A5026303520- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Lung Cancer Treatments and Mutations
- Respiratory Support and Mechanisms
- Sarcoidosis and Beryllium Toxicity Research
- Medical Imaging and Pathology Studies
- Tracheal and airway disorders
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Sepsis Diagnosis and Treatment
- Neuroendocrine Tumor Research Advances
- Inhalation and Respiratory Drug Delivery
- Pulmonary Hypertension Research and Treatments
- Lung Cancer Diagnosis and Treatment
- Antifungal resistance and susceptibility
- Vasculitis and related conditions
- Tumors and Oncological Cases
- Cancer Treatment and Pharmacology
- Lung Cancer Research Studies
- Porphyrin Metabolism and Disorders
- Pneumonia and Respiratory Infections
- Thermal Regulation in Medicine
- IgG4-Related and Inflammatory Diseases
- Pneumocystis jirovecii pneumonia detection and treatment
- Testicular diseases and treatments
- Nosocomial Infections in ICU
- Neuroblastoma Research and Treatments
Tokyo Medical University Hachioji Medical Center
2024
International University of Health and Welfare
2017-2023
Japan Anti Tuberculosis Association
2021
Chiba University
2013-2018
Chiba University Hospital
2014-2018
Fujita Health University
2018
Shinshu University
2004-2014
Shinonoi General Hospital
2014
Tokyo Medical University
2012-2013
Azumi Hospital
2005-2010
Background —P-selectin plays key roles in mediating inflammation through promoting adherence of leukocytes to activated platelets and endothelium. This process is one the initial events atherosclerosis restenosis after coronary angioplasty. Methods Results —Using a rat balloon-injury model, we examined role P-selectin vascular inflammatory processes. In acute phase, immunohistochemistry revealed that was intensely expressed on both covering denuded segment endothelial cells inflamed...
A 71-year-old man was admitted with malaise, mild fever, anorexia, body weight loss, lower back pain, thirst, and polydipsia. He showed bilateral swelling of the submandibular glands. Examinations panhypopituitarism a high serum IgG4 concentration. Fluorodeoxyglucose positron emission tomography (FDG-PET) revealed uptake in pituitary gland, hilar mediastinal lymph nodes, mass consistent retroperitoneal fibrosis, but not pancreas. Biopsy specimens from gland indicated sialadenitis fibrosis...
To determine the prevalence of lung abnormalities on chest computed tomography (CT) in patients with microscopic polyangiitis (MPA), to assess responsiveness such initial treatment, and associations between these patient disease characteristics mortality.We retrospectively identified 167 consecutive hospital-based MPA 3 hospitals Japan. We longitudinally collected clinical information for 150 patients, whom CT images obtained before treatment were available. then determined presence 22...
<i>Background:</i>Interleukin (IL)-13 has recently been reported as the major T-helper 2 cytokine involved in mucus overproduction and oversecretion allergic airways. However, relationship between human calcium-activated chloride channel-1 (hCLCA1) MUC5AC induced by IL-13 vitro not fully investigated. <i>Objectives:</i> The present study examines whether induces expression of hCLCA1 normal bronchial epithelial (NHBE) cells. We also investigated development goblet cell...
Lung cancer is frequently complicated by interstitial lung disease (ILD). Treatment protocols for patients with ILD have not been established; surgery, chemotherapy, and radiotherapy can all cause acute exacerbation of ILD. This study evaluated the toxicity efficacy carbon ion (CIRT) in non-small cell (NSCLC) ILD.Between June 2004 November 2014, 29 diagnosed NSCLC were treated CIRT. No patient was eligible curative surgery or conventional secondary to Owing prior symptomology, radiation...
Purpose: Acute exacerbation (AE) is an important outcome of idiopathic pulmonary fibrosis (IPF) and nonspecific interstitial pneumonia (NSIP). Recombinant human soluble thrombomodulin (rhTM) a new drug for the treatment disseminated intravascular coagulation in Japan. The objective this study was to evaluate efficacy rhTM AE IPF/NSIP. Methods: Twenty-two patients with AE-idiopathic (16 IPF six NSIP) were enrolled our study. Among them, eleven treated (rhTM group), without (non-rhTM group)....
Objective Bacteremia is one of the most serious health problems associated with high morbidity and mortality. The aim this study was to identify risk factors for bacteremia in daily medical care facilitate rapid accurate clinical decisions about treatment.Patients Methods We studied 306 inpatients retrospectively. Age, peripheral neutrophil count, C-reactive protein (CRP), platelets, serum total cholesterol, protein, albumin cholinesterase were compared patients positive- negative-blood...
Abstract: Endotoxin‐removal direct hemoperfusion column containing polymyxin B immobilized fibers (PMX‐DHP) is an effective procedure for the treatment of sepsis‐induced acute respiratory distress syndrome (ARDS). We investigated retrospectively effects and appropriate timing PMX‐DHP induction directly induced ARDS in 38 patients. was carried out twice two hours. Blood pressure, heart rate (HR) PaO 2 /FIO (PF) ratio, leukocytes, platelets, endotoxin, inflammatory cytokines clusters...
We have developed a new internal cooled electrode for radiofrequency ablation (RFA) (Japan Application no. 2006-88228) suitable forceps channel bronchoscopy. Here, we present our clinical experience with bronchoscopy-guided RFA under computed tomography (CT) monitoring patients peripheral-type non-small-cell lung cancer (NSCLC). Bronchoscopy-guided was performed in two (80 and 70 years old) NSCLC, who had no lymph node involvement distant metastases (T1N0M0), but not indicated surgery...
Abstract: Post‐intubation tracheal stenosis is usually caused by pressure necrosis at the cuff. Despite fact that this phenomenon well known and both large volume low cuffs have been developed, lesion nevertheless continues to occur. Although best results for reconstruction are obtained an experienced surgeon, not all patients able undergo operation either medical or personal reasons. Argon plasma coagulation (APC) using flexible bronchoscopy has successfully employed in treatment of...
In 2005, a 46-year-old woman consulted our department for an evaluation of chest radiographic abnormality. She had undergone successful living renal transplantation in 1999 after being treated by dialysis four years. A computed tomographic scan revealed progressive bilateral fluffy, poorly defined small nodules and the bronchoscopic study unique linear nodular lesion pattern. Based on findings these modalities, we confirmed diagnosis metaplastic pulmonary calcification. This is first report...
A 52-year-old Japanese woman presented with optical symptoms, including left-sided myodesopsia, blurred vision, narrowed visual field, and diminished acuity. Ocular evaluation revealed a metastatic tumor in the choroid. Further examinations identified pulmonary adenocarcinoma as primary tumor. Because an epidermal growth factor receptor gene ( EGFR ) mutation was detected biopsy specimen, gefitinib treatment initiated. Dramatic responses were obtained foci. Optical symptoms improved remained...
Chronic obstructive pulmonary disease (COPD) is a major public health problem. This study was performed to determine whether the low attenuation area (LAA) and visual score provided by low-dose computed tomography (CT) can be used detect occult parenchymal disease, such as insidious COPD.Each participant underwent CT scan function tests. The LAA% of corresponding lung calculated. cut-off level between normal density LAA defined -960 HU, severity emphysematous change (visual score) were...
A 66-year-old male treated with everolimus for renal cell carcinoma developed exertional dyspnea. Chest computed tomography revealed diffuse interstitial shadows on both lungs. Bronchoalveolar lavage and the drug-induced lymphocyte stimulation test confirmed diagnosis of lung disease due to therapy. However, discontinuation in combination corticosteroid therapy did not prevent progression. On basis a PCR assay Pneumocystis jirovecii elevated β-D-glucan levels, trimethoprim-sulfamethoxazole...
The prognosis of patients with an acute exacerbation interstitial pneumonia (AE-IP) is poor. Pirfenidone (PFD) reduces the disease progression in idiopathic pulmonary fibrosis.The purpose this study was evaluating whether administration PFD improved outcomes AE-IP.We conducted a retrospective 31 AE-IP who did not recover between 7 and 14 days after initial treatment. Fourteen received within 2 weeks (PFD group) AE, while 17 were treated without (non-PFD group). patients' clinical data...