A5044730707- Vasculitis and related conditions
- Systemic Lupus Erythematosus Research
- Renal Diseases and Glomerulopathies
- Chronic Lymphocytic Leukemia Research
- Otitis Media and Relapsing Polychondritis
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Immune Cell Function and Interaction
- Urticaria and Related Conditions
- Pharmacological Effects of Natural Compounds
- Enzyme-mediated dye degradation
- Chronic Myeloid Leukemia Treatments
- Heparin-Induced Thrombocytopenia and Thrombosis
- Lymphoma Diagnosis and Treatment
- Rheumatoid Arthritis Research and Therapies
- Autoimmune and Inflammatory Disorders Research
- Neuroinflammation and Neurodegeneration Mechanisms
- T-cell and B-cell Immunology
- Toxin Mechanisms and Immunotoxins
- Chromium effects and bioremediation
- Microbial Metabolism and Applications
- Inflammasome and immune disorders
- Stress Responses and Cortisol
- Liver Diseases and Immunity
- Vagus Nerve Stimulation Research
- Plant-Microbe Interactions and Immunity
Saitama Medical University
2015-2025
Social Insurance Saitama Chuo Hospital
2015-2025
Kyushu University
2023
Osaka City University
2020-2021
Keio University
2015-2020
Kyoto Pharmaceutical University
2010-2016
Yamaguchi University
2013
Kyoto University
2006-2008
The University of Tokyo
2008
<h3>Importance</h3> The current standard induction therapy for antineutrophil cytoplasm antibody (ANCA)–associated vasculitis is the combination of high-dose glucocorticoids and cyclophosphamide or rituximab. Although these regimens have high remission rates, they are associated with considerable adverse events presumably due to glucocorticoids. <h3>Objective</h3> To compare efficacy between a reduced-dose glucocorticoid plus rituximab regimen in ANCA-associated vasculitis. <h3>Design,...
Impact of stress on diseases including gastrointestinal failure is well-known, but molecular mechanism not understood. Here we show underlying using EAE mice. Under conditions, caused severe with high-mortality. Mechanistically, autoreactive-pathogenic CD4+ T cells accumulated at specific vessels boundary area third-ventricle, thalamus, and dentate-gyrus to establish brain micro-inflammation via stress-gateway reflex. Importantly, induction by cytokine injection was sufficient fatal failure....
Interferon alpha (IFNα) is one of the most famous drugs for treatment chronic hepatitis C and various types human malignancy. Protein drugs, including IFNα, are generally administered by subcutaneous or intramuscular injection due to their poor permeability low stability in bloodstream gastrointestinal tract. Therefore, present study, novel IFNα-coated polyvinyl alcohol-based microneedle arrays (IFNα-MNs) were fabricated transdermal delivery IFNα without painful injection. was rapidly...
Adoptive T‐cell therapy is an effective strategy for cancer immunotherapy. However, infused T cells frequently become functionally exhausted, and consequently offer a poor prognosis after transplantation into patients. transfer of tumor antigen‐specific stem cell memory ( SCM ) expected to overcome this shortcoming as are close naïve cells, but also highly proliferative, long‐lived, produce large number effector in response antigen stimulation. We previously reported that activated can be...
FoxP3
Abstract Bisphosphonates are widely used for the treatment and prevention of bone diseases, including Paget disease, hypercalcemia malignancy, postmenopausal osteoporosis. In this study, we developed a novel transdermal patch alendronate, nitrogen-containing bisphosphonate, diseases. The maximum permeation fluxes alendronate through rat human skin after application were 1.9 0.3 µg/cm2 per hour, respectively. bioavailability (BA) in rats was approximately 8.3% 1.7% oral administration. These...
Abstract Objectives Polymyalgia rheumatica (PMR) is a systemic inflammatory disease in the elderly of unknown etiology. While glucocorticoids are mainstay treatment for PMR, various glucocorticoid‐related adverse events common. Recently, several studies have reported efficacy tocilizumab (TCZ), an anti‐interleukin‐6 receptor antibody, PMR addition to accompanying reduction, or even tapering‐off, some cases. The objective this study was elucidate TCZ monotherapy absence PMR. Method We...
To evaluate the efficacy and safety of tocilizumab (TCZ) monotherapy for large vessel vasculitides (LVV), including Takayasu arteritis (TAK) GCA.Twelve patients with a newly diagnosed LVV (eight GCA, four TAK) were enrolled. One TAK patient withdrew consent, so 11 three analysed in prospective, open-label study. TCZ (8 mg/kg) monotherapy, without glucocorticoids or immunosuppressants, was administered every 2 weeks months then 4 10 months. Patients followed 1 year after final dose. Complete...
ABSTRACT Unlike general peroxidases, Pleurotus ostreatus MnP2 was reported to have a unique property of direct oxidization high-molecular-weight compounds, such as Poly R-478 and RNase A. To elucidate the mechanism for oxidation polymeric substrates by MnP2, series mutant enzymes were produced using homologous gene expression system, their reactivities characterized. A enzyme with an Ala substituting exposing Trp (W170A) drastically lost activity veratryl alcohol (VA), R-478, A, whereas...
IgG4-related disease (IgG4RD) is a unique systemic lymphoproliferative disorder characterized by elevated serum IgG4 levels and IgG4-producing plasma cell expansion in the affected tissues, which are accompanied fibrotic or sclerotic changes. Vascular lesions may also be part of IgG4RD as number case reports have discussed inflammatory abdominal aortic aneurysms associated with IgG4RD, but coronary artery seem to rare complications IgG4RD. A 71-year-old man suffered from multiple giant an...
Background Pulsed cyclophosphamide or mycophenolate mofetil for lupus nephritis has limited efficacy. We previously reported a case of mixed-class IV + V successfully treated with and tacrolimus. This study assessed the efficacy safety multitarget therapy tacrolimus treatment nephritis. Methods In prospective, single-arm, open label pilot study, we recruited 15 patients aged 18–64 years active who met American College Rheumatology criteria diagnosis systemic erythematosus (1997). The...
To assess the efficacy of tocilizumab (TCZ) monotherapy for remission induction microscopic polyangiitis (MPA) in a prospective single-arm, single-center, cohort, pilot study.Eligible patients were aged between 20 and 80 years newly diagnosed with MPA according to Watts' classification algorithm. Seven received 8 mg/kg intravenous TCZ fortnightly first 2 months (5 courses), monthly next 10 (10 courses). One year after monotherapy, followed-up without any treatment. The protocol did not...
Tocilizumab (TCZ) is a humanised anti-interleukin (IL)-6 receptor (IL-6R) monoclonal antibody that promising agent to treat various autoimmune diseases. However, the mechanism of TCZ efficacy unclear. This study aims elucidate relationship between Tregs and IL-6R blockade in autoimmunity-mediated renal disease based on TCZ-treated cohort patients with anti-neutrophil cytoplasmic (ANCA)-associated vasculitis (AAV) an experimental model crescentic glomerulonephritis (cGN).We examined multiple...
Abstract Recombinant DNAs are traditionally constructed using Escherichia coli plasmids. In the yeast Saccharomyces cerevisiae , chromosomal gene targeting is a common technique, implying that homologous recombination system could be applied for recombinant DNA construction. an attempt to use S. chromosome construction, we selected single ura3 Δ 0 locus as site. By selecting this locus, repeated surrounding URA3 sequences can performed. The described here has several advantages over...
Immune thrombocytopenia is an autoimmune disease that can cause bleeding in severe cases. Although available published data do not associate the BNT162b2 vaccine (Pfizer-BioNTech) with risk of developing thrombocytopenia, ChAdOx1 nCov-19 has raised concerns about its potential link thrombosis and thrombocytopenia. We would like to clarify whether administration may interfere pre-existing conditions it a Herein, we report three cases post-vaccine among patients rheumatoid arthritis (RA); one...
Journal Article Efficacy of weekly mizoribine pulse therapy in refractory lupus nephritis Get access Eiko Nishi, Nishi Department Rheumatology and Clinical Immunology, Saitama Medical Center, University, 1981 Kamoda, Kawagoe, 350-8550, Japan Search for other works by this author on: Oxford Academic Google Scholar Hideto Kameda, Kameda Division Rheumatology, Internal Medicine, School Keio 35 Shinanomachi, Shinjuku, Tokyo 160-8582, Hiroe Ogawa, Ogawa Hayato Nagasawa, Nagasawa Hirofumi Takei,...
Journal Article Corticosteroid- and cyclophosphamide-free treatment of anti-neutrophil cytoplasmic antibody-associated vasculitis using tocilizumab Get access Ryota Sakai, Sakai Department Rheumatology Clinical Immunology, Saitama Medical Center, University, 1981 Kamoda, Kawagoe, Japan Correspondence to: Kawagoe 350-8550, Japan. Tel: + 81-49-228-3574. Fax: E-mail: r_sakai@saitama-med.ac.jp Search for other works by this author on: Oxford Academic Google Scholar Akiko Shibata, Shibata Kentaro...