A5017622447- Neuroinflammation and Neurodegeneration Mechanisms
- Meningioma and schwannoma management
- Liver Disease Diagnosis and Treatment
- Neurofibromatosis and Schwannoma Cases
- Psoriasis: Treatment and Pathogenesis
- Immune Response and Inflammation
- Advanced Photocatalysis Techniques
- Traditional Chinese Medicine Analysis
- Genetic Associations and Epidemiology
- Neurological Disease Mechanisms and Treatments
- Flavonoids in Medical Research
- Hepatocellular Carcinoma Treatment and Prognosis
- Cancer Mechanisms and Therapy
- Immune cells in cancer
- Biochemical Analysis and Sensing Techniques
- Electronic and Structural Properties of Oxides
- Vascular Malformations Diagnosis and Treatment
- Stroke Rehabilitation and Recovery
- Dermatology and Skin Diseases
- Phytochemistry and biological activity of medicinal plants
- Heavy Metals in Plants
- Inflammation biomarkers and pathways
- Gut microbiota and health
- Sports injuries and prevention
- Alzheimer's disease research and treatments
Beijing University of Chinese Medicine
2022-2025
Third Affiliated Hospital of Southern Medical University
2024-2025
People's Liberation Army Air Force
2024-2025
Xijing Hospital
2025
Air Force Medical University
2025
East China University of Science and Technology
2022-2024
Chengdu Medical College
2024
North Sichuan Medical University
2024
Guangzhou Medical University
2023
Chinese People's Liberation Army
2022
Following traumatic brain injury (TBI), inhibition of the Na+-K+-Cl- cotransporter1 (NKCC1) has been observed to alleviate damage blood-brain barrier (BBB). However, underlying mechanism for this effect remains unclear. This study aimed investigate mechanisms by which inhibiting NKCC1 attenuates disruption BBB integrity in TBI. The TBI model was induced C57BL/6 mice through a controlled cortical impact device, and an vitro established using Transwell chambers. Western blot (WB) analysis used...
Defective carbon nitride enables the efficient visible-light photoreduction of CO 2 by optimizing its band structure, electronic and reducing reaction energy through defect-induced modifications.
Purinergic ligand-gated ion channel 7 receptor (P2X7R) is an ATP-gated cationic channel. It plays important role in central nervous system diseases such as cerebral hemorrhage and Parkinson's disease, closely related to neuroinflammatory reactions associated with disease progression. In the present study, we evaluated of P2X7R neuroinflammation brain edema after traumatic injury (TBI). We also investigated mechanisms potential therapeutic drugs. vivo experiments, C57BL/6 mice were randomly...
Background: Neuroinflammation is the pathological basis of many neurological diseases, including neurodegenerative diseases and stroke. Hua-Feng-Dan (HFD) a well-established traditional Chinese medicine that has been used for centuries to treat stroke various other brain-related ailments. Objective: Our study aims elucidate molecular mechanism by which HFD mitigates neuroinflammation combining network pharmacology in vitro experiments. Methods: TCMSP SymMap databases were extract active...
The relationship between the brain and fatigue is gaining increasing attention, with numerous studies indicating that certain specific regions may be closely linked to fatigue. Our study aimed identify exhibiting significant causal relationships discover potential neurotherapeutic targets associated fatigue, in pursuit of seeking new approaches for treatment. A bidirectional two-sample Mendelian randomization (TSMR) method was employed investigate cortical subcortical gray matter volumes 83...
Rationale: Damage to white matter and myelin poses a significant challenge neurological recovery in the chronic phase of intracerebral hemorrhage (ICH). The repair damage post-ICH largely depends on activation differentiation oligodendrocyte precursor cells (OPCs) into oligodendrocytes, process that is significantly influenced by inflammatory microenvironment. Lipocalin-2 (Lcn2) regulate phenotypic transformation microglia thus modulates inflammation. However, exact role Lcn2 facilitating...
Background: Glioma is globally recognised as one of the most frequently occurring primary malignant brain tumours, making identification glioma biomarkers critically significant. The protein KIF18A (Kinesin Family Member 18A) a member kinesin superfamily microtubule-associated molecular motors and has been shown to participate in cell cycle mitotic metaphase anaphase. This first investigation into expression its prognostic value, potential biological functions, effects on immune system...
Abstract Objective The purpose of this study was to identify significant prognostic factors associated with facial paralysis after vestibular schwannoma (VS) surgery and develop a novel nomogram for predicting nerve (FN) outcomes. Methods Retrospective data were retrieved from 355 patients who underwent microsurgery via the retrosigmoid approach VS between December 2017 2022. Univariate multivariate logistic regression analysis used construct radiographic features‐based predict risk surgery....
There is yet no effective drug for Alzheimer’s disease (AD) which one of the world’s most common neurodegenerative diseases. The Qin-Zhi-Zhu-Dan Formula (QZZD) derived from a widely used Chinese patent drug–Qing-Kai-Ling Injection. It consists Radix Scutellariae , Fructus Gardeniae and Pulvis Fellis Suis . Recent study showed that QZZD its components played important roles in anti-inflammation, antioxidative stress preventing brain injury. was noted had protective effects on brain, but...
Vestibular schwannoma (VS) is the most common benign tumor of posterior fossa. The recurrence VS has always received widespread attention. This study aimed to develop a nomogram predict Recurrence-free survival (RFS) following resection VS.A total 425 patients with who underwent at Department Neurosurgery in Chinese PLA General Hospital between January 2014 and December 2020 were enrolled this retrospective study. medical records follow-up data collected. Cox regression analysis was used...
Background: Qinzhi Zhudan Formula (QZZD), optimized from Angong Niuhuang Wan, consists of Radix Scutellariae, Fructus Gardeniae and Pulvis Fellis Suis. We had investigated the neuroprotective effects QZZD its active components, demonstrated that it could treat cerebral ischemia dementia through multiple pathways mechanisms. Nevertheless, toxicological data on this formula still remains limited. In study, we sought to examine during treatment recovery periods. Methods: potential toxicities in...
Abstract Many clinical studies have demonstrated a correlation between psoriasis vulgaris and dementia, yet this remains controversial. Our study employed the Mendelian randomization (MR) method to investigate causal relationship dementia. Data were obtained from summary statistics of genome‐wide association IEU‐OpenGWAS project database. In univariate (UVMR) analysis, was used as exposure. Alzheimer disease (AD), vascular dementia (VaD), with Lewy bodies (DLB), Parkinson's (PDD)...
We report 26 cases of eye injuries resulting from cobra venom sprayed by Naja atra. This accounts for 14.5% patients (26/173) treated who presented to the emergency department a snakebite treatment center in Guangzhou, South China. Pain, blurred vision, lacrimation, photophobia, and foreign body sensation were most common symptoms, found 24 patients. Ophthalmic examination revealed eyelid swelling conjunctival congestion. Eye slit lamp showed obvious punctate corneal epithelial defects four...
Based on the theory of consolidating root and cultivating primary, paper collates reviews theoretical evidences characteristics Xin'an medical masters in treatment bi syndrome with acupuncture moxibustion so as to provide ideas for further research. thoroughly acquainted primary moxibustion, emphasizing regulation qi blood, yin yang, nutrient defensive qi; replenishing middle jiao (spleen stomach) lower (kidney). The acupoint selection was distinctive, which, acupoints were selected...
Ethnopharmacological relevance: Qinzhizhudan Formula (QZZD) is composed of Scutellaria baicalensis Georgi (Huang Qin) extract, Gardenia jasminoides (Zhizi) extract and Suis Fellis Pulvis (Zhudanfen) (ratio 10:6:1.5). This formula optimized from Qingkailing (QKL) injection. Regarding brain injury, QZZD protective. However, the mechanism by which treats vascular dementia (VD) has not been elucidated.Aim studyTo ascertain QZZD's effect on treatment VD further investigate molecular...
Hepatocellular carcinoma (HCC) is one of the most common and malignant tumor with poor prognosis in world. Most HCC patients were diagnosed progressive stage, especially portal vein thrombus (PVTT), a median survival time (MST) 2.7 months (1). According to Barcelona Clinic Liver Cancer (BCLC) treatment guidelines, Sorafenib recommended as first-line PVTT (2). However, effect limited. Studies have shown that MST using only 5.5 months, accompanied many side effects, life quality non-ideal (3)....