A5101859693- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Advanced Radiotherapy Techniques
- Medical Imaging Techniques and Applications
- Wireless Power Transfer Systems
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Energy Harvesting in Wireless Networks
- Radiation Therapy and Dosimetry
- Neonatal Respiratory Health Research
- Radiation Dose and Imaging
- Lymphatic System and Diseases
- Semiconductor Lasers and Optical Devices
- COVID-19 Clinical Research Studies
- Inhalation and Respiratory Drug Delivery
- Radiation Detection and Scintillator Technologies
- Advanced X-ray and CT Imaging
- Engineering Applied Research
- Digital Radiography and Breast Imaging
- Lymphatic Disorders and Treatments
- Cardiac Arrhythmias and Treatments
- Pleural and Pulmonary Diseases
- Occupational and environmental lung diseases
- Respiratory Support and Mechanisms
- Pulmonary Hypertension Research and Treatments
- Nitric Oxide and Endothelin Effects
- Eosinophilic Disorders and Syndromes
Tokyo Medical University Hospital
2019-2025
Tokyo Medical University
1966-2025
Tokushima University
2012-2025
Toyohashi University of Technology
2016-2025
Nagoya University Hospital
2015-2024
Biology of Infection
2024
Hokkaido University Hospital
2024
Ibaraki Prefectural University of Health Sciences
2002-2023
Tokyo Medical and Dental University
1990-2020
Mitsubishi Electric (Germany)
2010-2020
A randomised, double-blind, phase II, dose escalation trial was conducted to assess the safety, tolerability and pharmacokinetics of tyrosine kinase inhibitor nintedanib, alone when added ongoing pirfenidone therapy, in Japanese patients with idiopathic pulmonary fibrosis. 50 were randomised receive nintedanib or placebo one three cohorts (nintedanib mg twice daily 100 for 14 days, 150 28 days). Patients receiving at inclusion stratified every group placebo. Adverse events reported nine out...
Matrix metalloproteinase-9 (MMP-9) is a matrix-degrading enzyme implicated in many biological processes, including inflammation. It produced by cells, fibroblasts. When cultured three-dimensional (3D) collagen gels, fibroblasts contract the surrounding matrix, function that thought to model contraction characterizes both normal wound repair and fibrosis. The current study was designed evaluate role of endogenously MMP-9 fibroblast 3D gels. Fibroblasts from mice lacking expression human lung...
Bone marrow (stem/progenitor) cells have been shown to "differentiate" into in multiple tissues, including lung. A low number of hematopoietic stem/progenitor also circulate peripheral blood. The physiologic roles these are still uncertain. This study was designed test, using parabiotic mice that were joined surgically, whether blood contributed the regeneration lung after injury. Parabiotic generated surgically by joining green fluorescent protein transgenic and wild-type littermates. These...
Background Excess amounts of NO produced by an inducible synthase (iNOS) in response to cytokines may be cytotoxic and can destructive tissue. We investigated the role development myocardial damage effects aminoguanidine (AG), inhibitor iNOS, on experimental autoimmune myocarditis rats. Methods Results Autoimmune was induced 20 Lewis rats injection porcine cardiac myosin. Ten were administered AG. The severity evaluated measuring size myocarditic lesion serum levels CK-MB. Serum determined...
Objective The prognosis of idiopathic pulmonary fibrosis (IPF) patients with acute exacerbation (AE) is reported to be extremely poor. Several clinical studies suggest that direct hemoperfusion polymyxin B-immobilized fiber (PMX) may have beneficial effects on AE in interstitial pneumonia (IP). aim this multicenter retrospective analysis was investigate whether PMX treatment could provide improvement oxygenation and survival benefits IPF AE. Methods We conducted a study 160 IP (including 73...
Podoplanin (Aggrus), which is a type I transmembrane sialomucin-like glycoprotein, highly expressed in malignant pleural mesothelioma (MPM). We previously reported the generation of rat anti-human podoplanin Ab, NZ-1, inhibited podoplanin-induced platelet aggregation and hematogenous metastasis. In this study, we examined antitumor effector functions NZ-1 NZ-8, novel rat-human chimeric Ab generated from including Ab-dependent cellular cytotoxicity (ADCC) complement-dependent against MPM...
Podoplanin is a platelet aggregation‐inducing factor associated with tumor metastasis, malignant progression, and cancer stem cells. We produced rat–human chimeric anti‐podoplanin m A b, NZ ‐8, from rat b ( ‐1). Although both ‐1 ‐8 possess high binding affinities neutralizing activities of aggregation, the antibody‐dependent cellular cytotoxicity complement‐dependent were much higher than ‐1. Furthermore, inhibited growth podoplanin‐expressing tumors in vivo . Both also suppressed...
Rationale: Acute exacerbation during the course of idiopathic pulmonary fibrosis causes a poor prognosis. Coagulation abnormalities and endothelial damage are involved in its pathogenesis. Thrombomodulin alfa, recombinant human soluble thrombomodulin, has anticoagulant antiinflammatory effects. Several clinical studies have shown that thrombomodulin alfa may improve survival acute exacerbation.Objectives: To determine efficacy safety compared with placebo fibrosis.Methods: This randomized,...
Section:ChooseTop of pageAbstract <<Materials and MethodsResultsDiscussionReferencesCITING ARTICLES
Objective: This study was aimed to investigate the effect of polymyxin B-immobilized fiber column (PMX) hemoperfusion treatment on acute exacerbation idiopathic pulmonary fibrosis (IPF). Patients and Methods: Six patients with a clinical diagnosis (IPF) who developed were included in this study. Although five six treated high-dose corticosteroid therapy, mechanical ventilation necessary for all due severe respiratory failure. Blood endotoxin levels undetectable patients. PMX performed these...
Reminiscence intervention is effective for increasing self-esteem and decreasing behavioural disturbances in individuals with dementia. This paper introduces the concept of a "personalised reminiscence photo video" as convenient method intervention. The video utilises slideshow personal photos narration, background music, pan/zoom visual effects. A group 15 dementia watched personalised videos well two types TV shows: variety show news show. Eighty percent subjects (12 out 15) showed more...
Recent reports suggest that polymyxin B (PMX)-immobilized fiber may have beneficial effects in idiopathic pulmonary fibrosis (IPF) with acute exacerbation (AE). High mobility group box-1 (HMGB-1) is an important pro-inflammatory mediator contributes to lung inflammation. This study was aimed investigate whether PMX treatment affects serum HMGB-1 levels and oxygenation IPF patients AE.Twenty AE were treated by PMX. carried out once daily for 2 successive days. Serum measured before after...
Podoplanin (PDPN/Aggrus/T1α) binds to C-type lectin-like receptor-2 (CLEC-2) and induces platelet aggregation. PDPN is associated with malignant progression, tumor metastasis, poor prognosis in several types of cancer. Although many anti-human (hPDPN) monoclonal antibodies (mAbs), such as D2-40 NZ-1, have been established, these epitopes are limited the aggregation-stimulating (PLAG) domain (amino acids 29-54) hPDPN. Recently, we developed a novel mouse anti-hPDPN mAb, LpMab-7, which more...
Podoplanin (aggrus) is highly expressed in several types of cancers, including malignant pleural mesothelioma (MPM). Previously, we developed a rat anti‐human podoplanin mAb, NZ‐1, and rat–human chimeric antibody, NZ‐8, derived from which induced antibody‐dependent cellular cytotoxicity (ADCC) complement‐dependent against podoplanin‐positive MPM cell lines. In this study, showed the antitumor effect NZ‐12, novel antibody an orthotopic xenograft SCID mouse model. Treatment with NZ‐1 NK...
Podoplanin is expressed in many cancers, including oral cancers and brain tumors. The interaction between podoplanin its receptor C-type lectin-like 2 (CLEC-2) has been reported to be involved cancer metastasis tumor malignancy. We previously established monoclonal antibodies (mAbs) against human using the cancer-specific mAb (CasMab) technology. LpMab-23 (IgG1, kappa), one of mouse anti-podoplanin mAbs, was shown a CasMab. However, we have not usefulness for antibody therapy...
Section:ChooseTop of pageAbstract <<Materials and MethodsResultsDiscussionReferencesCITING ARTICLES
Abstract Background Fourteen-membered ring macrolides have been effective in reducing chronic airway inflammation and also preventing lung injury fibrosis bleomycin-challenged mice via anti-inflammatory effects. EM703 is a new derivative of erythromycin (EM) without the bactericidal We investigated antifibrotic effects an experimental model bleomycin-induced subsequent mice. Methods Seven-week-old male ICR were used. All experiments used eight mice/group, unless otherwise noted figure...
Reminiscence therapy, which is effective for increasing the selfesteem of and reducing behavioral disturbances in individuals with dementia, usually conducted a group led by experienced staff. However, due to shortage care attendants, only limited number patients at home can receive benefits this therapy. To provide therapy anytime or anywhere, we have developed networked reminiscence system that combines IP videophones photo- video-sharing mechanism based on Web technology. First, prepared...
Polymyxin B-immobilized fiber (PMX) treatment has beneficial effects in patients with acute lung injury/acute respiratory distress syndrome or exacerbation of idiopathic pulmonary fibrosis. This study was aimed to clarify the mechanism PMX for interstitial pneumonia (IP).Sixteen consecutive IP were included. The treated once daily 2 successive days at a flow rate 80-100 ml/min 6 h. Cells adsorbed by analyzed morphologically electron microscopy. Surface markers these cells determined...
Abstract Human podoplanin (h PDPN ), a platelet aggregation‐inducing transmembrane glycoprotein, is expressed in different types of tumors, and it binds to C‐type lectin‐like receptor 2 ( CLEC ‐2). The overexpression h involved invasion metastasis. Anti‐h monoclonal antibodies (mAbs) such as NZ ‐1 have shown antitumor antimetastatic activities by binding the aggregation‐stimulating PLAG ) domain . Recently, we developed novel mouse anti‐h mAb, LpMab‐2, using cancer‐specific mAb (CasMab)...
Podocalyxin (PODXL) overexpression is associated with progression, metastasis, and poor outcomes in cancers. We recently produced the novel anti-PODXL monoclonal antibody (mAb) PcMab-47 (IgG1, kappa). Herein, we engineered into 47-mG2a, a mouse IgG2a-type mAb, to add antibody-dependent cellular cytotoxicity (ADCC). further developed 47-mG2a-f, core fucose-deficient type of 47-mG2a augment its ADCC. Immunohistochemical analysis oral cancer tissues using revealed that latter stained squamous...