A5100417085- Pancreatic function and diabetes
- Diabetes and associated disorders
- Medicinal Plant Pharmacodynamics Research
- Advanced Glycation End Products research
- IL-33, ST2, and ILC Pathways
- Adipokines, Inflammation, and Metabolic Diseases
- Free Radicals and Antioxidants
- Nitric Oxide and Endothelin Effects
- Immune Cell Function and Interaction
- Parathyroid Disorders and Treatments
- Healthcare and Venom Research
- Cancer and Skin Lesions
- Anesthesia and Neurotoxicity Research
- Diet and metabolism studies
- Phytochemistry and Biological Activities
- Cardiovascular Disease and Adiposity
- Computational Drug Discovery Methods
- Cardiovascular Function and Risk Factors
- Dermatologic Treatments and Research
- Animal Nutrition and Physiology
- Diet, Metabolism, and Disease
- Cancer Diagnosis and Treatment
- Cardiovascular and exercise physiology
- Traditional Chinese Medicine Studies
- Biochemical Acid Research Studies
China Pharmaceutical University
2013-2025
Yingkou Institute of Technology
2024
Zhejiang Hospital
2024
Peking University Third Hospital
2024
Peking University
2022-2024
Tongji Hospital
2024
Huazhong University of Science and Technology
2024
University of Illinois Urbana-Champaign
2024
Luoyang Normal University
2022
Harbin Medical University
2019-2020
The fibroblast growth factor (FGF23) plasma level is high in cardiac and renal failure associated with poor clinical prognosis of these disorders. Both diseases are paralleled by hyperaldosteronism. Excessive FGF23 levels hyperaldosteronism further observed Klotho-deficient mice. present study explored a putative aldosterone sensitivity Fgf23 transcription secretion the involvement sensitive serum & glucocorticoid inducible kinase SGK1, SGK1 NFκB store operated Ca2+ entry (SOCE). Serum were...
Recent studies showed that alpha cells, especially immature cells and proalpha might be the precursors of beta cells. Exposure to glucagon-like peptide 1 (GLP1) can ameliorate hyperglycemia in diabetic mice restore cell mass. In present study, we adopted single high-dose (60 mg/kg, i.p.) streptozotocin (STZ) model diabetes mellitus (DM) randomly assigned short-tail (SD) rats a normal group, GLP1 groups (50 μ g/kg, 100 200 g/kg), (200 g/kg) with exendin (9-39) LY294002 group. We found...
ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTSynthesis and structural spectroscopic characterization of the Germanazene [GeN(2,6-i-Pr2C6H3)]3 tin lead tetramers [SnN(BMes2)]4, [SnN(2,6-i-Pr2C6H3)]4, [PbN(2,6-i-Pr2C6H3)]4Hong Chen, Ruth A. Bartlett, H. V. Rasika Dias, Marilyn M. Olmstead, Philip P. PowerCite this: Inorg. Chem. 1991, 30, 18, 3390–3394Publication Date (Print):September 1, 1991Publication History Published online1 May 2002Published inissue 1 September...
Background:The peptide glucagon-like peptide-1 (GLP-1) is a hormone secreted by intestinal L cells in response to food intake. GLP-1 has been proposed as the basis of emerging therapy for patients with type 2 diabetes. However, effects on vascular injury diabetes have not identified. Advanced glycation end products (AGEs) induce endothelial cell apoptosis and implicated process complications from diabetes.Material/Methods:The aim this work was investigate whether how protects induced AGEs....
Objectives . Glucose fluctuations are both strong predictor of diabetic complications and crucial factor for beta cell damages. Here we investigated the effect intermittent high glucose (IHG) on apoptosis proliferation activity in INS-1 cells potential mechanisms. Methods Cells were treated with normal (5.5 mmol/L), constant (CHG) (25 IHG (rotation per 24 h 11.1 or 25 mmol/L) 7 days. Reactive oxygen species (ROS), xanthine oxidase (XOD) level, apoptosis, viability, cycle, expression...
Abstract Background and Purpose The sirtuin 3 (SIRT3) signalling pathway is an essential target for various cardiovascular diseases (CVDs), although effective interventions in myocardial ischaemia‐induced mitochondrial dysfunction remain to be elucidated. Here, we discovered a potent SIRT3 activator explored its efficacy mechanism against dysfunction. Experimental Approach Molecular docking screened activators among the 10 more common rare ginsenosides. In vivo, left coronary artery ligation...
In this study, we investigated the interaction between exercise-induced mitochondrial adaptation of large vessels and effects chronic anabolic androgenic steroids (AASs). Four groups Sprague–Dawley rats were studied: (i) sedentary, (ii) sedentary + nandrolone-treated, (iii) aerobic exercise trained, (iv) trained nandrolone-treated. Aerobic training increased levels aortic endothelial nitric oxide synthase (eNOS) heme oxygenase-1 (HO-1) in accordance with improved acetylcholine-induced...
Abstract Objectives Proinflammatory cytokines triggered by surgery and postoperative pain are major causes of delirium (POD). This study investigated the effects flurbiprofen axetil on POD when used for analgesia after noncardiac in elderly patients. Methods Patients over 65 years old were randomly divided into two groups: sufentanil group (S group), which 150 μg was patient‐controlled (PCA) pump 3 days; combined with (SF 300 mg PCA days. The Confusion Assessment Method scale evaluation....
The neogenesis of insulin-producing cells (IPCs) from non-beta-cells has emerged as a potential method for treating diabetes mellitus (DM). Many groups have documented that activation pancreatic transcription factor(s) in hepatocytes can improve the hyperglycemia diabetic mice. In present study, we explored novel protocol reprogrammed primary into functional IPCs by using multicistronic vectors carrying and duodenal homeobox-1 (Pdx1), neurogenin 3 (Ngn3), v-musculoaponeurotic fibrosarcoma...
Recent studies showed that in patients with type 2 diabetes mellitus (T2DM), Sodium-dependent glucose transporters inhibitor (SGLT2I) may cause potential adverse effects on the skeleton such as increasing risk of fracture. This is possibly mediated by induced all SGLT2I class drugs, but whether Dapagliflozin aggravates osteoporosis T2DM remains controversial. Therefore, we designed this study to explore how affects metabolism and quality bone animal models. The effect was evaluated male ZDF...
Diabetes mellitus has been considered as a major health problem in the world today. This study aimed to investigate hypoglycemic and antioxidative effects of peptide MC62 which was synthesized by solid-phase synthesis method against diabetes induced streptozotocin. administered daily injected intraperitoneally diabetic mice at dose 1 μmol/kg body weight for 20 days. The levels fasting blood glucose HbA1C, pancreatic islet damage, associated changes activities were evaluated...
Abstract Carbazole derivatives can be used as antioxidants in the lubricating oil industry. The alkylation of carbazole with 2-chloro-2-methylpropane and 2-bromopropane catalyzed by anhydrous aluminum chloride was studied. Initially, 3,6-di-iso-propylcarbazole 3,6-di- tert -butylcarbazole were using dichloromethane dibromomethane solvents at room temperature, respectively. synthesis conditions optimized. Subsequently, effects reaction time, catalyst dosage, molar ratio to alkylating agent...
Prostate cancer (PCa) is a malignant tumor with higher mortality rate in the male reproductive system. In this study, hydroxyazine derivatives were synthesized different structure from traditional anti-prostate drugs. evaluation of vitro cytotoxicity and antagonistic activity PC-3, LNCaP, DU145 androgen receptor, it was found that mono-substituted on phenyl group (4, 6, 7, 9) displayed strong cytotoxic activities, compounds 11-16 showed relatively potency against AR (Inhibition% >55)....