A5055000437- Corneal surgery and disorders
- Glaucoma and retinal disorders
- Corneal Surgery and Treatments
- Ophthalmology and Visual Impairment Studies
- Ocular Surface and Contact Lens
- Intraocular Surgery and Lenses
- Conducting polymers and applications
- VLSI and Analog Circuit Testing
- Perovskite Materials and Applications
- Organic Electronics and Photovoltaics
- Speech Recognition and Synthesis
- Crystallization and Solubility Studies
- Speech and Audio Processing
- Immunotherapy and Immune Responses
- X-ray Diffraction in Crystallography
- Nerve injury and regeneration
- Cancer-related molecular mechanisms research
- Advanced Chemical Sensor Technologies
- Gas Sensing Nanomaterials and Sensors
- Low-power high-performance VLSI design
- Glycosylation and Glycoproteins Research
- Music and Audio Processing
- Electrospun Nanofibers in Biomedical Applications
- Cosmology and Gravitation Theories
- Cancer Immunotherapy and Biomarkers
Affiliated Eye Hospital of Wenzhou Medical College
2016-2025
Wenzhou Medical University
2016-2025
Second Xiangya Hospital of Central South University
2021-2025
Central South University
2020-2025
First Affiliated Hospital of Wenzhou Medical University
2023-2025
Shanghai Institute of Organic Chemistry
2024-2025
Atara Biotherapeutics (United States)
2020-2025
University of Science and Technology of China
2023-2025
Jiangxi University of Science and Technology
2025
University of Chinese Academy of Sciences
2025
Abstract Purpose: We generated a humanized antibody, HuLuc63, which specifically targets CS1 (CCND3 subset 1, CRACC, and SLAMF7), cell surface glycoprotein not previously associated with multiple myeloma. To explore the therapeutic potential of HuLuc63 in myeloma, we examined detail expression profile CS1, binding properties to normal malignant cells, antimyeloma activity preclinical models. Experimental Design: was analyzed by gene profiling immunohistochemistry myeloma samples numerous...
Abstract Immunotherapies targeting the programmed death 1 (PD-1) coinhibitory receptor have shown great promise for a subset of patients with cancer. However, robust and safe combination therapies are still needed to bring benefit cancer immunotherapy broader patient populations. To search an optimal strategy combinatorial immunotherapy, we compared antitumor activity anti–4-1BB/anti–PD-1 that anti–PD-1/anti–LAG-3 in poorly immunogenic B16F10 melanoma model. Pronounced tumor inhibition...
Abstract RNA methylation is an important epigenetic modification. Recent studies on mainly focus the m 6 A modification of mRNA, but very little known about 5 C NSUN2 methyltransferase responsible for multiple RNAs. In this study, we knocked down gene in HepG2 cells by CRISPR/Cas9 technology and performed high-throughput RNA-BisSeq. An tumor-related lncRNA H19 was identified to be targeted NSUN2. Studies have shown that expression abnormally elevated has a carcinogenic effect many types...
Black TiO2 has triggered worldwide research interest due to its excellent photocatalytic properties. However, the understanding of structure–property relationships and a more effective, facile versatile method produce it remain great challenges. We have developed approach synthesize black nanoparticles with significantly improved light absorption in visible infrared regions. The experimental results show that oxygen vacancies are major factors responsible for coloration. More importantly,...
Abstract The effective molecular design of non‐fullerene acceptors is important to high‐efficiency organic solar cells. Herein, asymmetric alkyl chain engineering applied a new acceptor named DTC11. Compared with the model accpetor DTY6 two long‐branched chains (2‐decyltetradecyl) on dithie‐nothiophen[3.2‐b]‐pyrrolobenzothiadiazole central unit, DTC11 owns 2‐decyltetradecyl and an undecyl in inner bay side unit. It found that such modification long chains, crystallinity, absorption...
Abstract The simultaneous improvement of efficiency and stability organic solar cells (OSCs) for commercialization remains a challenging task. Herein, we designed asymmetric acceptors DT‐C8Cl DT‐C8BTz with functional haloalkyl chains, in which the halogen atoms could induce noncovalent interactions heteroatoms like O, S, Se, etc ., thus leading to appropriately manipulated film morphology. Consequently, binary devices based on D18: achieved champion power conversion (PCE) 19.40 %. higher PCE...
Obesity refers to a significant contributor the development of obstructive sleep apnea (OSA). Early prediction OSA usually leads better treatment outcomes, and this study aims employ novel metabolic markers, visceral adiposity index (VAI), lipid accumulation product (LAP) evaluate relationship OSA.
PURPOSE: To evaluate a combination of topography-guided custom ablation and corneal collagen cross-linking (CXL) in single procedure for the treatment keratectasia. METHODS: Twelve eyes 12 patients with keratectasia were treated CXL. Topography-guided was performed using transepithelial technique iVIS Suite 1 kHz flying spot excimer laser. Collagen immediately after ablation, according to standard protocol. Postoperative follow-up examinations at 1, 3, 6, months. Uncorrected visual acuity...
IL-33 may play a role in the vascular remodelling of hypoxic pulmonary hypertension (PH) but precise mechanisms are still unclear. We hypothesized that hypoxia promotes expression and its receptor ST2 on endothelial cells, which turn leads to dysfunction cells smooth muscle contributing PH. Immunohistochemistry showed immunoreactivity for was significantly increased lung tissue murine model hypoxia-induced PH (HPH) subjects with bronchiectasis-PH. trans-Thoracic echocardiography haemodynamic...
A straightforward protocol for diarylannulated sulfone construction is efficiently established via SO2/I exchange of iodonium(III) salts. Readily available inorganic Na2S2O5 was served as a safe and convenient SO2 surrogate. Diverse functionalized sulfones were smoothly achieved in good to excellent yields with great functional group compatibility. Organic light emitting diodes (OLEDs) material molecules subsequently this method gram scale. The unsymmetrical conjugated systems donor-acceptor...
Abstract A straightforward multicomponent decarboxylative cross coupling of redox‐active esters (N‐hydroxyphthalimide ester), sodium dithionite, and electrophiles was established to construct sterically bulky sulfones. The inorganic salt dithionite not only served as the sulfur dioxide source, but also acted an efficient radical initiator for decarboxylation. Notably, diverse naturally abundant carboxylic acids artificially prepared carboxyl‐containing drugs with multiple heteroatoms...
Rationale: Peripheral nerve injury (PNI) is a great challenge for regenerative medicine. Nerve autograft the gold standard clinical PNI repair. Due to its significant drawbacks, artificial guidance conduits (NGCs) have drawn much attention as replacement therapies. We developed combinatorial NGC consisting of longitudinally aligned electrospun nanofibers and porcine decellularized matrix hydrogel (pDNM gel). The in vivo capacity facilitating tissue regeneration functional recovery was...
The elaborate control of the vertical phase distribution within an active layer is critical to ensuring high performance organic solar cells (OSCs), but challenging. Herein, a self-stratification realised by adding novel polyfluoroalkyl-containing non-fullerene small-molecule acceptor (NFSMA), EH-C8 F17 , as guest into PM6:BTP-eC9 blend. A favourable morphology was obtained with upper acceptor-enriched thin and lower undisturbed bulk heterojunction layer. Consequently, power conversion...
Organic optoelectronic materials enable cutting-edge, low-cost organic photodiodes, including solar cells (OSCs) for energy conversion and photodetectors (OPDs) image sensors. The bulk heterojunction (BHJ) structure, derived by blending donor acceptor in a single solution, has dominated the construction of active layer, but its morphological evolution during film formation poses great challenge obtaining an ideal nanoscale morphology to maximize exciton dissociation minimize nongeminate...