Glycosylation and Glycoproteins Research
- Genetics and Neurodevelopmental Disorders
- Epigenetics and DNA Methylation
- Chronic Lymphocytic Leukemia Research
- Cancer, Lipids, and Metabolism
Huashan Hospital
2024-2025
Fudan University
2024-2025
Beijing Anzhen Hospital
2021-2024
Capital Medical University
2021-2024
Wenzhou Medical University
2019
Second Affiliated Hospital & Yuying Children's Hospital of Wenzhou Medical University
2019
Ningbo No. 2 Hospital
2019
Third People's Hospital of Hangzhou
2015
Anhui Medical University
2015
Columbia University Irving Medical Center
2015
Objective Hereditary transthyretin amyloidosis (ATTRv) is an autosomal dominant genetic disease characterized by the misfolding and deposition of (TTR) protein. This study aimed to describe clinical characteristics ATTRv in a large multicenter Chinese cohort. Methods Patients from 14 centers were included study. The all patients summarized. peripheral blood white cell mitochondrial DNA (mtDNA) was detected offspring different genders. Results A total 202 individuals with 148 families...
<title>Abstract</title> <bold>Background:</bold>Glutamine-fructose-6-phosphate transaminase 1 (GFPT1) is the key enzyme initiating protein O- and N-glycosylation at postsynaptic membrane. Variants in<italic> GFPT1</italic> gene cause congenital myasthenic (GFPT1-CMS). However, understanding of phenotype genetic spectrum GFPT1-CMS remains limited. <bold>Methods</bold>: A total 24 patients with from 22 Han Chinese families across four neuromuscular disease centers were included in this study....
Molecular characterizations, including microsatellite instability (MSI) and the CpG island methylator phenotype (CIMP) showed strong associations in colorectal carcinoma (CRC) provided a deeper understanding of etiology disease. However, global relationship between epigenetic alternations changes mRNA expression CRC remains largely undefined, especially regarding roles DNA methyltransferases (DNMTs). Here, we conducted systematic network comparison to explore conservation co-expressed...
ObjectiveTo investigate whether and how simvastatin mediates protection from lethal sepsis, using a mouse model.MethodsSixty C57BL/6 mice were selected divided into three groups ("control," "model," "observation"; n = 20 per group). Mice in the model observation underwent cecal ligation puncture; group received simvastatin. After 24 hours of induced serum concentrations IL-6, TNF-α, IL-1, IL-10 measured by ELISA. Serum malondialdehyde (MDA) superoxide dismutase (SOD) activities quantified...
Familial hypercholesterolemia (FH) is a common inherited metabolic disease that causes premature atherosclerosis, cardiovascular disease, and even death at young age. Approximately 95% of FH-causing genetic variants have been identified are in the LDLR gene. However, only 10% FH population worldwide has diagnosed adequately treated, due to existence numerous unidentified variants, uncertainties pathogenicity scoring many substantial number individuals lacking access testing.
Background GlcNAc2-epimerase (GNE) myopathy is a rare autosomal recessive disorder caused by pathogenic variants in the GNE gene, which essential for sialic acid biosynthesis pathway. Objective This multi-centre study aimed to delineate clinical phenotype and variant spectrum Chinese patients, enhancing our understanding of genetic diversity manifestation across different populations. Methods We retrospectively analysed from 113 integrating these data with external online databases global...
There have been many researches on the roles of regulatory T cells in pathogenesis systemic lupus erythematosus, psoriasis, autoimmune bullous diseases, etc. With discovery B secreting interleukin 10(IL-10), namely B10 cells, human body, it has revealed that and IL-10 negative immunoregulatory effect, can protect against diseases. Many studies shown number function as well level are abnormal above suggesting a relationship between these abnormalities occurrence development diseases. Key...
Abstract Background: Homozygous/compound heterozygous familial hypercholesterolemia (HoFH/cHeFH) is characterized by extremely elevated low-density lipoprotein-cholesterol (LDL-C) levels that have been reported to contribute a long-term chronic systemic inflammation. The aims of this study are describe the inflammatory profile HoFH/cHeFH patients and explore effect PCSK9 inhibitor (PCSK9i) on series biomarkers, neutrophil-lymphocyte ratio (NLR), platelet-lymphocyte (PLR), monocyte-HDL (MHR),...