A5101409227- Gut microbiota and health
- Infant Nutrition and Health
- Cancer, Hypoxia, and Metabolism
- Bacterial biofilms and quorum sensing
- Neonatal Respiratory Health Research
- Nanoparticles: synthesis and applications
- Epigenetics and DNA Methylation
- Antibiotic Resistance in Bacteria
- Histone Deacetylase Inhibitors Research
- Diet and metabolism studies
- Cardiac Fibrosis and Remodeling
- Spectroscopy and Chemometric Analyses
- Enzyme-mediated dye degradation
- Mycotoxins in Agriculture and Food
- Advanced Nanomaterials in Catalysis
- Diabetes Treatment and Management
- Antimicrobial agents and applications
- Chemokine receptors and signaling
- Soil and Water Nutrient Dynamics
- Atrial Fibrillation Management and Outcomes
- Obesity and Health Practices
- Growth and nutrition in plants
- Microtubule and mitosis dynamics
- Protein Degradation and Inhibitors
- Adenosine and Purinergic Signaling
University of Hong Kong
2023-2025
Army Medical University
2022-2024
Institute of Bast Fiber Crops
2024
Chinese Academy of Agricultural Sciences
2024
State Key Laboratory of Synthetic Chemistry
2024
China Medical University
2024
First Hospital of China Medical University
2024
Sun Yat-sen University Cancer Center
2018-2023
Sun Yat-sen University
2018-2023
Nanjing Agricultural University
2023
The rapid emergence of antimicrobial resistance (AMR) pathogens highlights the urgent need to approach this global burden with alternative strategies. Cefiderocol (Fetroja®) is a clinically-used sideromycin, that utilized for treatment severe drug-resistant infections, caused by Gram-negative bacteria; there evidence cefiderocol-resistance occurring in bacterial strains however. To increase efficacy and extend life-span sideromycins, we demonstrate strong synergisms between cefiderocol...
Gastric cancer (GC) is the fifth most commonly diagnosed worldwide, and its poor prognosis predominantly attributed to distant metastasis. The liver primary site of GC However, there no universally approved treatment regimen for metastasis in GC. aim this article review current research status trends worldwide.
Scope Necrotizing enterocolitis (NEC) is a devastating disease that highly lethal in premature infants. Human milk oligosaccharides (HMOs) efficiently reduce the incidence of NEC. However, protective mechanism HMO treatment unknown. It hypothesized HMOs protect against NEC by inhibiting damage to intestinal epithelial cells. Methods and results C57BL/6 pups are challenged with hypoxia cold stress induce All sacrificed after 72 h. found administration reduces concentrations IL‐8 serum ileum...
Pasteurization is carried out in dairy industries to kill harmful bacteria present raw milk. However, endospore-forming bacteria, such as Bacillus, cannot be completely eliminated by pasteurization. In this study, a total of 114 Bacillus strains were isolated from 133 pasteurized milk samples. Antibiotic susceptibility tests showed that the percentage with intrinsic resistance ampicillin and penicillin 80 86%, respectively. Meanwhile, some isolates had acquired resistance, including...
Both melanoma cells and tissues were allowed to interact with a phage library for discovering cell/tissue dual-homing tumor-destructing bionanofibers.
Human milk oligosaccharides (HMOs) play key roles in shaping infant fecal microbiota, and HMOs profiles have been reported to vary according the mother's glycosyltransferase phenotype. In this study, of human from secretor or non-secretor mothers collected at 2 months postpartum were analyzed by liquid chromatography quadrupole time-of-flight tandem mass spectrometry. 16S rRNA sequencing was used characterize microbiota breastfed infants. The amount total fucosylated higher than mothers,...
Li, Xiaoxu, Zhijun Pu, Gang Xu, Yidong Yang, Yu Cui, Xiaoying Zhou, Chenyuan Wang, Zhifeng Zhong, Simin Jun Yin, Fabo Shan, Chengzhong Li Jiao, Dewei Chen, and Jian Huang. Hypoxia-induced myocardial hypertrophy companies with apoptosis enhancement p38-MAPK pathway activation. High Alt Med Biol. 00:00–00, 2024.
With excessive nitrogen (N) input, high nitrous oxide (N2O) emissions are frequently observed in greenhouse vegetable fields. We hypothesized that the underlying production mechanisms can be derived across a wide selection of fields middle and lower reaches Yangtze River. Thus, we investigated emission characteristics relative contributions ammonia-oxidizing archaea (AOA) bacteria (AOB) other microbial processes to N2O from five long-term through an incubation experiment with combined...
Type 2 diabetes (T2D) is a disease of global concern characterized by hyperglycemia and insulin resistance. Many studies found that glucagonlike peptide-1 (GLP-1) an incretin hormone can alleviate T2D. Recently, probiotics their combination with prebiotics have been to show great potentials blood glucose regulation T2D alleviation. Given the important role GLP-1 in T2D, screening capacity promoting secretion help for providing novel application treatment. In current study, we evaluated...
The object of this research was to report a draft proteome human fallopian tube (hFT) comprises 5416 identified proteins, which could be considered as physiological reference complement Human Proteome Draft. proteomic raw data and metadata were stored in an integrated resources centre iProX (IPX00034300). This hFT contains many markers newly by mass spectrum. 660 high-, 3605 medium- 1181 low-abundant proteins. Ribosome, cytoskeleton, vesicle protein folding associated proteins showed obvious...
The aim of this work is to study the potential degradation polyvinyl alcohol (PVA) by a novel fungus Eutypella sp. BJ isolated from soil compost. When it was cultured on semi-synthetic medium containing PVA at 30 °C and 160 rpm for 8 days, removal rates 1788, 1799 2488 reached 87.40%, 86.31% 44.80%, respectively. Gel permeation chromatography (GPC) analysis revealed significant reductions number average molecular weight 1788 47 358 13 345 71 387 24 238, respectively, after days. Fourier...
Given the probiotic effects previously found in Bifidobacterium animalis subsp. lactis MN-Gup (MN-Gup) and its great application potential dairy products, this study aimed to investigate of fermented milk containing or MN-Gup-based synbiotics on high fat diet (HFD)-induced obesity rats. Galacto-oligosaccharides (GOS) xylo-oligosaccharides (XOS) were selected as tested prebiotics due their promotion growth vitro. After nine weeks HFD feeding, obese rats intervened with (MN-Gup FM) + GOS FM,...
In this paper, a method for rapid detection of cordycepin in food was established based on surface-enhanced Raman spectroscopic analysis method. The substrates were screened and the conditions sample pretreatment methods optimized. optimal substrate gold nanocolloid, as follows: addition amount nanocolloid 200 μL 5 μL. Under conditions, limit 1 mg/L, performed by methanol extraction. Based spectroscopy (SERS) method, two Cordyceps militaris detected, which confirmed practical application
We previously found that overexpression of the gene known as amplified in breast cancer 1 (AIB1) was associated with lymph node metastasis and poor prognosis patients lung adenocarcinoma. However, role AIB1 malignancy remains unknown. The present study aimed to investigate function process adenocarcinoma cell metastasis.A series vivo vitro assays were performed elucidate AIB1, while real-time PCR Western blotting utilized identify potential downstream targets metastasis. Rescue experiments...
Right ventricular remodeling and its function are closely related to the symptom severity survival of hypoxia pulmonary hypertension, but molecular mechanisms cardiomyocyte hypertrophy myocardial injury remain unclear. It evaluated cardiac (by right catheterization measure systolic pressure mean artery pressure), tissue morphology（Haematoxylin Eosin）, (Wheat Germ Agglutinin Staining), then RNA sequencing was applied explore mechanism, which results were verified by western blot in final....
Synbiotics, combining specific probiotics and selected prebiotics, may benefit health issues like obesity, but evidence remains inconsistent.
Objective: This study is aimed to analyze the long-term safety and effectiveness of second-generation cryoballoon (CB2) ablation in treatment atrial fibrillation (AF). Methods: Data from 760 consecutive patients Department Cardiology, General Hospital Northern Theater Command August 2016 December 2018 with drug-refractory symptomatic AF undergoing pulmonary vein isolation (PVI) using CB2 were assessed. Procedure-related freedom flutter/atria tachycardia through 3 years determined. The risk...