A5100659114- Cardiovascular Function and Risk Factors
- Cardiac Imaging and Diagnostics
- Cardiomyopathy and Myosin Studies
- Cardiovascular Disease and Adiposity
- Advanced MRI Techniques and Applications
- Systemic Lupus Erythematosus Research
- Acute Myocardial Infarction Research
- Cardiovascular Effects of Exercise
- Radiomics and Machine Learning in Medical Imaging
- Pregnancy and preeclampsia studies
- Reproductive System and Pregnancy
- Cardiac electrophysiology and arrhythmias
- Tissue Engineering and Regenerative Medicine
- Coronary Interventions and Diagnostics
- Cancer, Hypoxia, and Metabolism
- Mesenchymal stem cell research
- Cardiac Fibrosis and Remodeling
- Angiogenesis and VEGF in Cancer
- Pulmonary Hypertension Research and Treatments
- Cardiac Valve Diseases and Treatments
- Viral Infections and Immunology Research
- Hyperglycemia and glycemic control in critically ill and hospitalized patients
- Cardiac Arrhythmias and Treatments
- Extracellular vesicles in disease
- Pregnancy and Medication Impact
Renji Hospital
2016-2025
Shanghai Jiao Tong University
2016-2025
State Key Laboratory of Oncogene and Related Genes
2021-2025
Zhejiang University
2024
First Affiliated Hospital of Xi'an Jiaotong University
2024
Stomatology Hospital
2024
First Affiliated Hospital Zhejiang University
2024
Xiangya Hospital Central South University
2018-2023
GTx (United States)
2023
Central South University
2018-2023
Cardiac fibrosis after myocardial infarction (MI) has been identified as a key factor in the development of heart failure. Although dysregulation microRNA (miRNA) is involved various pathophysiological processes heart, role miRNA regulation MI not clear. Previously we observed correlation between and miR-24 expression hypertrophic hearts, herein assessed how regulates MI. Using qRT-PCR, showed that was down-regulated heart; change closely related to extracellular matrix (ECM) remodelling. In...
Retrieval-Augmented Generation (RAG) is an advanced technique designed to address the challenges of Artificial Intelligence-Generated Content (AIGC). By integrating context retrieval into content generation, RAG provides reliable and up-to-date external knowledge, reduces hallucinations, ensures relevant across a wide range tasks. However, despite RAG's success potential, recent studies have shown that paradigm also introduces new risks, including robustness issues, privacy concerns,...
Abstract Introduction and objectives The aging population is expected to reach 2 billion by 2050, but the impact of somatic symptom disorder (SSD) on elderly has been insufficiently addressed. We aimed clarify prevalence SSD in China identify physical psychological differences between non-elderly. Methods In this prospective multi-center study, 9020 participants aged (2206 non-elderly adults 6814 adults) from 105 communities Shanghai were included (Assessment Somatic Symptom Chinese...
Peroxisome proliferator-activated receptor γ (PPARγ) has been shown to be a therapeutic target for preeclampsia (PE). Angiopoietin-like protein 4 (ANGPTL4) is multifunctional secretory involved in regulating lipid metabolism and angiogenesis various tissues. However, the expression of PPARγ ANGPTL4 their interaction PE remain elusive. Here we showed that agonist rosiglitazone upregulated secretion dose-dependent manner HTR8/SVneo cells, human umbilical vein endothelial cells (HUVECs)...
Abstract Hypoxia inducible factor‐1α (HIF‐1α) is a key determinant of oxygen‐dependent gene regulation in angiogenesis. HIF‐1α overexpression may be beneficial cell therapy hypoxia‐induced pathophysiological processes, such as ischemic heart disease. To address this issue, human peripheral blood mononuclear cells (PBMNCs) were induced to differentiate into endothelial progenitor (EPCs), and then transfected with either an HIF‐1α‐expressing or control vector cultured under normoxia hypoxia....
It is uncertain whether adjunctive thrombolysis beneficial for patients with ST-segment-elevation myocardial infarction undergoing percutaneous coronary intervention (PCI) within 120 minutes of presentation. This study was to determine in presenting a single bolus recombinant staphylokinase (r-SAK) before timely PCI leads improved patency the infarct-related artery and reduces infarct size. an open-label, prospective, multicenter, randomized study. We enrolled aged 18 75 years who were 12...
Cardiac magnetic resonance imaging (MRI) has enabled the assessment of myocardial features, from tissue characteristics to functional changes, in patients with systemic lupus erythematosus (SLE). Echocardiography, however, detects cardiac decompensation. This study was undertaken investigate use MRI explore early warning signs silent involvement and determine treatment timing SLE.Clinical studies were performed 50 drug-naive new-onset SLE, 60 longstanding healthy subjects a 3-center...
Abstract The majority of advanced breast cancers exhibit strong aggressiveness, heterogeneity, and drug resistance, currently, the lack effective treatment strategies is one main challenges that cancer research must face. Therefore, developing a feasible preclinical model to explore tailored treatments for refractory urgently needed. We established organoid biobanks from 17 patients with characterized them by immunohistochemistry (IHC) next generation sequencing (NGS). In addition, we in...
Progressive right ventricle (RV) failure and death in connective tissue disease (CTD) are related to RV hypertrophy (RVH) dilation, irrespective of pulmonary arterial hypertension (PAH). Therefore, detecting cardiac impairment before RVH determining predictors is crucial for timely intervention. The present prospective cohort study aimed identify markers that occur investigate RVH. CTD was diagnosed based on clinical features, laboratory findings imaging data. functions patients with were...
A noninvasive, easy operation, and accurate diagnostic protocol is highly demanded to assess systemic lupus erythematosus (SLE) activity during pregnancy, promising real-time monitoring the whole gestational period reduce adverse pregnancy outcomes. Here, machine learning of serum metabolic fingerprints (SMFs) developed SLE for pregnant women. The SMFs are directly extracted through a hollow-cobalt oxide/carbon (Co3 O4 /C)-composite-assisted laser desorption/ionization mass spectrometer (LDI...
Background Myocardial bridge contributes to chest pain, often accompanied by non-specific complaints. Aims Our study aims determine somatic symptom disorder (SSD) prevalence in patients with myocardial bridge, investigating associated clinical and psychological features. Method In this prospective cross-sectional study, we enrolled 1357 participants (337 1020 without bridge) from Shanghai Renji Hospital. The Somatic Symptom Scale-China questionnaire was used assess SSD. Depressive anxiety...
Abstract Feature tracking in cine cardiac magnetic resonance (CMR) is a quantitative technique to assess heart structure and function. We investigated 4-dimensional (4D) dynamics morphology of the mitral annulus (MA) using novel system based on radially rotational long-axis CMR series. A total 30 normal controls patients with regurgitation were enrolled. The spatiotemporal changes MA characterized by an in-house developed program. Dynamic morphological parameters extracted from all 18 radial...