A5027592431- Pregnancy and preeclampsia studies
- Reproductive System and Pregnancy
- Birth, Development, and Health
- Prenatal Screening and Diagnostics
- Maternal and fetal healthcare
- Gestational Diabetes Research and Management
- Assisted Reproductive Technology and Twin Pregnancy
- Preterm Birth and Chorioamnionitis
- Maternal and Perinatal Health Interventions
- Icing and De-icing Technologies
- MicroRNA in disease regulation
- Ectopic Pregnancy Diagnosis and Management
- Aerodynamics and Fluid Dynamics Research
- Smart Materials for Construction
- Pregnancy and Medication Impact
- Circular RNAs in diseases
- Pelvic floor disorders treatments
- Cryospheric studies and observations
- Cancer-related molecular mechanisms research
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Global Maternal and Child Health
- Transplantation: Methods and Outcomes
- Fetal and Pediatric Neurological Disorders
- PI3K/AKT/mTOR signaling in cancer
- Enzyme function and inhibition
Hefei Infectious Disease Hospital
2024-2025
Anhui Provincial Children's Hospital
2024-2025
Nanjing Drum Tower Hospital
2016-2025
Anhui Medical University
2024-2025
Zhejiang University
2024
Jiaxing University
2024
Beijing University of Technology
2024
First Hospital of Jiaxing
2024
State Key Laboratory of Natural Medicine
2023
China Pharmaceutical University
2023
Balanced immune responses are essential for the maintenance of successful pregnancy. Aberrant system during pregnancy increase risk preeclampsia. Toll-like receptor 4 (TLR4) plays a crucial role in activation at maternal-fetal interface. This study aimed to generate rat model preeclampsia by lipopolysaccharide (LPS, TLR4 agonist) administration on gestational day (GD) 5 as rats subjected placentation immediately after implantation between GDs and 5, assess contribution signaling development...
BACKGROUND: This trial aimed to assess the efficacy, acceptability, and safety of a first-trimester screen-and-prevent strategy for preterm preeclampsia in Asia. METHODS: Between August 1, 2019, February 28, 2022, this multicenter stepped wedge cluster randomized included maternity/diagnostic units from 10 regions The started with period where all recruiting centers provided routine antenatal care without study-related intervention. At regular 6-week intervals, one was transit...
Objective This study aimed to determine the optimal Foley catheter balloon volume (30-mL vs. 80-mL) and maximum time for cervical ripening (12 hours 24 hours) improve vaginal delivery rate within of induction. Methods We conducted an open-label, randomized controlled trial in a teaching hospital China. Women with term singleton pregnancy, cephalic presentation, intact membrane unfavorable cervix (Bishop score <6) were randomly allocated, 1:1:1:1 ratio, receive either one four treatments: (1)...
Problem Extensive studies have demonstrated that Th1 type immunity is predominant in pre‐eclampsia, but there little concern with regard to the intracellular mechanisms behind this initial T‐cell polarization. In study, we investigated whether imbalance of transcription factors contributes it. Method study A total 15 pre‐eclamptic patients and healthy pregnant women were enrolled study. The expression levels for (T‐bet), Th2 (GATA3), Th17 (RORc) Treg (FOXP3) cells, together Th1/Th2 status,...
A hot-air film-heating method designed for the anti-icing system of a small aeroengine cone is studied as well an experimental study on its performance. Experiments are conducted under different icing conditions and hot air parameters in wind tunnel, using full-scale model aeroengine. The temperature distributions surface measured by thermocouples. Experiment results show that film effective leading edge. Also presented numerical simulation distribution condition. flowfield around obtained...
To (i) evaluate the applicability of European-derived biomarker multiples median (MoM) formulae for risk assessment preterm pre-eclampsia (PE) in seven Asian populations, spanning east, southeast and south regions continent, (ii) perform quality-assurance (QA) measurements (iii) establish criteria prospective ongoing QA measurements.This was a prospective, non-intervention, multicenter study 4023 singleton pregnancies, at 11 to 13 + 6 weeks' gestation, recruiting centers China, Hong Kong,...
Significance Preeclampsia (PE) is a severe trophoblast-related disorder that threatens the health of mother and fetus. Impaired placentation in early stages pregnancy subsequent systemic endothelial cell activation constitute principle pathogenic mechanisms PE. Currently, molecules involved pathogenesis PE link two this remain elusive. Our study demonstrates CD81 associated with key pathological changes occur both placenta maternal cells patients (sPE). Importantly, overexpression induces...
Abstract Immune activation at the maternal-fetal interface is a main pathogenic factor of preeclampsia (PE). Neutrophils (PMNs) are activated in PE patients, but mechanism and consequences PMN need to be further explored. Here, we demonstrated that interleukin-32 (IL-32) expression was significantly upregulated syncytiotrophoblasts (STBs) IL-32β major isoform with increased placenta severe (sPE) patients. Furthermore, level IL-32 correlated its serum sPE indicating derived mainly from...
Preeclampsia is a common and severe pregnancy complication. The syndrome highly heterogeneous, making accurate classification difficult, which not conductive to find ways predict prevent this syndrome. Recently, we reported that high placental miR-155 defined new subtype of preeclampsia. Here, aimed examine whether maternal sero-miR-155 could be marker identify subtype. To explore the patients with no matter in first third trimester, conducted case-control longitudinal cohort study. We...
ABSTRACT Objective To examine whether aspirin delays gestational age at delivery (GAD) in pregnancies with placental dysfunction (PD) phenotypes (preeclampsia [PE], small‐for‐gestational‐age [SGA], abruption and/or stillbirth). Design A secondary analysis of a multicentre stepped‐wedge cluster randomised trial. Setting 18 maternity/diagnostic units Asia. Population Singleton examined 11–13 +6 weeks. Methods model which the effect is to delay GAD PD was developed. Main Outcome Measures PD....
Background: The rates of preterm birth in Chinese women and the potential effects differing environments are poorly understood. Aim: To determine rate China, Hong Kong Western Australia. Methods: were obtained from records 26 611 pregnancies Jiangsu Province mainland 48 976 185 798 Results: Preterm increased 2.6 2.9% urban rural Province, respectively, 2.5% China-born Australia who required an interpreter; to 4.9% did not require 5.6% non-resident Kong; 7.6% for resident Kong. Within...
Icing and anti-icing characteristics of engine inlet guide vanes are studied in this paper. Experiments carried out an icing wind tunnel under different conditions. The tests performed at a freestream velocity , angle attack 0 deg, static temperature the range . environment parameters include mean volume diameter liquid water content 0.5 to experiment is on full-scale vanes. distributions vane surface measured by thermocouples. leading-edge ice shapes compared effects temperature, content,...
Introduction Preeclampsia is a disease with an unknown pathogenesis and one of the leading causes maternal perinatal morbidity. At present, early identification high-risk groups for preeclampsia timely intervention aspirin effective preventive method against preeclampsia. This study aims to develop robust prediction model good performance by machine learning algorithms based on characteristics, biophysical biochemical markers at 11–13 + 6 weeks’ gestation, providing tool screening Methods...
Objective This study speculates that gestational diabetes mellitus (GDM) may reduce fetal telomere length (TL),which be related to modification of methylation in the promoter region telomerase (TE) gene region. Methods In this study, umbilical cord blood samples from patients with and without GDM (N = 100 each) were analyzed by prospective case-control. The TL, TE expression levels, levels TERT TERC regions two groups measured. significance level each CpG locus employed logistic regression...
Preeclampsia (PE) is a pregnancy-related syndrome characterized by new-onset hypertension and proteinuria after gestational 20 weeks. Oxidative stress, resulting from the imbalance between production of oxidants antioxidants in placentas, recognized as key pathology PE. To date, molecules that regulate remain unclear. CD151, member tetraspanins, an important regulator many physiological functions. However, function CD151 oxidative stress its association with complications are currently...
The anti-icing performance of a small engine inlet strut was investigated. Experiments were conducted in an icing wind tunnel under different conditions. experiments performed at the freestream velocity range and static temperature . environment conditions include mean volume diameter liquid water content 1.0 A full-scale used hot-air heat transfer. distributions on surface measured by thermocouples. characteristics mass transfer temperatures velocities, contents, flow rates analyzed. Ice...