Toshimasa Shimizu
A5056424845- Systemic Lupus Erythematosus Research
- Rheumatoid Arthritis Research and Therapies
- Salivary Gland Disorders and Functions
- Autoimmune and Inflammatory Disorders Research
- Inflammasome and immune disorders
- Eosinophilic Disorders and Syndromes
- Systemic Sclerosis and Related Diseases
- Salivary Gland Tumors Diagnosis and Treatment
- Vasculitis and related conditions
- Inflammatory Myopathies and Dermatomyositis
- Viral Infections and Immunology Research
- Musculoskeletal synovial abnormalities and treatments
- Renal Diseases and Glomerulopathies
- Monoclonal and Polyclonal Antibodies Research
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Atherosclerosis and Cardiovascular Diseases
- Immune Cell Function and Interaction
- Lymphoma Diagnosis and Treatment
- Biosimilars and Bioanalytical Methods
- T-cell and Retrovirus Studies
- Immunodeficiency and Autoimmune Disorders
- Chronic Lymphocytic Leukemia Research
- Sarcoidosis and Beryllium Toxicity Research
- Galectins and Cancer Biology
- IgG4-Related and Inflammatory Diseases
Nagasaki University
2016-2025
Nagasaki University Hospital
2014-2025
Central Japan Railway (Japan)
2024
Ehime University
2014-2022
Weatherford College
2020-2022
Infectious Disease Models and Innovative Therapies
2022
Inserm
2022
Chugai Pharma (United States)
2022
Kyowa Kirin (Japan)
2022
Eisai (Japan)
2022
We investigated the relationships among M1 monocytes, M2 osteoclast (OC) differentiation ability, and clinical characteristics in patients with rheumatoid arthritis (RA).Peripheral blood mononuclear cells (PBMCs) were isolated from RA healthy donors, we then number of monocytes or by fluorescence-activated cell sorting. also obtained cultured CD14-positive PBMCs donors to investigate OC vitro.Forty 20 included. Twenty-two (55%) anticitrullinated protein antibody (ACPA) positive. The median...
The aim of this study was to evaluate the clinical manifestations and prevalence familial Mediterranean fever (FMF) in Japanese patients with unexplained rheumatic manifestations. We enrolled 601 or suspected FMF throughout Japan between 2009 2015. Patients were divided into three groups according Tel Hashomer criteria: sure FMF, probable non-FMF patients, including definitive diseases. Mutation detection exons 1, 2, 3, 10 gene MEFV performed by direct sequencing. A total 192 (31.9 %)...
Abstract Myositis-specific autoantibodies, such as anti-melanoma differentiation associated gene 5 (MDA5) and anti-anti-amino acyl-tRNA synthetases (ARS) antibodies, are with interstitial lung diseases (ILD), which determine the prognosis of polymyositis/dermatomyositis (PM/DM) patients. However, there is a paucity data on clinical correlation between anti-Sjögren syndrome-related antigen A (anti-SSA)/Ro52 antibodies in PM/DM. We investigated prevalence myositis-specific autoantibodies...
Polymyositis/dermatomyositis (PM/DM) is an autoimmune disease that sometimes complicated with rapidly progressive interstitial lung (RPILD). However, serum and biomarkers can predict RPILD development remain unclear.To determine potential in patients PM/DM-ILD.In total, 49 PM/DM-ILD were enrolled. We measured the levels of 41 cytokines/chemokines, ferritin anti-MDA5 antibody, compared them between (n = 23) non-RPILD 26) groups, ranked by their importance through random forest analysis. To...
To compare the efficacy and safety of tofacitinib baricitinib in patients with RA a real-world setting. A total 242 who were treated (n = 161) or 81) enrolled. We evaluated between using multivariable analyses to avoid confounding. Their clinical disease activity AEs for 24 weeks. The mean (SD) DAS28-ESR change from baseline weeks was 1.57 (1.55) (tofacitinib) 1.46 (1.36) (baricitinib). There no significant difference response two groups (adjusted difference, 0.04; 95% CI, -0.35 0.28). not...
To characterize 414 patients with primary SS who developed haematological malignancies and to analyse how the main SS- lymphoma-related features can modify presentation patterns outcomes.By January 2021, Big Data Sjögren Project Consortium database included 11 966 fulfilling 2002/2016 classification criteria. Haematological diagnosed according World Health Organization (WHO) were retrospectively identified.There (355 women, mean age 57 years) (in 43, malignancy preceded at least one year...
Abstract Objectives To efficiently detect somatic UBA1 variants and establish a clinical scoring system predicting patients with pathogenic in VEXAS (vacuoles, E1 enzyme, X-linked, autoinflammatory, somatic) syndrome. Methods Eighty-nine Japanese clinically suspected syndrome were recruited [81 males 8 females; median age of onset 69.3 years (interquartile range 62.1–77.6)]. Peptide nucleic acid–clamping PCR (PNA-PCR), regular targeting exon 3 clustering subsequent Sanger sequencing...
We retrospectively evaluated the effectiveness of combined use salivary gland ultrasonography (US) and 2016 American College Rheumatology/European League Against Rheumatic Disease (ACR/EULAR) classification criteria for improving diagnostic efficiency in patients with Sjögren's syndrome (SS). A US-based disease grading system was developed using a cohort comprising 213 SS or non-SS who fulfilled minimum requirements classifying based on American-European Consensus Group (AECG) ACR criteria....
Fibroblast-like synovial cells (FLS) have multilineage differentiation potential including osteoblasts. We aimed to investigate the role of microRNAs during osteogenic rheumatoid arthritis (RA)-FLS. RA-FLS were differentiated in medium for 21 days. Osteogenic was evaluated by alkaline phosphatase (ALP) staining and Alizarin Red staining. MicroRNA (miRNA) array analysis performed differentially expressed miRNAs differentiation. Expression miR-218-5p (miR-218) determined quantitative real-time...
HLA-DRB1 alleles are major determinants of genetic predisposition to rheumatic diseases. We assessed whether DRB1 associated with susceptibility particular clinical features adult onset Still's disease (AOSD) in a Japanese population by determining the allele distributions.DRB1 genotyping 96 patients AOSD and 1,026 healthy controls was performed. Genomic DNA samples from were also genotyped for MEFV exons 1, 2, 3, 10 direct sequencing.In AOSD, we observed predisposing association DRB1*15:01...
Rationale: As the initial treatment of rapidly progressive interstitial lung disease (RPILD) with antimelanoma differentiation-associated gene 5 antibody (anti-MDA5 Ab)-positive dermatomyositis (DM) patients, a combination corticosteroids, cyclophosphamide, and calcineurin inhibitor is recommended. However, some these patients have poor prognoses despite such intensive treatment. Other more effective treatments are desired. We report case an anti-MDA5 Ab-positive DM patient who had developed...
What baseline predictors would be involved in mortality people with primary Sjögren syndrome (SjS) remains uncertain. This study aimed to investigate the characteristics collected at time of diagnosis SjS associated and identify risk factors for all-cause death deaths related systemic activity measured by ESSDAI score.In this international, real-world, retrospective, cohort study, we retrospectively data from 27 countries on causes Big Data Registry. Inclusion criteria consisted fulfilling...
The aim of this study was to determine the expressions Toll-like receptors (TLRs) 7-9 and type I interferon (IFN) signal in labial salivary glands (LSGs) cultured gland epithelial cells (SGECs) from primary Sjögren's syndrome (pSS) patients. We performed an immunohistochemistry analysis LSGs 11 patients with pSS as defined by American-European Consensus Group classification criteria five healthy subjects. patients' SGECs were analyzed immunofluorescence western blotting. IFN-α expression...
O067 / #277 Topic: AS21 - Pregnancy and Reproductive Health ABSTRACT CONCURRENT SESSION 11: PREGNANCY IN SLE 24-05-2025 10:40 AM 11:40 Background/Purpose Systemic lupus erythematosus (SLE) often develops at a young age leading to concerns regarding pregnancy, childbirth, childcare. Although recent advances in treatment have increased safety during the situation of patients with raising children alongside their is unknown. The quality life (QOL) healthy individuals tends decline from...
We evaluated the efficacy and safety of tofacitinib in patients with rheumatoid arthritis (RA) a real-world setting.Seventy consecutive patients, for whom was initiated between November 2013 May 2016, were enrolled. All fulfilled 2010 ACR/EULAR classification criteria RA. received 5 mg twice daily followed 24 weeks. Clinical disease activity indicated by score (DAS)28-ESR, simplified index, clinical index as well adverse events (AEs) evaluated. Statistical analysis performed to determine...
To identify potential biomarkers to distinguish adult-onset Still's disease (AOSD) from sepsis.We recruited 70 patients diagnosed with AOSD according the Yamaguchi criteria, 22 sepsis, and 118 age-matched controls. Serum levels of 40 cytokines were analyzed using multi-suspension cytokine array. We performed a cluster analysis each in sepsis groups order specific molecular networks. Further, multivariate classification (random forest analysis) logistic regression used rank by their...