A5100357582- Cancer-related molecular mechanisms research
- Molecular Biology Techniques and Applications
- Single-cell and spatial transcriptomics
- Metabolomics and Mass Spectrometry Studies
- Adipose Tissue and Metabolism
- Meteorological Phenomena and Simulations
- RNA Research and Splicing
- Gut microbiota and health
- Iron Metabolism and Disorders
- Trace Elements in Health
- Gene expression and cancer classification
- Connective Tissue Growth Factor Research
- Muscle Physiology and Disorders
- Amino Acid Enzymes and Metabolism
- Climate variability and models
- Peroxisome Proliferator-Activated Receptors
- Adipokines, Inflammation, and Metabolic Diseases
- Cancer-related gene regulation
- Ubiquitin and proteasome pathways
- Bacterial Genetics and Biotechnology
- Genomics and Phylogenetic Studies
- Microbial Inactivation Methods
- Animal Nutrition and Physiology
- CRISPR and Genetic Engineering
- Meat and Animal Product Quality
China Agricultural University
2020-2025
Tobacco Research Institute
2025
Dongfang Electric Corporation (China)
2025
Yuhuangding Hospital
2025
Wenzhou Medical University
2011-2025
Sun Yat-sen University
2015-2025
Minzu University of China
2025
Nanjing University of Chinese Medicine
2024-2025
Nanjing Drum Tower Hospital
2025
Huzhou University
2025
The manner in which hydrogen sulfide (H2S) suppresses neuroinflammation is poorly understood. We investigated whether H2S polarized microglia to an anti-inflammatory (M2) phenotype by activating AMP-activated protein kinase (AMPK).Three structurally unrelated donors (5-(4-hydroxyphenyl)-3H-1,2-dithiocyclopentene-3-thione [ADT-OH], (p-methoxyphenyl) morpholino-phosphinodithioic acid [GYY4137], and sodium hydrosulfide [NaHS]) enhanced AMPK activation BV2 microglial cells the presence absence...
Abstract Understanding the evolution of heatwaves is important for their prediction, mitigation, and adaptation. While most studies focused on either temporal variability at individual station (or grid point) or spatial variation over fixed durations, daily joint space time remains largely unexplored. Here, we investigate multi‐dimensional characteristics spatiotemporally contiguous across China during 1961–2018 using observational data from a 3D perspective (i.e., latitude × longitude...
Skeletal muscle development is a multistep process whose understanding central in broad range of fields and applications, from the potential medical value to human society, its economic associated with improvement agricultural animals. initiates somites, precursor cells generated dermomyotome dermomyotome-derived myotome before differentiation ensues, developmentally regulated that well characterized model organisms. However, regulation skeletal ontogeny during embryonic remains poorly...
Intrauterine adhesions (IUAs), also known as Asherman's syndrome (AS), represent a significant cause of uterine infertility for which effective treatment remains elusive. The endometrium's ability to regenerate cyclically depends heavily on the growth and regression its blood vessels. However, trauma endometrial basal layer can disrupt subepithelial capillary plexus, impeding regeneration. This damage results in replacement native cells with fibroblasts myofibroblasts, ultimately leading...
Chronic kidney disease (CKD) is characterized by the accumulation of protein-bound uremic toxins (PBUTs), which play a pathophysiological role in renal fibrosis (a common pathological process resulting CKD progression). Accumulation PBUT hippuric acid (HA) positively correlated with progression patients, suggesting that HA may promote fibrosis. Oxidative stress most important factor affecting PBUTs nephrotoxicity. Herein, we assessed ability to disrupting redox homeostasis. In HK-2 cells,...
High-frequency bipolar high-voltage pulsed electric field can be used in tumor ablation to uniform the distribution ablated region and inhibit muscle contraction effectively. Developing a high-frequency power generator (HBPPG) with wide range of specifications, such as voltage magnitude, waveform, repetition rate, pulsewidth, is great significance for promoting clinical application irreversible electroporation. Hence, this article, novel modular HBPPG circuit topology proposed application....
The neonicotinoid pesticide, imidacloprid (IMI), is frequently detected in the environment and foods. It absorbed metabolized by intestine; however, its effects on intestinal barrier integrity are not well studied. We investigated whether IMI disrupts permeability of epithelial via vivo tests male Wistar rats, vitro assays using human cell line, Caco-2, silico analyses. A repeated oral dose 90-day toxicity study was performed (0.06 mg/kg body weight/day). exposure significantly increased...
In China, indigenous pigs are popular due to their excellent meat quality and unique flavor. this study, the flavor was investigated using Guangdong small-ear spotted pig (GD) hybrid progeny, which produced high-end pork in Chinese market. Two-dimensional gas chromatography-time-of-flight mass spectrometry (GC × GC-TOF MS) used analyze quantify volatile organic compounds (VOCs) two types for identifying of these very pigs. The is imparted by alkanes, aldehydes, ketones, ethers. Flavor...
Abstract Although it is known that the frequency and intensity of heatwaves are affected by El Niño–Southern Oscillation (ENSO), unknown ENSO modulations on moving properties (e.g., distance speed) spatiotemporally contiguous heatwaves. Here, we investigate relationship between patterns We show likely more frequent, persistent, longer‐traveling, but slower‐moving during Niño than La Niña episodes. The differences in tropical influenced persistent high‐pressure anomalies. During following...
To compare central corneal thickness (CCT), anterior chamber depth (ACD), and keratometry (K) readings measured using optical low-coherence reflectometry (OLCR) biometry high-resolution rotating Scheimpflug photography.Eye Hospital of Wenzhou Medical College, Wenzhou, China.Comparative case series.The CCT, ACD endothelium to lens, epithelium K (mean; in flattest meridian; steepest meridian) were 5 times the LenStar/Biograph OLCR biometer 3 with Pentacam system eyes healthy volunteers....
Single cell RNA sequencing (scRNA-seq) is applied to assay the individual transcriptomes of large numbers cells. The gene expression at single-cell level provides an opportunity for better understanding function and new discoveries in biomedical areas. To ensure that based data are interpreted appropriately, it crucial develop computational methods. In this article, we try re-construct a neural network on Gene Ontology (GO) dimension reduction scRNA-seq data. By integrating GO with both...
Abstract Heatwaves detrimentally affect human health and ecosystems. While previous studies focused on either temporal changes or spatial extents of heatwaves, their spatiotemporal contiguity propagation patterns are unclear. Here, we investigate the climatology, long-term trends, interannual variations spatiotemporally contiguous heatwaves across China during 1961 to 2018. Two distinct identified by introducing a events tracking (SCET) method k-means clustering. Type 1 mostly generate over...
Diabetic cardiomyopathy is characterized by interstitial fibrosis and cardiomyocyte hypertrophy apoptosis. Also known as CCN2, connective tissue growth factor (CTGF) implicated in the fibrosis; however, whether it contributes to cardiomyocytes changes adverse effects of high glucose lipids on these cells remains unknown. Hearts from streptozotocin-induced diabetic rats had elevated CTGF pathological myocardial hypertrophy, fibrosis, Rat H9c2 were then treated with recombinant human (rh)CTGF,...
Abstract The nutritional value and eating qualities of beef are enhanced when the unsaturated fatty acid content fat is increased. Long-chain acyl-CoA synthetase 1 (ACSL1) plays key roles in transport degradation, as well lipid synthesis. It has been identified a plausible functional positional candidate gene for manipulations composition bovine skeletal muscle. In present study, we determined that ACSL1was highly expressed subcutaneous adipose tissue longissimus thoracis . To elucidate...
Probiotics are widely known for their health benefits. Mitochondrial dysfunction is related to obesity. The aim of this study was illuminate whether Bifidobacterium animalis subsp. lactis A6 (BAA6) could improve obesity due increased mitochondrial biogenesis and function adipose tissues. Four-week-old male C57BL/6 mice were fed with a high-fat diet (HFD) 17 weeks. For the final eight weeks, HFD group divided into three groups including HFD, BAA6 (HFD + group), Akkermansia muciniphila (AKK)...
The aim of this study was to investigate the effect dietary protein level (soybean meal) on growth performance, flesh quality grass carp, and related molecular mechanisms. results showed that appropriate levels improved hardness, pH muscle while decreasing crude lipid content cooking loss altering antioxidant capacity metabolic enzymes activities. In addition, promoted gene expression myhc-1, myhc-4, myf5, myod, myog, fgf6a, whereas inhibited myhc-7, myhc-2, mrf4, mstn. Transcriptome...
Krüppel-like factor 4 (KLF4) is an evolutionarily conserved zinc finger-containing transcription that regulates diverse cellular processes such as cell proliferation, apoptosis, and differentiation. Our previous study showed KLF4 expression upregulated in skeletal muscle ontogeny during embryonic development pigs, suggesting its importance for function. We revealed here plays a critical role regeneration. Specific knockout of impaired formation further affecting physical activity also...