A5019331714- Rheumatoid Arthritis Research and Therapies
- Systemic Lupus Erythematosus Research
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Autoimmune and Inflammatory Disorders Research
- Chronic Lymphocytic Leukemia Research
- Lymphoma Diagnosis and Treatment
- Monoclonal and Polyclonal Antibodies Research
- T-cell and B-cell Immunology
- Immune Cell Function and Interaction
- Sarcoidosis and Beryllium Toxicity Research
- Tuberculosis Research and Epidemiology
- Spondyloarthritis Studies and Treatments
- Systemic Sclerosis and Related Diseases
- Immunodeficiency and Autoimmune Disorders
- Pneumocystis jirovecii pneumonia detection and treatment
- Inflammatory Myopathies and Dermatomyositis
- SARS-CoV-2 and COVID-19 Research
- Vasculitis and related conditions
- Mycobacterium research and diagnosis
- Biosimilars and Bioanalytical Methods
- Autoimmune Bullous Skin Diseases
- Streptococcal Infections and Treatments
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Pneumonia and Respiratory Infections
- Asthma and respiratory diseases
Tokyo National Hospital
2018-2025
National Sagamihara Hospital
2015-2024
Center for Rheumatology
2007-2023
University of Tsukuba
2014-2018
National Hospital Organization
2007-2017
Nagasaki Medical Center
2013-2015
Tokyo Metropolitan Geriatric Hospital
2015
Tokyo Women's Medical University
2015
Juntendo University
2015
Tokyo Medical and Dental University
2015
Given the phenotypic similarities between rheumatoid arthritis (RA)–associated interstitial lung disease (ILD) (hereafter, RA-ILD) and idiopathic pulmonary fibrosis, we hypothesized that strongest risk factor for development of gain-of-function MUC5B promoter variant rs35705950, would also contribute to ILD among patients with RA.
<b>Objectives:</b> To compare disease activity and the improvement of evaluated between by Disease Activity Score 28 using erythrocyte sedimentation rate (DAS28-ESR) DAS28 C-reactive protein (DAS28-CRP) in Japanese patients with rheumatoid arthritis (RA). <b>Methods:</b> Data from 3073 RA registered large cohort database (<i>NinJa</i>: National Database Rheumatic Diseases iR-net Japan) 2003 was used to calculate DAS28-ESR DAS28-CRP activities were evaluated. Improvements also according...
Objective. To compare tumor necrosis factor-α (TNF-α) inhibitors to nonbiological disease-modifying antirheumatic drugs (DMARD) for the risk of serious infection in Japanese patients with rheumatoid arthritis (RA). Methods. Serious infections occurring within first year observation period were examined using records recruited Registry Rheumatoid Arthritis Patients Longterm Safety (REAL), a hospital-based prospective cohort RA. The analysis included 1144 patients, 646 whom treated either...
To evaluate the efficacious noninferiority of subcutaneous tocilizumab injection (TCZ-SC) monotherapy to intravenous TCZ infusion (TCZ-IV) in Japanese patients with rheumatoid arthritis (RA) an inadequate response synthetic and/or biologic disease-modifying antirheumatic drugs (DMARDs).This study had a double-blind, parallel-group, double-dummy, comparative phase III design. Patients were randomized receive TCZ-SC 162 mg every 2 weeks or TCZ-IV 8 mg/kg 4 weeks; no DMARDs allowed during...
Aim To determine whether the age at onset of rheumatoid arthritis (RA) has increased in Japan using a nationwide database (National Database Rheumatic Diseases by iR-net Japan, NinJa). Method We analyzed data RA patients who had been diagnosed with early (disease duration < 2 years) and newly registered 2003, 2008 or 2013. Results The numbers developed 2002–2003, 2007–2008, 2012–2013 were 536, 812 1864, respectively. mean significantly from 55.8 years 2002–2003 57.0 2007–2008 to 59.9...
To investigate the duration of remission and low disease activity (LDA) after cessation tocilizumab (TCZ) treatment in rheumatoid arthritis patients who showed or LDA as assessed by DAS28 response to preceding TCZ monotherapy, explore factors contributing prolonged efficacy duration.Disease was monitored for 56 weeks. The rate continued estimated Kaplan-Meier curves.A total 187 were eligible. At baseline this study, median 7.8 years, period 4.0 years 1.5. at 52 weeks 13.4 % according...
Objective. Recent advances in the management of patients with rheumatoid arthritis (RA) increased rates disease remission and patient life expectancy, while malignancy has become a more common cause death. Here, we report incidence nationwide survey Japanese RA compared to general population, focusing on risk lymphoma, which often arises RA. Methods. Data occurrence were collected from registered cohort database, National Database Rheumatic Diseases by iR-net Japan, 2003 2012. To adjust for...
The proteasome activator PA28 binds to both ends of the central catalytic machine, known as 20 S proteasome, in opposite orientations form enzymatically active proteasome. family is composed three members designated α, β, and γ; PA28α PA28β heteropolymer mainly located cytoplasm, whereas PA28γ forms a homopolymer that predominantly occurs nucleus. Available evidence indicates involved processing intracellular antigens, but function remains elusive. To investigate role <i>in vivo</i>, we...
Objective: We investigated the rheumatoid arthritis (RA) diagnostic performances of anti‐cyclic citrullinated peptide antibody (anti‐CCP) and antifilaggrin (AFA) in comparison with RF matrix metalloproteinase‐3 (MMP‐3).Methods: used a second generation enzyme‐linked immunosorbent assay (ELISA) kit for detection anti‐CCP. constructed recombinant human filaggrin, which was vitro by peptidylarginine deiminase, subsequently it as coating antigen AFA‐ELISA. A total 549 RA patients 208 other...
The Toll-like receptor 7 (TLR7) gene, encoded on human chromosome Xp22.3, is crucial for type I interferon production. A recent multicenter study in East Asian populations, comprising Chinese, Korean and Japanese participants, identified an association of a TLR7 single-nucleotide polymorphism (SNP) located the 3' untranslated region (3' UTR), rs3853839, with systemic lupus erythematosus (SLE), especially males, although some difference was observed among tested populations. To test whether...
TNFAIP3 interacting protein 1, TNIP1 (ABIN-1) is involved in inhibition of nuclear factor-κB (NF-κB) activation by with TNF alpha-induced 3, A20 (TNFAIP3), an established susceptibility gene to systemic lupus erythematosus (SLE) and rheumatoid arthritis (RA). Recent genome-wide association studies revealed SLE the Caucasian Chinese populations. In this study, we investigated whether was replicated a Japanese population. addition, RA also examined.A case-control study conducted on single...
To investigate associations between continuous treatments with tumor necrosis factor (TNF) antagonists and risk for developing serious infections (SIs) over 3 years in Japanese patients rheumatoid arthritis (RA) enrolled the Registry of RA Patients Long-Term Safety (REAL) database.We analyzed 727 who had started either infliximab or etanercept (the anti-TNF group; 1,480.1 patient-years [PY]) 571 conventional nonbiologic disease-modifying antirheumatic drugs unexposed 1,104.1 PY) at time...
Introduction Interstitial Lung Disease (ILD) is frequently associated with Rheumatoid Arthritis (RA) as one of extra-articular manifestations. Many studies for Human Leukocyte Antigen (HLA) allelic association RA have been reported, but few validated in an subpopulation ILD. In this study, we investigated the HLA class II alleles ILD RA. Methods An study was conducted on HLA-DRB1, DQB1, and DPB1 450 Japanese patients that were or not diagnosed ILD, based findings computed tomography images...
Rheumatoid arthritis (RA) is a chronic systemic inflammatory disease. Certain HLA-DRB1 "shared-epitope" alleles are reported to be positively associated with increased RA susceptibility, whereas some of the other may negatively associated. However, studies on latter rare. Here, we focus protective effects DRB1 in Japanese patients an association study. Relative predispositional (RPE) were analyzed by sequential elimination carriers each allele strongest association. The investigated...
Systemic sclerosis (SSc) is an autoimmune disease for which multiple susceptibility genes have been reported. Genome-wide association studies shown that large numbers of are shared among diseases. Recently, our group identified 9 novel associated with rheumatoid arthritis (RA) in a Japanese population. The aim this study was to elucidate whether the 18 displayed associations or suggestive RA previous SSc Japanese.We performed included 415 patients and 16,891 control subjects, followed by...
Many studies on associations between human leukocyte antigen (HLA) allele frequencies and susceptibility to systemic lupus erythematosus (SLE) have been performed. However, few protective with HLA-DRB1 alleles reported. Here, we sought protective, as well predispositional, of in Japanese SLE patients. An association study was conducted for Relative predispositional effects were analyzed by sequential elimination carriers each the strongest association. We also explored DRB1 phenotypes...
Objectives: Interstitial lung disease (ILD) is a life-threatening extra-articular manifestation of rheumatoid arthritis (RA). We aimed to clarify the relationship between chronic ILD with pattern usual interstitial pneumonia (UIP) or non-UIP and mortality in RA patients.Methods: retrospectively surveyed information consecutive patients who visited our hospital from 2009 2014. The their (UIP non-UIP) detected by high-resolution computed tomography was examined.Results: Of 2702 enrolled, 261...
Our objective was to investigate trends in the treatment of patients with late-onset rheumatoid arthritis (LORA) using data from National Database Rheumatic Diseases Japan (NinJa).