A5101461590- Gut microbiota and health
- Gastrointestinal motility and disorders
- Bacteriophages and microbial interactions
- Clostridium difficile and Clostridium perfringens research
- Helicobacter pylori-related gastroenterology studies
- Diet and metabolism studies
- Cardiac Arrest and Resuscitation
- Cardiac Ischemia and Reperfusion
- Probiotics and Fermented Foods
- Neonatal Respiratory Health Research
- Proteins in Food Systems
- Food composition and properties
- Anesthesia and Neurotoxicity Research
- Anesthesia and Sedative Agents
- Infant Nutrition and Health
- Dialysis and Renal Disease Management
- Intensive Care Unit Cognitive Disorders
- Integrated Energy Systems Optimization
- Respiratory viral infections research
- Food Chemistry and Fat Analysis
- Nanocomposite Films for Food Packaging
- MicroRNA in disease regulation
- Tracheal and airway disorders
- Chronic Kidney Disease and Diabetes
- Digestive system and related health
Columbia University
2021-2025
China Agricultural University
2017-2024
Columbia University Irving Medical Center
2024
Beijing Anzhen Hospital
2024
Capital Medical University
2024
Beijing Hospital
2024
Xi'an Jiaotong University
2014-2024
Southeast University
2024
First Affiliated Hospital of Wenzhou Medical University
2022
Wenzhou Medical University
2022
Objective Patients with renal failure suffer from symptoms caused by uraemic toxins, possibly of gut microbial origin, as deduced studies in animals. The aim the study is to characterise relationships between intestinal microbiome composition, toxins and human end-stage disease (ESRD). Design Characterisation microbiome, serum faecal metabolome phenotypes a cohort 223 patients ESRD 69 healthy controls. Multidimensional data integration reveal links these datasets use chronic kidney (CKD)...
Abstract Current treatment for functional dyspepsia (FD) has limited and unsustainable efficacy. Probiotics have the sustainable potential to alleviate FD. This randomized controlled clinical trial (Chinese Clinical Trial Registry, ChiCTR2000041430) assigned 200 FD patients receive placebo, positive-drug (rabeprazole), or Bifidobacterium animalis subsp . lactis BL-99 (BL-99; low, high doses) 8-week. The primary outcome was response rate (CRR) of score after 8-week treatment. secondary...
This study investigated allergy immunotherapy potential of Lactobacillus paracasei L9 to prevent or mitigate the particulate matter 2.5 (PM2.5) enhanced pre-existing asthma in mice. Firstly, we used a mouse model (a 21-day ovalbumin (OVA) sensitization and challenge model) followed by PM2.5 exposure twice on same day last challenge. was collected from urban area Beijing underwent analysis for metals polycyclic aromatic hydrocarbon contents. The results showed that airway hyper-responsiveness...
The gut microbiota plays a crucial role in regulating host metabolism and producing uremic toxins patients with end-stage renal disease (ESRD). Our objective is to advance toward holistic understanding of the ecosystem its functional capacity such patients, which still lacking.Herein, we explore microbiome 378 hemodialytic ESRD 290 healthy volunteers from two independent cohorts via deep metagenomic sequencing metagenome-assembled-genome-based characterization their feces. findings reveal...
Sleep deprivation (SD) leads to impaired intestinal barrier function and flora disorder, especially a reduction in the abundance of next generation probiotic Faecalibacterium prausnitzii (F. prausnitzii). However, it remains largely unclear whether F. can ameliorate SD-induced damage. A 72 h SD mouse model was used this research, with or without addition prausnitzii. The findings indicated that pre-colonization could protect against tissue damage from SD, enhance goblet cell count MUC2...
Neuronal-regulated cell death (RCD) due to the accumulation of ROS within central nervous system (CNS) is one crucial causes diseases. Caspase-dependent apoptosis only form RCD. As research progressed, several nonapoptotic pathway RCDs were identified. Ferroptosis a RCD characterized by lipid peroxidation and plasma membrane damage. Polygonatum cyrtonema Hua. Polysaccharides (PCP) are an effective antioxidant. Based on this, protective effect mechanism PCP against H2O2-induced microglial...
Probiotics are widely known for their health benefits. Mitochondrial dysfunction is related to obesity. The aim of this study was illuminate whether Bifidobacterium animalis subsp. lactis A6 (BAA6) could improve obesity due increased mitochondrial biogenesis and function adipose tissues. Four-week-old male C57BL/6 mice were fed with a high-fat diet (HFD) 17 weeks. For the final eight weeks, HFD group divided into three groups including HFD, BAA6 (HFD + group), Akkermansia muciniphila (AKK)...
Adenomatous polyps (APs) with inflammation are risk factors for colorectal cancer. However, the role of inflammation-related gut microbiota in promoting progression APs is unknown.
Background: Postoperative delirium (POD) and postoperative cognitive dysfunction (POCD) are common complications among elderly patients after major surgery. Dexmedetomidine (DEX) is less frequently explored for its effects on neurocognitive disorders. This study investigated the effect optimal dosage of DEX patient-controlled analgesia (PCA) POD early POCD Methods: Patients in four groups received continuous infusion 0, 100, 200, 400 μg with sufentanil 150 PCA immediately The were assessed...
Chronic kidney disease (CKD) is associated with gut microbiome dysbiosis, but the role of intestinal flora in CKD treatment remains to be elucidated. Fecal microbiota transplantation (FMT) can utilized re-establish healthy for a variety diseases, which offers new insight treating CKD. First, 5/6 nephrectomy rats (Donor CKD) and sham Sham) were used as donors FMT, fecal metagenome analyzed explore potential therapeutic targets. Then, assess effect FMT on CKD, sterilized 1/2 transplanted from...
Human milk oligosaccharides (HMOs) play key roles in shaping infant fecal microbiota, and HMOs profiles have been reported to vary according the mother's glycosyltransferase phenotype. In this study, of human from secretor or non-secretor mothers collected at 2 months postpartum were analyzed by liquid chromatography quadrupole time-of-flight tandem mass spectrometry. 16S rRNA sequencing was used characterize microbiota breastfed infants. The amount total fucosylated higher than mothers,...
Momordica Charantia Polysaccharide (MCP), the main active ingredient of M. charantia, exhibits multiple pharmacological properties. However, its effects and mechanisms against ulcerative colitis (UC) remain unclear. In this study, we employed a dextran sulfate sodium (DSS)-induced experimental model to investigate therapeutic potential MCP. Our results revealed that prophylactic MCP dramatically attenuated pathological symptoms associated with in mice, including body weight loss, reduction...
Inflammatory bowel disease (IBD) refers to a pair of prevalent conditions (Crohn's and ulcerative colitis) distinguished by persistent inflammation the large intestine. Procyanidin C1 (PCC1) is naturally occurring substance derived from grape seeds that has demonstrated notable anti-inflammatory properties. This study examines potential utility PCC1 as treatment for IBD subsequently host-cell- microbiome-related mechanisms underlying detected therapeutic benefits. Working with classic...
While chief executive officer (CEO) competitive aggressiveness can be frequently observed in industries with heavy R&D (research and development) investment, studies on its impact strategies hiring for competing firms are rare. This article builds a Cournot-based game model to examine this issue obtain many novel findings duopolistic market. In particular, compared two noncompetitive CEOs, CEOs may hinder rather than stimulate investment when the of remains relatively weak. Our analysis...
Abstract Objectives Proinflammatory cytokines triggered by surgery and postoperative pain are major causes of delirium (POD). This study investigated the effects flurbiprofen axetil on POD when used for analgesia after noncardiac in elderly patients. Methods Patients over 65 years old were randomly divided into two groups: sufentanil group (S group), which 150 μg was patient‐controlled (PCA) pump 3 days; combined with (SF 300 mg PCA days. The Confusion Assessment Method scale evaluation....