Abstract Cancer cells use autophagy for growth, survival, and cytoprotection from chemotherapy. Therefore, inhibitors appear to be good candidates cancer treatment. Our group previously reported that macrolide antibiotics, especially azithromycin (AZM), have potent inhibitory effects, combination treatment with tyrosine kinase or proteasome enhances their anti–cancer activity. In this study, we evaluated the effect of therapy DNA‐damaging drugs AZM in non–small‐cell lung (NSCLC) cells. We...

Abstract Background Predicting the incidence of chemotherapy‐triggered acute exacerbation interstitial lung disease (AE‐ILD) in patients with cancer is important because AE‐ILD confers a poor prognosis. The Glasgow prognostic score (GPS), which an inflammation‐based index composed serum levels C‐reactive protein and albumin, predicts prognosis small cell (SCLC) without ILD. In this study, we investigated survival outcome based on GPS ILD associated SCLC who were receiving chemotherapy....

Background Interstitial lung disease (ILD) in patients with non‐small cell cancer (NSCLC) worsens the prognosis for overall survival (OS) due to chemotherapy‐triggered acute exacerbation (AE)‐ILD. The Glasgow Prognostic Score (GPS), which is based on serum C‐reactive protein and albumin levels, has been suggested as a reliable prognostic tool mortality patients, including NSCLC. In this study, we investigated whether GPS predictor AE‐ILD NSCLC pre‐existing ILD. Methods We conducted...

The features of intralobar pulmonary sequestration vary on computed tomography (CT). Many cases demonstrate a mass or cystic lesion within lower lobe. We report herein case 55-year-old, female patient presenting with right back pain. Contrast enhanced (CE) CT revealed multiple, nodular, lesions suggesting recurrent infections surrounding focal emphysema. Three-dimensional (3D) reconstruction demonstrated sequestrated lung segment systemic, arterial blood supply. Based these findings, was...

While recent evidence has suggested that sarcopenia could predict chemotoxicity, its association with chemotherapy-triggered interstitial lung disease (ILD) exacerbations yet to be investigated. Thus, the present study sought determine whether ILD and overall survival (OS) in patients ILD-complicated non-small cell cancer (NSCLC).From January 2010 July 2020, 74 NSCLC who received chemotherapy were retrospectively After categorizing according presence or absence of based on psoas muscle...

Key Clinical Message Pancreaticopleural fistula should be considered in alcohol abusers with pleural effusion, which can exhibit a black color.

Solid tumors are predisposed to hypoxia, which induces tumor progression, and causes resistance treatment. Hypoxic cells exploit auto- mitophagy facilitate metabolism mitochondrial renewal. Azithromycin (AZM), a widely used macrolide, inhibits autophagy in cancer cells. The aim of the present study was determine whether AZM targeted hypoxic by inhibiting mitophagy. Lung cell lines (A549, H1299 NCI-H441) were cultured for up 72 h under normoxic (20% O2) or (0.3% conditions presence absence...

Computed tomography is useful for the diagnosis of coronavirus disease (COVID-19) pneumonia. However, many types interstitial lung diseases and even bacterial pneumonia can show abnormal chest shadows that are indistinguishable from those observed in COVID-19 Thus, it necessary to identify biomarkers efficiently distinguish pneumonia-like diseases. Herein, we investigated usefulness serum Krebs von den Lungen 6 (KL-6) surfactant protein D (SP-D) identifying patients with among consistent...

The double-ring sign found in contrast-enhanced computed tomography, which reflects inflammatory changes the adventitia and oedema of intima, is thought to be characteristic Takayasu arteritis; however, herein, it was also observed for granulocyte colony-stimulating factor-induced vasculitis.If a double‐ring contrast‐enhanced this should raise concern not only arteritis, but colony‐stimulating factor‐induced vasculitis.

Anti-melanoma differentiation-associated gene 5 antibody (anti-MDA5 Ab) has to be reported often cause rapidly progressive interstitial lung disease (RP-ILD) especially in East Asian countries. Even with the recommended rapid administration of immunosuppressive agents high-dose corticosteroids, intravenous pulse cyclophosphamide, and calcineurin inhibitors, prognosis anti-MDA5 Ab-related RP-ILD is poor. Plasma exchange (PE) been effective for steroid-refractory Ab. However, timing,...

We present the case of a patient with lung adenocarcinoma stage IVB diagnosed as orbital apex syndrome (OAS) associated intraorbital metastasis cancer. When patients cancer have diplopia, ptosis or ocular motility disorder, identifying OAS is important.

Obstructive bronchiolitis (OB) is an intractable disease causing stenosis in the surrounding bronchiolar region and lumen obstruction. Causes of OB are lung hematopoietic stem-cell transplantation, collagen diseases, infections, foods, but there very few reports drug-induced [1]. Imatinib a drug used for treatment leukemia, gastrointestinal stromal tumors, etc. Although some imatinib-induced injury as complication (Ohnishi et al., 2006; Ma 2003; Yamasawa 2008; Koide 2011) [[2], [3], [4],...

Abstract We report a case of neurogenic pulmonary edema (NPE) caused by middle cerebral artery infarction involving the right insular cortex. Hyperactivity cortex, which regulates sympathetic function, can cause NPE. The NPE should be considered in differential diagnosis dyspneic patients with cortex infarction.

Key Clinical Message Sarcoidosis may occur after treatment with pulmonary tuberculosis and requires differential diagnosis from reactivation. Miliary sarcoidosis should be promptly differentiated miliary associated high mortality. Abstract Clinical, histological, radiological similarities between render challenging. The association these two diseases has long been discussed, although the coexistence or subsequent occurrence of is rare. We report a case that developed 30 years tuberculous...

In malignant pleural mesothelioma patients, effusion may improve during the course of disease. Pleural with nodular shadows bordering pleura should be followed up even if improves.

Objective The current standard treatment for locally advanced, unresectable stage III non-small-cell lung cancer (NSCLC) is concurrent chemoradiation therapy (CCRT) and durvalumab administration. Although reports have indicated that the prognosis of squamous cell carcinoma poorer than adenocarcinoma, real-world data are currently inadequate.

Chylothorax is reported as a postoperative complication, mainly in the field of thoracic surgery, but there are only 14 reports spinal surgery. A 64-year-old woman underwent fusion surgery by anterior and posterior approach for her scoliosis. She developed leg edema right pleural effusion 2 months after Laboratory findings showed decreased total protein albumin levels serum. The color thoracentesis sample was pinkish white, Triglyceride level high. So, found to be associated with...

We report a 69-year-old man who presented to our hospital with cough and sputum production. He had been in close contact six domestic cats. smoking history of 40 pack-years A chest computed tomography scan revealed multiple consolidations cavities both lung fields. Pasteurella multocida was cultured from his sputum. On bronchoscopic evaluation, the flexible bronchoscope navigated through right middle lobe bronchus, which opened inside cavity, allowing visualization spider-web-appearing...

<b>Rationale:</b> Wasting of the subcutaneous adipose tissue (SAT) is one clinical characteristics patients with pulmonary emphysema, although visceral fat accumulation has been also reported. The capacity SAT to store surplus lipid would determine overflow lipid, resulting metabolic disorders like accumulation. aim this study explore and vesceral adipocytes in emphysema. <b>Methods:</b> We evaluated formalin-fixed, paraffin-embedded human samples obtained from smokers emphysema healthy...

<title>Abstract</title> <bold>Background: </bold>Neutrophilic airway inflammation is one of the features severe asthma. Neutrophil gelatinase-associated lipocalin (NGAL), or lipocalin-2, a glycoprotein associated with neutrophilic and can be detected in blood. Recently, blood NGAL levels have been reported to elevated chronic obstructive pulmonary disease. However, clinical significance serum patients asthma has not elucidated. The aim this study was explore association between level...