A5060555424- Vasculitis and related conditions
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Systemic Lupus Erythematosus Research
- Pneumocystis jirovecii pneumonia detection and treatment
- Sarcoidosis and Beryllium Toxicity Research
- Benford’s Law and Fraud Detection
- Eosinophilic Disorders and Syndromes
- Inflammatory Myopathies and Dermatomyositis
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Otitis Media and Relapsing Polychondritis
- Computability, Logic, AI Algorithms
- Rheumatoid Arthritis Research and Therapies
- Heparin-Induced Thrombocytopenia and Thrombosis
- Drug-Induced Adverse Reactions
- Autoimmune and Inflammatory Disorders Research
- Monoclonal and Polyclonal Antibodies Research
- advanced mathematical theories
- Peripheral Neuropathies and Disorders
- Mathematical Dynamics and Fractals
- Inflammasome and immune disorders
- Pneumonia and Respiratory Infections
- Digital Media Forensic Detection
- Advanced Topology and Set Theory
- Immunotherapy and Immune Responses
- Advanced Mathematical Theories and Applications
The University of Tokyo
2020-2025
Tokyo Medical and Dental University
2006-2023
Ome Municipal General Hospital
2013-2023
Tokyo Metropolitan Geriatric Hospital
2015
National Center for Global Health and Medicine
2015
National Hospital Organization
2015
Tokyo Women's Medical University
2015
Juntendo University
2015
Yokohama City University
2012
Hosei University
1990-2010
RNF213 was recently reported as a susceptibility gene for moyamoya disease (MMD). Our aim to clarify the correlation between genotype and MMD phenotype.The entire coding region of sequenced in 204 patients with MMD, corresponding variants were checked 62 pairs parents, 13 mothers 4 fathers patients, 283 normal controls. Clinical information collected. Genotype-phenotype correlations statistically analyzed.The c.14576G>A variant identified 95.1% familial 79.2% sporadic 1.8% controls, thus...
Abstract Rheumatoid arthritis (RA) is characterized by proliferation of synoviocytes that produce inflammatory cytokines and chemokines. The expressed chemokines are thought to be involved in the migration cells into synovium. In this study we show CCL2/monocyte chemotactic protein-1, CCL5/RANTES, CXCL12/stromal cell-derived factor-1 enhanced IL-6 IL-8 production fibroblast-like (FLS) from patients with RA, their corresponding receptors, CCR2, CCR5, CXCR4, respectively, were RA FLS....
Abstract Objective Rheumatoid arthritis (RA) is characterized by chronic inflammation of multiple joints. Large numbers T cells, which produce type 1 cytokines, infiltrate into RA synovium. Chemokines and chemokine receptors are considered to contribute the cell infiltration. In this study, we examined role CX3CL1/fractalkine its receptor CX3C (CX3CR1) in migration Methods Using flow cytometry, immunohistochemistry, reverse transcription–polymerase chain reaction, analyzed CX3CR1 expression...
To investigate associations between continuous treatments with tumor necrosis factor (TNF) antagonists and risk for developing serious infections (SIs) over 3 years in Japanese patients rheumatoid arthritis (RA) enrolled the Registry of RA Patients Long-Term Safety (REAL) database.We analyzed 727 who had started either infliximab or etanercept (the anti-TNF group; 1,480.1 patient-years [PY]) 571 conventional nonbiologic disease-modifying antirheumatic drugs unexposed 1,104.1 PY) at time...
The Japan Research Committee for Intractable Vasculitis has fully revised the clinical practice guidelines (CPG) management of antineutrophil cytoplasmic antibody-associated vasculitis (AAV) to improve and standardize medical treatment disease in Japan.The previous CPG was published a classical review style Japanese 2011 2014. We adopted Grading Recommendations Assessment, Development Evaluation system this revision, various stakeholders, including patients, participated it. expected users...
Sulfamethoxazole-trimethoprim (SMX/TMP) is a standard drug for the prophylaxis of Pneumocystis pneumonia (PJP) in immunosuppressed patients with systemic rheumatic diseases, but sometimes discontinued due to adverse events (AEs). The objective this non-blinded, randomized, 52-week non-inferiority trial was quest an effective chemoprophylaxis regimen PJP low discontinuation rate. Results at week 24 were reported.Adult diseases who started prednisolone ≥0.6 mg/kg/day randomized into three...
The objective of this study was to compare the American College Rheumatology/European Alliance Associations for Rheumatology 2022 criteria with previous classification algorithm anti-neutrophil cytoplasmic antibody-associated vasculitis.We used data from two nationwide, prospective, inception cohort studies. enrolled patients were classified as having eosinophilic granulomatosis polyangiitis (EGPA), (GPA), or microscopic (MPA) according new criteria; these compared Watts' algorithm.Among 477...
We performed a retrospective analysis to establish statistical model for the prediction of Pneumocystis pneumonia (PCP) in patients with connective tissue diseases (CTD) undergoing medium- or high-dose corticosteroid therapy, identify independent risk factors PCP and evaluate efficacy prophylactic use trimethoprim-sulfamethoxazole (TMP/SMX) against PCP. One hundred twenty-four who were receiving equivalent more than 30 mg/day prednisol-one (PSL) classified into two groups according presence...
We performed a retrospective analysis to establish statistical model for the prediction of Pneumocystis pneumonia (PCP) in patients with connective tissue diseases (CTD) undergoing medium- or high-dose corticosteroid therapy, identify independent risk factors PCP and evaluate efficacy prophylactic use trimethoprim–sulfamethoxazole (TMP/SMX) against PCP. One hundred twenty-four who were receiving equivalent more than 30 mg/day prednisolone (PSL) classified into two groups according presence...
Anti-tumor necrosis factor therapy does not diminish the immune response to influenza vaccine in Japanese patients with rheumatoid arthritis Get access Tetsuo Kubota, Kubota Tokyo Medical and Dental University Graduate School of Health Sciences,1-5-45 Yushima, Bunkyo-ku, 113-8519, Japan Correspondence to: Tel./Fax +81-3-5803-5369 e-mail: tetsuo.kubota.mtec@tmd.ac.jp Search for other works by this author on: Oxford Academic Google Scholar Tokiko Nii, Nii Toshihiro Nanki, Nanki Department...
Journal Article Anti-tumor necrosis factor therapy does not diminish the immune response to influenza vaccine in Japanese patients with rheumatoid arthritis Get access Tetsuo Kubota, Kubota Tokyo Medical and Dental University Graduate School of Health Sciences,1-5-45 Yushima, Bunkyo-ku, 113-8519, Japan Correspondence to: Tel./Fax +81-3-5803-5369 e-mail: tetsuo.kubota.mtec@tmd.ac.jp Search for other works by this author on: Oxford Academic Google Scholar Tokiko Nii, Nii Toshihiro Nanki, Nanki...
Abstract Genome-wide association studies of systemic lupus erythematosus (SLE) in Chinese and Korean populations demonstrated strong single nucleotide polymorphisms (SNPs) located the GTF 2 I-NCF1 region, rs73366469 ( GTF2I ), rs117026326 rs80346167( GTF2IRD1 ) rs201802880 NCF1 ). This region has also been associated with susceptibility to Sjögren syndrome rheumatoid arthritis; however, sclerosis (SSc) ANCA-associated vasculitis (AAV) have not reported. Here we made an attempt confirm their...
It is known that the cyclin-dependent kinase inhibitor (CDKI) gene p21(Cip1) suppresses rheumatoid inflammation by down-modulating type I interleukin-1 receptor (IL-1RI) expression and inhibiting JNK activity. The purpose of this study was to determine whether CDK activity directly modulates production inflammatory molecules in patients with arthritis (RA).Genes for CDKIs p16(INK4a) p18(INK4c), a constitutively active form retinoblastoma (RB) product, cyclin D1, CDK-4, were transferred into...
A 64-year-old woman with rheumatoid arthritis (RA) began to complain of recurrent non-productive cough 5 months after starting adalimumab. The chest radiograph and high-resolution computed tomographic findings revealed diffuse ground-glass attenuation. Her clinical course suggested that interstitial pneumonia (IP) may have been induced by adalimumab, she was successfully treated a medium dose corticosteroid. This case indicates adalimumab-associated IP should be considered if RA patient...
Abstract Objective It is controversial whether the use of biological disease‐modifying antirheumatic drugs (DMARDs) increases risk herpes zoster (HZ). We aimed to evaluate risks HZ in tumor necrosis factor inhibitor (TNFI) and non‐TNFI users with rheumatoid arthritis (RA) over 3 years Japan. Method Using Japanese health insurance database, we assigned patients at least one RA diagnostic code prescription for any DMARDs (RA cases) recorded between January 2005 December 2013 group. randomly...
Interstitial pneumonitis (IP) associated with polymyositis and dermatomyositis (PM/DM) is a serious complication that affects prognosis. We therefore undertook retrospective multicenter study to examine the efficacy of combination treatment cyclosporin A (CsA) corticosteroids. Fifty-three IP patients PM/DM (9 PM, 44 DM) were analyzed. Thirty-two treated CsA plus corticosteroids 23 included in study. Four parameters, i.e., subjective symptoms, ausculatory sound, chest radiographs, respiratory...
Abstract Forced expression of a cyclin-dependent kinase inhibitor gene, p21Cip1 in the synovial tissues was effective treating animal models rheumatoid arthritis. Synovial hyperplasia treated joints suppressed, reflecting inhibitory effect on cell cycle progression. Additionally, lymphocyte infiltration, inflammatory cytokines, and destruction bone cartilage were inhibited. To determine why regulator gene exerted such anti-inflammatory effects, we investigated by fibroblasts with or without...