A5101398365- Genetic factors in colorectal cancer
- Colorectal Cancer Screening and Detection
- Colorectal Cancer Surgical Treatments
- Pancreatic and Hepatic Oncology Research
- Gastric Cancer Management and Outcomes
- Hepatitis B Virus Studies
- Hepatocellular Carcinoma Treatment and Prognosis
- Cancer Genomics and Diagnostics
- Calcium signaling and nucleotide metabolism
- Sirtuins and Resveratrol in Medicine
- Ocular Diseases and Behçet’s Syndrome
- Inflammatory Bowel Disease
- interferon and immune responses
- COVID-19 Clinical Research Studies
- Head and Neck Surgical Oncology
- Sinusitis and nasal conditions
- Body Composition Measurement Techniques
- Chronic Lymphocytic Leukemia Research
- RNA modifications and cancer
- Systemic Lupus Erythematosus Research
- Nutrition and Health in Aging
- Dental Implant Techniques and Outcomes
- Cancer-related Molecular Pathways
- Urinary and Genital Oncology Studies
- Cancer, Lipids, and Metabolism
Nankai University
2021-2025
Tianjin People's Hospital
2021-2024
Certain subgroups are at an increased risk of false fecal immunochemical test (FIT) results; however, related studies limited, and the available evidence is conflicting. To evaluate factors associated with false-positive false-negative FIT results. This retrospective study was based on database Tianjin Colorectal Cancer Screening Program from 2012 to 2020. A total 4129947 residents aged 40-74 years completed least one FIT. Of these, 24890 asymptomatic participants who underwent colonoscopy...
ABSTRACT Background The microsatellite status (dMMR vs. pMMR) in colorectal cancer can serve as a guiding factor for patient prognosis and treatment, where dMMR indicates better often obviates the need adjuvant chemotherapy (ACT). Conversely, higher lymph node ratio (LNR) is associated with poorer prognosis. This study aims to elucidate prognostic significance of LNR MMR relation ACT stages II III cancer. Methods A total 1946 patients who underwent radical resection were pathologically...
Recent studies have shown that deficient mismatch repair (dMMR) rectal cancer may be related to treatment resistance, resulting in a worse prognosis than proficient MMR (pMMR) cancer. The purpose of this study was explore whether surgery plus other treatments (radiotherapy and chemotherapy) can bring more benefits these patients alone.A retrospective 168 with adenocarcinoma who underwent total mesorectal excision conducted using immunohistochemical methods determine status propensity score...
Methylated syndecan2 (mSDC2) in stool samples has been found to be associated with colorectal cancer (CRC) and precancerous lesions. However, the available data are limited, no previous studies have compared analysis of mSDC2 other diagnostic tests. Thus, we aimed evaluate clinical performance a test compare its that blood-based tests for methylated septin9 (mSEPT9), carcinoembryonic antigen (CEA), carbohydrate 19-9 (CA19-9) 724 (CA724) detecting neoplasms.The gold standard technique was...
Abstract Objectives Our aim was to investigate the prevalence and predictive variables of sarcopenia. Methods We recruited participants from Peking Union Medical College Hospital Multicenter Prospective Longitudinal Sarcopenia Study (PPLSS). Muscle mass quantified using bioimpedance, muscle function grip strength gait speed. Logistic regression revealed relationships between sarcopenia nutritional, lifestyle, disease, psychosocial physical variables. Results The sarcopenic obesity 9.2%‐16.2%...
Previous studies have concluded that colorectal cancer patients with deficient mismatch repair (dMMR) usually a good prognosis. However, some suggested the prognosis of rectal dMMR appears to be worse. Our aim was investigate chemoradiotherapy resistance in tumors.A retrospective study 217 locally advanced adenocarcinoma treated and total mesorectal excision surgery conducted using immunohistochemistry determine MMR status propensity score matching models reduce potential confounders....
INTRODUCTION: To define the prognosis of colorectal cancer (CRC) in young patients and to compare their postoperative treatment with that older patients. METHODS: This multicenter study enrolled 5,457 primary CRC who underwent surgical resection. The overall survival (OS), clinicopathologic characteristics, 253 aged 18–44 years 5,204 44–80 were analyzed. RESULTS: OS rate was 77.1% for 74.2% ( P = 0.348). Landmark analysis showed a significant difference between patients, 63.8% deaths among...
BACKGROUND We aimed to evaluate the ability of circulating cell-free methylated SETP9 DNA (mSEPT9) identify recurrence and determine its clinical utility in adjuvant chemotherapy (ACT) regimen decisions. MATERIAL AND METHODS This study enrolled 426 patients with stage II-III CRC who received radical resection between January 8, 2018, November 30, 2020. The median follow-up duration was 15.8 months (range, 8.1-43.4 months). primary endpoint recurrence-free survival (RFS). A propensity score...
Immunotherapy has revolutionized cancer treatment and become one of the five pillars therapy. The clinical applications immunotherapy have been adapted to range from management melanoma most tumor types. As immunotherapies expand, understanding treatment-related adverse events these drugs becomes critical in practice. We report a rare case ocular immune-related side effects associated with camrelizumab that resulted vision loss. A 56-year-old male patient was diagnosed small cell lung...
Abstract Background There have been controversial voices on if hepatitis B virus infection decreases the risk of colorectal liver metastases or not. This study aims to find association between HBV and postoperative survival cancer in patients. Methods Patients who underwent curative surgical resection for January 2011 December 2012 were included. grouped according anti-HBc. Differences overall survival, time progress, hepatic metastasis-free groups significant predictors analyzed. Results...
Abstract Purpose: This study aims to the find association between HBV infection and postoperative survival risk of liver metastasis in colorectal cancer patients. Methods: Patients who underwent curative surgical resection for (CRC) January 2011 December 2012 were included. grouped according anti-HBc. Differences overall (OS), time progress (TTP) hepatic metastasis-free (HMFS) groups significant predictors analyzed. Results: 327 patients are comprised 202 anti-HBc negative cases 125 positive...
We evaluate the prognostic value of chemotherapy and other factors on overall survival among colon patients with deficient mismatch repair (dMMR), determine optimum time to start after surgery. Data 306 cancer dMMR who received radical surgery were collected from three Chinese centers between August 2012 January 2018. Overall (OS) was assessed Kaplan-Meier method log-rank. Cox regression analysis used assess influencing prognosis factors. The median follow-up for all 45.0 months (range,...
We evaluated the prognostic role of deficient mismatch repair (dMMR) systems in stage II and III colon cancer patients during different postoperative periods. also assessed whether aged ≥75 could benefit from chemotherapy.This retrospective study was conducted across three medical centers China. Kaplan-Meier survival methods Cox proportional hazards models were used to evaluate differences overall (OS) disease-free (DFS) rates. Propensity score matching performed reduce imbalances baseline...
Objective To provide anatomical basis for maxillary sinus floor elevation and other clinical oral surgery by discussing the relationships between posterior superior alveolar artery(PSAA) floor, PSAA ridge. Methods Ten sides of wet skull specimens fixed 10% formaldehyde were exquisitely dissected from June 2015 to December 2015.The locations sinus, ridge studied respectively. The group set up. second molar area, first premolar area selected as positions measurement in every group....