A5047061905- Planetary Science and Exploration
- Astro and Planetary Science
- Glioma Diagnosis and Treatment
- Space Exploration and Technology
- Spacecraft Dynamics and Control
- Space exploration and regulation
- Spacecraft and Cryogenic Technologies
- Spacecraft Design and Technology
- Meningioma and schwannoma management
- Gas Dynamics and Kinetic Theory
- Space Satellite Systems and Control
- Rocket and propulsion systems research
- Solar and Space Plasma Dynamics
- Neurofibromatosis and Schwannoma Cases
- Supply Chain and Inventory Management
- Scheduling and Optimization Algorithms
- Coronary Interventions and Diagnostics
- Cerebrovascular and Carotid Artery Diseases
- Cardiac Imaging and Diagnostics
- Cancer-related Molecular Pathways
- Brain Metastases and Treatment
- Reconstructive Surgery and Microvascular Techniques
- Auction Theory and Applications
- Hedgehog Signaling Pathway Studies
- Sarcoma Diagnosis and Treatment
Hirosaki University
2025
Nippon Medical School
2006-2024
Chiba Hokusou Hospital
2018-2024
Kanagawa University
2016-2023
Japan Aerospace Exploration Agency
2010-2020
Institute of Space and Astronautical Science
2006-2018
Bunkyo University
2012-2016
Niigata University
2014-2015
Josai University
2015
Hokkaido University
1998-2012
In this study we established the simultaneous status of TP53, p16, p14 ARF and PTEN tumor suppressor genes in 34 randomly chosen human glioma cell lines. Nine lines (26.4%) harbored mutations or deletions all four 22 (64%) had alterations at least three. Mutations/deletions were found following frequencies: TP53 (76.5%), (64.7%), p16 (64,7%), (73.5%). Thus, there was a high incidence cellular pathways involving p53 transcription factor (94.1%), retinoblastoma protein (64.7%) phosphatase...
cDNA clones for rat acyl-CoA oxidase were isolated. The 3.8-kilobase mRNA sequence of the enzyme was completely covered by two overlapping clones. composite consisted 3741 bases and contained a 1983-base open reading frame which encodes polypeptide 661 amino acid residues. Two species identified. They differed in their coding nucleotide sequences, only within small region. same number nucleotides can be translated common frame. are 55% 50% homologous above region at levels, respectively....
Abstract For the studies on mechanism of induction peroxisomal beta-oxidation enzymes and biogenesis organelle, we have isolated cDNA clones for rat enoyl-CoA: hydratase-3-hydroxyacyl-CoA dehydrogenase bifunctional enzyme. On blotting experiments with liver RNA, cDNAs hybridized to a 3.0-kilobase RNA which was increased 5-7-fold by administration di-(2-ethylhexyl)phthalate rats. Nucleotide sequencing carried out four cloned one obtained primer extension method. By overlapping these sequences...
cDNA clones of rat peroxisomal 3-ketoacyl-CoA thiolase were isolated.By blotting analysis using the cDNAs as probes, mRNA for this enzyme was estimated to be about 1.9-kilobase pairs.Elevation levels in liver with administration di(2-ethylhexy1)phthalate also evident.Sequencing revealed 1,272 bases open reading frame which encoded 424 amino acid residues.Amino sequence data on six tryptic peptides and terminus purified confirmed sequence.The precursor contains at its a peptide extension 26...
AKATSUKI is the Japanese Venus Climate Orbiter that was designed to investigate climate system of Venus. The orbiter launched on May 21, 2010, and it reached December 7, 2010. Thrust applied by orbital maneuver engine in an attempt put into a westward equatorial orbit around with 30-h period. However, this operation failed because malfunction propulsion system. After failure, spacecraft orbited Sun for 5 years. On 2015, once again approached insertion successful, whereby apoapsis ~440,000 km...
✓ Because intracranial germinomas are readily curable with radiation and chemotherapy or therapy alone, the role of radical surgery has become debatable. This study assesses optimum degree surgical resection for germinomas. Twenty-nine patients who underwent germinoma were retrospectively analyzed (male/female ratio 27:2, median age 18 years). Among these 29 there 10 solitary pineal, seven neurohypophyseal/hypothalamic, 12 multifocal disseminated tumors. Biopsy samples obtained in 16...
Fas/APO-1 (CD95) is a cell surface receptor that mediates apoptosis when it reacts with Fas ligand (FasL) or antibody. We previously reported expression predominantly induced in perinecrotic glioma cells, suggesting induction associated and necrosis formation, histological hallmark of glioblastomas. In this study, we assessed the FasL 10 glioblastoma lines 14 astrocytic brain tumors (three low-grade astrocytomas 11 glioblastomas). Reverse transcriptase (RT)-PCR revealed all primary express...
After the arrival of Akatsuki spacecraft Japan Aerospace Exploration Agency at Venus in December 2015, radio occultation experiment, termed RS (Radio Science), obtained 19 vertical profiles Venusian atmosphere by April 2017. An onboard ultra-stable oscillator is used to generate stable X-band downlink signals needed for experiment. The quantities be retrieved are atmospheric pressure, temperature, sulfuric acid vapor mixing ratio, and electron density. Temperature were successfully down ~ 38...
Object. Although curative, radiation, which is conventionally administered for germinomas, causes significant neurological sequelae. This study aimed at reducing the volume and dose of radiation to a localized level 24 Gy by pretreating patient with chemotherapy. Methods. Seventeen patients were divided into two risk groups based on serological findings extent tumor. They treated chemotherapy prior receiving therapy. Six solitary pure germinomas three or four cycles cisplatin etoposide (EP...
Overlapping genomic clones containing the entire sequence of rat acyl-CoA oxidase gene were isolated and characterized.This spans about 25 kilobases, there are 14 exons 13 introns.All exon-intron junction sequences agree with GT/ AG rule.The results Southern blot analyses indicated that occurs once per haploid genome.
Abstract Real-time scheduling in flexible manufacturing systems (FMS) is a difficult problem because of the complexities and dynamic behaviour FMS. In this paper, transient-based real-time algorithm which selects dispatching rule dynamically for next short time period order to respond changes system state proposed. algorithm, interval associated with selected defined based on transient as predicted by discrete event simulation. Simulation also applied evaluate performance candidate rules interval.
Background: Although autologous fat injection (fat grafting) to the breast was performed widely throughout twentieth century, authors at their hospital have recently had repair damage suffered by a number of patients subjected this procedure. The are concerned that procedure is being incorrectly untrained and untutored individuals, especially in Japan. report several cases complications after Several related issues discussed. Methods: retrospectively reviewed 12 who received grafts required...
The Akatsuki spacecraft of Japan was launched on May 21, 2010. planned to enter a Venus-encircling near-equatorial orbit in December 7, 2010; however, the Venus insertion maneuver has failed, and at present is orbiting Sun. There possibility conducting an again several years later. main goal mission understand Venusian atmospheric dynamics cloud physics, with explorations ground surface interplanetary dust also being themes. angular motion roughly synchronized zonal flow near base for 20...
The ultraviolet imager (UVI) has been developed for the Akatsuki spacecraft (Venus Climate Orbiter mission). UVI takes (UV) images of solar radiation reflected by Venusian clouds with narrow bandpass filters centered at 283 and 365 nm wavelengths. There are absorption bands SO2 unknown absorbers in these wavelength regions. UV provide spatial distribution absorber around cloud top altitudes. also allow us to understand morphologies haze properties. Nominal sequential 2-h intervals used...
Enoyl-CoA hydratase:3-hydroxyacyl-CoA dehydrogenase bifunctional enzyme is a monomeric protein which catalyzes the second and third reactions of peroxisomal @-oxidation system.We cloned gene for this from rat genomic libraries.The spans about 31 kilobases consists seven exons six introns.The transcription initiation site was located 24 nucleotides upstream initiator methionine codon, ATG, determined by S 1 nuclease mapping primer extension analysis.The 5"flanking region lacks typical TATA...
Research on the optimization of stochastic systems via simulation often centers development algorithms for which global convergence can be guaranteed. On other hand, commercial software applications that perform optimation typically employ search heuristics have been successful in deterministic settings. Such give up order to more generally applicable and yield rapid progress towards good solutions. Unfortunately, do not always formally account randomness responses, meaning their may no...
A 47-year-old male underwent stereotactic radiosurgery (25 Gy) for a cerebral arteriovenous malformation located in the right caudate nucleus, using linear accelerator. Complete obliteration of nidus was confirmed 20 months after radiosurgery. However, hypointense mass on T2-weighted magnetic resonance imaging developed area adjacent to approximately 80 months. The gradually increased size and induced severe perifocal edema over 2 years. successfully excised. Histological examination...