A5051610382- Pregnancy and preeclampsia studies
- Prenatal Screening and Diagnostics
- Maternal and fetal healthcare
- Fetal and Pediatric Neurological Disorders
- Birth, Development, and Health
- Maternal and Perinatal Health Interventions
- Assisted Reproductive Technology and Twin Pregnancy
- Parvovirus B19 Infection Studies
- Gestational Diabetes Research and Management
- Ectopic Pregnancy Diagnosis and Management
- Endometrial and Cervical Cancer Treatments
- Renal and related cancers
- Cardiovascular Issues in Pregnancy
- Pregnancy-related medical research
- Reproductive System and Pregnancy
- Uterine Myomas and Treatments
- Cervical Cancer and HPV Research
- Congenital Heart Disease Studies
- Reproductive tract infections research
- Ovarian cancer diagnosis and treatment
- Neonatal Respiratory Health Research
- Pelvic floor disorders treatments
- Congenital Anomalies and Fetal Surgery
- Congenital Diaphragmatic Hernia Studies
- Preterm Birth and Chorioamnionitis
Showa University
2016-2025
Showa University Hospital
2004-2025
Japanese Foundation for Research and Promotion of Endoscopy
2024
Nippon Foundation
2024
Showa University Northern Yokohama Hospital
2018-2024
The Cancer Institute Hospital
2023
National Cancer Research Institute
2022
National Cancer Centre Japan
2022
Komatsu (Japan)
2022
Hudson Institute
2019-2020
Abstract The ‘ C linical G uidelines for O bstetrical P ractice, 2011 edition’ were revised and published as a 2014 edition (in J apanese) in A pril by the apan S ociety of bstetrics ynecology ssociation bstetricians ynecologists. aims this publication include determination current standard care practices pregnant women apan, widespread use practices, enhancement safety obstetrical practice, reduction burdens associated with medico‐legal medico‐economical problems, better understanding...
Abstract Clinical guidelines for obstetrical practice were first published by the Japan Society of Obstetrics and Gynecology (JSOG) Association Obstetricians Gynecologists (JAOG) in 2008, a revised version was 2011. The aims this publication include determination current standard care practices pregnant women Japan, widespread use practices, enhancement safety practice, reduction burdens associated with medico‐legal medico‐economical problems, better understanding between maternity‐service...
To clarify the problems related to maternal deaths in Japan, including diseases themselves, causes, treatments and hospital or regional systems.Descriptive study.Maternal death registration system established by Japan Association of Obstetricians Gynecologists (JAOG).Women who died during pregnancy within a year after delivery, from 2010 2014, throughout (N=213).The preventability each death.Maternal were frequently caused obstetric haemorrhage (23%), brain disease (16%), amniotic fluid...
Artificial Intelligence (AI) technologies have recently been applied to medical imaging for diagnostic support. With respect fetal ultrasound screening of congenital heart disease (CHD), it is still challenging achieve consistently accurate diagnoses owing its manual operation and the technical differences among examiners. Hence, we proposed an architecture Supervised Object detection with Normal data Only (SONO), based on a convolutional neural network (CNN), detect cardiac substructures...
Diagnostic support tools based on artificial intelligence (AI) have exhibited high performance in various medical fields. However, their clinical application remains challenging because of the lack explanatory power AI decisions (black box problem), making it difficult to build trust with professionals. Nevertheless, visualizing internal representation deep neural networks will increase and improve confidence professionals decisions. We propose a novel learning-based explainable “graph chart...
Invasive placenta, often involving placenta accreta, increta, and percreta, is a life-threatening complication of pregnancy characterized by invasion placental villi into the underlying myometrium. usually diagnosed as result abnormalities encountered during removal at delivery. Because profuse hemorrhaging in early postpartum period, blood transfusion or emergency hysterectomy required patients with invasive placenta. also associated high maternal morbidity risk mortality. Therefore,...
Abstract Objectives To evaluate the accuracy of sonographic identification site umbilical cord insertion (CI) at 18–20 weeks gestation, to compare sensitivities for detection a velamentous (VCI) secondary CI into anterior, posterior or fundal wall, and intrapartum complications VCI upper, middle lower third uterus. Methods As part routine ultrasound scan weeks' gestation we evaluated abnormal (VCI marginal CI) location in uterus 3446 pregnancies. In cases CI, was further classified as being...
Objective: To investigate maternal and neonatal outcomes after antioxidant supplementation relatively early in pregnancy (8 to 12 weeks) for pregnant women with low status. Methods: A randomized, double-blind, placebo-controlled trial of daily was performed on screening positive status at 8 weeks gestation. Low defined as a superoxidedismutase (SOD) level below 1102 U/g Hb or 164 U/mL. The group received the following antioxidants daily: vitamins (1000 IU), B6 (2.2 mg), B12 μg), C (200 E...
Endometrial cancers exhibit a different mechanism of tumorigenesis and progression depending on histopathological clinical types. The most frequently altered gene in estrogen-dependent endometrioid endometrial carcinoma tumors is PTEN. Microsatellite instability another important genetic event this type tumor. In contrast, p53 mutations or Her2/neu overexpression are more frequent non-endometrioid tumors. On the other hand, it possible that clear cell may arise from unique pathway which...
Abstract Objective To evaluate the direct alterations in mRNA expression among chorionic villous samples from 11 weeks' pregnant women who would develop preeclampsia (PE) later pregnancy. Method Case‐control study encompassing five destined to PE [cases matched 1:5 for gestational age (GA) with 25 controls]. We quantified on tissue sampling (CVS) of normal and patients. then assessed expressions vascular endothelial growth factor (VEGFA), VEGFA receptor 1 (Flt‐1), endoglin (Eng), placental...
To report the 1-year experience of a nationwide demonstration project to introduce noninvasive prenatal testing aneuploidy from maternal plasma and discuss how implement this program in Japan.The test was conducted detect high-risk pregnant women with adequate genetic counseling. The clinical data, results, pregnancy outcomes were recorded.Of 7740 tested, 142 (1.8%) had positive 7594 (98.1%) negative four (0.1%) results that not reportable. Of who tested positive, 13 cases resulted...
Image segmentation is the pixel-by-pixel detection of objects, which most challenging but informative in fundamental tasks machine learning including image classification and object detection. Pixel-by-pixel required to apply support fetal cardiac ultrasound screening; we have detect substructures precisely are small change shapes dynamically with heartbeats, such as ventricular septum. This task difficult for general methods DeepLab v3+, U-net. Hence, here proposed a novel method named...
Abstract Background We investigated the utility of a molecular classifier tool and genetic alterations for predicting prognosis in Japanese patients with endometrial cancer. Methods A total 1029 cancer from two independent cohorts were classified into four subtype groups. The primary secondary endpoints relapse-free survival (RFS) overall (OS), respectively. Results Among 265 who underwent initial surgery, according to immunohistochemistry, DNA polymerase epsilon exonuclease domain mutation...
In 1997, Lo et al. (1) first described the presence of fetal DNA in maternal plasma and serum. Cell-free offered a new source genetic material for noninvasive prenatal diagnosis. They developed real-time, quantitative PCR assay to measure concentration analyzed SRY, single-copy Y-chromosome-specific sequence, quantify number genome-equivalents per milliliter blood when woman carries male fetus (2). The results revealed that concentrations during third trimesters were 3.4% 6.2%, respectively....
The purpose of this study was to determine if apoptosis occurs in fetal cells that have crossed into the maternal circulation, which would potentially explain difference between number intact and amount DNA detectable plasma. We flow-sorted nucleated erythrocytes (FNRBCs) using antibody gamma chain haemoglobin confirmed them be origin by FISH analysis chromosome-specific probes. Fetal were then analysed microscopically for presence terminal UdTP nuclear end labelling (TUNEL) staining....
To investigate whether maternal history and ultrasound findings can be predictors for massive hemorrhage during Cesarean section in patients with placenta previa adherence of the placenta.We reviewed 127 singleton pregnancies previa. Maternal history, antenatal placenta, including location, presence placental lacunae, lack a clear zone, sponge-like cervix marginal sinus cases were retrospectively, their association amount bleeding was analyzed.Logistic regression analysis revealed that...
ABSTRACT Persistent infection with oncogenic human papillomaviruses (HPVs) causes cervical cancer, accompanied by the accumulation of somatic mutations into host genome. There are concomitant genetic changes in HPV genome during viral infection; however, their relevance to carcinogenesis is poorly understood. Here, we explored within-host diversity performing deep-sequencing analyses whole-genome sequences clinical specimens. The whole genomes types 16, 52, and 58 were amplified...
Objective Maternal cigarette smoking is reportedly associated with miscarriage, fetal growth restriction and placental abruption, paradoxically a decreased risk of developing preeclampsia. In the present study, we investigated gene expression levels villous tissues in early gestation. We compared genes related to angiogenesis apoptosis obtained from non-smoking pregnant women. Materials Methods collected tissue samples 57 women requesting surgical termination due non-medical reasons at 6–8...