A5056269279- Vasculitis and related conditions
- Systemic Lupus Erythematosus Research
- Rheumatoid Arthritis Research and Therapies
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Urticaria and Related Conditions
- Sarcoidosis and Beryllium Toxicity Research
- Otitis Media and Relapsing Polychondritis
- Renal Diseases and Glomerulopathies
- Eosinophilic Disorders and Syndromes
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Autoimmune and Inflammatory Disorders Research
- IgG4-Related and Inflammatory Diseases
- Musculoskeletal synovial abnormalities and treatments
- Peripheral Neuropathies and Disorders
- Inflammatory Myopathies and Dermatomyositis
- Dermatology and Skin Diseases
- Cytokine Signaling Pathways and Interactions
- Autoimmune Bullous Skin Diseases
- Mast cells and histamine
- Systemic Sclerosis and Related Diseases
- Heparin-Induced Thrombocytopenia and Thrombosis
- Cell Adhesion Molecules Research
- CNS Lymphoma Diagnosis and Treatment
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Asthma and respiratory diseases
University of Yamanashi Hospital
2019-2025
University of Yamanashi
2015-2025
Third Way
2021
Addenbrooke's Hospital
2015-2020
University of Cambridge
2015-2018
Chiba University Hospital
2011-2016
Chiba University
2011-2015
National Hospital Organization
2015
Ministry of Health Labour and Welfare
2013
<h3>Importance</h3> The current standard induction therapy for antineutrophil cytoplasm antibody (ANCA)–associated vasculitis is the combination of high-dose glucocorticoids and cyclophosphamide or rituximab. Although these regimens have high remission rates, they are associated with considerable adverse events presumably due to glucocorticoids. <h3>Objective</h3> To compare efficacy between a reduced-dose glucocorticoid plus rituximab regimen in ANCA-associated vasculitis. <h3>Design,...
Abstract Objective The 2010 American College of Rheumatology/European League Against Rheumatism (ACR/EULAR) classification criteria for rheumatoid arthritis (RA) refer to a possible use ultrasound “for confirmation the clinical findings.” We undertook this study determine optimized definition ultrasound‐detected synovitis ACR/EULAR and assess impact its on accuracy RA classification. Methods One hundred nine patients with musculoskeletal symptoms ≤3 years were enrolled in study. Patients...
Objective This prospective study aimed to determine whether the comprehensive ultrasonographic assessment of synovial inflammation predicts relapse after discontinuation treatment with a biologic agent in patients rheumatoid arthritis (RA) clinical remission. Methods RA remission (Disease Activity Score 28 joints [DAS28] <2.6) receiving who agreed discontinue were recruited. Patients underwent ultrasound scan on 134 sites 40 and prospectively followed up for 6 months. Physicians evaluated...
Objective. To describe pulmonary involvement at time of diagnosis in antineutrophil cytoplasmic antibodies (ANCA)-associated vasculitis (AAV), as defined by computed tomography (CT). Methods. Patients with thoracic CT performed on or after the onset AAV (n = 140; 75 women; granulomatosis polyangiitis, n 79; microscopic polyangiitis MPA, 61) followed a tertiary referral center clinic were studied. Radiological patterns evaluated from studies using predefined protocol, and compared to...
Objective. This study aimed to determine whether [18F]fluorodeoxyglucose-PET/CT ([18F]FDG-PET/CT) discriminates PM/DM from non-muscular diseases and also FDG uptake in proximal muscles reflects the activity severity of muscular inflammation PM/DM.
Although several miRNAs have been shown to regulate autoimmune pathogenesis by affecting lymphocyte function, the roles of in SSc remain unclear. Therefore purpose this study was identify that play a role quantitative PCR screening serum miRNAs.Ninety-five were predicted target SSc-related genes [IL-4, TGF-β, CTGF, PDGF-B, PDGF receptor (PDGFR) α/β and COL1A2) silico analyses selected. The expression these sera patients healthy controls measured PCR. Involvement miR-30b, which most strongly...
To determine the prevalence of lung abnormalities on chest computed tomography (CT) in patients with microscopic polyangiitis (MPA), to assess responsiveness such initial treatment, and associations between these patient disease characteristics mortality.We retrospectively identified 167 consecutive hospital-based MPA 3 hospitals Japan. We longitudinally collected clinical information for 150 patients, whom CT images obtained before treatment were available. then determined presence 22...
Objective. Patients with eosinophilic granulomatosis polyangiitis (EGPA) frequently experience relapses, which lead to cumulative organ damage. In this retrospective observational study, we aimed reveal the risk factors for relapse in EGPA. Methods. A total of 188 Japanese patients EGPA diagnosed between 1996 and 2015 were identified from medical records 10 hospitals. The diagnosis was based on American College Rheumatology 1990 criteria or Lanham’s criteria. Baseline characteristics,...
Abstract Background Adult-onset Still’s disease (AOSD) is a rare systemic autoinflammatory which encompasses patients with heterogenous presentation and wide range of clinical courses. In this study, we aimed to identify potential subgroups AOSD reveal risk factors for relapse. Methods We included total 216 who received treatment in nine hospitals between 2000 2019. All fulfilled the Yamaguchi classification criteria. retrospectively collected information about baseline characteristics,...
ObjectiveGlomerulonephritis is frequent in ANCA-associated vasculitis (AAV) and crucial to disease outcomes. We conducted a detailed assessment of renal pathology Japanese patients with AAV, developed new score that would predict outcome.MethodsTwo-hundred-twenty-one who were diagnosed AAV underwent kidney biopsy enrolled. Data on glomerular, tubular, interstitial, vascular lesions from biopsies analyzed; the three established classification prognostic scoring systems (Berden Classification,...
Objective. Our prospective study aimed to demonstrate that the cumulative synovial power Doppler (PD) ultrasound scores correlate with radiographic progression better than conventional measures in patients rheumatoid arthritis (RA). We also investigated difference between antirheumatic agents. Methods. Sixty-nine RA who had recently received either methotrexate (MTX; n = 23), tumor necrosis factor (TNF) antagonists (n 28), or tocilizumab (TCZ; 18) were enrolled. Patients underwent clinical,...
Objectives The LoVAS trial reported non-inferiority in remission induction rates between the reduced-dose and conventional high-dose glucocorticoid regimens plus rituximab for antineutrophil cytoplasm antibody (ANCA)-associated vasculitis at 6 months; however, maintenance requirements long-term outcomes are unknown. Methods A total of 140 patients with new-onset ANCA-associated without severe glomerulonephritis or alveolar haemorrhage were randomised to receive prednisolone (0.5 mg/kg/day)...
Spontaneous pneumomediastinum (SPNM) historically has been considered a poor prognostic factor in dermatomyositis/polymyositis patients complicated with interstitial lung disease (ILD). However, there is lack of actual data regarding the association between SPNM occurrence and mortality patients. This study aimed to assess myositis ILD according antimelanoma differentiation-associated gene 5 (MDA5) antibody status.Dermatomyositis/polymyositis who were hospitalised at five Japanese hospitals...
To investigate the association between decreased serum IgG levels caused by remission-induction immunosuppressive therapy of antineutrophil cytoplasmic antibody-associated vasculitis (AAV) and development severe infections.We conducted a retrospective cohort study patients with new-onset or relapsing AAV enrolled in J-CANVAS registry, which was established at 24 referral sites Japan. The minimum up to weeks incidence infection 48 after treatment initiation were evaluated. After multiple...
Rituximab (RTX) has been reported to effectively maintain remission in anti-neutrophil cytoplasmic antibody-associated vasculitis (AAV). In this multicenter study involving 57 patients who achieved after 24 weeks, we evaluated the effectiveness of RTX maintaining with AAV. Patients were divided into three groups based on administration: continuous, induction phase-only, and maintenance phase-only groups. The continuous group had a rate 48 weeks treatment compared (100% vs. 88.2%, p = 0.29)....
Cytomegalovirus (CMV) reactivation during immunosuppressive therapy poses a risk of severe infections. This study aimed to investigate the factors CMV in patients with microscopic polyangiitis and granulomatosis using nationwide cohort Japan. retrospective used data from Japan Collaborative Registry anti-neutrophil cytoplasmic antibody-associated vasculitis. The outcome was as up 48 weeks after treatment initiation. We explored for by comparing two groups. Of 454 patients, occurred 89...
ABSTRACT Muscle symptoms including myalgia are common in patients with anti‐neutrophil cytoplasmic antibody‐associated vasculitis (AAV). biopsy (MB) is sometimes used the diagnosis of AAV, but which AAV benefit from MB remains unclear. We retrospectively assessed clinical characteristics Japanese who underwent and examined relationship between showing positive results for muscular kidney involvement. enrolled all 38 118 also MB. Clinical histopathological findings on biopsies were or...
A 17-year-old Japanese woman diagnosed with granulomatosis polyangiitis (GPA) and was treated immunotherapy suddenly developed an impaired consciousness, left hemiplegia, conjugate eye deviation to the right. Magnetic resonance imaging showed acute cerebral infarction in right striatum middle artery (MCA) occlusion. As her GPA had worsened recently, intravenous methylprednisolone (IVMP) started. Immediately after IVMP started, recanalization of MCA detected on repeat angiography. Aspirin...
Objective Cutaneous polyarteritis nodosa (cPAN) is a rare necrotizing vasculitis that primarily affects small-to-medium-sized arteries in subcutaneous tissue. cPAN often characterized by chronic and relapsing disease presents with skin ulcers, livedo, painful erythema. In this study, we evaluated the efficacy of anti-TNF-α inhibitor treatment for cPAN-associated refractory leg ulcers. Methods This retrospective study was conducted between 2016 2023 at three medical institutions Japan...
Abstract Objectives Anti-melanoma differentiation-associated gene 5 (MDA5) antibody-positive dermatomyositis (MDA5-DM) is a subtype of characterized by frequent interstitial lung disease and reduced muscle involvement. This study aimed to determine the short-term long-term outcomes patients with MDA5-DM. Methods Information on baseline characteristics, treatments MDA5-DM including survival, relapse titre anti-MDA5 antibody, was retrospectively collected. Descriptive statistics regarding...