Ginsenoside Rb1, a diol-type ginseng saponin, has various positive effects on the central nervous system. This study aimed to evaluate antidepressant of Rb1 chronic social defeat stress (CSDS) induced behavioral deficits and exact neural cascades linked with inflammatory processes. The results tests such as interaction, tail suspension, forced swimming revealed that oral treatment (35 70 mg/kg) alleviates depression-like behavior. increased antioxidant enzyme activity (SOD CAT) reduced lipid...

Cichorium intybus L. oligo-polysaccharides (CIOs), obtained from L., is a mixture of oligosaccharides and polysaccharides. This study explores the antianxiety antidepressant effects mechanisms CIOs by using acute behavioral despair chronic unpredictable mild stress mice models measuring levels 5-HT expression proteins related to BDNF/ERK PI3K/Akt/mTOR pathways. Moreover, 56 male C57BL/6N were used test despair. They randomized into seven groups (Control, Citalopram, CIO 12.5 mg/kg, 25 100...

This study aimed to investigate the effects and underlying molecular mechanisms of icariin (ICA) curcumol on autophagy, ferroptosis, lipid metabolism in prostate cancer (PCa), vitro vivo. Normal epithelial cells RWPE-1 PCa cell lines DU145 PC-3 were treated with ICA curcumol. Ferrostatin-1 (Fer-1) or 3-MA was added treat cells. In addition, we knocked down miR-7. The mechanism after knockdown miR-7 verified by nude mice tumorigenesis experiments. had no significant effect viability cells,...

Guilu-Erxian-Glue (GLEXG) is a traditional Chinese formula used to improve male reproductive dysfunction.To investigate the ferroptosis resistance of GLEXG in improvement semen quality oligoasthenospermia (OAS) rat model.Male Sprague-Dawley (SD) rats were administered Tripterygium wilfordii polyglycoside, compound extracted from Hook F. (Celastraceae), at dose 40 mg/kg/day, establish an OAS model. Fifty-four SD randomly divided into six groups: sham, model, low-dose (GLEXGL, 0.25 g/kg/day),...

Abstract Background Prostate cancer (PCa) incidence and mortality rates are rising. Our previous research has shown that the combination of icariin (ICA) curcumol (CUR) induced autophagy ferroptosis in PCa cells, altered lipid metabolism. We aimed to further explore effects ICA CUR on gut microbiota, metabolism, immunity PCa. Methods A mouse subcutaneous RM-1 cell tumor model was established. 16 S rRNA sequencing performed detect changes fecal microbiota. SCFAs feces, effect ICA-CUR T-cell...

Ginsenoside Rb1 (Rb1), an important bioactive ingredient of Panax ginseng, has potent neuroprotective effects. The objective the study is to elucidate impact treatment on chronic social defeat stress (CSDS)-induced depressive-like behaviors and its related mechanism. According obtained results, daily oral administration (35 70 mg/kg) imipramine (15 for 28 days significantly reversed avoidance behavior, anhedonia, behavioral despair via CSDS exposure, as demonstrated by considerable elevation...

Curcumol has been reported to exert anti‑tumor activity, but its intrinsic molecular mechanism in prostate cancer remains be elucidated. The present study aimed analyze the effect of curcumol on and identify possible internal regulatory pathway using <em>in vitro</em> cell culture vivo</em> tumor model experiments. cytotoxicity was detected a Cell Counting Kit‑8 assay it found that had no obvious toxicity or side effects RWPE‑1 cells. Wound healing, Transwell flow cytometry assays...

Microgravity experienced during space flight is known to exert several negative effects on the learning ability and memory of astronauts. Few effective strategies are currently available counteract these effects. Rg1 Rb1, major steroidal components ginseng, have shown potent neuroprotective with a high safety profile. The present study aimed investigate Rb1 simulated microgravity-induced dysfunction its underlying mechanism in hindlimb suspension (HLS) rat model. Administration (30 60...

Chronic stress can impact brain function through various mechanisms, contributing to the development of anxiety disorders. unpredictable mild (CUMS) is a well-established model for studying effects chronic stress. This study assessed impacts different durations CUMS on anxiety-like behavior, inflammation, and tryptophan metabolism in female C57BL/6N mice. The results revealed significant behavioral changes after 2-4 weeks CUMS. Specifically, open arms ratio time elevated plus maze (EPM)...

Chronic restraint stress (CRS) is a classic animal model of that can lead to various physiological and psychological dysfunctions, including systemic neuroinflammation memory deficits. Fresh Gastrodia elata Blume (FG), the unprocessed raw tuber Blume, has been reported alleviate symptoms headache, convulsions, neurodegenerative diseases, while protective effects FG on CRS-induced cognitive deficits remain unclear. This work aimed evaluate through multiplex behavior tests further explore...

In aerospace medicine, the influence of microgravity on cognition has always been a risk factor threatening astronauts’ health. The traditional medicinal plant and food material Gastrodia elata Blume used as therapeutic drug for neurological diseases long time due to its unique neuroprotective effect. To study effect fresh (FG) cognitive impairment caused by microgravity, hindlimb unloading (HU) was stimulate weightlessness in mice. (0.5 g/kg or 1.0 g/kg) intragastrically administered daily...

Network pharmacology and bioinformatics were used to study puerarin's molecular mechanism in treating osteoarthritis from the perspective of ferroptosis, revealing a new treatment target. Ferroptosis-related targets obtained FerrDb. Puerarin action retrieved TCMSP, Pharmmappe, SwissTargetPrediction, Targetnet databases, supplemented with PubMed. The gene expression profiles GSE12021, GSE55235, GSE82107 using "Osteoarthritis" as search term GEO database, differential screening analysis was...

Curcumin, a polyphenolic compound derived from the turmeric plant (Curcuma longa), has been extensively studied for its anti-inflammatory and anti-proliferative properties. The safety efficacy of curcumin have thoroughly validated. Nevertheless, underlying mechanism treating osteoarthritis remains ambiguous. This study aims to reveal potential in by using metabolomics transcriptomics. Firstly, we validated effect on inflammatory factors human articular chondrocytes. Secondly, explored...

This study aimed to learn the antineoplastic activity of curcumol (Cur) on prostate cancer (PCa) and elucidate its potential molecular mechanism.The proliferation, invasion, migration PCa cells (PC3 22RV1) were detected by cell counting kit 8 (CCK8), transwell, wound healing assay, respectively. The expression genes proteins was analyzed quantitative real-time polymerase chain reaction (qRT-PCR) western blotting (WB), protein in tissues tested through immunohistochemistry (IHC)...

Benign prostatic hyperplasia (BPH) is a common disease in the current ageing male population. This research aims to study effects of Kelong‐Capsules (KLC) on testosterone‐induced BPH. Thirty rats were randomly divided into normal group, model and three treatment groups. Three groups given KLC (3.6 g/kg), (7.2 finasteride (0.9 mg/kg), respectively, for 28 days after establishing animal model. The BPH rat models evaluated by Traditional Chinese Medicine (TCM) symptoms prostate index (PI)....

Depression and anxiety are serious psychiatric disorders with significant physical mental health impacts, necessitating the development of safe effective treatments. This study aimed to evaluate efficacy

Background: Ureaplasma urealyticum (UU) infection is the most common cause of male infertility. Zhibai Dihuang Decoction (ZBDHD) can improve rate forwarding motility sperm, sperm deformity rate, seminal plasma zinc and refined berry sugar levels. Methods: The potential targets ZBDHD are obtained from Encyclopedia Traditional Chinese Medicine (ETCM). Orchitis-related were collected Genecards OMIM databases. Cytoscape Database for Annotation, Visualization Integrated Discovery (DAVID) utilized...