- Plant Pathogens and Fungal Diseases
- Endoplasmic Reticulum Stress and Disease
- melanin and skin pigmentation
- Fungal Plant Pathogen Control
- Autophagy in Disease and Therapy
- Microtubule and mitosis dynamics
- Hippo pathway signaling and YAP/TAZ
- Caveolin-1 and cellular processes
- Cardiac Ischemia and Reperfusion
- Cellular Mechanics and Interactions
- Renal Diseases and Glomerulopathies
- Mitochondrial Function and Pathology
- Plant-Microbe Interactions and Immunity
- Horticultural and Viticultural Research
- Immune Cell Function and Interaction
- Mycorrhizal Fungi and Plant Interactions
- Powdery Mildew Fungal Diseases
- Bioactive natural compounds
- Pancreatic function and diabetes
- Axon Guidance and Neuronal Signaling
- Adenosine and Purinergic Signaling
- Quinazolinone synthesis and applications
- Acne and Rosacea Treatments and Effects
- Ferroptosis and cancer prognosis
- RNA regulation and disease
First Affiliated Hospital of Wenzhou Medical University
2021-2025
Wenzhou Medical University
2021-2025
Jiangsu University
2022-2023
Institute of Plant Protection
2023
Guizhou University
2023
Heilongjiang University of Chinese Medicine
2022-2023
Beijing Academy of Agricultural and Forestry Sciences
2023
Shanghai University of Traditional Chinese Medicine
2022
Beijing Radiation Center
2022
Hebei University of Technology
2022
Rationale: Optic neuritis is one of main symptoms in multiple sclerosis (MS) that causes visual disability. Astrocytes are pivotal regulators neuroinflammation MS, and astrocytic yes-associated protein (YAP) plays a critical role neuroinflammation. Meanwhile, YAP signaling involved impairment, including glaucoma, retinal choroidal atrophy detachment. However, the roles underlying mechanisms demyelination MS-related optic (MS-ON) remains unclear. Methods: To assess functions MS-ON,...
Background . Heat shock protein 70 (Hsp70) has been shown to exert cardioprotection. Intracellular calcium ([Ca 2+ ] i ) overload induced by p38 mitogen-activated kinase (p38 MAPK) activation contributes cardiac ischemia/reperfusion (I/R) injury. However, whether Hsp70 interacts with MAPK signaling is unclear. Therefore, this study investigated the regulation of in I/R-induced Methods Neonatal rat cardiomyocytes were subjected oxygen-glucose deprivation for 6 h followed 2 reoxygenation...
Endoplasmic reticulum stress (ERS)-mediated myocardial inflammation and apoptosis plays an important role in ischemia/reperfusion (I/R) injury. Dexmedetomidine has been used clinically with sedative, analgesic, anti-inflammatory properties. This study aimed to determine the effects of dexmedetomidine pretreatment on inflammation, apoptosis, expression ERS signaling during I/R injury.Rats underwent ischemia for 30 min reperfusion 6 h, H9c2 cardiomyocytes were subjected oxygen-glucose...
Grapevine trunk diseases (GTDs) are disease complexes that major threats to viticulture in most grapevine growing regions. The microbiomes colonizing plant belowground components form complex associations with plants, play important roles promoting productivity and health natural environments, may be related GTD development. To investigate between fungal communities symptomatic or asymptomatic grapevines, associated three soil-plant compartments (bulk soils, rhizospheres, roots) were...
Hepatocellular carcinoma development is closely related to the changes in tissue mechanics induced by excess collagen deposition and crosslinking, which leads liver fibrosis malignant progression. The role of matrix stiffness has been widely assessed using various linearly elastic materials. However, liver, like many soft tissues, also exhibits nonlinear elasticity strain-stiffening, allowing cells mechanically interact with their micromilieus attracted much attention cellular processes...
Abstract Background: Tinengotinib is a novel multi-kinase inhibitor that targets cell proliferation, angiogenesis, and immune-oncology pathways by inhibiting Aurora kinases A/B, Janus (JAK) receptor tyrosine (FGFRs VEGFRs). Here we present the safety pharmacokinetics (PK) of tinengotinib monotherapy in different doses dosing schedules from multicenter, open label phase Ib/II study patients (pts) with advanced solid tumors. Methods: Eligible pts received Arm A (12 mg once daily (QD)) C QD 5,...
Ischemia-reperfusion (IR) injury often affects transplant and native kidneys alike. IR is one of the main causes acute kidney (AKI) further associated with progression chronic disease. Our previous study revealed renoprotection erythropoietin derived cyclic helixB surface peptide (CHBP) against injury. However, precise role underlying mechanism endoplasmic reticulum stress (ERS) in induced by or CHBP respectively have not been fully defined. This using mouse epithelial cells (TCMK-1) that...
Background: Glioma is globally recognised as one of the most frequently occurring primary malignant brain tumours, making identification glioma biomarkers critically significant. The protein KIF18A (Kinesin Family Member 18A) a member kinesin superfamily microtubule-associated molecular motors and has been shown to participate in cell cycle mitotic metaphase anaphase. This first investigation into expression its prognostic value, potential biological functions, effects on immune system...
Abstract T cells synthesize a large number of proteins during their development, activation, and differentiation. The build‐up misfolded unfolded in the endoplasmic reticulum, however, causes reticulum (ER) stress. Thus, can maintain ER homeostasis via reticulum‐associated degradation, protein response, autophagy. In cell‐mediated diseases, such as rheumatoid arthritis, systemic lupus erythematosus, Sjogren's syndrome, type 1 diabetes vitiligo, stress caused by changes internal...
Background. Vitamin D can play a vital role in autoimmune diseases. Epidemiologic evidence demonstrates vitamin deficiency excited adult patients with vitiligo. Objectives. To investigate 25-hydroxyvitamin (25(OH)D) levels children vitiligo and explore possible relevant factors. Methods. A total of 114 100 controls were included our case-control study. We analyzed the required data collected by questionnaire examination to reveal correlation 25(OH)D levels. Results. The mean serum 43.62 ±...
Pitaya, or dragon fruit, is a typical tropical fruit with an appealing taste and diverse health benefits to humans. The plantation of pitaya in Guizhou province China has greatly boosted the income local farmers alleviated poverty. However, frequent occurrence postharvest diseases brought large economic loss. To find solution, we set out identify disease-causing agents pitaya. Several fungi were isolated from diseased identified as species based on ITS1 sequence similarity. Of them,...
3090 Background: TT-00420 is a spectrum-selective multi-kinase inhibitor that targets cell proliferation, angiogenesis, and immune-oncology pathways by inhibiting Aurora kinases A/B Janus (JAK) involved in cytokine signaling receptor tyrosine (FGFRs VEGFRs) the tumor microenvironment. has demonstrated anti-tumor activity both vitro vivo preclinical models of solid tumors, including triple-negative breast cancer (TNBC) cholangiocarcinoma (CCA). Methods: The phase I, first-in-human dose...
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Farfugium japonicum (L.) Kitam (with the common name leopard plant) is known as a garden and medical herb, belongs to family Asteraceae. In May 2019, leaf spot disease was observed on upper surface of F. in Changsha city, Hunan province, China. More than 98% plants were infected Donghu district (28°13' N; 112°56' E). Leaf symptoms included small (1 10 mm diameter), brown spots that circular, tan gray center distinct brownish-yellow margins. Severely affected leaves blighted dying. For...
Fraxinus rhynchophylla Hance, is a deciduous trees cultivated on commercial scale focused medicinal and wood production. In September 2021, leaf spot was observed F. in Heilongjiang Province (127.34°E, 45.19°N), China. These symptoms were 100% plants the incidence of diseased leaves per plant reached 70% fields measuring 90 ha. Disease small yellow flecks initially, then turned to gray necrotic spot. Ten collected randomly from 5 surface disinfested. Tissue samples (2 × 2 mm) cut at...