A5013531016- Pregnancy and preeclampsia studies
- Neurological Complications and Syndromes
- Birth, Development, and Health
- Maternal and fetal healthcare
- Moyamoya disease diagnosis and treatment
- Neonatal Respiratory Health Research
- Assisted Reproductive Technology and Twin Pregnancy
- Neonatal and fetal brain pathology
- Gestational Diabetes Research and Management
- Renin-Angiotensin System Studies
- Traumatic Brain Injury and Neurovascular Disturbances
- Blood Coagulation and Thrombosis Mechanisms
- Ovarian function and disorders
- Clinical practice guidelines implementation
- Reproductive System and Pregnancy
- Preterm Birth and Chorioamnionitis
- Cardiovascular Health and Disease Prevention
- Cardiovascular Issues in Pregnancy
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Neuroscience of respiration and sleep
- Connective tissue disorders research
- Cerebrovascular and Carotid Artery Diseases
- Health Promotion and Cardiovascular Prevention
- Protein Tyrosine Phosphatases
- Maternal Mental Health During Pregnancy and Postpartum
Ladies College
2013-2024
Nagoya University Hospital
2001-2004
Nagoya University
1993-2004
Ministry of Education, Culture, Sports, Science and Technology
2002
Toyohashi Municipal Hospital
1997-2000
GTx (United States)
1999
Abstract The ‘ C linical G uidelines for O bstetrical P ractice, 2011 edition’ were revised and published as a 2014 edition (in J apanese) in A pril by the apan S ociety of bstetrics ynecology ssociation bstetricians ynecologists. aims this publication include determination current standard care practices pregnant women apan, widespread use practices, enhancement safety obstetrical practice, reduction burdens associated with medico‐legal medico‐economical problems, better understanding...
The 2017 clinical guidelines for obstetrical practice by the Japan Society of Obstetrics and Gynecology Association Obstetricians Gynecologists were revised published as 2020 edition (in Japanese). aim these is to present appropriate standard obstetric diagnosis management procedures that have reached consensus among Japanese obstetricians. include 113 questions an appendix, followed answers (CQ&A; originally 112 in edition), a discussion, list references, some tables figures presenting...
The purpose of this study was to elucidate the mechanisms underlying regulation feto-placental circulation mediated by renin-angiotensin system under preeclamptic conditions. We measured angiotensin-converting enzyme (ACE) activity, protein expression, and mRNA expression in uncomplicated placentas examined localization ACE. In addition, ACE activity human umbilical venous endothelial cells (HUVECs) hypoxic conditions were analyzed. placental tissues from preeclampsia all significantly...
To compare ophthalmic arterial velocimetry in normotensive and preeclamptic gravidas with without photophobia.Ophthalmic arteries were studied by color-flow Doppler ultrasonography 118 pregnant women, 20 preeclampsia no visual symptoms, 11 preeclampsia, photophobia, retinal edema.The pulsatility index (PI) correlated negatively gestational age (y = -0.01x + 1.84, r -0.41, P<.01). Pulsatility preeclamptics photophobia (0.71+/-0.17) was lowest among the three groups (P<.01) highest women...
Abstract Aim The aim of this study was to analyze the causes and outcomes for intracerebral hemorrhage ( ICH ) occurring during pregnancy postnatally. Material Methods A nationwide pregnancy‐related in J apan performed. We contacted 1582 facilities identify women with or postnatally between 1 anuary 2006 31 D ecember 2006. total 1012 (70%) responded completed questionnaires. Risk factors , neurological features, onset diagnosis time O – time), obstetric data were recorded. Results...
Local concentrations of the vasopressor peptide, angiotensin II (AngII), depend upon balance between synthesis and degradation. Previous studies blood pressure (BP) regulation have focused primarily on generation AngII its receptors, less attention has been devoted to Aminopeptidase A (APA, EC 3.4.11.7) is responsible for N-terminal cleavage AngII, a hydrolytic event that serves as rate-limiting step in To evaluate physiological role APA, we examined BP homeostasis APA-deficient mice. We...
Some pregnant women develop significant proteinuria in the absence of hypertension. However, clinical significance isolated gestational (IGP) is not well understood. This study aimed to determine prevalence IGP singleton pregnancies and proportion with who subsequently developed preeclampsia (IGP-PE) among all PE cases.This was an observational 6819 at 12 centers, including 938 least once determination protein-to-creatinine ratio (P/Cr). Significant pregnancy (SPIP) defined as P/Cr (mg/mg)...
The aim of this study was to determine the relation between perinatal outcomes and umbilical cord coiling as evaluated by a modified index.In retrospective study, 200 consecutive cords were examined. An venous arterial index calculated dividing total number coils length individually. Umbilical with indices in lowest decile, highest remaining deciles defined hypocoiled, hypercoiled, normocoiled, respectively. subjects hypocoiled hypercoiled compared those normocoiled cords.In 69.5% subjects,...
Background. To clarify the cerebral hemodynamics in pre‐eclamptic pregnant women, we investigated blood flow velocity of arteries. Methods. The mean and pulsatility index (PI) middle artery (MCA) internal carotid (ICA) normal women (n=35) preeclamptic patients (n=18) were examined transcranially using pulsed‐wave Doppler technique with a 2 MHz probe. In two post‐partum visual disturbance, PI MCA ICA every day. Results. (89.7±20.5 cm/s) was significantly higher than that (53.6±16.9...
The dipstick test is widely used as a primary screening for detection of significant proteinuria in pregnancy (SPIP). However, it often shows false positive result. This study was performed to determine which pregnant women should be recommended undergo determination urinary protein-to-creatinine ratio (mg/mg, P/Cr test) after confirmation SPIP. multicenter, prospective, and observational 2212 urine specimens from 1033 who underwent simultaneous tests the same spot samples at least once....
We evaluated 31 pairs of twins: six with twin-twin transfusion syndrome, four discordant, and 21 concordant twins. The criterion for the retrospective diagnosis discordancy was a difference in birth weight 20% larger infant's weight. Using pulsed Doppler evaluation umbilical artery each twin, pulsatility index (PI) used to evaluate arterial waveforms. differences PI from syndrome cases between 24-31 weeks significantly exceeded those without this (P less than .05). Seven had inter-twin above...
Achalasia is rare motor disorder of esophageal smooth muscle. It has been linked to malnutrition during pregnancy leading maternal and fetal mortality. We report a case achalasia with intrauterine death who succeeded in following good outcome after operative treatment. A 34-year-old pregnant woman had at 27 gestational weeks due severe persistent pregnancy. was diagnosed postpartum myotomy-fundoplasty performed. She normal delivery healthy baby 21 months the operation. This suggests effect...
Placental leucine aminopeptidase (P-LAP), also called oxytocinase, is an enzyme responsible for hydrolyzing oxytocin. This identical to cystine aminopeptidase. We examined the tissue distribution of P-LAP in normal adult mice and mothers fetuses during mouse pregnancy using immunohistochemical (IHC) analysis. P-LAP-immunoreactive protein was expressed various organs a cell- gestational stage-dependent manner. In kidney, located distal collecting tubules but not proximal tubules. The islet...
Abstract Background Few reports have presented an overall view of pregnant women with coronavirus disease 2019 (COVID-19) across entire country and throughout the gestation period. Furthermore, no such are available for Japan. We examined clinical characteristics outcomes COVID‑19 on a national scale in Methods A nationwide questionnaire-based survey all 2,185 maternity services Japan was conducted between July August 2020. Information regarding maternal epidemiological, clinical, treatment,...
Diaphragmatic eventration is a rare abnormality, which has the similar ultrasonographic features to congenital diaphragmatic hernia. Therefore, these two diseases are difficult differentiate from each other prenatally. We present here case in presence of was strongly suggested by magnetic resonance imaging (MRI) and ultrasonography. A 26-year-old pregnancy woman, gravida 0, para week 35, admitted our hospital with an abnormality fetal thorax. MRI ultrasonography showed interesting helped it
To our knowledge, there has been no report on longitudinal monitoring of fetal behavior in the anencephalic fetus.A 30-year-old woman was diagnosed with a twin pregnancy at 8 weeks' gestation; week 20, one twins identified as anencephalic. From 25-36 gestation, behavioral patterns each fetus were recorded weekly videotape for 60 minutes, then compared morphologic findings after birth.Our data comparing normal and fetuses indicate that development central nervous system above medulla...