A5005294787- Acute Kidney Injury Research
- Parathyroid Disorders and Treatments
- Renal Diseases and Glomerulopathies
- Dialysis and Renal Disease Management
- Chronic Kidney Disease and Diabetes
- Genetic Syndromes and Imprinting
- Cardiac Arrest and Resuscitation
- Blood Pressure and Hypertension Studies
- Vasculitis and related conditions
- Trauma, Hemostasis, Coagulopathy, Resuscitation
- Cardiac, Anesthesia and Surgical Outcomes
- Mechanical Circulatory Support Devices
- Sepsis Diagnosis and Treatment
- Hemodynamic Monitoring and Therapy
- Cancer Immunotherapy and Biomarkers
- Vitamin D Research Studies
- Thyroid and Parathyroid Surgery
- Nutrition and Health in Aging
- Body Composition Measurement Techniques
- Renal cell carcinoma treatment
- Cardiac Structural Anomalies and Repair
- Magnesium in Health and Disease
- Trauma and Emergency Care Studies
- Nutritional Studies and Diet
- Metabolism, Diabetes, and Cancer
Jiangsu Province Hospital
2016-2025
Nanjing Medical University
2016-2025
Ningbo No. 2 Hospital
2025
Changzhou No.2 People's Hospital
2024
Northwest Women's and Children's Hospital
2024
First Affiliated Hospital of Soochow University
2023
Soochow University
2023
Hangzhou Hospital of Traditional Chinese Medicine
2019-2022
Zhejiang University of Technology
2021
Pediatric Nephrology of Alabama
2013-2017
The previously published "Dose Response Multicentre International Collaborative Initiative (DoReMi)" study concluded that the high mortality of critically ill patients with acute kidney injury (AKI) was unlikely to be related an inadequate dose renal replacement therapy (RRT) and other factors were contributing. This follow-up aimed investigate impact daily fluid balance accumulation on without AKI (N-AKI), RRT (AKI-RRT) receiving adequate RRT.We prospectively enrolled all consecutive...
Importance Despite the expansion of published electronic alerts for acute kidney injury (AKI), there are still concerns regarding their effect on clinical outcomes patients. Objective To evaluate AKI alert combined with a care bundle and patients hospital-acquired AKI. Design, Setting, Participants This single-center, double-blind, parallel-group randomized trial was conducted in tertiary teaching hospital Nanjing, China, from August 1, 2019, to December 31, 2021. The inclusion criteria were...
// Chuanyan Zhao 1, * , Zhuyun Chen Jia Qi 2 Suyan Duan 1 Zhimin Huang Chengning Zhang Lin Wu Ming Zeng Bo Ningning Wang Huijuan Mao Aihua 3, 4 Changying Xing Yanggang Yuan Department of Nephrology, the First Affiliated Hospital Nanjing Medical University, Nanjing, China Pharmacy, Xinhua to Shanghai Jiaotong University School Medicine, Shanghai, 3 Children's Hospital, Institute Pediatrics, These authors are contributed equally this work Correspondence to: Yuan, email: ygyuan@njmu.edu.cn...
Background/Aims: Cisplatin is widely used to treat malignancies. However, its major limitation the development of dose-dependent nephrotoxicity. The precise mechanisms cisplatin-induced kidney damage remain unclear. Previous study demonstrated central role mitochondrial ROS (mtROS) in pathogenesis cisplatin purpose this was explore mechanism mtROS regulation Methods: p53, MnSOD and p66shc were detected at mRNA protein levels by qPCR western blot HK2 cells. determined DCFDA MitoSOX staining....
Glucocorticoids (GCs) are commonly used in the treatment of nephrotic syndrome. However, high doses and long periods GC therapy can result severe side effects. The present study aimed to selectively deliver albumin‑methylprednisolone (MP) nanoparticles towards glomerular podocytes, which highly express specific neonatal Fc receptor (FcRn) albumin. Bovine serum albumin (BSA) was labeled with a fluorescent dye linked modified MP via an amide bond. outcome nanoparticle named BSA633‑MP showed...
Parathyroidectomy (PTX) is an effective treatment for severe secondary hyperparathyroidism (SHPT); however, persistent SHPT may occur because of supernumerary and ectopic parathyroids. Here a diagnostic accuracy study intraoperative perioperative serum intact parathyroid hormone (iPTH) was performed to predict successful surgery in 501 patients, who received total PTX + autotransplantation without thymectomy. Serum iPTH values before incision (io-iPTH0), 10 20 min after removing the last...
Objective: To determine the relationship between obesity and risk of AKI after cardiac surgery (CS-AKI) in a cohort study. Methods: A total 1,601 patients undergoing were collected their incidence CS-AKI recorded. They divided into underweight, normal weight, overweight, obese groups. Logistic regression was used to estimate association BMI (body mass index) risk. Then meta-analysis published studies conducted confirm this result using PubMed Embase databases. Results: significant observed...
Abstract Long‐term peritoneal dialysis is accompanied by functional and histopathological alterations in the membrane. In long process of dialysis, high‐glucose solution (HGPDS) will aggravate fibrosis, leading to decreased effectiveness ultrafiltration failure. this study, we found that coincidence elevated TGF‐β1 expression, autophagy, apoptosis fibrosis membrane from patients with dialysis. The membranes were performed immunocytochemistry transmission electron microscopy. Human...
Acute kidney injury (AKI) places a heavy burden on the healthcare system in China and is usually misdiagnosed. However, there are limited studies that have described epidemiology diagnosis of AKI China. The aim this study was to describe incidence hospitalized adult patients tertiary teaching hospital southeast All from October 1, 2013 September 30, 2014 First Affiliated Hospital Nanjing Medical University were screened using Lab Administration Network. definition staging based KDIGO...
Objective To investigate the effects of coupled plasma filtration adsorption (CPFA) on immune function patients with multiple organ dysfunction syndrome (MODS). Methods This study was a prospective, pilot, before-and-after self-crossover, clinical trial. Seven diagnosed MODS and severe infection were randomly allocated to both 10 hours CPFA high-volume hemofiltration (HVHF) 12-hour interval in random order. Serum concentrations 7 cytokines including tumor necrosis factor-α (TNF-α),...
Haff disease, first identified in Europe, is unexplained rhabdomyolysis a person who ingested fish within the 24 hours before onset of illness. Cases disease after consumption fresh water have never been reported China but frequently from Baltic region. We describe five cases muscle weakness and that occurred eating crayfish discuss different epidemiologic etiologic aspects this disease.
To investigate the role and possible mechanism of α-Klotho in calcification osteogenic transition cultured VSMCs.VSMCs were vitro divided into 5 groups, each using a different medium: (1) control; (2) β-GP; (3) β-GP + Klotho; (4) LiCl; (5) Klotho LiCl. Calcium deposits visualized Alizarin Red S staining. The calcium concentrations determined by o-cresolphthalein complexone method. BMP2, Runx2 β-catenin levels estimated western blotting, level α-SMA was immunofluorescence at day 12.β-GP...
Significance Statement Activation of the type 1 IL-1 receptor (IL-1R1) triggers a critical innate immune signaling cascade that contributes to pathogenesis AKI. However, blockade in AKI has not consistently demonstrated kidney protection. The current murine experiments show IL-1R1 activation proximal tubule exacerbates toxin-induced and cell death through local suppression apolipoprotein M. By contrast, endothelial cells ameliorates by restoring VEGFA-dependent viability. Using this...
No drug has been shown to be effective in preventing cardiac surgery-associated acute kidney injury (CSA-AKI). In different clinical settings, sodium-glucose transporter 2 (SGLT2) inhibitors confer renal protection and may promising candidates. We examined the association between preoperative dapagliflozin use incidence prognosis of CSA-AKI. Data were obtained for consecutive patients undergoing surgery with cardiopulmonary bypass December 2020 November 2022 at a large teaching hospital...
Acute kidney injury (AKI) is often associated with oxidative stress, which leads to a range of pathological changes, including inflammation and cell apoptosis. These mechanisms highlight the crucial role eliminating ROS in pathogenesis AKI. This study presented ROS-activated drug delivery system, NPSPBA@Hib, designed for targeted anti-inflammatory antioxidant hibifolin (Hib) kidneys, marking its inaugural application AKI therapy. The loading Hib was up be 15% by conversely binding...
Kidney fibrosis is the final pathological outcome of progressive chronic kidney disease (CKD). The unilateral ureteral obstruction (UUO) model widely used to elucidate molecular and cellular mechanisms underlying interstitial identify potential therapeutic targets. This established in mice through surgical ligation a ureter, procedure that relatively straightforward easy perform. However, UUO mouse known exhibit significant variability inconsistency, influenced by factors such as strain,...