A5102022376- Genetic factors in colorectal cancer
- Colorectal Cancer Screening and Detection
- Colorectal Cancer Surgical Treatments
- Colorectal Cancer Treatments and Studies
- Pelvic floor disorders treatments
- Congenital gastrointestinal and neural anomalies
- Gastrointestinal motility and disorders
- Helicobacter pylori-related gastroenterology studies
- MicroRNA in disease regulation
- Anorectal Disease Treatments and Outcomes
- Cancer Genomics and Diagnostics
- Wound Healing and Treatments
- Maternal Mental Health During Pregnancy and Postpartum
- Epigenetics and DNA Methylation
- COVID-19 Impact on Reproduction
- T-cell and B-cell Immunology
- Hepatitis C virus research
- Sirtuins and Resveratrol in Medicine
- Digestive system and related health
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Mesenchymal stem cell research
- Immunotherapy and Immune Responses
- RNA modifications and cancer
- Gastroesophageal reflux and treatments
- PARP inhibition in cancer therapy
Qingdao Municipal Hospital
2020-2024
Qingdao University
2020-2024
Tianjin People's Hospital
2016-2023
Nankai University
2013-2023
Union Hospital
2010-2017
Tianjin University of Traditional Chinese Medicine
2016
Central South University
2015
The application of circulating, cell-free, methylated Septin9 (mSEPT9) DNA in screening and recurrence monitoring is highly promising. CpG island methylator phenotype (CIMP) associated with microsatellite instability (MSI). present study was performed to determine the diagnostic accuracy mSEPT9 for colorectal cancer (CRC) evaluate its utility CRC monitoring.For diagnosis CRC, peripheral detection fecal occult blood test (FOBT) were 650 subjects, then level CEA, CA19-9 CA724 quantified 173...
We previously reported that polyploid giant cancer cells (PGCCs) exhibit stem cell properties and can generate daughter with the epithelial-mesenchymal transition phenotype. This study investigated role of PGCC formation in prognostic value neoadjuvant chemoradiation therapy (nCRT) locally advanced rectal (LARC). The morphological characteristics were observed patients LARC after nCRT. Colorectal lines treated irradiation or chemotherapeutic drugs, metastasis-related proteins detected. 304...
Pathological scars (PS), including hypertrophic (HTS) and keloids, are a common complication of poor wound healing that significantly affects patients’ quality life. Currently, there several treatment options for PS, surgery, drug therapy, radiation biological therapy. However, these treatments still face major challenges such as low efficacy, high side effects, risk recurrence. Therefore, the search safer more effective is particularly urgent. New materials often have less immune rejection,...
Objectives The aim of this study is to evaluate the three-dimensional anorectal pressure topography normal healthy adults and patients with paradoxical puborectalis syndrome (PPS) using a novel high-resolution manometry (3D-HRM) anorectum. Methods 3D-HRM probe has 6.4 cm long sensing segment that composed 256 independent transducers around its circumference. It generates 3D topographic profile We evaluated 41 women 38 men PPS (median age 52 years), compared them 37 34 who were 51 years). was...
Recent studies have shown that deficient mismatch repair (dMMR) rectal cancer may be related to treatment resistance, resulting in a worse prognosis than proficient MMR (pMMR) cancer. The purpose of this study was explore whether surgery plus other treatments (radiotherapy and chemotherapy) can bring more benefits these patients alone.A retrospective 168 with adenocarcinoma who underwent total mesorectal excision conducted using immunohistochemical methods determine status propensity score...
Background Skin grafting with the preservation of denatured dermis is a novel strategy for treatment burn-injured skin. Denatured has ability to restore morphology and function normal skin, but underlying molecular mechanism elusive. MicroRNAs (miRNA) are small noncoding RNAs regulate physiology as well disease development. In this study, we assessed potential role miRNA-23b (miR-23b) in regulation cell proliferation migration heat-denatured fibroblasts identified mechanism. Methods The...
Rectal cancer is a common malignant tumor of the digestive tract, with high incidence and mortality. This study aimed to identify potential biomarkers therapeutic targets for rectal adenocarcinoma (RAC) metastasis. The expression profiling RAC patients metastasis without was downloaded from Cancer Genome Atlas (TCGA) database. datasets were used genes associated Fifty up-regulated seventeen down-regulated identified in primary loci compared non-metastasis. Sixty-seven dysregulated gens...
Previous studies have concluded that colorectal cancer patients with deficient mismatch repair (dMMR) usually a good prognosis. However, some suggested the prognosis of rectal dMMR appears to be worse. Our aim was investigate chemoradiotherapy resistance in tumors.A retrospective study 217 locally advanced adenocarcinoma treated and total mesorectal excision surgery conducted using immunohistochemistry determine MMR status propensity score matching models reduce potential confounders....
The objective of the present study was to screen key genes ribavirin in hepatocellular carcinoma (HCC) and provide novel therapeutic targets for HCC treatment. mRNA expression datasets GSE23031 GSE74656, as well microRNA (miRNA) dataset GSE22058 were downloaded from Gene Expressed Omnibus database. In dataset, there three cell lines treated with PBS ribavirin. GSE74656 five tissues adjacent selected. 96 differentially expressed (DEGs) miRNAs identified via limma package R. Ontology (GO)...
Abstract Background and Aim Progesterone receptor, inflammation, neurotransmitter expression, fibrosis are involved in slow‐transit constipation. The aim of the present study was to examine whether patients with constipation have an overexpression progesterone receptor serotonin, which may impair muscularis propria colorectal wall. Methods High‐resolution colon manometry used record peristaltic contractions proximal ascending sigmoid patients. Protein samples prepared from frozen tissue...
// Dan Wang 1, * , Shengyun Liang 2, Zhao Zhang 3, Guoru 2 Yuan Hu 4 Shengran 5 Xipeng 3 Santasree Banerjee 6, 1 Department of Pathology, Tianjin Medical University General Hospital, 300052, China Shenzhen Institutes Advanced Technology, Chinese Academy Sciences, 518055, Colorectal Surgery, Union Center, 300121, Hematology, Third Affiliated Sun Yat-Sen University, Guangzhou 510006, School Life Science and Biopharmaceuticals, Guangdong Pharmaceutical 6 Cell Biology Genetics, Medicine,...
INTRODUCTION: To define the prognosis of colorectal cancer (CRC) in young patients and to compare their postoperative treatment with that older patients. METHODS: This multicenter study enrolled 5,457 primary CRC who underwent surgical resection. The overall survival (OS), clinicopathologic characteristics, 253 aged 18–44 years 5,204 44–80 were analyzed. RESULTS: OS rate was 77.1% for 74.2% ( P = 0.348). Landmark analysis showed a significant difference between patients, 63.8% deaths among...
Familial adenomatous polyposis (FAP) is an autosomal dominant precancerous condition which associated with germline mutations of the APC gene. Clinically, FAP characterized by development multiple colorectal adenomas or polyps finally result in cancer 40 years age patient, if no surgical interventions have been undertaken. In this study, we present a clinical molecular study four generation Chinese family FAP. Diagnosis was made on basis manifestations, history and medical (colonoscopy...
Germline mutations of the APC gene are associated with an autosomal dominant precancerous condition, termed familial adenomatous polyposis (FAP). FAP is clinically manifested by presence multiple colorectal adenomas or polyps. Gradually, these polyps inevitably result in cancer third-to fourth decade life. Surgical interventions total proctocolectomy best possible treatment for FAP. Here, we present a clinical molecular study five generation Chinese family Diagnosis was made on basis...
BACKGROUND Familial adenomatous polyposis (FAP), which has a very high tendency of progression to colorectal cancer, is mainly caused by mutations the coli (APC) gene. This study systematically screened APC and observed correlation with clinical manifestations FAP. MATERIAL AND METHODS Eighty subjects (probands their family members 22 FAP pedigrees) were enrolled, underwent abdominal ultrasound, computed tomography, colonoscopic examinations, assessed for between January 2010 June 2015 at...
Different clinical treatments are available to treat patients with constipation. We aimed study the etiology and direct treatment in a case series of constipation by use high-resolution colonic manometry (HRCM).High-resolution was used record colorectal peristaltic contractions entire colon patients. Based on results HRCM, 151 were classified into groups received different such as total or subtotal colectomy, local excision, conservative treatment. Paraffin-embedded samples obtained after...
Abstract Background Familial adenomatous polyposis (FAP) is an autosomal dominantly inherited disease which primarily manifested with developing adenomas or polyps in colon rectum. It caused by the germline mutations coli ( APC ) gene. Patients FAP are usually “hundreds even thousands” However, without proper clinical diagnosis and timely surgical interventions, colorectal adenomas, gradually increase size numbers finally leads to cancer (CRC) at mean age of 36 years patient. Methods In this...
BACKGROUND:The aim of this study was to evaluate the curative effect transvaginal mesh repair (TVMR) and stapled transanal rectal resection (STARR) in treating outlet obstruction constipation caused by rectocele. MATERIAL AND METHODS:Patients who had rectocele were retrospectively analyzed 39 patients enrolled study. Patients assigned either TVMR or STARR group. Postoperative factors such as complications, pain, recurrence rate, operative time compared between 2 groups. RESULTS:Total...
We evaluate the prognostic value of chemotherapy and other factors on overall survival among colon patients with deficient mismatch repair (dMMR), determine optimum time to start after surgery. Data 306 cancer dMMR who received radical surgery were collected from three Chinese centers between August 2012 January 2018. Overall (OS) was assessed Kaplan-Meier method log-rank. Cox regression analysis used assess influencing prognosis factors. The median follow-up for all 45.0 months (range,...
We evaluated the prognostic role of deficient mismatch repair (dMMR) systems in stage II and III colon cancer patients during different postoperative periods. also assessed whether aged ≥75 could benefit from chemotherapy.This retrospective study was conducted across three medical centers China. Kaplan-Meier survival methods Cox proportional hazards models were used to evaluate differences overall (OS) disease-free (DFS) rates. Propensity score matching performed reduce imbalances baseline...