A5100430863- Radiomics and Machine Learning in Medical Imaging
- Bladder and Urothelial Cancer Treatments
- Esophageal Cancer Research and Treatment
- MRI in cancer diagnosis
- Eosinophilic Esophagitis
- Arctic and Antarctic ice dynamics
- Glioma Diagnosis and Treatment
- Helicobacter pylori-related gastroenterology studies
- Advanced Neuroimaging Techniques and Applications
- Urinary and Genital Oncology Studies
- Methane Hydrates and Related Phenomena
- Functional Brain Connectivity Studies
- Tissue Engineering and Regenerative Medicine
- Eosinophilic Disorders and Syndromes
- Esophageal and GI Pathology
- Intraocular Surgery and Lenses
- IL-33, ST2, and ILC Pathways
- Retinal and Macular Surgery
- Gastroesophageal reflux and treatments
- Colorectal Cancer Screening and Detection
- Electrospun Nanofibers in Biomedical Applications
- Anesthesia and Pain Management
- Climate change and permafrost
- Prostate Cancer Diagnosis and Treatment
- Cryospheric studies and observations
Hangzhou Medical College
2024-2025
Xijing Hospital
2009-2024
Air Force Medical University
2015-2024
Chinese PLA General Hospital
2017-2024
First Institute of Oceanography
2009-2024
Union Hospital
2014-2024
Huazhong University of Science and Technology
2014-2024
Lanzhou University
2018-2024
Shandong University of Science and Technology
2024
Ministry of Natural Resources
2014-2024
Background Patients who have esophageal eosinophilia without gastroesophageal reflux disease (GERD) nevertheless can respond to proton pump inhibitors (PPIs), which anti-inflammatory actions independent of effects on gastric acid secretion. In cell cultures, omeprazole has been reported inhibit Th2 cytokine-stimulated expression eotaxin-3, an eosinophil chemoattractant contributing in eosinophilic esophagitis (EoE). The objective this study was elucidate molecular mechanisms underlying PPI...
Accurate glioma grading plays an important role in the clinical management of patients and is also basis molecular stratification nowadays.To verify superiority radiomics features extracted from multiparametric MRI to evaluate potential different sequences or parametric maps.Retrospective; radiomics.A total 153 including 42, 33, 78 with Grades II, III, IV gliomas, respectively.3.0T MRI/T1 -weighted images before after contrast-enhanced, T2 -weighted, multi-b-value diffusion-weighted 3D...
The retinoic acid receptor-related orphan receptors alpha and gamma (RORalpha (NR1F1) RORgamma (NR1F3)) are nuclear perform critical roles in regulation of development, metabolism, immune function. Cholesterol cholesterol sulfate have been suggested to be RORalpha ligands, but the physiological significance is unclear. To date, no endogenous ligands described. Here, we demonstrate that 7-oxygenated sterols function as high affinity for both by directly binding their ligand-binding domains...
Purpose To 1) describe textural features from diffusion‐weighted images (DWI) and apparent diffusion coefficient (ADC) maps that can distinguish low‐grade bladder cancer high‐grade, 2) propose a radiomics‐based strategy for grading using texture features. Materials Methods In all, 61 patients with (29 in high‐ 32 groups) were enrolled this retrospective study. Histogram‐ gray‐level co‐occurrence matrix (GLCM)‐based radiomics extracted cancerous volumes of interest (VOIs) on DWI corresponding...
Gastroesophageal reflux is associated with adenocarcinoma in Barrett's esophagus, but the incidence of this tumor rising, despite widespread use acid-suppressing medications. This suggests that refluxed material other than acid might contribute to carcinogenesis. We looked for potentially carcinogenetic effects two bile acids, deoxycholic (DCA) and ursodeoxycholic (UDCA), on epithelial cells vitro vivo. exposed (BAR-T) DCA or UDCA studied generation reactive oxygen/nitrogen species...
Background Noninvasive detection of isocitrate dehydrogenase (IDH) and TP53 mutations are meaningful for molecular stratification lower‐grade gliomas (LrGG). Purpose To explore potential MRI features reflecting IDH LrGG, propose a radiomics strategy detecting them. Study Type Retrospective, radiomics. Population/Subjects A total 103 LrGG patients were separated into development ( n = 73) validation 30) cohorts. Field Strength/Sequence T 1 ‐weighted (before after contrast‐enhanced), 2...
Hippocampal morphological change is one of the main hallmarks Alzheimer's disease (AD). However, whether hippocampal radiomic features are robust as predictors progression from mild cognitive impairment (MCI) to AD dementia and these provide any neurobiological foundation remains unclear. The primary aim this study was verify can serve magnetic resonance imaging (MRI) markers for AD. Multivariate classifier-based support vector machine (SVM) analysis provided individual-level predictions...
<h3>BACKGROUND AND PURPOSE:</h3> The heterogeneity of glioblastoma contributes to the poor and variant prognosis. aim this retrospective study was assess with MR imaging textures evaluate its impact on survival time. <h3>MATERIALS METHODS:</h3> A total 133 patients primary who underwent postcontrast T1-weighted (acquired before treatment) whose data were filed times selected from Cancer Genome Atlas. On basis overall survival, divided into 2 groups: long-term (≥12 months, <i>n</i> = 67)...
Background Noninvasive detection of isocitrate dehydrogenase 1 mutation (IDH1(+)) and loss nuclear alpha thalassemia/mental retardation syndrome X‐linked expression ((ATRX(–)) are clinically meaningful for molecular stratification low‐grade gliomas (LGGs). Purpose To study a radiomic approach based on multiparametric MR noninvasively determining status IDH1(+) ATRX(–) in patients with LGG. Study Type Retrospective, radiomics. Population Fifty‐seven LGG ( n = 36 19 17 ATRX(+) patients)...
Background Preoperative discrimination between nonmuscle‐invasive bladder carcinomas (NMIBC) and the muscle‐invasive ones (MIBC) is very crucial in management of patients with cancer (BC). Purpose To evaluate discriminative performance multiparametric MRI radiomics features for precise differentiation NMIBC from MIBC, preoperatively. Study Type Retrospective, radiomics. Population Fifty‐four postoperative pathologically proven BC lesions (24 30 MIBC groups) were included. Field...
Precise segmentation of bladder walls and tumor regions is an essential step towards non-invasive identification stage grade, which critical for treatment decision prognosis patients with cancer (BC). However, the automatic delineation in magnetic resonance images (MRI) a challenging task, due to important shape variations, strong intensity inhomogeneity urine very high variability across population, particularly on tumors appearance. To tackle these issues, we propose use deep fully...
Abstract Bladder cancer is one of the most common and highly vascularized cancers. To better understand its genomic structure underlying etiology, we conduct whole-genome targeted sequencing in urothelial bladder carcinomas (UBCs, type cancer). Recurrent mutations noncoding regions affecting gene regulatory elements structural variations (SVs) leading to disruptions are prevalent. Notably, find recurrent ADGRG6 enhancer FRS2 duplications which associated with higher protein expression tumor...
Although most studies on treatments for eosinophilic esophagitis (EoE) have focused effects in the epithelium, EoE is a transmural disease. Eosinophils that infiltrate subepithelial layers of esophagus lead to fibrosis and serious complications EoE, current therapies shown minimal this fibrosis. We aimed elucidate T helper (Th)2 cytokine esophageal fibroblasts explore potential fibroblast-targeted EoE.We established telomerase-immortalized from human biopsies. stimulated these with Th2...
Preoperative prediction of bladder cancer (BCa) recurrence risk is critical for individualized clinical management BCa patients.To develop and validate a nomogram based on radiomics predictors personalized the first 2 years (TFTY) risk.Retrospective.Preoperative MRI datasets 71 patients (34 recurrent) were collected, divided into training (n = 50) validation cohorts 21).3.0T MRI/T2 -weighted (T2 W), multi-b-value diffusion-weighted (DW), dynamic contrast-enhanced (DCE) sequences.Radiomics...
<h3>Objective</h3> Oesophagitis might result from the effects of chemokines produced by oesophageal cells in response to gastro-oesophageal reflux, and not solely direct, caustic refluxed gastric juice. Proton pump inhibitors (PPI) can block chemokine production through mechanisms independent their antisecretory effects. We studied omeprazole on epithelial exposed acidic bile salts. <h3>Design</h3> Human primary telomerase-immortalised squamous were salt medium with or without pretreatment....
Cancer-related inflammation recently has been proposed as a major physiological hallmark of malignancy. Some genetic alterations known to promote cellular proliferation and induce malignant transformation also may participate in an intrinsic inflammatory pathway that produces cancer-promoting microenvironment. Little is about this Barrett's esophagus. We have used series nontransformed transformed human epithelial cell lines developed our laboratory explore the potential contribution...
The present study aimed to investigate the therapeutic effect of injections local bone marrow mesenchymal stem cells (BMSCs) on osteoarthritis (OA) temporomandibular joint (TMJ) and explore role stromal cell–derived factor 1 (SDF-1) regulated activation, normal T-cell expressed secreted (RANTES) in this effect. Fundamentally, OA TMJ was induced by unilateral anterior crossbite mice. Exogenous green fluorescent protein–labeled BMSCs (GFP-BMSCs) were weekly injected into region for 4, 8, 12...