A5062570697- Microbial Natural Products and Biosynthesis
- Marine Sponges and Natural Products
- Fungal Biology and Applications
- X-ray Diffraction in Crystallography
- Crystallization and Solubility Studies
- Natural product bioactivities and synthesis
- Phytochemistry and Biological Activities
- Alkaloids: synthesis and pharmacology
- Chemical synthesis and alkaloids
- Traditional and Medicinal Uses of Annonaceae
- Biological Activity of Diterpenoids and Biflavonoids
- Pancreatic function and diabetes
- Traditional Chinese Medicine Analysis
- Urinary Tract Infections Management
- Renal cell carcinoma treatment
- Metabolism, Diabetes, and Cancer
- Bioactive natural compounds
- Oxidative Organic Chemistry Reactions
- Circular RNAs in diseases
- Nanoplatforms for cancer theranostics
- Pelvic floor disorders treatments
- Sesquiterpenes and Asteraceae Studies
- Chromatography in Natural Products
- Plant Toxicity and Pharmacological Properties
- Radical Photochemical Reactions
Sun Yat-sen University
2019-2024
Panyu District Central Hospital
2018-2024
Guangzhou Medical University
2018-2024
Fujian Medical University
2024
Union Hospital
2024
Roche (China)
2020-2021
Hubei University
2021
North China University of Science and Technology
2019
North China University of Science and Technology Affiliated Hospital
2019
State Power Investment Corporation (China)
2018
Background Noninvasive methods for the early identify diagnosis of prostatitis, benign prostatic hyperplasia (BPH), and prostate cancer (PCa) are current clinical challenges. Methods The serum metabolites 20 healthy individuals patients with BPH, or PCa were identified using untargeted liquid chromatography-mass spectrometry (LC-MS). In addition, targeted LC-MS was used to verify organic acid in a validation cohort. Results Organic had good sensitivity specificity differentiating PCa. Three...
Two new octaketides, cytosporones W (1) and X (2), along with eight known cytosporone derivatives [(±)-3-9], were isolated from mangrove endophytic fungus Diaporthe sp. ZJHJYZ-1. Compounds 1 2 a pair of epimers, whose configuration C-1 could mutually convert, causing racemization the lactone ring. The planar structures compounds elucidated through detailed 1D, 2D NMR, HR-ESI-MS analysis. ECD spectra comparison modified Mosher ester method applied to determine absolute 2. In bioassays, (±)-3...
This multicenter retrospective study aimed to assess the efficacy, intrarenal pressure (IRP), and complications of retrograde surgery (RIRS) using a flexible navigable suction ureteral access sheaths (FANS-UAS) in reverse Trendelenburg lithotomy position (RTLP) for treating kidney upper stones measuring 2–6 cm. Conducted at six medical centers Fujian Province from 2022 2024, included 231 patients with median stone size 26 mm. The immediate stone-free rate (ISFR) was 90.48%, while SFR...
Discrimination between urosepsis and febrile urinary tract infections is important in therapeutic decision-making to indicate suitable treatments avoid sepsis-related organ failure. Accurate diagnosis time-consuming susceptible false-positive results. Moreover, patient responses are complex varied. Therefore, this study aimed develop a new, early diagnostic predictor that could discriminate patients with those using combination of initial procalcitonin albumin levels. We conducted...
One new diterpenoid, diaporpenoid A (1), two sesquiterpenoids, diaporpenoids B–C (2,3) and three α-pyrone derivatives, diaporpyrones A–C (4–6) were isolated from an MeOH extract obtained cultures of the mangrove endophytic fungus Diaporthe sp. QYM12. Their structures elucidated by extensive analysis spectroscopic data. The absolute configurations determined electronic circular dichroism (ECD) calculations a comparison specific rotation. Compound 1 had unusual 5/10/5-fused tricyclic ring...
The icetexane-based diterpenes (-)-barbatusol, (+)-demethylsalvicanol, and (-)-brussonol were synthesized. Synthetic demethylsalvicanol was dimerized to produce (+)-grandione using aqueous Diels-Alder conditions.
Ovarian cancer is a common tumor of the reproductive system, and primarily responds to cytoreductive surgery cisplatin (DDP)-based chemotherapy. However, chemoresistance results in high ovarian mortality. Therefore, aim present study was investigate effects metformin on apoptosis autophagy drug-resistant SKOV3/DDP cells. To do so, MTT assay, flow cytometry, electron microscopy western blotting were used study. Metformin could inhibit growth SKOV3 cells concentration- time-dependent manner...
Two new 3-decalinoyltetramic acid derivatives with peroxide bridge fusarisetins E (1) and F (2), one chromone fusarimone A (5), two benzofurans fusarifurans (9) B (10), three isocoumarins fusarimarins A-C (11-13), as well five known analogues 3, 4, 6-8 14 were isolated from mangrove endophytic fungus Fusarium sp. 2ST2. Their structures absolute configurations established by spectroscopic analysis, density functional theory-gauge invariant atomic orbital NMR calculation DP4+ statistical...
Mangrove endophytic fungi represent significant and sustainable sources of novel metabolites with unique structures excellent biological activities, attracting extensive chemical investigations. In this research, two heterodimeric tetrahydroxanthones, aflaxanthones A (1) B (2), dimerized via an unprecedented 7,7′-linkage, a sp3-sp3 dimeric manner, were isolated from the mangrove fungus Aspergillus flavus QQYZ. Their elucidated through high resolution electrospray ionization mass spectroscopy...
This study reports an effective and facile strategy for developing multifunctional nanoplatforms by the in situ doping of manganese metal into stellate mesoporous silica nanoparticles (Mn-SMSN). The resulting Mn-SMSN@DOX-IR-780 effectively integrated enhanced chemodynamic therapy (CDT) combined with tumor imaging a single platform after additional loading doxorubicin hydrochloride (DOX) IR-780 iodide (IR-780) onto Mn-SMSN. demonstrated excellent vitro efficacy killing cancer cells inhibiting...
ADVERTISEMENT RETURN TO ISSUEPREVLetterNEXTTotal Synthesis of (−)-Salviasperanol§George Majetich, Ge Zou, and Jeremy GroveView Author Information Department Chemistry, University Georgia, Athens, Georgia 30602 Cite this: Org. Lett. 2008, 10, 1, 85–87Publication Date (Web):December 4, 2007Publication History Received21 July 2007Published online4 December inissue 1 January 2008https://pubs.acs.org/doi/10.1021/ol701743chttps://doi.org/10.1021/ol701743crapid-communicationACS...
The present study evaluated the effect of metformin on SKOV3 ovarian cancer cell line and investigated underlying mechanism. inhibitory rate cells was analyzed by MTT assay. apoptosis quantitatively measured using flow cytometry. intracellular autophagosomes observed electron microscopy. migration invasion capabilities were assessed scratch test Transwell Results demonstrated that. proliferation significantly inhibited in a time- concentration-dependent manner following treatment with...
Seven new polyketides, including four indenone derivatives, cytoindenones A–C (1, 3–4), 3′-methoxycytoindenone A (2), a benzophenone derivative, cytorhizophin J (6), and pair of tetralone enantiomers, (±)-4,6-dihydroxy-5-methoxy-α-tetralone (7), together with known compound (5) were obtained from the endophytic fungus Cytospora heveae NSHSJ-2 isolated fresh stem mangrove plant Sonneratia caseolaris. Compound 3 represented first natural monomer substituted by two benzene moieties at C-2 C-3....
A new α-pyrone, nocapyrone S (1), together with five known compounds (2-6), were isolated from the deep-sea actinomycete Nocardiopsis dassonvillei subsp. DSM 43111(T). Their structures determined by spectroscopic analyses. The absolute configuration of 1 was established quantum approaches. Cytotoxic activity evaluated against K562, MCF-7, SGC7901, A375, Hela, and HepG2 cell lines.
Polysubstituted bicyclic acetals are a class of privileged pharmacophores with unique 3D structure and an adjacent pair hydrogen bond acceptors. The key, fused acetal functionality is often assembled, via intramolecular cyclization, from linear substrates that not readily available. Herein, we report formal cycloaddition between cinnamyl alcohols cyclic enol ethers under ambient photoredox catalysis conditions. can be prepared in one step available building blocks. Employment sugar-derived...
Main observation and conclusion Co‐culturing the mangrove endophytic fungus Penicillium sclerotiorum THSH‐4 with ZJHJJ‐18 in PDB medium resulted production of nine new azaphilones derivatives, peniazaphilones A—I (1—9), six known derivatives (10—15). Their structures were elucidated by analysis detailed spectroscopic data, single‐crystal X‐ray diffraction, ECD spectra, 13 C NMR calculation DP4+ analysis. It is noteworthy that compound 1 an isoquinoline quinone moiety, was isolated from...
Abstract Objective To investigate the diagnostic value of urine cyclic RNA-0071196 (circRNA-0071196) in patients with bladder urothelial carcinoma (BUC). Method The expression circRNA-0071196 was detected samples using qRT-PCR from 40 BUC and 30 non-UBC at our department December 2018 to September 2021. difference compared between two groups, relationship UBC clinical pathological characteristics analyzed. Results (1) group significantly higher than that non-BUC ( P < 0.05). (2) not...
±)-Komaroviquinone (1) was synthesized from 3,4,5-trimethoxybenzoic acid in twenty-two steps.The key transformations this synthesis are: the construction of cycloheptane ring via a Friedel-Crafts cyclialkylation; (2) regiospecific benzylic oxidation; (3) conformationally controlled introduction C(10) hydroxyl group and (4) intramolecular hemi-acetal formation.The inhabitants mountains Uzbekistan use aerial parts perennial semishrub known as "buzbosh" to cure inflammatory diseases hypertony....