A5036233323- Immune Cell Function and Interaction
- Immunotherapy and Immune Responses
- T-cell and B-cell Immunology
- Cancer-related molecular mechanisms research
- RNA modifications and cancer
- Epigenetics and DNA Methylation
- MicroRNA in disease regulation
- Cancer Immunotherapy and Biomarkers
- Circular RNAs in diseases
- RNA Research and Splicing
- Histone Deacetylase Inhibitors Research
- Immune Response and Inflammation
- Ubiquitin and proteasome pathways
- Nanocluster Synthesis and Applications
- Immune cells in cancer
- Cancer-related gene regulation
- interferon and immune responses
- RNA Interference and Gene Delivery
- Carbon and Quantum Dots Applications
- CAR-T cell therapy research
- Prion Diseases and Protein Misfolding
- Cancer Genomics and Diagnostics
- Renal and related cancers
- Antibiotic Resistance in Bacteria
- Virus-based gene therapy research
Jiangsu University
2016-2025
Anyang Eye Hospital
2025
Jiangsu Vocational College of Medicine
2021-2023
First People's Hospital of Kunshan
2023
Jiangsu University of Science and Technology
2017-2021
Zhanjiang Experimental Station
2016
University of Chinese Academy of Sciences
2012
Institute of Computing Technology
2012
Binzhou Medical University
2012
Affiliated Hospital of Jiangsu University
2011-2012
The functional state of T cells is a key determinant for effective antitumor immunity and immunotherapy. Cellular metabolism, including lipid controls cell differentiation, survival, effector functions. Here, we report that development senescence driven by both malignant tumor regulatory general feature in cancers. Senescent have active glucose metabolism but exhibit unbalanced metabolism. This results changes expression metabolic enzymes, which, turn, alters species accumulation droplets...
More and more evidences demonstrate that the long non-coding RNAs (lncRNAs) play many key roles in diverse biological processes. There is a critical need to annotate functions of increasing available lncRNAs. In this article, we try apply global network-based strategy tackle issue for first time. We develop bi-colored network based function predictor, RNA predictor ('lnc-GFP'), predict probable lncRNAs at large scale by integrating gene expression data protein interaction data. The...
Carbon quantum dots (CDs) are promising nanomaterials in biomedical, photocatalytical and photoelectronic applications. However, determining how to explore an ideal precursor for a renewable carbon resource is still interesting challenge. Here, the first time, we report that wastes of bagasse as new were prepared fluorescent CDs by hydrothermal carbonization (HTC) process. The characterization results show such bagasse-derived monodispersed, contain quasi spherical particles with diameter...
T helper 17(Th17) cell is a new subset of CD4+ cells that produce proinflammatory cytokine interleukin-17 (IL-17). Th17 have recently been shown to play critical role in many autoimmune diseases had previously thought be Th1 dominant. Although Hashimoto's thyroiditis (HT) was Th1-type disease, the contributions pathogenesis remain unclear. In this study, we investigated expression levels Th1/Th17 cell-associated factors peripheral blood mononuclear (PBMC) and plasma from patients with HT by...
Doping carbon dots with nitrogen atoms considerably enhances their fluorescence properties. However, the mechanism by which are doped is not fully understood. We developed a facile bottom-up hydrothermal carbonization (HTC) process that uses glucose and glycine as precursors for synthesis of photoluminescent nitrogen-doped dots. The as-prepared were mono-dispersed spherical particles diameter -2.8 nm. assumed pyridinic type pyrrolic configurations to participate in nanocrystal structure It...
Abstract Metabolic disorder is one of the hallmarks cancers, and reprogramming metabolism becoming a novel strategy for cancer treatment. Citrate key metabolite critical metabolic regulator linking glycolysis lipid in cellular energy homeostasis. Here it reported that citrate treatment (both sodium citric acid) significantly suppresses tumor cell proliferation growth various types. Mechanistically, promotes excessive biosynthesis induces disruption cells, resulting senescence inhibition....
Background Recent studies have shown that systemic inflammation responses and hyperventilation are associated with poor outcomes in patients severe traumatic brain injury (TBI). The aim of this retrospective study was to investigate the relationships between immune index (SII = platelet × neutrophil/lymphocyte) peripheral blood CO 2 concentration at admission Glasgow Outcome Score (GOS) 6 months after discharge TBI. Methods We retrospectively analyzed clinical data for 1266 TBI three large...
Small cell lung cancer (SCLC) accounts for nearly 15% of human cancers and is one the most aggressive solid tumors. The SCLC cells are thought to derive from self-renewing pulmonary neuroendocrine by oncogenic transformation. However, whether possess stemness plasticity differentiation as normal stem has not been well understood thus far. In this study, we investigated expressions multilineage markers in line (NCI-H446) analyzed their clonogenicity, tumorigenicity, inducing differentiation....
Abstract AMPK is a serine/threonine protein kinase that acts as positive regulator of autophagy, by phosphorylating ULK1 at specific sites. A previous study demonstrated activation the macroautophagic system in scrapie-infected experimental rodents and certain human prion diseases, which essential negative mTOR severely inhibited. In this study, brains hamsters infected with scrapie strain 263 K cell line SMB-S15 were analysed. The results showed an up-regulated trend AMPK-Thr172,...
Type 2 diabetes mellitus (T2DM) is a leading cause of blindness, non-traumatic amputation and end-stage renal disease, as well major cardiovascular risk factor. To determine whether miR-125b miR-34a serve an important role in the development T2DM, current study investigated expression profile two microRNAs (miR-34a miR-125b) their relative genes peripheral blood mononuclear cells from 73 patients with T2DM 52 healthy donors by reverse transcription-quantitative polymerase chain reaction In...
The role of integrons in the spread antibiotic resistance has been well established. aim this study was to investigate profiles Pseudomonas aeruginosa isolated from patients Zhenjiang 13 antibiotics, and identify structure dissemination class 1 integrons.The Kirby-Bauer disk diffusion assay used determine rate P. resistance. Class multidrug-resistant isolates were amplified by PCR, their PCR products sequenced. We also analyzed integron structures containing same gene cassettes restriction...
Photoluminescent carbon dots (CDs) with graphite-like phase structure have been widely reported. Herein, we first report nitrogen-doped (NCDs) heterogeneous multi-layered structures by bottom-up hydrothermal carbonization process. The formation and surface passivation of NCDs was accomplished simultaneously. as-prepared possess stable photoluminescence, solubility in water various functional groups on their surface. XRD results clearly showed that there were two kinds interlayer lattice...
Abstract Epigenetic abnormalities play a vital role in the progression of ovarian cancer. Lysine-specific demethylase 1 (LSD1/KDM1A) acts as an epigenetic regulator and is overexpressed tumors. However, upstream LSD1 expression this cancer remains elusive. Here, we show that epidermal growth factor (EGF) signaling upregulates protein levels SKOV3 HO8910 cells overexpressing both EGF receptor. This effect correlated with decrease dimethylation H3K4, major substrate LSD1, LSD1-dependent...
Microbiota and its induced inflammation in colorectal mucosa have been considered risk factors for the development of carcinogenesis. Previous studies demonstrated that coexisting elements microbiota gut, such as short chain fatty acids (SCFAs) lipopolysaccharides (LPS), which exhibited regulatory effects on intestinal epithelial cells individually. Unfortunately, association between butyrate toll-like receptor (TLR) signaling pathway colon cancer is not fully elucidated. In present study,...
The vacuolar H+-ATPase (V-ATPase) is commonly highly activated in cancer cells and a potential target of anti-cancer therapy. Bafilomycin A1 specific inhibitor the c subunit V-ATPase. In present study, effects bafilomycin on BEL-7402 hepatocellular carcinoma HO-8910 ovarian cell lines were respectively studied. addition, A1-induced alterations mRNAs microRNAs (miRNAs) detected using microarray methods. results demonstrated that growth two was retarded metastatic inhibited by A1. Transmission...
Abstract Epithelial ovarian carcinoma (EOC) is the most lethal gynecologic malignancy. However, molecular mechanisms remain unclear. In this study, we found that miR-146b was downregulated in EOC and its expression level negatively correlated with pathological staging. Follow-up functional experiments illustrated overexpression of significantly inhibited cell migration invasion, increased proliferation, but it also improved response to chemotherapeutic agents. Mechanistically, demonstrated...