A5036074690- RNA modifications and cancer
- Cancer-related molecular mechanisms research
- Plant Water Relations and Carbon Dynamics
- Remote Sensing in Agriculture
- Gout, Hyperuricemia, Uric Acid
- Cancer-related gene regulation
- Molecular Biology Techniques and Applications
- Inflammasome and immune disorders
- Tree-ring climate responses
- Ferroptosis and cancer prognosis
- MicroRNA in disease regulation
- Autophagy in Disease and Therapy
- Antiplatelet Therapy and Cardiovascular Diseases
- Epigenetics and DNA Methylation
- RNA Research and Splicing
- Metabolomics and Mass Spectrometry Studies
- Circular RNAs in diseases
- Rangeland Management and Livestock Ecology
- Alcohol Consumption and Health Effects
- Acute Myocardial Infarction Research
- Systemic Lupus Erythematosus Research
- Spondyloarthritis Studies and Treatments
- Soil and Environmental Studies
- Meat and Animal Product Quality
- Immune cells in cancer
Xinjiang University
2023-2025
Panyu District Central Hospital
2019-2025
Guangzhou Medical University
2024-2025
Sichuan University
2024-2025
West China Hospital of Sichuan University
2024-2025
Jilin University
2024-2025
Jilin Medical University
2025
University of South China
2025
First Affiliated Hospital of Zhengzhou University
2019-2024
Guangdong Academy of Agricultural Sciences
2019-2024
Gene vectors have been extensively applied in various fields. However, the high economic cost of gene limits their development and application, there is an urgent demand for developing highly efficient with low cost, especially large-scale application. Here, we reported a simple but effective star polycation as vector pest management. Our was constructed by commercial cheap material sources, facile synthesis procedure simplified to two reaction steps, decreasing large extent. This showed...
Abstract Objectives N6‐methyladenosine (m6A) is a ubiquitous epigenetic RNA modification that plays pivotal role in tumour development and metastasis. In this study, we aimed to investigate the expression profiling, clinical significance, biological function regulation of m6A‐related genes hepatoblastoma (HB). Materials Methods The mRNA protein levels were analysed using Gene Expression Omnibus (GEO) tissue microarray (TMA) cohort. Kaplan‐Meier analysis was performed evaluate prognostic...
Purpose: The ectopic expression of N6-methyladenosine (m6A) associated genes is a common feature multiple tumors. However, little known about the status and prognostic value these in human breast cancer (BRC). Herein, we conducted comprehensive analysis to identify profiling clinical significance m6A-related genomic targets BRC. Materials Methods: data including 1109 BRC tissues 113 normal were obtained from Cancer Genome Atlas (TCGA) database evaluate mRNA levels targets. In addition, 6...
Purpose: Gastric cancer (GC) is a primary cause of cancer-associated mortality worldwide.N6-methyladenosine (m6A) one the most common RNA modifications that involves in progression numerous cancers.However, expression status and function m6A-related genes gastric still not well understood.The current study aimed to investigate determinate prognostic value cancer.Methods: m6A-asssociated gene was evaluated via analyzing data GC patients from Cancer Genome Atlas (TCGA) Gene Expression Omnibus...
Background: Osteosarcoma (OS) is the most common primary bone tumor. The disease has a poor prognosis due to delay in diagnosis and development of metastasis. N6-Methyladenosine (m6A)-related regulators play an essential role various tumors. In this study, comprehensive analysis was conducted elucidate relationship between expression profiles m6A-related molecules clinical outcome OS patients. Materials Methods: Public genome datasets tissue microarray (TMA) cohort were used analyze mRNA...
The excessive use of chemical pesticides brings many environmental problems. Botanical seem to be a good alternative control pests, but their slow action and lack residual constrain further application. Here, we developed star polycation (SPc) as the drug nanocarrier that could combine matrine into complex decrease its particle size nanoscale. combination SPc increased zeta potential noncovalent molecular interaction, such hydrogen bonds hydrophobic interactions playing an important role in...
BACKGROUND:Lung adenocarcinoma (LUAD) is the most common subtype of lung malignancy and leading cause cancer-related mortalities worldwide. N6-methyladenosine (m6A), prevalent internal modification mRNAs, plays crucial roles in regulating mRNA splicing, exportation, localization, translation, stability. This study assessed expression patterns prognostic value m6A-related genes LUAD. MATERIAL AND METHODS:The data 509 LUAD samples 20 normal were obtained from Cancer Genome Atlas (TCGA) to...
Skeletal muscle development is a multistep process whose understanding central in broad range of fields and applications, from the potential medical value to human society, its economic associated with improvement agricultural animals. initiates somites, precursor cells generated dermomyotome dermomyotome-derived myotome before differentiation ensues, developmentally regulated that well characterized model organisms. However, regulation skeletal ontogeny during embryonic remains poorly...
Abstract The modification and recognition of 5‐methylcytosine (m5C) are involved in the initiation progression various tumor types. However, precise role potential mechanism Y‐box‐binding protein 1 (YBX1) esophageal squamous cell carcinoma (ESCC) remains unclear. Here, it is found that YBX1 frequently upregulated ESCC compared with matched nontumor tissues. Gain‐ loss‐of‐function assays show promoted proliferation metastasis cells both vitro vivo. Functional studies revealed NOP2/Sun RNA...
Liquid-liquid phase separation (LLPS) is essential for the formation of membraneless organelles and significantly influences cellular compartmentalization, chromatin remodeling, gene regulation. Previous research has highlighted critical function liquid-liquid biopolymers in development hepatocellular carcinoma (HCC). This study conducted a comprehensive review 3,685 biopolymer regulators, leading to LLPS related Prognostic Risk Score (LPRS) HCC through bootstrap-based univariate Cox, Random...
Peritoneal fibrosis (PF) is a serious complication commonly associated with prolonged peritoneal dialysis. Mesenchymal stem cells (MSCs) and their exosomes (Exo) have shown significant therapeutic promise in treating fibrotic conditions. Danshensu (DSS), bioactive compound from the traditional Chinese herb Danshen reverses fibrosis. This study aims to investigate novel strategy enhance efficacy against PF by DSS preconditioning MSCs-derived (DSS-Exo). The vitro studies included effects of...
Abstract Hepatoblastoma (HB) is the most common hepatic neoplasm in childhood and therapeutic outcomes remain undesirable due to its recurrence metastasis. Increasing evidence shows that dipeptidase 1 (DPEP1) has pivotal function tumorigenesis multiple tumors. However, expression pattern, biological function, underlying mechanism of DPEP1 HB have not been reported. Here we showed was significantly upregulated associated with poor prognosis patients. In vitro vivo assays indicated silencing...
Abstract NSUN2 is a nuclear RNA methyltransferase which catalyzes 5-methylcytosine (m5C), posttranscriptional modification. Aberrant m5C modification has been implicated in the development of multiple malignancies. However, its function pancreatic cancer (PC) needs to be elucidated. Herein, we determined that was overexpressed PC tissues and related aggressive clinical features. Silence by lentivirus weakened capability proliferation, migration invasion cells vitro inhibited growth...
Abstract Background With increasing health awareness among consumers, the demand for healthier, tastier, higher quality and nutritional value pork is increasing. It has been shown that different dietary starch sources can alter carcass traits meat quality. However, research on effects of with clear amylose/amylopectin ratio amino acid fatty composition in Longissimus thoracis ( L . ) muscle pigs limited. This study aimed to investigate traits, quality, composition, mRNA expression levels...
Background Noninvasive methods for the early identify diagnosis of prostatitis, benign prostatic hyperplasia (BPH), and prostate cancer (PCa) are current clinical challenges. Methods The serum metabolites 20 healthy individuals patients with BPH, or PCa were identified using untargeted liquid chromatography-mass spectrometry (LC-MS). In addition, targeted LC-MS was used to verify organic acid in a validation cohort. Results Organic had good sensitivity specificity differentiating PCa. Three...
Under global warming, the gradual pattern of spring phenology along elevation gradients (EG) has significantly changed. However, current knowledge on phenomenon a more uniform is mainly focused effect temperature and neglected precipitation. This study aimed to determine whether occurs EG in Qinba Mountains (QB) explore precipitation this pattern. We used Savitzky-Golay (S-G) filtering extract start season (SOS) forest from MODIS Enhanced Vegetation Index (EVI) during 2001-2018 determined...
In the process of climate warming, drought has increased vulnerability ecosystems. Due to extreme sensitivity grasslands drought, grassland stress assessment become a current issue be addressed. First, correlation analysis was used determine characteristics normalized precipitation evapotranspiration index (SPEI) response difference vegetation (NDVI) multiscale (SPEI-1 ~ SPEI-24) in study area. Then, at different growth periods modeled using conjugate function analysis. Conditional...
Gram-negative bacterial infections pose a significant threat to public health. Toll-like receptor 4 (TLR4) recognizes lipopolysaccharide (LPS) and induces innate immune responses, autophagy, cell death, which have major impacts on the body’s physiological homeostasis. However, role of TLR4 in LPS-induced autophagy apoptosis large mammals, are closer humans than rodents many characteristics, remains unknown. So far, few reports focus relationship between TLR, mammal levels, we urgently need...