A5075995650- Vasculitis and related conditions
- Systemic Lupus Erythematosus Research
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Otitis Media and Relapsing Polychondritis
- Rheumatoid Arthritis Research and Therapies
- Eosinophilic Disorders and Syndromes
- Sarcoidosis and Beryllium Toxicity Research
- Inflammatory Myopathies and Dermatomyositis
- Renal Diseases and Glomerulopathies
- Autoimmune and Inflammatory Disorders Research
- Urticaria and Related Conditions
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Immune Cell Function and Interaction
- Immunodeficiency and Autoimmune Disorders
- Spectroscopy and Laser Applications
- T-cell and B-cell Immunology
- Monoclonal and Polyclonal Antibodies Research
- Cytokine Signaling Pathways and Interactions
- Metabolism and Genetic Disorders
- Cell Adhesion Molecules Research
- Systemic Sclerosis and Related Diseases
- Photonic and Optical Devices
- Semiconductor Lasers and Optical Devices
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Autoimmune Bullous Skin Diseases
Chiba University Hospital
2016-2025
Chiba University
2013-2024
University of Toyama
2024
Tokushima University
2024
Kumamoto University
2023
Kyorin University
2016-2021
University of Occupational and Environmental Health Japan
2021
Keio University
2021
Tokyo Women's Medical University
2021
University of Cambridge
2004-2016
Objectives The RITUXVAS trial reported similar remission induction rates and safety between rituximab cyclophosphamide based regimens for antineutrophil cytoplasm antibody (ANCA)-associated vasculitis at 12 months; however, immunosuppression maintenance requirements longer-term outcomes after in ANCA-associated renal are unknown. Methods Forty-four patients with newly diagnosed involvement were randomised, 3:1, to glucocorticoids plus either (375 mg/m 2 /week×4) two intravenous pulses (n=33,...
<h3>Importance</h3> The current standard induction therapy for antineutrophil cytoplasm antibody (ANCA)–associated vasculitis is the combination of high-dose glucocorticoids and cyclophosphamide or rituximab. Although these regimens have high remission rates, they are associated with considerable adverse events presumably due to glucocorticoids. <h3>Objective</h3> To compare efficacy between a reduced-dose glucocorticoid plus rituximab regimen in ANCA-associated vasculitis. <h3>Design,...
Evaluation of rituximab and glucocorticoids as therapy to induce remission after relapse in ANCA-associated vasculitis (AAV) a prospective observational cohort patients enrolled into the induction phase RITAZAREM trial.
Objective Following induction of remission with rituximab in anti-neutrophil cytoplasmic antibody-associated vasculitis (AAV) relapse rates are high, especially patients history relapse. Relapses associated increased exposure to immunosuppressive medications, the accrual damage and morbidity mortality. The RITAZAREM trial compared efficacy repeat-dose daily oral azathioprine for prevention relapsing AAV whom was reinduced rituximab. Methods an international randomised controlled, open-label,...
cDNA clones for rat acyl-CoA oxidase were isolated. The 3.8-kilobase mRNA sequence of the enzyme was completely covered by two overlapping clones. composite consisted 3741 bases and contained a 1983-base open reading frame which encodes polypeptide 661 amino acid residues. Two species identified. They differed in their coding nucleotide sequences, only within small region. same number nucleotides can be translated common frame. are 55% 50% homologous above region at levels, respectively....
Abstract For the studies on mechanism of induction peroxisomal beta-oxidation enzymes and biogenesis organelle, we have isolated cDNA clones for rat enoyl-CoA: hydratase-3-hydroxyacyl-CoA dehydrogenase bifunctional enzyme. On blotting experiments with liver RNA, cDNAs hybridized to a 3.0-kilobase RNA which was increased 5-7-fold by administration di-(2-ethylhexyl)phthalate rats. Nucleotide sequencing carried out four cloned one obtained primer extension method. By overlapping these sequences...
To investigate the long-term efficacy and safety of IL-6 receptor antibody tocilizumab in patients with Takayasu arteritis (TAK).Patients completing randomized, double-blind, placebo-controlled period TAKT (Takayasu Treated Tocilizumab) trial were followed up during open-label extended treatment weekly s.c. 162 mg for to 96 weeks or longer, oral glucocorticoid tapering performed at investigators' discretion. Endpoints extension analysis included steroid-sparing effects tocilizumab, imaging...
There are differences between Europe and Japan in the incidence antineutrophil cytoplasmic antibody (ANCA) serotype of patients with microscopic polyangiitis (MPA). However, phenotype or outcome have not been explored. We aimed to identify MPA Japan.Sequential cohorts renal limited vasculitis were collected from European Japanese centers (n = 147 n 312, respectively). Trial databases Vasculitis Society Myeloperoxidase (MPO)-ANCA-Associated (JMAAV) trial studied 254 48, evaluated baseline...
Anti-melanoma differentiation-associated protein 5 (MDA5) antibody-positive dermatomyositis (MDA5-DM) is frequently complicated with rapidly progressive-interstitial lung disease (RP-ILD). The prognosis of MDA5-DM RP-ILD mostly poor despite intensive treatment a combination high-dose glucocorticoids and single conventional immunosuppressants. It was reported that the triple therapy (high-dose glucocorticoids, cyclophosphamide tacrolimus) more effective than stepwise addition In addition,...
Objective We describe the demographics, clinical features, disease course, and survival of polyarteritis nodosa (PAN) through an international collaboration (GLOBAL‐PAN). Methods Patients with PAN were recruited between 1990 2020 from observational cohorts nine countries across Europe, Japan, North America. Eligibility was retrospectively defined using European Medicines Agency classification algorithm. related to hepatitis B virus (n = 12) two monogenic diseases mimicking PAN, deficiency...
We have isolated five cDNA clones for rat liver catalase (hydrogen peroxide:hydrogen peroxide oxidoreductase, EC 1.11.1.6). These overlapped with each other and covered the entire length of mRNA, which had been estimated to be 2.4 kilobases long by blot hybridization analysis electrophoretically fractionated RNA. Nucleotide sequencing was carried out on these composite nucleotide sequence determined. The 5' noncoding region contained 83 bases followed 1581 an open reading frame that encoded...
Three peroxisomal enzymes of &oxidation from rat liver were synthesized in a cell-free protein-synthesizing system derived lysate rabbit reticulocytes.The vitro products acyl-CoA oxidase (EC 1.3.99.3) and bifunctional protein containing enoyl-CoA hydratase 4.2.1.17)and 3-hydroxyacyl-CoA dehydrogenase 1.1.1.35)activities apparently the same size charge as subunit respective mature enzymes; that 3-ketoacyl-CoA thiolase 2.3.1.16)was about 3,000 Da larger more basic than its subunit.The free...
The aim of this prospective multicenter study was to identify biomarkers that can be used predict therapeutic responses tocilizumab in patients with rheumatoid arthritis (RA).We recruited RA who were treated for the first time, and determined at 6 months. In training cohort (n = 40), gene expression peripheral blood mononuclear cells (PBMCs) baseline analyzed using genome-wide DNA microarray, 41,000 probes derived from 19,416 genes. validation 20), levels candidate genes PBMCs real-time...
Abstract Background Relapses frequently occur in giant cell arteritis (GCA), and long-term glucocorticoid therapy is required. The identification of associated factors with poor treatment outcomes important to decide the algorithm GCA. Methods We enrolled 139 newly diagnosed GCA patients treated glucocorticoids between 2007 2014 a retrospective, multi-center registry. Patients were temporal artery biopsy, 1990 American College Rheumatology classification criteria, or large vessel lesions...
Abstract Background Systemic lupus erythematosus (SLE) is heterogeneous in organ involvement and disease severity, presenting a broad clinical phenotype. type I interferon (IFN) activity has been shown to be associated with nephritis, autoantibodies, treated SLE patients; however, these relationships are unknown treatment-naive patients. We aimed determine the relationship of systemic IFN phenotypes, activity, damage accrual patients before after induction maintenance therapy. Methods Forty...
An immunohistochemical study using monoclonal antibodies specific for the heavy chains of either human atrial (HC alpha) or ventricular beta) myosin was performed to clarify distribution each isozyme in normal as well pressure-overloaded hearts. In ventricles, all muscle fibers were stained by a antibody (HMC14) HC beta, whereas small number reacted with (CMA19) alpha. contrast, atria, almost CMA19, and relatively larger also HMC14. Furthermore, reactive HMC14 strikingly increased while...
<i>Background:</i> Lacrimal gland enlargement (LGE) is one of the characteristics Mikulicz’s disease (MD). Recently, marked serum IgG4 elevation and infiltration IgG4-positive plasmacytes in enlarged exocrine glands have been reported MD patients. However, little known about role CD4+ T cells their cytokines IgG4-related diseases. The aim this study was to evaluate patients with <i>Methods:</i> We investigated clinical 9 LGE elevated levels (named LGE). also examined...
To determine the prevalence of lung abnormalities on chest computed tomography (CT) in patients with microscopic polyangiitis (MPA), to assess responsiveness such initial treatment, and associations between these patient disease characteristics mortality.We retrospectively identified 167 consecutive hospital-based MPA 3 hospitals Japan. We longitudinally collected clinical information for 150 patients, whom CT images obtained before treatment were available. then determined presence 22...
Objective. Takayasu arteritis (TAK) and giant cell (GCA) are 2 major variants of large vessel vasculitis (LVV). The frequent involvement vessels in GCA has raised the possibility that TAK should be regarded as 1 disease. By detailed phenotyping a single-center cohort, we aimed to define differences between GCA. Methods. Forty-five patients (23 TAK, 22 GCA) were identified. Baseline characteristics, clinical symptoms, laboratory data, enhanced computed tomography/magnetic resonance imaging,...
Objective. There are differences in the frequencies of antineutrophil cytoplasmic antibodies (ANCA)–associated vasculitis subgroups between different geographic regions, and we have reported phenotype microscopic polyangiitis Europe Japan. In this retrospective observational study, compared phenotypes outcomes granulomatosis with (GPA) United Kingdom Methods. We identified 128 UK 82 Japanese patients GPA diagnosed 2000 2012. evaluated baseline characteristics including ANCA status organ...
Objective. Patients with eosinophilic granulomatosis polyangiitis (EGPA) frequently experience relapses, which lead to cumulative organ damage. In this retrospective observational study, we aimed reveal the risk factors for relapse in EGPA. Methods. A total of 188 Japanese patients EGPA diagnosed between 1996 and 2015 were identified from medical records 10 hospitals. The diagnosis was based on American College Rheumatology 1990 criteria or Lanham’s criteria. Baseline characteristics,...