A5063218283- Extracellular vesicles in disease
- MicroRNA in disease regulation
- Circular RNAs in diseases
- Probiotics and Fermented Foods
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Angiogenesis and VEGF in Cancer
- Gut microbiota and health
- Cardiovascular Disease and Adiposity
- Renin-Angiotensin System Studies
- Neuroinflammation and Neurodegeneration Mechanisms
- Cancer-related molecular mechanisms research
- Microbial Metabolites in Food Biotechnology
- Inflammatory Biomarkers in Disease Prognosis
- Neurological Disease Mechanisms and Treatments
- RNA modifications and cancer
- Drug Transport and Resistance Mechanisms
- Receptor Mechanisms and Signaling
- Ferroptosis and cancer prognosis
- Advanced Polymer Synthesis and Characterization
- Liver Disease Diagnosis and Treatment
- Protein Hydrolysis and Bioactive Peptides
- Food Quality and Safety Studies
- Gallbladder and Bile Duct Disorders
- Protein Interaction Studies and Fluorescence Analysis
- Immune cells in cancer
Marshall University
2020-2025
Nanjing Medical University
2023-2024
Sichuan University
2018-2023
Qingdao University
2014-2023
Qingdao Women and Children's Hospital
2015-2023
Jinan Central Hospital
2023
Huntington University
2023
Tianjin University of Science and Technology
2010-2022
State Key Laboratory of Biotherapy
2019-2021
Wright State University
2011-2020
Nanosilver is increasingly used in the food industry and biomedical applications. A lot of studies have been done to investigate potential toxicity nanosilver. But information on whether or how nanosilver particles bring changes genetic materials remains scant. In this study, replication fidelity rpsL gene was quantified when were present polymerase chain reactions (PCRs) cell cultures E. coli transformed with wild-type gene. Three types (silver nanopowder, SN; silver–copper SCN; colloidal...
circular RNAs (circRNAs) have been demonstrated to play a crucial role in cancer progression. KIAA1429, key component of the m6A methyltransferase complex, has recently reported promote hepatocellular carcinoma (HCC) progression by regulating methylation. The aim present study is investigate KIAA1429-mediated HCC
Glioma stem cells (GSCs) play an important role in glioblastoma prognosis. Exosomes (EXs) mediate cell communication by delivering microRNAs (miRs). Glioblastoma has a high level of miR-21 which could upregulate vascular endothelial growth factor (VEGF) expression. We hypothesized GSC-EXs can promote the angiogenic ability (ECs) through miR-21/VEGF signal. GSCs were isolated from U-251 with marker CD133. transfected without or scramble mimics used to produce GSC-EXscon, GSC-EXssc and...
Abstract Understanding the roles of noncoding RNAs (ncRNA) in tumorigenesis and metastasis would establish novel avenues to identify diagnostic therapeutic targets. Here, we aimed hepatocellular carcinoma (HCC)–specific ncRNA investigate their hepatocarcinogenesis metastasis. RNA-seq xenografts generated by lung identified long RNA small nucleolar host gene 10 (SNHG10) its homolog SCARNA13 as drivers for development HCC. SNHG10 expression positively correlated with 64 HCC cases, high or was...
Angiotensin-converting enzyme 2 (ACE2) is an emerging cardiovascular protective target that mediates the metabolism of angiotensin (Ang) II into Ang (1–7). Our group has demonstrated ACE2 overexpression enhances function endothelial progenitor cells (EPCs). Here, we investigated whether ACE2-primed EPCs (ACE2-EPCs) can protect cerebral microvascular (ECs) against injury and dysfunction in vitro model, with focusing on their exosomal cytokine paracrine effects mitochondria. Human were...
Oxidative stress-induced endothelial dysfunction plays a key role in ischemia/reperfusion injury. Recent evidence indicates that progenitor cell-derived microvesicles (EPC-MVs) can promote angiogenesis of cells (ECs). Here, we investigated the potential effects EPC-MVs on hypoxia/reoxygenation (H/R) injury human brain microvascular ECs (hb-ECs). MVs were prepared from EPCs cultured serum deprivation (SD) medium (starving stress, sEPC-MVs) or SD containing tumor necrosis factor- α (TNF )...
Abstract Backgrounds/aims Mesenchymal stromal cell-derived exosomes (MSC-EXs) could exert protective effects on recipient cells by transferring the contained microRNAs (miRs), and miR-132-3p is one of angiogenic miRs. However, whether combination MSC-EXs has better in ischemic cerebrovascular disease remains unknown. Methods Mouse MSCs transfected with scrambler control or mimics were used to generate miR-132-3p-overexpressed (MSC-EXs ). The EXs hypoxia/reoxygenation (H/R)-injured ECs ROS...
Exercise has cardiovascular benefits which might be related to endothelial progenitor cells (EPC). Meanwhile, there is evidence suggesting that EPC-derived exosomes (EPC-EX) promote vascular repair and angiogenesis through their carried microRNA (miR)-126. In this study, we investigated whether exercise could increase the levels of circulating EPC-EX miR-126 cargo, by protective function on (EC).Plasma from sedentary, low, or moderate mice, respectively, denoted as EPC-EX, were isolated...
Abstract Aims We previously showed that the protective effects of endothelial progenitor cells (EPCs)‐released exosomes (EPC‐EXs) on endothelium in diabetes. However, whether EPC‐EXs are diabetic ischemic stroke is unknown. Here, we investigated mice and tested miR‐126 enriched (EPC‐EXs miR126 ) have enhanced efficacy. Methods The db/db subjected to were intravenously administrated with 2 hours after stroke. infarct volume, cerebral microvascular density (MVD), blood flow (CBF), neurological...
Abstract Background We have previously verified the beneficial effects of exosomes from endothelial progenitor cells (EPC-EXs) in ischemic stroke. However, EPC-EXs hemorrhagic stroke not been investigated. Additionally, miR-137 is reported to regulate ferroptosis and be involved neuroprotection against Hence, present work explored miR-137-overexpressing on apoptosis, mitochondrial dysfunction, oxyhemoglobin (oxyHb)-injured SH-SY5Y cells. Methods The lentiviral was transfected into EPCs then...
Exosomes (EXs) are emerging as novel players in the beneficial effects induced by exercise on vascular diseases. We have recently revealed that moderate enhances function of circulating endothelial progenitor cell-derived EXs (cEPC-EXs) protecting cells against hypoxia injury. However, relationship between changes cEPC-EXs and ischemic stroke (IS) is unknown. Here, we investigated whether exercise-regulated EPC-EXs contribute to IS. C57BL/6 mice received treadmill (10 m/min) for 4-wks then...
Tumor-associated tertiary lymphoid structures (TLS) play a critical role in the progression of various tumors. However, dynamics lymphocyte recruitment during hepatocellular carcinoma (HCC) clinical have not been fully elucidated. In present study, tissue microarrays and hematoxylin-eosin staining were used to evaluate existence degree TLS HCC patients. Nine immune biomarkers intratumoral tissues examined by immunohistochemical staining. A total 462 patients recruited for study. Kaplan-Meier...
Kombucha, which is rich in tea polyphenols and organic acid, a kind of acidic soup beverage fermented by acetic acid bacteria, yeasts, lactic bacteria. Kombucha has been reported to possess anti-diabetic activity, but the underlying mechanism was not well understood. In this study, high-fat, high-sugar diet combined with streptozotocin (STZ) injection used induce T2DM model mice. After four weeks kombucha intervention, physiological biochemical index were measured determine diabetes-related...
For determining the implications of circulating endothelial progenitor cells (cEPCs) and cellular membrane microparticles (MPs) in diabetic stroke, levels EPCs, EPC-MPs, endothelium-derived MPs (EMPs) their correlations with blood glucose concentration, cerebral microvascular density (cMVD), ischemic damage were investigated type 2 db/db db/+ (wild-type control) mice. Therapeutic efficacy EPC infusion (preincubated MPs) was also explored. Ischemic stroke induced by middle artery occlusion...
Stem cell-derived exosomes (EXs) offer protective effects on various cells via their carried microRNAs (miRs). Meanwhile, miR-210 has been shown to reduce mitochondrial reactive oxygen species (ROS) overproduction. In this study, we determined the potential of endothelial progenitor EXs (EPC-EXs) hypoxia/ reoxygenation (H/R) injured (ECs) and investigated whether these could be boosted by loading.Human EPCs were used generate EPC-EXs, or transfected with scrambler control mimics EPC-EXssc...
ZW3 regulated the biomarkers and behaviors associated with tryptophan metabolism, HPA axis, immune system in depressed mice by regulating gut microbiota.