A5100760663- Bioinformatics and Genomic Networks
- Epilepsy research and treatment
- MicroRNA in disease regulation
- Cancer-related molecular mechanisms research
- Circular RNAs in diseases
- Enzyme Production and Characterization
- RNA Research and Splicing
- Rough Sets and Fuzzy Logic
- Extracellular vesicles in disease
- Advanced Proteomics Techniques and Applications
- Breast Cancer Treatment Studies
- Functional Brain Connectivity Studies
- Data Mining Algorithms and Applications
- RNA modifications and cancer
- RNA Interference and Gene Delivery
- Microbial Metabolic Engineering and Bioproduction
- Neural dynamics and brain function
- TGF-β signaling in diseases
- Neural Networks and Applications
- Obsessive-Compulsive Spectrum Disorders
- Animal Genetics and Reproduction
- Advanced Image and Video Retrieval Techniques
- Genomics and Rare Diseases
- Mitochondrial Function and Pathology
- Adipose Tissue and Metabolism
Sichuan University
2019-2025
West China Hospital of Sichuan University
2019-2025
Cornell University
2018-2025
China University of Geosciences
2025
Second Hospital of Anhui Medical University
2025
Anhui Medical University
2025
Inner Mongolia University
2025
Jiangnan University
2017-2025
Qingdao University
2025
Affiliated Hospital of Qingdao University
2025
The MS 6.9 Menyuan earthquake in Qinghai Province, west China is the largest by far 2022. occurs a tectonically active region, with background b-value of 0.87 within 100 km epicenter that we derived from unified catalog produced Earthquake Networks Center since late 2008. Field surveys have revealed surface ruptures extending 22 along strike, maximum ground displacement 2.1 m. We construct finite fault model constraints InSAR observations, which showed multiple segments during earthquake....
Connectivity webs mediate the unique biology of mammalian brain. Yet, while cell circuit maps are increasingly available, knowledge their underlying molecular networks remains limited. Here, we applied multi-dimensional biochemical fractionation with mass spectrometry and machine learning to survey endogenous macromolecules across adult mouse We defined a global "interactome" comprising over one thousand multi-protein complexes. These include hundreds brain-selective assemblies that have...
The novel diagnostic term Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD) requires at least one cardiovascular risk factor for diagnosis. While the relationship between gallstones and Non-Alcoholic Fatty (NAFLD) has been debated, association MASLD remains unclear. This cross-sectional study aimed to explore this using National Health Nutrition Examination Survey (NHANES) data from 2017 2020. Participants were stratified into two groups based on diagnosis, propensity score...
Abstract Targeted temperature management (TTM) is a vital intervention for cardiac arrest survivors to mitigate post-resuscitation myocardial dysfunction (PRMD). However, the optimal TTM remains topic of debate. This study investigates effects at different temperatures and explores underlying mechanisms using in vivo vitro models ischemia/reperfusion (I/R) injury following (CA) cardiopulmonary resuscitation (CPR). We found that 33 °C significantly improved hemodynamics function, reducing...
Triple-negative breast cancer (TNBC) is one of the most aggressive types with high recurrence, metastasis, and drug resistance. Recent studies report that long noncoding RNAs (lncRNAs)-mediated competing endogenous (ceRNA) play an important role in tumorigenesis resistance TNBC. Although elevated lncRNA DLX6 antisense RNA 1 (DLX6-AS1) has been observed to promote carcinogenesis various cancers, TNBC remained unclear. In this study, expression levels DLX6-AS1 were increased tissues cell lines...
Emerging evidence suggests that circular RNAs (circRNAs) are linked to the development and progression of human cancers. Nevertheless, their contribution breast cancer (BC) is still largely unknown. In current study, we screened identified a novel circRNA, circ-UBE2D2, which was highly expressed in BC cell lines tissues closely related aggressive clinical features dismal prognosis. Small interfering RNA (siRNA)–mediated circ-UBE2D2 silencing notably inhibited proliferation, migration...
Gastric cancer is a common malignancy worldwide and associated with high morbidity mortality rates. However, very little known about the underlying mechanism in human gastric cells. Baicalein (BAI), widely used Chinese herbal medicine, has shown anticancer effects on many types of cell lines. Here, we investigated molecular mechanisms BAI action proliferation migration. The results showed that can expressively inhibit proliferation, colony-forming ability migration dose-dependent manner,...
Chitosan is a biopolymer material extracted from marine biomass waste such as shrimp and crab shells, which has good biocompatibility degradability with great potential for application in the field of wastewater treatment soil remediation. The higher degree deacetylation (DD), better adsorption performance chitosan. Chitin deacetylase (CDA) can specifically catalyze deacetylate chitin green reaction that environmentally friendly. However, scarcity high yielding strains been regarded...
Abstract Hepatitis B virus (HBV) damages liver cells through abnormal immune responses. Mitochondrial metabolism is necessary for effector functions of white blood (WBCs). The aim was to investigate the altered counts and mitochondrial mass (MM) WBCs by two novel indicators mass, MM percentage low membrane potential, MMP %, due chronic HBV infection. lymphocytes, neutrophils monocytes in infection group were decline, especially lymphocyte ( p = 0.034) monocyte 0.003). degraded 0.003) %...
Background: Targeted liposome-polycation-DNA complex (LPD), mainly conjugated with antibodies using functionalized PEG derivatives, is an effective nanovector for systemic delivery of small interference RNA (siRNA). However, there are few studies reporting the effect different conjugation linkers on LPD gene silencing. To clarify influence antibody LPD, we prepared two immunoliposomes to deliver siRNA in which DSPE-PEG-COOH and DSPE-PEG-MAL, commonly used derivative linkers, were conjugate...
As a marker of malignant tumors, miRNA is closely related to the occurrence and metastasis tumors. How achieve rapid sensitive real-time detection important for clinical prevention treatment cancer. In this study, an intelligent platform based on smartphone image processing technology made point-of-care testing reality. This new smart approach could detect multiple targets simultaneously sensitively. Hydrogel microparticles different coding modes (shapes, numbers) were prepared by flow...
Docosahexaenoic acid (DHA)-rich oil sourced from microalgae can easily become oxidized. The objective of this work was to screen the optimal natural antioxidant mixture for protecting DHA-rich oil. Different antioxidants, encompassing tea polyphenols, vitamin E, rosemary extract, licorice root antioxidant, ascorbyl palmitate and lecithin were tested individually in combination an accelerated oxidation process. Three antioxidants namely extract with synergistic effects chosen, their...
We aimed to investigate Hydrogen Peroxide Inducible DNA Interstrand Cross-Linker (HP-ICL) as a targeted therapy for anaplastic thyroid cancer (ATC) due its higher H2O2 content compared normal cells. In vitro analysis included fluorescence microscopy levels, and exposure of ATC cells various HP-ICL concentrations followed by assessment cell viability, apoptosis, cycle, damage using MTT, flow cytometry, γH2AX assay. Protein levels related apoptosis the PI3K/AKT/mTOR pathway were measured...