A5100422735- Cancer-related molecular mechanisms research
- Circular RNAs in diseases
- RNA modifications and cancer
- MicroRNA in disease regulation
- RNA Research and Splicing
- Reproductive biology and impacts on aquatic species
- Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
- Genetic and phenotypic traits in livestock
- Sperm and Testicular Function
- Growth Hormone and Insulin-like Growth Factors
- Genetic Associations and Epidemiology
- Epigenetics and DNA Methylation
- Lipoproteins and Cardiovascular Health
- Plant nutrient uptake and metabolism
- Environmental Toxicology and Ecotoxicology
- Plant Stress Responses and Tolerance
- Genetic Mapping and Diversity in Plants and Animals
- Enterobacteriaceae and Cronobacter Research
- Lipid metabolism and disorders
- Listeria monocytogenes in Food Safety
- Aquaculture Nutrition and Growth
- Probiotics and Fermented Foods
- Natural product bioactivities and synthesis
- Ferroptosis and cancer prognosis
- Lipid metabolism and biosynthesis
Central South University
2017-2025
Shanghai Academy of Agricultural Sciences
2017-2025
Northwest University
2024-2025
Ministry of Agriculture and Rural Affairs
2023-2025
Xiangya Hospital Central South University
2017-2025
Mayo Clinic
2024
First Affiliated Hospital of Wannan Medical College
2012-2023
Northwest A&F University
2012-2023
Tianjin University
2022-2023
Capital Medical University
2018-2023
Abstract Ischemia-reperfusion (I/R) is a common pathology when the blood supply to an organ was disrupted and then restored. During reperfusion process, inflammation tissue injury were triggered, which mediated by immunocytes cytokines. However, mechanisms initiating I/R-induced driving activation remained largely unknown. In this study, we identified long non-coding RNA (lncRNA)-H19 as key onset of inflammation. We found that I/R increased lncRNA-H19 expression significantly promote NLRP3/6...
microRNAs (miRNAs) play a crucial role in tissue development and the pathology of various diseases. However, effects roles miRNAs macrophage polarization have yet to be investigated. In this study, we analyzed compared miRNA expression profiles bone marrow-derived macrophages (BMDMs) with two distinct polarizing conditions (classical activation 'M1' alternative 'M2') using microarray. total, 109 were differentially expressed between M1 M2. The differential selected was validated by real-time...
The bovine genetic resources in China are diverse, but their value and potential yet to be discovered. To determine the diversity population structure of Chinese cattle, we analyzed whole genomes 46 cattle from six phenotypically geographically representative breeds, together with 18 Red Angus genomes, 11 Japanese black taurine indicine available previous studies. Our results showed that originated hybridization between Bos taurus indicus. Moreover, found level variation depends upon degree...
Transforming growth factor-β/Smad3 signaling plays an important role in diabetic nephropathy, but its underlying working mechanism remains largely unexplored. The current study uncovered the pathogenic and of a novel Smad3-dependent long noncoding RNA (lncRNA) (LRNA9884) type 2 nephropathy (T2DN). We found that LRNA9884 was significantly upregulated kidney db/db mice at age 8 weeks preceding onset microalbuminuria associated with progression renal injury. induced by advanced glycation end...
Myocyte enhancer factor 2A (MEF2A) is widely distributed in various tissues or organs and plays crucial roles multiple biological processes. To examine the potential effects of MEF2A on skeletal muscle myoblast, functional role MFE2A myoblast proliferation differentiation was investigated. In this study, we found that mRNA expression level Mef2a dramatically increased during myogenesis bovine primary myoblast. Overexpression significantly promoted proliferation, while knockdown inhibited...
Increasing evidence indicates that long noncoding RNAs play important roles in development and progression of various cancers. Zinc finger antisense 1 is a novel RNA whose clinical significance, biological function, underlying mechanism are still undetermined glioma. In this study, we reported zinc expression was markedly upregulated glioma tightly correlated with stage. Moreover, patients high had shorter survival. Multivariate Cox regression analysis provided clue that, probably, level...
Accumulating evidence indicates that macrophage polarization plays a crucial role in coxsackievirus B3 (CVB3)-induced viral myocarditis (VM). Our previous study demonstrated long noncoding ribonucleic acid (lncRNA) AK085865 ablation confers susceptibility to VM by regulating polarization. However, the detailed molecular mechanisms which regulates remain be explored. In this study, we found specifically interacts with interleukin enhancer-binding factor 2 (ILF2) and facilitates M2 functioning...
Cold stress is known to influence tomato growth, development, and yield. In this study, we analyzed the germination of seeds treated with exogenous glycine betaine (GB) at a low temperature (14 °C). The results showed that cold inhibited seed germination, pretreatment GB reduced inhibition enhanced rate (GR), index (GI), viability temperatures. Analysis gene expression metabolism revealed positively regulated endogenous hormone gibberellin (GA) content negatively abscisic acid (ABA) content,...
Elucidating cellular architecture and cell-type evolution across species is central to understanding immune system function susceptibility disease. Adaptive immunity a shared trait of the common ancestor cartilaginous bony fishes. However, evolutionary features lymphocytes in these two jawed vertebrates remain unclear. Here, we present single-cell RNA sequencing atlas cells from (white-spotted bamboo shark) (zebrafish Chinese tongue sole) Cross-species comparisons show that same cell types...
Intramuscular fat (IMF) is known to enhance beef palatability and can be markedly increased by castration. However, there little understanding of the molecular mechanism underlying IMF deposition after castration cattle. We hypothesize that genetic regulators function differently in from bulls steers. Therefore, detecting serum testosterone lipid parameter, as well contents at 6, 12, 18 24 months, we have investigated differentially expressed (DE) microRNAs (miRNAs) mRNAs steers months age...
Melatonin (N-acetyl-5-methoxytryptamine) is a derivative of tryptophan which produced and secreted mainly by the pineal gland regulates variety important central peripheral actions. To examine potential effects melatonin on proliferation differentiation bovine intramuscular preadipocytes (BIPs), BIPs were incubated with different concentrations melatonin. supplementation at 1 mM significantly increased peroxisome proliferator-activated receptor γ (PPARγ), CCAAT/enhancer-binding protein...
Abstract The nutritional value and eating qualities of beef are enhanced when the unsaturated fatty acid content fat is increased. Long-chain acyl-CoA synthetase 1 (ACSL1) plays key roles in transport degradation, as well lipid synthesis. It has been identified a plausible functional positional candidate gene for manipulations composition bovine skeletal muscle. In present study, we determined that ACSL1was highly expressed subcutaneous adipose tissue longissimus thoracis . To elucidate...
The role of long non-coding ribonucleic acids (lncRNAs) during orthodontic tooth movement remains unclear. We explored the lncRNA landscape periodontal ligament stem cells (PDLSCs) subjected to compressive force.PDLSCs were static stress (2 g/cm2) for 12 hours. Total RNA was then extracted and sequenced measure changes in messenger (mRNA) expression levels. Quantitative real-time polymerase chain reaction (qRT-PCR) used validate levels certain lncRNAs. Differential analysis as well Gene...
Long non-coding RNAs (lncRNAs) play key roles in various biological processes. However, the of lncRNAs macrophage polarization remain largely unexplored. In this study, thousands were identified that are differentially expressed distinct polarized bone marrow-derived macrophages. Among them, Dnmt3aos (DNA methyltransferase 3A, opposite strand), as a known lncRNA, locates on antisense strand Dnmt3a. Functional experiments further confirmed highly M(IL-4) macrophages and participated...
There is no clear treatment guideline or individualized plan for triple-negative breast cancer (TNBC). The aim of this study was to investigate more effective targets TNBC-targeted therapy. MDA-MB-231 and BT549 cell lines were used explore the function LINC00649 on proliferation, invasion, migration TNBC cells. A mice subcutaneous tumor model a pulmonary metastasis established identify role growth in vivo. found be key molecule involved occurrence development by screening public databases...
Heat stress (HS) has been considered as a severe threat to crop yields in recent years. Sucrose, major product of photosynthesis, plays an important role plant growth and response. Sucrose phosphate synthase (SPS) is key rate-limiting enzyme the sucrose synthesis pathway plants. However, its molecular mechanism signaling remain unclear. In this study, we identified novel SPS gene (SlSPS) tomato generated over-expression knock-out SlSPS transgenic plants investigate biological functions...
Micro RNA (miRNA) plays important roles in macrophage polarization. However, the manner which miRNA regulate polarization response to dermatophagoides farinae protein 1(Der f1)-induced asthma has not been defined. This study aims explore role of miRNAs regulating macrophages asthma.The microRNAs may were selectd by Microarrays. The function miR-125b-5p and Der f1-induced detected vivo experiment. long non coding (lncRNA) AK089514/miR-125b-5p/TRAF6 axis was predicted bioinformatics confirmed...