A5086225984- Pregnancy and preeclampsia studies
- Birth, Development, and Health
- Cardiovascular Issues in Pregnancy
- Gestational Diabetes Research and Management
- Maternal and fetal healthcare
- COVID-19 Impact on Reproduction
- COVID-19 and healthcare impacts
- Hemoglobinopathies and Related Disorders
- Breastfeeding Practices and Influences
- Pregnancy and Medication Impact
- Prenatal Screening and Diagnostics
- Pharmacological Effects and Toxicity Studies
- Renal Diseases and Glomerulopathies
- Cardiovascular Function and Risk Factors
- Renal and related cancers
- Blood Coagulation and Thrombosis Mechanisms
- Maternal Mental Health During Pregnancy and Postpartum
- Neurological Complications and Syndromes
- Cardiac Structural Anomalies and Repair
- Parvovirus B19 Infection Studies
- Genetic Syndromes and Imprinting
- Takotsubo Cardiomyopathy and Associated Phenomena
- Gestational Trophoblastic Disease Studies
- Maternal and Perinatal Health Interventions
- Pulmonary Hypertension Research and Treatments
Hokkaido University Hospital
2016-2025
Hokkaido University
2014-2023
Hakodate Central General Hospital
2011
National Hospital Organization Hokkaido Medical Center
2010
Sapporo National Hospital
2010
Kobe University
1991
Background: Cell-free DNA (cfDNA) is present in healthy individuals but elevated those undergoing physical exertion, trauma, sepsis, and certain cancers. Maintaining cfDNA concentrations vital for immune homeostasis preventing inflammatory responses. Understanding release clearance essential using as a biomarker clinical diagnostics. We focused on the fragment size of investigated dynamics half-life, particularly 100–250 base pair fragments. Methods: Healthy, adult men (n = 5; age 40 ± 4.1...
Development of the adrenal cortex, a vital endocrine organ, originates in adrenogonadal primordium, common progenitor for both adrenocortical and gonadal lineages rodents. In contrast, we find that humans cynomolgus monkeys, lineage temporally spatially distinct fashion from lineage, arising earlier more anteriorly within coelomic epithelium. The primordium arises adrenogenic epithelium via an epithelial-to-mesenchymal transition, which then progresses into steroidogenic fetal zone direct...
Objective: Benzodiazepines are common therapies for mental illness and insomnia, used during pregnancy lactation. Although benzodiazepines have been shown to be transferred into breast milk, the amount is small compatible with breastfeeding. However, information not available all drugs. Therefore, we aimed determine milk plasma (M/P) ratio relative infant dose (RID), which as indicators of drug transfer safety such drugs lactating women breastfeeding infants. Methods: The study comprised 11...
Abstract Aim To evaluate psychological stress among pregnant and puerperal women in Japan during the coronavirus disease 2019 (COVID‐19) pandemic. Methods In this cross‐sectional study, we recruited who delivered between January September 2020 Japan, using an online questionnaire. Participants were divided into low, middle, high groups according to degree of epidemic their region residence. Related factors analyzed chi‐squared test. The relationship COVID‐19 regions depression risks anxiety...
Abstract We report a 32-year-old woman (1-gravid, 1-para) with vesicular lesion in her uterus that was pointed out on ultrasound at 8 weeks' gestation. Amniocentesis 15 gestation showed normal female karyotype, 46XX. As the pregnancy advanced, mole-like became relatively reduced. Throughout gestation, maternal human chorionic gonadotropin level normal, but serum alpha fetoprotein rose as progressed. Her fetus did not exhibit any remarkable anomalies. The patient visited our hospital...
This longitudinal study was performed to determine changes in echocardiography parameters association with various biomarker levels pregnancy/postpartum.Fifty-one healthy pregnant women underwent simultaneous determination of blood five biomarkers at each the first, second and third trimesters pregnancy, immediately postpartum within 1 week after childbirth approximately month postpartum. Data on 255 scans (five times per woman) were analysed.Left ventricular end-diastolic dimension, left...
Abstract Aim In Hokkaido, Japan, the number of people suffering from coronavirus disease 2019 (COVID‐19) is rapidly increased, and by end February 2020, there were already 70 confirmed cases disease. We investigated safety urgently initiated maternal telemedicine in preventing spread infection. Methods This retrospective, single‐institution study examined at department obstetrics Hokkaido University Hospital March 4 to April 2, 2020. The physicians remotely pregnant women their homes using a...
Abstract Objectives In Japan, the prevalence of irregular menstrual cycles and its association with frequency night shifts have scarcely assessed. The present study aimed to evaluate relationship between in Japanese female nurses. Methods We conducted a cross-sectional web-based self-administered questionnaire survey 2019. An cycle was defined as length ≤21 days or ≥39 at least few times over past year amenorrhea for 3 months. used Poison regression analysis robust error variance calculate...
Beckwith-Wiedemann syndrome (BWS) is a condition present from birth that involves excessive growth and linked to changes in specific genes located on chromosome 11p15.5. Prenatal diagnosis mainly based imaging findings such as macrosomia, macroglossia, omphalocele, but detection remains difficult. We report case of fetus suspected having BWS prenatal ultrasound MRI. A female infant was delivered via cesarean section at 37 weeks one day gestation, showing other clinical features consistent...
Some pregnant women develop significant proteinuria in the absence of hypertension. However, clinical significance isolated gestational (IGP) is not well understood. This study aimed to determine prevalence IGP singleton pregnancies and proportion with who subsequently developed preeclampsia (IGP-PE) among all PE cases.This was an observational 6819 at 12 centers, including 938 least once determination protein-to-creatinine ratio (P/Cr). Significant pregnancy (SPIP) defined as P/Cr (mg/mg)...
We aimed to evaluate the obstetric complications and risk factors for these events in pregnant women with rheumatic diseases (RDs).A single-center retrospective study of RDs at Hokkaido University Hospital between 2007 2016 was conducted. Clinical features maternal fetal outcomes were retrospectively collected. The rate pregnancy compared general population (GOP) Japan.Overall, 132 pregnancies 95 recorded. Underlying systemic erythematosus (SLE) (n = 57), antiphospholipid syndrome (APS) 35),...
Abstract To investigate the relationships between communicative and critical health literacy (CCHL) anxiety depressive symptoms (ADs) in pregnant women during coronavirus disease 2019 (COVID-19) pandemic. A cross-sectional study was conducted 5466 responded Japan September 2020. Kessler 6 scale (K6) score ≥ 10, an Edinburgh Postnatal Depression Scale (EPDS) 13, four CCHL groups were analyzed using a logistic regression model trend test. The proportions of with K6 10 EPDS 13 13.5 15.4%,...
Abstract Aims/Introduction This study aimed to investigate the neurodevelopment of infants born women with gestational diabetes mellitus (GDM). Materials and Methods Data from National Birth Cohort in Japan Environment Children's Study 2011 2014 ( n = 81,705) were used. uses GDM guidelines International Association Diabetes Pregnancy Groups. The Japanese translation Ages Stages Questionnaires, third Edition, was used assess following domains: communication skills, gross motor fine...
It is undetermined which blood variables related to iron storage during the first trimester of pregnancy could efficiently predict anemia occurring third trimester. Red cell count (RBC), hemoglobin concentration, hematocrit, ferritin, iron, and total binding capacity (TIBC) were assessed longitudinally first, second, trimesters 231 healthy Japanese women. None patients had in none used supplementation before second test. Anemia was defined as (Hb) < 11 g/dL for Hb 10.0 Forty-seven (20%)...
Abstract Aim Women with pre‐eclampsia (PE), placenta previa (PP), placental abruption (PA), and mesenchymal dysplasia (PMD) have been described as having permeability dysfunction. This study was performed to determine whether occult fetomaternal hemorrhage (FMH) is common in women such complications non‐reassuring fetal status. Methods Forty‐one antenatal 39 postnatal blood samples were obtained from 46 women, including 11 dysfunction (5, 3, 2, 1 PE, PP, PA, PMD, respectively) 35 controls...
Podocyte depletion in the kidney is associated with end-stage disease (ESKD). Pre-eclampsia (PE) increases risk of ESKD later life. This study was performed to determine whether nephrinuria (soluble nephrin urine) correlated proteinuria and/or podocyturia (podocytes PE women.Eighty-three urine samples, consisting 45 and 38 samples from 27 normotensive nine women, respectively, underwent simultaneous determination nephrin, protein, creatinine concentrations supernatant quantitative analysis...
Abstract Aim This study aimed to determine the weight gain during pregnancy that minimizes predicted probability of various perinatal adverse events according pre‐pregnancy body mass index (BMI) and make recommendations for optimal in Japan. Methods The Japan Society Obstetrics Gynecology database 2015–2017 was used. From 719 723 deliveries included this database, parturients with underlying diseases or missing data were excluded, 419 114 analyzed. A questionnaire survey also conducted weigh...
Abstract Background Breastfeeding is considered to be the most effective way of ensuring health and survival newborns. However, mammary transfer drugs administered mothers breastfeeding infants remains a pressing concern. Acetaminophen diclofenac sodium are widely prescribed analgesics for postpartum pain relief, but there have been few recent reports on these drugs, despite advances in analytic techniques. Methods We conducted study 20 from August 2019–March 2020. Blood milk samples...
Abstract Aim Perinatal telemedicine efforts have commenced worldwide in response to the COVID‐19 pandemic. As there been no prior studies on acceptance of by pregnant women, we conducted this survey investigate same. Methods We an anonymous questionnaire women who underwent check‐ups from March 4 June 30, 2020, using a mobile fetal heart rate monitor and video call system through Hokkaido University Hospital. Results Out 77 individuals received prenatal check‐ups, 54 (70%) had complications,...