A5100703295- Cardiomyopathy and Myosin Studies
- Cardiovascular Function and Risk Factors
- Cardiovascular Effects of Exercise
- RNA modifications and cancer
- Cardiac Arrhythmias and Treatments
- Medical Imaging Techniques and Applications
- Congenital heart defects research
- Advanced MRI Techniques and Applications
- Photoacoustic and Ultrasonic Imaging
- Cardiac Imaging and Diagnostics
- Congenital Heart Disease Studies
- Cardiac Structural Anomalies and Repair
- Hepatocellular Carcinoma Treatment and Prognosis
- Advanced X-ray and CT Imaging
- Cancer-related molecular mechanisms research
- Luminescence Properties of Advanced Materials
- Cardiovascular Disease and Adiposity
- Endometrial and Cervical Cancer Treatments
- Cancer-related gene regulation
- Cardiac Valve Diseases and Treatments
- Perovskite Materials and Applications
- Cancer, Lipids, and Metabolism
- Receptor Mechanisms and Signaling
- Optical Imaging and Spectroscopy Techniques
- Cancer, Hypoxia, and Metabolism
Air Force Medical University
2016-2025
Sun Yat-sen University
2021-2025
Xijing Hospital
2016-2025
Capital Medical University
2010-2025
Changchun University of Technology
2024-2025
First Affiliated Hospital of Zhengzhou University
2018-2025
Beijing YouAn Hospital
2025
Tianjin Infectious Diseases Hospital
2025
Shandong First Medical University
2025
Shandong Academy of Chinese Medicine
2025
Abstract Background The long non-coding RNA PVT1 (lncRNA PVT1) has been reported to act as an oncogenic regulator of several cancers. However, its expression and function in gallbladder cancer (GBC) remain largely unknown. Methods In situ hybridization (ISH) quantitative real-time PCR (qPCR) were performed detect the miR-143 GBC tissues cell lines. Immunohistochemistry (IHC) assays assess hexokinase 2 (HK2) protein. relationships among PVT1, HK2 evaluated using dual-luciferase reporter,...
We compared the contributions of bright light during night shift and dark goggles daylight for phase shifting circadian rhythm temperature to realign with a 12-hour sleep. After 10 baseline days there were 8 night-work/day-sleep days. Temperature was continuously recorded from 50 subjects. There four groups in 2 × design: (bright, dim), (yes, no). Subjects exposed (about 5,000 lux) 6 hours on first shifts. Dim <500 lux. Both significant factors producing The combination plus most effective,...
Purpose: The ectopic expression of N6-methyladenosine (m6A) associated genes is a common feature multiple tumors. However, little known about the status and prognostic value these in human breast cancer (BRC). Herein, we conducted comprehensive analysis to identify profiling clinical significance m6A-related genomic targets BRC. Materials Methods: data including 1109 BRC tissues 113 normal were obtained from Cancer Genome Atlas (TCGA) database evaluate mRNA levels targets. In addition, 6...
Background: Osteosarcoma (OS) is the most common primary bone tumor. The disease has a poor prognosis due to delay in diagnosis and development of metastasis. N6-Methyladenosine (m6A)-related regulators play an essential role various tumors. In this study, comprehensive analysis was conducted elucidate relationship between expression profiles m6A-related molecules clinical outcome OS patients. Materials Methods: Public genome datasets tissue microarray (TMA) cohort were used analyze mRNA...
BACKGROUND:Lung adenocarcinoma (LUAD) is the most common subtype of lung malignancy and leading cause cancer-related mortalities worldwide. N6-methyladenosine (m6A), prevalent internal modification mRNAs, plays crucial roles in regulating mRNA splicing, exportation, localization, translation, stability. This study assessed expression patterns prognostic value m6A-related genes LUAD. MATERIAL AND METHODS:The data 509 LUAD samples 20 normal were obtained from Cancer Genome Atlas (TCGA) to...
Patients with hypertrophic obstructive cardiomyopathy (HOCM) and drug-refractory symptoms outflow gradients have limited nonsurgical treatment options. The feasibility of percutaneous intramyocardial septal radiofrequency ablation (PIMSRA) has been reported previously; however, procedural medium-term outcomes are unknown.To describe the safety PIMSRA in a large patient cohort HOCM.This was single-arm, open-label study patients HOCM. presenting to Xijing Hospital Xi'an, China, between October...
Abstract The modification and recognition of 5‐methylcytosine (m5C) are involved in the initiation progression various tumor types. However, precise role potential mechanism Y‐box‐binding protein 1 (YBX1) esophageal squamous cell carcinoma (ESCC) remains unclear. Here, it is found that YBX1 frequently upregulated ESCC compared with matched nontumor tissues. Gain‐ loss‐of‐function assays show promoted proliferation metastasis cells both vitro vivo. Functional studies revealed NOP2/Sun RNA...
Hypertrophic cardiomyopathy (HCM) is a common heritable heart disease. Although HCM has been reported to be associated with many variants of genes involved in sarcomeric protein biomechanics, pathogenic have not identified patients partial HCM. FARS2 (the mitochondrial phenylalanyl-tRNA synthetase), type aminoacyl-tRNA synthetase, plays role the translation machinery. Several
Abstract Hepatic encephalopathy (HE) is a neurological disease occurring in patients with hepatic insufficiency and/or portal-systemic blood shunting based on cirrhosis. The pathogenesis not completely clear till now, but it believed that hyperammonemia the core of HE. Hyperammonemia caused by increased sources ammonia and decreased metabolism further causes mental problems through gut–liver–brain axis. vagal pathway also plays bidirectional role Intestinal microorganisms play an important...
Abstract NSUN2 is a nuclear RNA methyltransferase which catalyzes 5-methylcytosine (m5C), posttranscriptional modification. Aberrant m5C modification has been implicated in the development of multiple malignancies. However, its function pancreatic cancer (PC) needs to be elucidated. Herein, we determined that was overexpressed PC tissues and related aggressive clinical features. Silence by lentivirus weakened capability proliferation, migration invasion cells vitro inhibited growth...
Neurogenesis in the hippocampus is actively involved neural circuit plasticity and learning function of mammals, but it may decrease dramatically with aging aging-related neurodegenerative disorder Alzheimer’s disease. Accumulating studies have indicated that Wnt/β-catenin signaling critical control proliferation differentiation fate stem cells or progenitors hippocampus. In this study, biological effects low-dose radiation stimulating signaling, cell neurogenesis were interestingly...
Bisphenol A (BPA) exposure results in numerous developmental and functional abnormalities reproductive organs rodent models, but limited data are available regarding BPA effects the primate uterus. To determine if maternal oral affects fetal uterine development a non-human model, pregnant rhesus macaques carrying female fetuses were exposed orally to 400 µg/kg or vehicle control daily from gestation day (GD) 50–100 GD100–165. Fetal uteri collected at completion of treatment (GD100 GD165);...
Background Computer-aided detection (CAD) systems may be used to help radiologists interpret automated breast (AB) US images. However, the optimal use of CAD with AB has, knowledge authors, not been determined. Purpose To compare performance and reading time different readers by using system detect cancer in modes. Materials Methods In this retrospective study, 1485 images (282 malignant lesions, 695 benign 508 healthy) 1452 women (mean age, 43.7 years; age range, 19–82 years) including 529...
Objective The objective is to evaluate the 5-year follow-up results of percutaneous intramyocardial septal radiofrequency ablation (PIMSRA) for hypertrophic obstructive cardiomyopathy (HOCM), including clinical status, electrocardiographic and echocardiographic characteristics. Methods 27 patients (age: 44.3±15.5 years; 67% men, 33% women) with severely symptomatic HOCM who underwent PIMSRA from October 2016 September 2017 were included. Their resting exercise stress echocardiography,...
We compared bright-light durations of 6, 3 and 0 hours (i.e. dim light) during simulated night shifts for phase shifting the circadian rectal temperature rhythm to align with a 12-hour shift sleep schedule. After 10 baseline days there were 8 consecutive night-work, day-sleep days, 8-hour (dark) periods. The bright light (about 5,000 lux, around minimum) was used all shifts, <500 lux. This field study in which subjects (n = 46) went outside after slept at home. Substantial adaptation large...
Studies show that patients with hepatocellular carcinoma (HCC) have poor prognosis, particularly when are diagnosed at late stages of the disease development. The flap endonuclease 1 (FEN1) gene is overexpressed in multiple malignant tumors and may promote tumor aggressiveness. However, its expression profile functional roles HCC still unclear. Here, we evaluated molecular mechanisms FEN1 HCC. was using mRNA data from TCGA GEO databases. also confirmed by immunohistochemistry (IHC) a tissue...
We report the first cell-penetrating Ub-Dha probes based on thiazolidine-protected cysteines, which were successfully used to label and enrich E1–E2–E3 enzymes in live cells combination with label-free quantification (LFQ) mass spectrometry.