A5102980835- Peptidase Inhibition and Analysis
- Protease and Inhibitor Mechanisms
- Neonatal Respiratory Health Research
- Cancer, Lipids, and Metabolism
- Angiogenesis and VEGF in Cancer
- Sepsis Diagnosis and Treatment
- Tendon Structure and Treatment
- Shoulder Injury and Treatment
- Connective tissue disorders research
- Immune Response and Inflammation
- S100 Proteins and Annexins
- Occupational exposure and asthma
- Respiratory Support and Mechanisms
- IL-33, ST2, and ILC Pathways
- Asthma and respiratory diseases
- Bacterial Identification and Susceptibility Testing
- Cancer, Hypoxia, and Metabolism
- Infective Endocarditis Diagnosis and Management
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Neuroscience of respiration and sleep
- Lung Cancer Diagnosis and Treatment
- HER2/EGFR in Cancer Research
- Liver physiology and pathology
- Hemostasis and retained surgical items
- Cardiac Fibrosis and Remodeling
Zhongshan Hospital
2025
Fudan University
2024-2025
Shandong Provincial Hospital
2024
Shandong First Medical University
2024
University of Benin
2023
Medical Center Hospital
2022
Second Xiangya Hospital of Central South University
2017-2018
Central South University
2017-2018
Hunan University of Traditional Chinese Medicine
2017
Hebei Medical University
2017
Section:ChooseTop of pageAbstract <<Materials and MethodsResultsDiscussionReferencesCITING ARTICLES
Asthma is characterized by chronic inflammation of the airway wall with presence activated T helper 2 (Th2) lymphocytes. The current study assessed ability Th2 cytokines to modulate fibroblast-mediated contraction collagen gels determine if could contribute tissue remodeling altering mesenchymal cell contraction. Human fetal lung fibroblasts, human adult bronchial fibroblasts and smooth muscle cells were cast into native type I allowed contract in or absence IL (interleukin)-4, IL-5, IL-10,...
Section:ChooseTop of pageAbstract <<Materials and MethodsResultsDiscussionReferencesCITING ARTICLES
To investigate the clinical significance of circulating hepatocyte growth factor (HGF) and role peripheral blood mononuclear cells (monocytes), which are a possible source HGF, in patients with acute myocardial infarction.37 infarction 13 normal control subjects were recruited. Peripheral venous samples drawn from infarct 1, 7, 14, 21 days after onset. Monocytes isolated at those times. HGF concentrations serum culture medium monocytes incubation for 24 hours (monocyte levels) measured by...
Abstract Objective This clinical study was designed to evaluate the efficacy and safety of this therapy in treatment respiratory urinary infections caused by ceftriaxone-resistant bacteria comparison with effect cefoperazone/sulbactam on cefoperazone-resistant bacteria. Methods A total 285 patients aged from 18 65 years old, a or tract bacterial infection, were enrolled into multicentre, open-label, controlled study, that either isolated patients, whose condition had not improved after three...
Extended culture of monocytes and fibroblasts in three-dimensional collagen gels leads to degradation the (see linked study this issue, "Fibroblasts contract degrade extended co-culture"). The current study, therefore, was designed evaluate production matrix-degrading metalloproteinases by these cells co-culture determine if neutrophil elastase could collaborate activation enzymes. Since co-cultures produce prostaglandin E2 (PGE2), role PGE2 process also evaluated. Blood from healthy donors...
Cigarette smoke exposure has been associated with a variety of diseases, including emphysema. The current study evaluated the interaction cell density and cigarette extract (CSE) on fibroblast contraction collagen gels. Protein levels transforming growth factor (TGF)-beta1, fibronectin, PGE(2), TGF-beta1 mRNA were quantified. Although both 5 10% CSE inhibited by low-density fibroblasts (1 x 10(5) cell/ml), only 5% augmented in higher-density cultures (3-5 cells/ml). also fibronectin...
Toll-like receptor 4 (TLR4) is a transmembrane pattern‑recognition expressed in immune cells and the heart. Activation of TLR4 signaling during sepsis results release cardiac depression mediators that may impair heart function. The present study aimed to determine whether contributes development severe sepsis‑induced myocardial dysfunction. A cecum ligation puncture (CLP) procedure was employed establish models. Wild type (WT) knock‑out (TLR4‑KO) mice were divided into four groups: WT‑sham,...
Myeloid differentiation factor 88 (MyD88) and Toll or interleukin-1 receptor-domain-containing adaptor-inducing interferon-β (IFN-β) (TRIF) are two pivotal downstream adaptors of Toll-like receptors. Activation MyD88 TRIF signaling in cardiac immune pathology severe inflammation negatively influences heart function. In the present study, septic injury was induced C57BL/6 mice by cecum ligation puncture (CLP). A total 64 were divided randomly into following four groups (n=16/group; 8 for...
The gram-positive cocci is the most common pathogens of infective endocarditis (IE), and it rarely induced by gram negative bacteria. Only one prior case has been described, in which a patient reported with IE caused M. morganii, who suffered from multiple myeloma received high dosages corticosteroids, chemotherapy immunomodulatory agents. seldom diagnosed patients without underlying valvular abnormalities. important risk factors are intravenous drug abuse, implanted foreign material central...
Abstract Introduction The metastases of lung cancer to bilateral choroids symmetrically and simultaneously are very rare. Almost all patients with choroid metastasis can be treated external beam radiotherapy in order increase quality life preserve vision. Material Methods We documented a case studied the effect icotinib on choroidal eyes from pulmonary adenocarcinoma. Results A 49‐year‐old Chinese man presented vision losing for 4 weeks, it was as an initial presentation clinical....
Mononuclear phagocytes can interact with mesenchymal cells and extracellular matrix components that are crucial for connective tissue rearrangement. We asked whether blood monocytes alter remodeling mediated by human lung fibroblasts cultured in a three-dimensional collagen gel. Blood from healthy donors (>95% pure) were cast into type I gels contained fibroblasts. Monocytes coculture inhibited the fibroblast-mediated gel contractility time- concentration-dependent manner. The concentration...
The guidelines recommend early caffeine administration for preterm infants requiring non-invasive mechanical ventilation since earlier treatment is associated with better outcomes. objective was to evaluate the impact of therapy (within 24 hours after birth) on respiratory outcomes in very who were initially receiving invasive ventilation.
To investigate the roles of myeloid differentiation factor 88 (MyD88) and TIR domain-containing adaptor inducing interferon-β (TRIF) in sepsis-induced myocardial dysfunction, to analyze whether strain rate (SR) can be early sensitive evaluation for septic heart failure.Sixty-four healthy male C57BL/6 mice were divided into four groups by random number table (n = 16 each group): sham group, cecum ligation puncture (CLP)-induced sepsis model anti-MyD88 group anti-TRIF group. The injected with...
Acute lung injury (ALI) which is resulted from endotoxemia principally, can develop into acute respiratory distress syndrome (ARDS) in a short time. Because of its poor curative effect and high mortality, it the focus clinical basic science research all In recent years, researchers have done lots experiments on anti-inflammatory,anti-oxidant anti-coagulation respects, but largescale tests are deficient or no efficient. At present, major method to treat ALI/ARDS--mechanical ventilation has...