A5038860730- Cardiomyopathy and Myosin Studies
- Cardiovascular Effects of Exercise
- Cardiac Arrhythmias and Treatments
- Cardiovascular Function and Risk Factors
- Machine Learning in Healthcare
- Frailty in Older Adults
- Pediatric health and respiratory diseases
- Sleep and related disorders
- Chemical Synthesis and Reactions
- Metal-Organic Frameworks: Synthesis and Applications
- Healthcare cost, quality, practices
- Nutritional Studies and Diet
- Intensive Care Unit Cognitive Disorders
- Sepsis Diagnosis and Treatment
- RNA regulation and disease
- Immune Cell Function and Interaction
- Lipid metabolism and disorders
- Trypanosoma species research and implications
- Viral Infections and Immunology Research
- Parkinson's Disease Mechanisms and Treatments
- Sphingolipid Metabolism and Signaling
- Inflammasome and immune disorders
- interferon and immune responses
- Nutrition and Health in Aging
- Artificial Intelligence in Healthcare and Education
Fujian Provincial Hospital
2023-2025
Fujian Medical University
2023-2025
Fujian Institute of Research on the Structure of Matter
2025
Fuzhou University
2025
Chinese Academy of Sciences
2025
Air Force Medical University
2022-2024
Xijing Hospital
2022-2024
Fujian Provincial People's Hospital
2024
Patients with hypertrophic obstructive cardiomyopathy (HOCM) and drug-refractory symptoms outflow gradients have limited nonsurgical treatment options. The feasibility of percutaneous intramyocardial septal radiofrequency ablation (PIMSRA) has been reported previously; however, procedural medium-term outcomes are unknown.To describe the safety PIMSRA in a large patient cohort HOCM.This was single-arm, open-label study patients HOCM. presenting to Xijing Hospital Xi'an, China, between October...
Objective The objective is to evaluate the 5-year follow-up results of percutaneous intramyocardial septal radiofrequency ablation (PIMSRA) for hypertrophic obstructive cardiomyopathy (HOCM), including clinical status, electrocardiographic and echocardiographic characteristics. Methods 27 patients (age: 44.3±15.5 years; 67% men, 33% women) with severely symptomatic HOCM who underwent PIMSRA from October 2016 September 2017 were included. Their resting exercise stress echocardiography,...
Background Immunity and neuroinflammation play crucial roles in the pathogenesis of Parkinson’s disease (PD). Nonetheless, prior investigations into correlation between immune inflammation PD have produced varying results. Identifying specific cell phenotypes that are truly associated with is challenging, causal relationship cells remains elusive. Methods This study conducted a comprehensive two-sample Mendelian randomization (MR) analysis, employing five distinct analytical approaches, to...
Abstract: Sepsis is a severe systemic inflammatory response commonly occurring in infectious diseases, caused by infection with virulent pathogens. In the pathogenesis of sepsis, cyclic guanosine monophosphate (GMP)-adenosine (AMP) synthase-stimulator interferon genes (cGAS-STING) signaling pathway serves crucial role as fundamental immunoregulatory mechanism. This activates STING upon recognizing intracellular DNA damage and pathogen-derived DNA, subsequently inducing production numerous...
Background The epidemiological association between frailty and insomnia is well established, yet the presence of a common genetic etiology still uncertain. Further exploration needed to ascertain causal relationship insomnia. Methods Utilizing data obtained from genome-wide studies (GWAS) summaries, we utilized linkage disequilibrium score regression (LDSC) determine correlation existing determination causality was achieved through application two-sample Mendelian randomization. We...
Sepsis associated encephalopathy (SAE) is prevalent among elderly patients in the ICU and significantly affects patient prognosis. Due to symptom similarity with other neurological disorders absence of specific biomarkers, early clinical diagnosis remains challenging. This study aimed develop a predictive model for SAE patients. The data sepsis were extracted from MIMIC IV database (version 3.1) divided into training test sets 7:3 ratio. Feature variables selected using LASSO-Boruta combined...
Abstract Background Sepsis is a critical and life-threatening clinical syndrome. Abnormal plasma lipid levels are associated with disease progression. However, causal links remain uncertain due to limitations of observational studies. Methods This study conducted comprehensive two-sample Mendelian randomization (MR) analysis utilizing publicly available pooled genome-wide association (GWAS) data on 179 phospholipid subtypes, 731 immune cell phenotypes, genetic related sepsis-related...
ABSTRACT Sleep deprivation (SD) adversely affects cognition, as well physical and mental health, is closely linked to an increased risk of cardiovascular disease. The therapeutic efficacy underlying mechanisms aromatherapy with Nardostachys jatamansi DC. essential oil on SD‐induced myocardial injury remain poorly understood. This study aimed evaluate the potential in mitigating elucidate associated mechanisms. Electroencephalogram (EEG) recordings behavioral tests were employed sleep...
Insomnia, recognized as a prevalent sleep disorder, has garnered extensive attention within the realm of public health. Recent studies indicate close interaction between immune system and sleep; however, specific mechanism remains not yet fully understood. Based on publicly available Genome-Wide Association Study (GWAS) data, we used two-sample Mendelian randomization (MR) analyses to investigate associations 731 cell traits insomnia risk. Five MR analysis methods comprehensive sensitivity...
Objective Echocardiography-guided Percutaneous IntraMyocardial Septal Radiofrequency Ablation (PIMSRA, Liwen procedure) is a novel treatment option for hypertrophic obstructive cardiomyopathy (HOCM). The impact of PIMSRA on myocardial mechanics unknown. Methods Between October 2016 and June 2019, 3-dimentional speckle tracking echocardiography were performed in 82 patients. Echocardiographic imaging, qualitative quantitative clinical assessment completed at baseline, immediately...
ABSTRACT BACKGROUND Echocardiography-guided percutaneous intramyocardial septal radiofrequency ablation (PIMSRA, Liwen procedure) is a novel treatment option for hypertrophic obstructive cardiomyopathy (HOCM). The safety and feasibility of using this procedure cryoablation are unknown. OBJECTIVE To establish canine model echocardiography-guided (PIMSCA). METHODS Eight canines underwent PIMSCA had electrocardiography, echocardiography, myocardial contrast echocardiography (MCE), (ECG),...