A5100736428- Systemic Lupus Erythematosus Research
- Rheumatoid Arthritis Research and Therapies
- Pulmonary Hypertension Research and Treatments
- Systemic Sclerosis and Related Diseases
- Vasculitis and related conditions
- Platelet Disorders and Treatments
- Monoclonal and Polyclonal Antibodies Research
- Atherosclerosis and Cardiovascular Diseases
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Aortic Disease and Treatment Approaches
- Aortic aneurysm repair treatments
- Vascular Anomalies and Treatments
- Cell Adhesion Molecules Research
- Cardiovascular Function and Risk Factors
- Autoimmune and Inflammatory Disorders Research
- Congenital Heart Disease Studies
- Peripheral Neuropathies and Disorders
- Autophagy in Disease and Therapy
- Heparin-Induced Thrombocytopenia and Thrombosis
- Inflammatory Myopathies and Dermatomyositis
- Venous Thromboembolism Diagnosis and Management
- Bone health and treatments
- T-cell and B-cell Immunology
- Renal Diseases and Glomerulopathies
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
Hokkaido University
2016-2025
Kobe City Medical Center General Hospital
2025
Osaka City General Hospital
2021-2025
University of Toyama
2025
Showa University
2023-2025
Tohoku University
2023
Gunma Saiseikai Maebashi Hospital
2018
University Hospital of Zurich
2013-2018
Hacettepe University
2018
Keio University
2004-2015
Abstract Objective To define the antiphospholipid score (aPL‐S) by testing multiple antibodies (aPL) and to evaluate its efficacy for diagnosis of syndrome (APS) predictive value thrombosis. Methods This study comprised 2 independent sets patients with autoimmune diseases. In first set (n = 233), aPL profiles were analyzed. Five clotting assays lupus anticoagulant 6 enzyme‐linked immunosorbent (IgG/IgM anticardiolipin antibodies, IgG/IgM anti–β ‐glycoprotein I, phosphatidylserine‐dependent...
Abstract Dysregulation of Th17 and Treg cells contributes to the pathophysiology many autoimmune diseases. Herein, we show that itaconate, an immunomodulatory metabolite, inhibits cell differentiation promotes by orchestrating metabolic epigenetic reprogramming. Mechanistically, itaconate suppresses glycolysis oxidative phosphorylation in Th17- Treg-polarizing T cells. Following treatment with S-adenosyl-L-methionine/S-adenosylhomocysteine ratio 2-hydroxyglutarate levels are decreased...
To investigate the role of autophagy in regulation cell death rheumatoid arthritis synovial fibroblasts (RASFs).RASFs and osteoarthritis (OASFs) were treated with thapsigargin (TG), an inducer endoplasmic reticulum (ER) stress, MG132, a proteasome inhibitor. Then, 3-methyladenine was used as inhibitor bafilomycin A1 lysosome Polyubiquitinated proteins, p62, induction evaluated by immunoblotting, immunofluorescence microscopy, immunohistochemistry, respectively. OASFs transfected small...
To assess the value of a combination anti-β2 -glycoprotein I (anti-β2 GPI) domain antibody and anti-phosphatidylserine/prothrombin complex (anti-PS/PT) tests for diagnosis antiphospholipid syndrome (APS).This cross-sectional study involved cohort patients who visited our clinic from April 2005 to March 2013. Tests GPI antibodies, IgG anti-PS/PT IgM together with criteria-defined antibodies (aPL), were performed in all patients. The total score (aPL-S) was calculated each patient according...
Objective: To study the clinical and immunological manifestations of antiphospholipid syndrome (APS) in Japanese population by a single-centre registration. Methods: In this retrospective cohort study, 141 consecutive patients with APS, fulfilling Sydney revised Sapporo criteria for definite who visited our autoimmune clinic from 1988 to 2010, were recruited followed up. All interviewed underwent general physical examination qualified rheumatologists on day blood sampling. Results: The...
The objective of this study was to clarify the long-term outcome in patients with lupus nephritis (LN) according International Society Nephrology and Renal Pathology classification. This retrospective analysis comprised 186 Japanese given a diagnosis LN by renal specimen mean observation period 12 years. Primary end point defined as death or end-stage disease, standardized mortality ratios were calculated. Five presented histopathological class I, 62 II, 21 III III+V, 73 IV IV+V 25 V....
To evaluate the risk of reactivation resolved hepatitis B virus (HBV) by immunosuppressive therapy in patients with autoimmune diseases.Thirty-five diseases were included our study; all surface antigen (HBsAg)-negative and antibody against core antigen-positive. They followed for 8-124 weeks clinical outcomes analyzed, including serum levels HBV-DNA aminotransferase every 4 during their underlying diseases. If was detected therapy, HBsAg, HBsAg (anti-HBs), e (HBeAg), HBeAg also monitored...
Objective To evaluate the sustained remission and low disease activity after discontinuation of tocilizumab in patients with rheumatoid arthritis who were treated alone or combination methotrexate. Methods The SURPRISE study was a 2-year, open-label randomised controlled study. Among had been to additional (ADD-ON) switch (SWITCH) first year, those achieved based on score for 28 joints (DAS28-ESR<2.6) discontinued at week 52 observed following weeks. endpoint second year included...
We aimed to investigate the involvement of macroautophagy/autophagy in autoimmunity rheumatoid arthritis (RA) through citrullination VIM (vimentin) and its interaction with MHC class II synovial fibroblasts (SFs). The cell surface expression B7 costimulatory molecules on SFs was analyzed by flow cytometry after treatment IFNG/IFN-γ (interferon gamma). Intracellular citrullinated autoantigens were immunoblotting using serum from anti-citrullinated peptide antibodies (ACPA)-positive patient as...
To investigate the association between decreased serum IgG levels caused by remission-induction immunosuppressive therapy of antineutrophil cytoplasmic antibody-associated vasculitis (AAV) and development severe infections.We conducted a retrospective cohort study patients with new-onset or relapsing AAV enrolled in J-CANVAS registry, which was established at 24 referral sites Japan. The minimum up to weeks incidence infection 48 after treatment initiation were evaluated. After multiple...
To evaluate which variables predict interictal psychosis in epilepsy.The authors reviewed the biological backgrounds, clinical characteristics, and EEG findings 246 patients with epilepsy 658 control no psychotic history. With a logistic regression approach, significance of each variable for development was evaluated.There are significant differences family history psychosis, age at onset epilepsy, type lateralization epileptiform discharges, level intelligence between those without it....
To investigate the role of protein tyrosine phosphatase nonreceptor type 2 (PTPN2) in pathogenesis rheumatoid arthritis (RA).Synovial tissue samples from patients with RA and osteoarthritis (OA) were stained for PTPN2. Synovial fibroblasts stimulated tumor necrosis factor (TNF) interleukin-1β (IL-1β), lipopolysaccharide (LPS), TRAIL, or thapsigargin. The expression PTPN2 synovial peripheral blood mononuclear cells (PBMCs) was analyzed by real-time polymerase chain reaction Western blotting....
Warfarin is regarded as the standard treatment for preventing thrombotic events in APS, but recurrence rate still high. Dual antiplatelet therapy (DAPT) has been shown to be effective prevention of acute coronary syndrome or stroke. The objective this study was evaluate efficacy DAPT thrombosis APS patients with history arterial thrombosis.This retrospective cohort conducted at Hokkaido University Hospital between 1990 and 2016. secondary prophylactic effects safety warfarin monotherapy...