A5016962380- Nanoplatforms for cancer theranostics
- Nanoparticle-Based Drug Delivery
- Cancer-related molecular mechanisms research
- Advanced Nanomaterials in Catalysis
- MicroRNA in disease regulation
- RNA Interference and Gene Delivery
- RNA modifications and cancer
- Cancer Genomics and Diagnostics
- X-ray Diffraction in Crystallography
- Crystallization and Solubility Studies
- Ferroptosis and cancer prognosis
- Cancer, Hypoxia, and Metabolism
- Peptidase Inhibition and Analysis
- Covalent Organic Framework Applications
- Cancer Cells and Metastasis
- Metal-Organic Frameworks: Synthesis and Applications
- Medicinal Plant Pharmacodynamics Research
- Colorectal and Anal Carcinomas
- Hepatocellular Carcinoma Treatment and Prognosis
- Lung Cancer Treatments and Mutations
- Luminescence and Fluorescent Materials
- Cancer, Lipids, and Metabolism
- Ubiquitin and proteasome pathways
- Angiogenesis and VEGF in Cancer
- RNA Research and Splicing
Southeast University
2021-2025
Second Affiliated Hospital of Zhejiang University
2025
Shenyang Normal University
2025
Xi'an Medical University
2022-2025
Beike Biotechnology (China)
2024
Qufu Normal University
2024
Guangdong Academy of Medical Sciences
2022-2024
Guangdong Provincial People's Hospital
2022-2024
First Affiliated Hospital of Hunan University of Traditional Chinese Medicine
2023-2024
BGI Group (China)
2024
Abstract The utility of circulating tumor DNA (ctDNA) as a biomarker in patients with advanced cancers receiving immunotherapy is uncertain. We therefore analyzed pretreatment (n = 978) and on-treatment 171) ctDNA samples across 16 advanced-stage types from three phase I/II trials durvalumab (± the anti-CTLA4 therapy tremelimumab). Higher variant allele frequencies (VAF) were associated poorer overall survival (OS) other known prognostic factors, but not objective response, suggesting role...
Immunotherapy has evolved as a critical option to treat diverse cancers. The active response immunotherapy relies on the unique interaction between cancer and tumor microenvironment (TME). Angiogenesis is one of hallmarks cancer. However, association angiogenesis clinical outcome, immune cell infiltration, remains unknown in gastric (GC).We systematically assessed 36 angiogenesis-associated genes (AAGs) comprehensively identified correlation transcriptional patterns, prognosis, infiltration....
Abstract The combination of reactive oxygen species‐involved chemodynamic therapy (CDT) and photothermal (PTT) holds great promise in enhancing anticancer effects. Herein, a multifunctional Fe‐doped polyoxometalate (Fe‐POM) cluster is fabricated via simple method. Fe‐POM can not only be utilized as PTT agents to generate hyperthermia effect for cancer cell killing under near‐infrared (NIR) II laser (1060 nm) irradiation, but also used CDT convert endogenous less‐reactive H 2 O into harmful...
Objective Previous observational studies demonstrated that a subset of patients with systemic lupus erythematosus (SLE) have markedly short telomere length in leukocytes. This study was undertaken to test whether leukocyte is causally associated risk SLE. Methods A 2‐sample Mendelian randomization (MR) analysis conducted estimate causality on SLE European populations. replication MR using Asian genetic data also conducted. reverse then performed the effects length. The autoantibodies...
This study utilised the Global Burden of Disease data (2010-2021) to analyse rates and trends in point prevalence, annual incidence years lived with disability (YLDs) for major chronic liver diseases, such as hepatitis B, C, metabolic dysfunction-associated disease, cirrhosis other diseases. Age-standardised per 100,000 population YLDs were compared across regions countries, well socio-demographic index (SDI). Trends expressed percentage changes (PC) estimates reported uncertainty intervals...
Glioma is the most frequent form of malignant brain tumors. Surgical debulking a major strategy for glioma treatment. However, there great challenge neurosurgeons to intraoperatively identify true margins because its infiltrative nature. Tumor residues or microscopic satellite foci left in resection bed are main reasons leading early recurrence as well poor prognosis. In this study, surface-enhanced resonance Raman scattering (SERRS) probe was developed guide resection. probe, molecular...
Glycyrrhizic acid (GA) is the main active ingredient extracted from Chinese herb licorice root, and it shows anti-tumor effects in many cancer types, while its role gastric (GC) still unknown. In this study, we evaluated of GA on GC cells explored underlying mechanisms.
(1) Background: Pancreatic cancer is increasingly becoming the leading cause of deaths worldwide. In eukaryotic cells, m6A most abundant mRNA methylation modification. (2) Methods: We performed a bioinformatic multidimensional analysis using files containing clinical data patients and m6A-related gene expression differences downloaded from web-based databases, statistical image mapping mainly R-package. Next, we studied RBM15 in paracancerous tissues. then validated these findings two cell...
Background Multidrug resistance (MDR) in gastric cancer remains a major challenge to clinical treatment. Activating transcription factor 4 (ATF4) is stress response gene involved homeostasis and cellular protection. However, the expression function of ATF4 MDR unknown. In this study, we investigate whether play role its potential mechanisms. Methodology/Principal Findings We demonstrated that overexpression confered phenotype cells, while knockdown variants induced re-sensitization. study...
The Delta-12 oleate desaturase gene (FAD2-1), which converts oleic acid into linoleic acid, is the key enzyme determining fatty composition of seed oil. In this study, we inhibited expression endogenous GmFad2-1b by using antisense RNA in soybean Williams 82. By employing cotyledonary-node method, a part cDNA 801 bp was cloned for construction pCAMBIA3300 vector under promoter BCSP. Leaf painting, LibertyLink strip, PCR, Southern blot, qRT-PCR, and analysis were used to detect insertion...
A synergetic phototheranostic system, combining diagnostic photo-imaging and phototherapies [such as photothermal therapy photodynamic (PDT)], shows great potential in today's tumor precise therapy. Herein, we fabricate near-infrared (NIR) light-harvesting fullerene-based nanoparticles (DAF NPs) for photoacoustic (PA) imaging-guided PDT. The fullerene derivatives (DAF) absorbing the NIR region have been synthesized by conjugating NIR-absorbing antenna with fullerene. In addition, DAF NPs...
Docetaxel (DTX) resistance reduces therapeutic efficacy in prostate cancer (PCa). Accumulating reports support the role of phytochemicals reversal DTX resistance. This study aimed to determine whether Epimedium brevicornu and Curcuma zedoaria extracts (ECe), specially icariin-curcumol, attenuates explore their potential mechanisms.Regulatory pathways were predicted between ECe active ingredients PCa using network pharmacology. DTX-resistant cell LNCaP/R established based on DTX-sensitive...
Abstract Background Prostate cancer (PCa) incidence and mortality rates are rising. Our previous research has shown that the combination of icariin (ICA) curcumol (CUR) induced autophagy ferroptosis in PCa cells, altered lipid metabolism. We aimed to further explore effects ICA CUR on gut microbiota, metabolism, immunity PCa. Methods A mouse subcutaneous RM-1 cell tumor model was established. 16 S rRNA sequencing performed detect changes fecal microbiota. SCFAs feces, effect ICA-CUR T-cell...
The development of highly selective, chemically stable and moisture-resistant adsorbents is a key milestone for gas separation. Porous carbons featured with random orientation cross-linking turbostratic nanodomains usually have wide distribution micropores. Here we developed thermoregulated phase-transition-assisted synthesis carbon nanoplates more than 80 % sp2 carbon, unimodal ultramicropore controllable thickness. thin structure allows oriented growth crystallites, stacking crystallites...
Cadmium sulphide (CdS) quantum dots (QDs), sensitizing hierarchical bismuth oxychloride (BiOCl) photocatalysts, were synthesized via a facile solvothermal approach and characterized in detail. The as-prepared CdS–BiOCl photocatalyst possessed an extended light absorption range efficient charge separation properties simultaneously compared with pure BiOCl, especially the visible region. results revealed that newly formed oxygen vacancies will play important role degradation process, which...
A novel pH ratiometrically responsive surface-enhanced resonance Raman scattering (SERRS) probe was developed for tumor acidic margin delineation and image-guided surgery.
Combination therapy such as photodynamic (PDT)-enhanced chemotherapy is regarded a promising strategy for cancer treatment. Boron-dipyrromethene (BODIPY), close relatives of porphyrins, was widely used in PDT. However, poor water solubility, rapid metabolism by the body and lack targeting limits its clinical application. Lenvatinib, first-line drug molecular-targeted liver cancer, restricted application side effects. Herein, to achieve synergy between PDT chemotherapy, we synthesized two...