A5085667848- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Inflammatory Myopathies and Dermatomyositis
- Sarcoidosis and Beryllium Toxicity Research
- Rheumatoid Arthritis Research and Therapies
- Systemic Sclerosis and Related Diseases
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Gout, Hyperuricemia, Uric Acid
- Eosinophilic Disorders and Syndromes
- Monoclonal and Polyclonal Antibodies Research
- Salivary Gland Disorders and Functions
- Systemic Lupus Erythematosus Research
- Urticaria and Related Conditions
- Telomeres, Telomerase, and Senescence
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Case Reports on Hematomas
- Musculoskeletal Disorders and Rehabilitation
- Asthma and respiratory diseases
- Drug-Induced Ocular Toxicity
- Drug-Induced Hepatotoxicity and Protection
- Ocular Diseases and Behçet’s Syndrome
- Vasculitis and related conditions
- Spondyloarthritis Studies and Treatments
- Traumatic Ocular and Foreign Body Injuries
- Oral Health Pathology and Treatment
- Salivary Gland Tumors Diagnosis and Treatment
Assistance Publique – Hôpitaux de Paris
2015-2025
Brigham and Women's Hospital
2023-2025
Université Paris Cité
2014-2025
Inserm
2017-2025
Hôpital Bichat-Claude-Bernard
2015-2025
Université Claude Bernard Lyon 1
2017-2025
Physiopathologie et Epidémiologie des Maladies Respiratoires
2021-2024
Hôpital Lapeyronie
2024
Sorbonne Paris Cité
2014-2024
Harvard University
2023-2024
Given the phenotypic similarities between rheumatoid arthritis (RA)–associated interstitial lung disease (ILD) (hereafter, RA-ILD) and idiopathic pulmonary fibrosis, we hypothesized that strongest risk factor for development of gain-of-function MUC5B promoter variant rs35705950, would also contribute to ILD among patients with RA.
Despite its high prevalence and mortality, little is known about the pathogenesis of rheumatoid arthritis-associated interstitial lung disease (RA-ILD). Given that familial pulmonary fibrosis (FPF) RA-ILD frequently share usual pattern pneumonia common environmental risk factors, we hypothesised two diseases might additional including FPF-linked genes. Our aim was to identify coding mutations FPF-risk genes associated with RA-ILD.We used whole exome sequencing (WES), followed by restricted...
Patients at high risk of rheumatoid arthritis-associated interstitial lung disease (RA-ILD) would benefit from being identified before the onset respiratory symptoms; this can be done by screening patients with use chest high-resolution computed tomography (HRCT). Our objective was to develop and validate a score for who have subclinical RA-ILD.
To examine the course of interstitial lung disease associated with rheumatoid arthritis (RA-ILD) in France on treatment Janus kinase inhibitors (JAKis) using MAJIK-SFR registry. Prospective national multicentre observational study identifying patients RA-ILD from Pulmonary assessment data were collected at JAKi initiation and follow-up visits (6 months, 12 months a median 21 postinclusion), including chest high-resolution CT (HRCT), pulmonary function tests (forced vital capacity (FVC)...
Background: Risk factors and screening strategies for rheumatoid arthritis-associated interstitial lung disease (RA-ILD) have received limited evaluation in patients with early RA. We investigated RA-ILD prevalence, risk factors, the performance of proposed methodologies a multicenter, prospective study Methods: Participants RA, defined as being within two years RA diagnosis, were enrolled at five US sites assessed high-resolution computed tomography (HRCT) chest imaging, pulmonary function...
Regulator of telomere length 1 ( RTEL1 ) mutations have been evidenced in 5–9% familial pulmonary fibrosis; however, the phenotype patients with interstitial lung disease (ILD) and is poorly understood. Whole exome sequencing was performed 252 probands ILD we included all mutation. expression evaluated by immunochemistry lungs controls, as well telomerase reverse transcriptase TERT mutation carriers. We identified 35 subjects from 17 families. Median age at diagnosis 53.1 years (range...
Shortened telomere lengths (TLs) can be caused by single nucleotide polymorphisms and loss-of-function mutations in telomere-related genes (TRG), as well ageing lifestyle factors such smoking. Our objective was to determine if shortened TL is associated with interstitial lung disease (ILD) individuals rheumatoid arthritis (RA). This the largest study demonstrate replicate that peripheral blood leukocytes-TL ILD patients RA compared without a multinational cohort, short PBL-TL baseline...
Myositis associated interstitial lung disease (ILD) seems to be an under-recognized entity. In this multicenter, retrospective study, we recorded between 9/12/2019 and 30/9/2021 consecutive patients who presented in five different ILD centers from two European countries (Greece, France) received a multidisciplinary diagnosis of myositis associated-ILD. The primary outcome was all-cause mortality over 1 year specific subgroups patients. Secondary outcomes included comparison characteristics...
The incorporation of machine learning is becoming more prevalent in the clinical setting. By predicting outcomes, can provide clinicians with a valuable tool for refining precision medicine approaches and improving treatment outcomes. This was post hoc analysis pooled patient-level data from global, real-world ACTION ASCORE trials patients rheumatoid arthritis (RA) initiating abatacept. Patient demographic disease characteristics were input across 10 models used to predict 12-month...
Inflammatory lung disease in Still's (SD) has recently been described. Among its manifestations, pulmonary arterial hypertension (PAH) is a rare and life-threatening event, with only few case reports published. The objective was to report the largest adult cohort of PAH occurring context SD. We identified 16 SD patients (PAH+) by call for observations from CRI-IMIDIATE (Club Rhumatismes & Inflammation - Immune-Mediated Disease Alliance Translational Clinical Research) network...
Objectives Interstitial lung disease (ILD) is a severe extra-articular manifestation of rheumatoid arthritis (RA). The objectives this study were to estimate mortality rate in patients with RA-ILD and identify factors affecting mortality. Methods Data from French national claims database (Système National des Données de Santé) 2013 2018 analysed. Adults an RA diagnosis (International Classification Diseases (ICD)-10 codes M05, M06.0, M06.8 M06.9) included. ILD was defined ICD-10 code J84....
Rheumatoid arthritis-associated interstitial lung disease (RA-ILD) includes multiple subtypes with varying histopathology, prognosis, and potential treatments. Limited research has investigated risk factors for different RA-ILD subtypes. Therefore, we examined demographic, serologic, lifestyle associations
Interstitial lung disease (ILD) is a common complication of rheumatoid arthritis (RA) usually diagnosed with high-resolution CT (HRCT), but emerging data suggest the interest ultrasonography (LUS) for screening RA-ILD. This study aimed to determine ability LUS screen ILD in RA. was an observational monocenter RA patients. All patients underwent pulmonary and rheumatology clinical evaluation, immunology screening, HRCT LUS, function tests (PFTs). US assessment occurred same day as HRCT,...