Objective: To minimize the effect of muscle contractions during irreversible electroporation (IRE), this paper attempts to research ablation and by applying high-frequency IRE (H-FIRE) liver tissue in vivo. Methods: An insulated needle electrode was produced painting an insulating coating on outer surface tip. A series experiments were conducted using electrodes traditional apply H-FIRE pulses monopolar rabbit tissues. The finite element model established determine lethal thresholds Muscle...

Irreversible electroporation, as a nonthermal therapy of prostate cancer, has been used in clinic for several years. The mechanism irreversible electroporation ablation is thermal independent; thus, the main structures (eg, rectum, urethra, and neurovascular bundle) are spared during treatment, which leads to retention function. However, various clinical trials have shown that muscle contractions occur this therapy, warrants deep anesthesia. Use high-frequency bipolar pulses proposed reduce...

For irreversible-electroporation (IRE)-based therapies, the underlying electric field distribution in target tissue is influenced by electroporation-induced conductivity changes and important for predicting treatment zone. Objective: In this study, we characterized liver during high-frequency irreversible electroporation (H-FIRE) treatments of widths 5 10 μs proposed a method ablation zones. Methods: To achieve this, created finite-element model treated with H-FIRE IRE pulses based on...

High-frequency bipolar high-voltage pulsed electric field can be used in tumor ablation to uniform the distribution ablated region and inhibit muscle contraction effectively. Developing a high-frequency power generator (HBPPG) with wide range of specifications, such as voltage magnitude, waveform, repetition rate, pulsewidth, is great significance for promoting clinical application irreversible electroporation. Hence, this article, novel modular HBPPG circuit topology proposed application....

In vivo studies of tumor-cell apoptosis induced by nanosecond pulsed electric field require high-voltage pulses delivered to the biological tissues. this paper, a newly developed all-solid-state pulse generator based on Marx concept is proposed for application. The comprises four parts: dc charging power, solid-state circuit using metal-oxide-semiconductor field-effect transistors, control field-programmable gate array, and load. This has capability producing repetitive with voltage up 8 kV,...

A bipolar pulse has been proved to be more advanced in the treatment of tumor because elimination muscle contractions and effect for ablating nonuniform tissue. In this paper, a new type modular pulsed-power generator based on Marx with double power charging is proposed. The concept two series capacitors parallel by sources, respectively, then connecting through solid-state switches different control strategies. Utilizing number fast switches, can connected polarities, so that positive or...

Pulsed electric fields have recently been the focus of considerable attention because their potential application in biomedicine. However, practical clinical applications are limited by poor understanding interaction mechanism between pulsed and cells, particularly process electroporation its effect on parameter selection. This paper established a multishelled dielectric model based finite elements to simulate analyze processes involved electroporation. In particular, include dynamic...

In order to meet the requirements of high voltage, power, and compactness for pulse generators used in field liquid food sterilization, an all-solid-state Marx generator based on a novel magnetic isolated drive is proposed. The circuit uses core transfer control signal, which adopts stacking inverse paralleled secondary side winding. It only needs one signal realize synchronous conduction main switch or bypass complementary both. maximum width not limited by saturation. topology simple,...

With the increasingly extensive and in-depth applications of all solid-state high-voltage nanosecond pulse generators in defense industrial fields, development traditional faces many key issues, such as drive isolation, compact design, reduced weight. Hence, a novel circuit topology for self-triggered high-frequency generator is proposed. Through high potential energy-gaining technology interstage capacitance, this does not need complicated metal-oxide-semiconductor field-effect transistor...

In order to solve problems, such as the nonadjustable drive pulsewidth of semiconductor lasers, in this article, an all-solid-state modular pulse current generator (PCG) topology based on a coupling inductor is proposed. Each stage PCG consists one inductor, two switches, and diode. The inductors are charged series discharged parallel load by controlling timing. design makes it possible increase energy storage density system. To reduce requirement for high-voltage power supply, capacitor...

A high-intensity pulsed magnetic field generator, as a high-power current generator with inductive loads, can be used in transcranial stimulation, tumor therapy, and so on. This article presents new type of pulse called the Marx-based modular energy-saving (MEPG) that improve output performance conventional generators biomedical field. The MEPG includes front-end energy-feeding circuit series discharging modules at different levels. It regulate coils, which turn controls from coils....

Glioblastoma (GBM) is the deadliest type of cancer and current clinical treatments for malignant gliomas have many side effects. The article discusses possibility that nanosecond pulsed electric fields (nsPEFs) can be focused on tumors local killing. As well as utilizing CANCAN (canceled bipolar) effect to reduce neurostimulation thus overcome effects such seizures edema. In this paper, we use cell ablation viability experiments investigated BPC (Bipolar cancellation) U87-MG cells under...

Two major reasons why chemotherapy and immunotherapy have limited efficacy in treating gliomas are the blood-brain barrier dense, solid structure of glioma. Pulsed electric fields been a powerful tool for ablating tumors, narrowing pulse duration can improve field homogeneity penetrating into tumor. In this study, we used multicellular tumor spheroids (MCTSs) as model to explore potential ultrashort nanosecond pulses inhibit cell activity while disrupting their dense drug-resistant barriers....

The degree of texturing the grains in epitaxial situ Y-Ba-Cu-O films was studied by x-ray pole-figure measurements. These high Tc and Jc laser deposited were all aligned with c axis perpendicular to substrate surface. It found that on SrTiO3(001) LaAlO3(001) totally YBCO a parallel 〈100〉 direction substrate. For MgO(001), 4% are 〈110〉 direction. yttria stabilized zirconia (001), axes distributed between directions observations consistent lattice mismatch various crystal orientations.

Atmospheric-pressure plasma jets (APPJs) are widely used in biomedical treatment, surface modification, and sterilization, among others because of their advantages simple structure, strong chemical activities, nonthermal effects, convenient handling. In this paper, a nanosecond-pulse power generator based on Marx circuit is proposed. The apparatus consists with crowbar switch needle-ring structure electrode. modularly designed ten stages; MOSFETs as the main each stage. A field-programmable...

Irreversible electroporation (IRE) is an emerging technology for the non-thermal ablation of tumors, but it challenged due to unintended induction muscle contractions, which must be avoided by neuromuscular blockade in clinic. In this study, high frequency irreversible (H-FIRE), replaces monopolar IRE pulses with a burst bipolar pulses, was used tissues on rabbit liver through Plate Electrodes. The bursts different individual pulse durations maintain constant total energized time (100 μs),...